Gene Symbol: unc-13
Description: unc-13
Alias: CG2999, DUNC-13, Dmel\CG2999, Dunc-13, Dunc13, Munc-13, Munc-13/UNC-13, UNC-13, UNC-13-B, Unc-13, dUNC-13, dUnc-13, drunc13, dunc-13, l(4)ry16, unc, unc-13, CG2999-PA, CG2999-PB, CG2999-PC, CG2999-PD, CG2999-PE, CG2999-PF, CG2999-PG, lethal (4) ry16, unc-13-PA, unc-13-PB, unc-13-PC, unc-13-PD, unc-13-PE, unc-13-PF, unc-13-PG, uncoordinated-13
Species: fruit fly

Top Publications

  1. Jepson J, Savva Y, Yokose C, Sugden A, Sahin A, Reenan R. Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets. J Biol Chem. 2011;286:8325-37 pubmed publisher
    ..Our data demonstrate that network-wide temporal and spatial regulation of ADAR activity can tune the complex system of RNA-editing sites and modulate multiple ethologically relevant behavioral modalities. ..
  2. Aravamudan B, Fergestad T, Davis W, Rodesch C, Broadie K. Drosophila UNC-13 is essential for synaptic transmission. Nat Neurosci. 1999;2:965-71 pubmed
    The UNC-13 protein family has been suggested to be critical for synaptic vesicle dynamics based on its interactions with Syntaxin, Munc-18 and Doc 2alpha...
  3. Savva Y, Jepson J, Chang Y, Whitaker R, Jones B, St Laurent G, et al. RNA editing regulates transposon-mediated heterochromatic gene silencing. Nat Commun. 2013;4:2745 pubmed publisher
    ..Lastly, systemic differences in RNA editing activity generates interindividual variation in silencing state within a population. Our data reveal a global role for RNA editing in regulating gene expression. ..
  4. Hoopengardner B, Bhalla T, Staber C, Reenan R. Nervous system targets of RNA editing identified by comparative genomics. Science. 2003;301:832-6 pubmed
    ..These results point to a pivotal role for RNA editing in nervous system function. ..
  5. Locke J, Podemski L, Aippersbach N, Kemp H, Hodgetts R. A physical map of the polytenized region (101EF-102F) of chromosome 4 in Drosophila melanogaster. Genetics. 2000;155:1175-83 pubmed
    ..A minimal tiling set of the clones we have mapped will facilitate both the assembly of the DNA sequence of the chromosome and a functional analysis of its genes. ..
  6. Podemski L, Sousa Neves R, Marsh J, Locke J. Molecular mapping of deletion breakpoints on chromosome 4 of Drosophila melanogaster. Chromosoma. 2004;112:381-8 pubmed
    ..This will substantially reduce the amount of DHPLC analysis required to match each mutation to a predicted transcript on chromosome 4. ..
  7. Xu X, Wes P, Chen H, Li H, Yu M, Morgan S, et al. Retinal targets for calmodulin include proteins implicated in synaptic transmission. J Biol Chem. 1998;273:31297-307 pubmed
    ..Thus, it appears that calmodulin functions as a Ca2+ sensor for a broad diversity of retinal proteins, some of which are implicated in synaptic transmission. ..
  8. Böhme M, Beis C, Reddy Alla S, Reynolds E, Mampell M, Grasskamp A, et al. Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling. Nat Neurosci. 2016;19:1311-20 pubmed publisher
    ..Here we found that distances can be defined by targeting two unc-13 (Unc13) isoforms to presynaptic AZ subdomains...
  9. Das J, Xu S, Pany S, Guillory A, Shah V, ROMAN G. The pre-synaptic Munc13-1 binds alcohol and modulates alcohol self-administration in Drosophila. J Neurochem. 2013;126:715-26 pubmed publisher
    ..Munc13-1 can functionally complement the Dunc13 haploinsufficient ethanol self-administration phenotype in Drosophila melanogaster, indicating that this protein ..

More Information


  1. Wang W, Thornton K, Berry A, Long M. Nucleotide variation along the Drosophila melanogaster fourth chromosome. Science. 2002;295:134-7 pubmed publisher
    ..Finally, contrary to the expectation of no recombination, we identified six recombination events within the chromosome. Thus, positive Darwinian selection and recombination have affected the evolution of this chromosome...
  2. Adolfsen B, Littleton J. Genetic and molecular analysis of the synaptotagmin family. Cell Mol Life Sci. 2001;58:393-402 pubmed
    ..Here we review the current literature on the function of the synaptotagmin family and discuss the implications for synaptic transmission and membrane trafficking. ..
  3. Küppers B, Sanchez Soriano N, Letzkus J, Technau G, Prokop A. In developing Drosophila neurones the production of gamma-amino butyric acid is tightly regulated downstream of glutamate decarboxylase translation and can be influenced by calcium. J Neurochem. 2003;84:939-51 pubmed
  4. Huang F, Woodruff E, Mohrmann R, Broadie K. Rolling blackout is required for synaptic vesicle exocytosis. J Neurosci. 2006;26:2369-79 pubmed
    ..We conclude that RBO plays an essential role in neurotransmitter release, downstream of SV docking, likely mediating SV fusion. ..
  5. Rieder L, Savva Y, Reyna M, Chang Y, Dorsky J, Rezaei A, et al. Dynamic response of RNA editing to temperature in Drosophila. BMC Biol. 2015;13:1 pubmed publisher
    ..Environmental cues, in this case temperature, rapidly reprogram the Drosophila transcriptome through RNA editing, presumably resulting in altered proteomic ratios of edited and unedited proteins. ..
  6. Stocker J, Huang H, Wang H, Chang H, Chiu C, Cho C, et al. Reduction of RNA A-to-I editing in Drosophila acclimated to heat shock. Kaohsiung J Med Sci. 2013;29:478-83 pubmed publisher
    ..However, how RNA editing confers heat resistance is more complicated and requires further investigation. ..
  7. Jepson J, Reenan R. Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila. J Biol Chem. 2009;284:31391-400 pubmed publisher
  8. Zhang Y, Broadie K. Cloning, mapping and tissue-specific expression of Drosophila clathrin-associated protein AP50 gene. Gene. 1999;233:171-9 pubmed
    ..The two other Drosophila members of the medium-chain family of clathrin-associated protein complexes, AP47 and mu3, have also been identified and mapped to 85D20-D27 and 6E1-E4, respectively. ..
  9. Richmond J, Broadie K. The synaptic vesicle cycle: exocytosis and endocytosis in Drosophila and C. elegans. Curr Opin Neurobiol. 2002;12:499-507 pubmed
    ..Work in the past year has revealed that Unc-13 and Rab3a-interacting molecule regulate the conformational state of syntaxin to prime synaptic vesicle fusion...
  10. Spradling A, Rubin G. Transposition of cloned P elements into Drosophila germ line chromosomes. Science. 1982;218:341-7 pubmed
    ..Thus P elements can efficiently and selectively transpose from extrachromosomal DNA to the DNA of germ line chromosomes in Drosophila embryos. These observations provide the basis for efficient DNA-mediated gene transfer in Drosophila. ..
  11. Kadener S, Rodriguez J, Abruzzi K, Khodor Y, Sugino K, Marr M, et al. Genome-wide identification of targets of the drosha-pasha/DGCR8 complex. RNA. 2009;15:537-45 pubmed publisher
    ..e., excess Drosha cleaves pasha/DGCR8 primary transcripts and leads to a reduction in pasha/DGCR8 mRNA levels and Pasha/DGCR8 synthesis. ..
  12. Graze R, Novelo L, Amin V, Fear J, Casella G, Nuzhdin S, et al. Allelic imbalance in Drosophila hybrid heads: exons, isoforms, and evolution. Mol Biol Evol. 2012;29:1521-32 pubmed publisher
    ..However, there is no evidence that adaptive evolution drives most of the cis regulatory divergence that is observed. The majority of genes showed patterns consistent with stabilizing selection and neutral evolutionary processes. ..
  13. Bhogal B, Jepson J, Savva Y, Pepper A, Reenan R, Jongens T. Modulation of dADAR-dependent RNA editing by the Drosophila fragile X mental retardation protein. Nat Neurosci. 2011;14:1517-24 pubmed publisher
    ..These results link dFMR1 with the RNA-editing pathway and suggest that proper NMJ synaptic architecture requires modulation of dADAR activity by dFMR1. ..
  14. Aravamudan B, Broadie K. Synaptic Drosophila UNC-13 is regulated by antagonistic G-protein pathways via a proteasome-dependent degradation mechanism. J Neurobiol. 2003;54:417-38 pubmed
    b>UNC-13 is a highly conserved plasma membrane-associated synaptic protein implicated in the regulation of neurotransmitter release through the direct modulation of the SNARE exocytosis complex...
  15. Renden R, Berwin B, Davis W, Ann K, Chin C, Kreber R, et al. Drosophila CAPS is an essential gene that regulates dense-core vesicle release and synaptic vesicle fusion. Neuron. 2001;31:421-37 pubmed
    ..We conclude that dCAPS is required for dense-core vesicle release and that a dCAPS-dependent mechanism modulates synaptic vesicle release at glutamatergic synapses. ..
  16. Korhonen L, Lindholm D. The ubiquitin proteasome system in synaptic and axonal degeneration: a new twist to an old cycle. J Cell Biol. 2004;165:27-30 pubmed
    ..Increased knowledge of the UPS in synaptic and axonal reactions may provide novel drug targets for treatments of neuronal injuries and neurodegenerative disorders. ..
  17. Uytterhoeven V, Lauwers E, Maes I, Miskiewicz K, Melo M, Swerts J, et al. Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy. Neuron. 2015;88:735-48 pubmed publisher
  18. Reddy Alla S, Böhme M, Reynolds E, Beis C, Grasskamp A, Mampell M, et al. Stable Positioning of Unc13 Restricts Synaptic Vesicle Fusion to Defined Release Sites to Promote Synchronous Neurotransmission. Neuron. 2017;95:1350-1364.e12 pubmed publisher
    ..Thus, release site generation by the Unc13A C terminus and their specific AZ localization via the N terminus ensure efficient transmission and prevent ectopic, temporally imprecise release. ..