Gene Symbol: unc-104
Description: uncoordinated-104
Alias: CG8566, DUNC104, DUnc-104, DmCG8566, DmDUnc104, DmKlp53D, Dmel\CG8566, Dunc104, Imac, KIF 1B, KIF1A, KIF1A/1B, Klp53D, Unc-104, Unc104, bris, imac, unc104, uncoordinated-104, CG8566-PB, CG8566-PC, CG8566-PD, CG8566-PE, CG8566-PF, CG8566-PG, CG8566-PH, CG8566-PI, D uncoordinated protein 104, Kinesin-3, Kinesin4B, bristly, immaculate connections, kinesin 3, unc-104 ortholog, unc-104-PB, unc-104-PC, unc-104-PD, unc-104-PE, unc-104-PF, unc-104-PG, unc-104-PH, unc-104-PI
Species: fruit fly

Top Publications

  1. Pack Chung E, Kurshan P, Dickman D, Schwarz T. A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport. Nat Neurosci. 2007;10:980-9 pubmed
    ..Here we have isolated mutations in immaculate connections (imac; CG8566), a previously uncharacterized Drosophila gene encoding a member of the Kinesin-3 family...
  2. Medina P, Swick L, Andersen R, Blalock Z, Brenman J. A novel forward genetic screen for identifying mutations affecting larval neuronal dendrite development in Drosophila melanogaster. Genetics. 2006;172:2325-35 pubmed
    ..In a fortuitous observation, we observed that the structure of dendritic arborization (da) neuron dendritic filopodia changes in response to a changing environment. ..
  3. Kural C, Kim H, Syed S, Goshima G, Gelfand V, Selvin P. Kinesin and dynein move a peroxisome in vivo: a tug-of-war or coordinated movement?. Science. 2005;308:1469-72 pubmed
    ..Furthermore, we found that dynein and kinesin do not work against each other in vivo during peroxisome transport. Rather, multiple kinesins or multiple dyneins work together, producing up to 10 times the in vitro speed. ..
  4. Barkus R, Klyachko O, Horiuchi D, Dickson B, Saxton W. Identification of an axonal kinesin-3 motor for fast anterograde vesicle transport that facilitates retrograde transport of neuropeptides. Mol Biol Cell. 2008;19:274-83 pubmed
    ..This suggests that Unc-104, a member of an anterograde kinesin subfamily, contributes to an organelle-specific dynein-driven retrograde transport mechanism. ..
  5. Cao J, Ni J, Ma W, Shiu V, Milla L, Park S, et al. Insight into insulin secretion from transcriptome and genetic analysis of insulin-producing cells of Drosophila. Genetics. 2014;197:175-92 pubmed publisher
    ..Among these novelties is unc-104, a kinesin 3 family gene, which is more highly expressed in IPCs compared to most other neurons...
  6. Chen L, Stone M, Tao J, Rolls M. Axon injury and stress trigger a microtubule-based neuroprotective pathway. Proc Natl Acad Sci U S A. 2012;109:11842-7 pubmed publisher
    ..We conclude that axon injury or stress triggers a microtubule-based neuroprotective pathway that stabilizes neurons against degeneration. ..
  7. Kurshan P, Oztan A, Schwarz T. Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions. Nat Neurosci. 2009;12:1415-23 pubmed publisher
    ..Our results indicate that alpha(2)delta proteins have functions that are independent of their roles in the biophysics and localization of Ca(2+) channels and that synaptic architecture depends on these functions. ..
  8. Toda H, Mochizuki H, Flores R, Josowitz R, Krasieva T, Lamorte V, et al. UNC-51/ATG1 kinase regulates axonal transport by mediating motor-cargo assembly. Genes Dev. 2008;22:3292-307 pubmed publisher
    ..Thus, our data provide insight into axonal transport regulation that depends on the phosphorylation of adaptor proteins. ..
  9. Reid D, Muyskens J, Neal J, Gaddini G, Cho L, Wandler A, et al. Identification of genetic modifiers of CagA-induced epithelial disruption in Drosophila. Front Cell Infect Microbiol. 2012;2:24 pubmed publisher
    ..Collectively, these results point to new cellular pathways whose disruption by CagA are likely to contribute to H. pylori-associated disease pathology. ..

More Information


  1. Holbrook S, Finley J, Lyons E, Herman T. Loss of syd-1 from R7 neurons disrupts two distinct phases of presynaptic development. J Neurosci. 2012;32:18101-11 pubmed publisher
    ..R7 defect and provide a possible explanation for this disparity: we show that Liprin-? promotes Kinesin-3/Unc-104/Imac-mediated axon transport independently of Syd-1 and that Kinesin-3/Unc-104/Imac is required for normal R7 bouton ..
  2. Ally S, Larson A, Barlan K, Rice S, Gelfand V. Opposite-polarity motors activate one another to trigger cargo transport in live cells. J Cell Biol. 2009;187:1071-82 pubmed publisher
    ..These results demonstrate that mechanical interactions between opposite-polarity motors are necessary and sufficient for bidirectional organelle transport in live cells. ..
  3. Rui Y, Bai J, Perrimon N. Sarcomere formation occurs by the assembly of multiple latent protein complexes. PLoS Genet. 2010;6:e1001208 pubmed publisher
    ..Thus, sarcomere formation occurs by the coordinated assembly of multiple latent protein complexes, as opposed to sequential assembly. ..
  4. Kern J, Zhang Y, Kramer S, Brenman J, Rasse T. The kinesin-3, unc-104 regulates dendrite morphogenesis and synaptic development in Drosophila. Genetics. 2013;195:59-72 pubmed publisher
    ..exchange of a conserved residue (R561H) in the forkhead-associated domain of the kinesin-3 family member Unc-104/KIF1A as the genetic cause for defects in synaptic terminal- and dendrite morphogenesis...
  5. Wang Y, Cruz T, Irion U, Moussian B. Differentiated muscles are mandatory for gas-filling of the Drosophila airway system. Biol Open. 2015;4:1753-61 pubmed publisher
    ..We think that in analogy to the function of smooth muscles in vertebrate lungs, a balance of physical forces between muscles and the elasticity of tracheal walls may be decisive for tracheal terminal differentiation in Drosophila. ..
  6. Kim A, Endow S. A kinesin family tree. J Cell Sci. 2000;113 Pt 21:3681-2 pubmed
  7. Sugie A, Hakeda Suzuki S, Suzuki E, Silies M, Shimozono M, Möhl C, et al. Molecular Remodeling of the Presynaptic Active Zone of Drosophila Photoreceptors via Activity-Dependent Feedback. Neuron. 2015;86:711-25 pubmed publisher
    ..of microtubule meshwork organization downstream of the divergent canonical Wnt pathway, potentially via Kinesin-3 Imac. These data reveal that active zone composition can be regulated in vivo and identify the underlying molecular ..
  8. Johnson E, Fetter R, Davis G. Negative regulation of active zone assembly by a newly identified SR protein kinase. PLoS Biol. 2009;7:e1000193 pubmed publisher
    ..This mechanism could contribute to the speed and specificity with which AZs are assembled throughout the nervous system. ..
  9. Dagenbach E, Endow S. A new kinesin tree. J Cell Sci. 2004;117:3-7 pubmed