Gene Symbol: uex
Description: unextended
Alias: 41Ad, CG40084, CG42595, CR41594, Dmel\CG42595, Dmel_CG40084, Dmel_CR41594, EMS45-73, GroupIII, IR3, l(2)41Ad, l(2)EMS34-7, l(2)IR3, l(2R)A', l(2R)EMS45-73, l(2Rh)IR3, unextended, CG42595-PE, CG42595-PF, CG42595-PG, CG42595-PH, lethal (2) IR3, uex-PE, uex-PF, uex-PG, uex-PH
Species: fruit fly

Top Publications

  1. Hilliker A, Holm D. Genetic analysis of the proximal region of chromosome 2 of Drosophila melanogaster. I. Detachment products of compound autosomes. Genetics. 1975;81:705-21 pubmed
    ..The data further demonstrate that rolled, and probably light, are located within the proximal heterochromatin. Thus, functional genetic loci are found in heterochromatin, albeit at low density. ..
  2. Dimitri P, Arca B, Berghella L, Mei E. High genetic instability of heterochromatin after transposition of the LINE-like I factor in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1997;94:8052-7 pubmed
    ..Together, these data indicate that I factors transpose with high frequency into pericentric regions of chromosome 2 and may play a role in the evolution of constitutive heterochromatin. ..
  3. Hilliker A. Genetic analysis of the centromeric heterochromatin of chromosome 2 of Drosophila melanogaster: deficiency mapping of EMS-induced lethal complementation groups. Genetics. 1976;83:765-82 pubmed
    ..Thus functional genetic loci are found in heterochromatin, albeit at a very low density relative to euchromatin. ..
  4. Lyttle T. The effect of novel chromosome position and variable dose on the genetic behavior of the Responder (Rsp) element of the Segregation distorter (SD) system of Drosophila melanogaster. Genetics. 1989;121:751-63 pubmed
    ..Possible explanations for such behavior are discussed. ..
  5. Eberl D, Duyf B, Hilliker A. The role of heterochromatin in the expression of a heterochromatic gene, the rolled locus of Drosophila melanogaster. Genetics. 1993;134:277-92 pubmed
  6. Cenci G, Belloni G, Dimitri P. 1(2)41Aa, a heterochromatic gene of Drosophila melanogaster, is required for mitotic and meiotic chromosome condensation. Genet Res. 2003;81:15-24 pubmed
    ..Taken together, these findings indicate that 1(2)41Aa is a novel cell cycle gene required for proper chromosome condensation in both somatic and germ line cells. ..
  7. Dimitri P, Corradini N, Rossi F, Vernì F, Cenci G, Belloni G, et al. Vital genes in the heterochromatin of chromosomes 2 and 3 of Drosophila melanogaster. Genetica. 2003;117:209-15 pubmed
    ..Repetitive loci, such as Responder and the ABO elements, which are also located in the heterochromatin of chromosome 2, are not discussed here because they have been reviewed in detail elsewhere. ..
  8. Coulthard A, Alm C, Cealiac I, Sinclair D, Honda B, Rossi F, et al. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Genetics. 2010;185:479-95 pubmed publisher
    ..of these essential loci, CG41265 and CG42595, are synonymous with the previously characterized loci l(2)41Ab and unextended, respectively...
  9. Ganetzky B. On the components of segregation distortion in Drosophila melanogaster. Genetics. 1977;86:321-55 pubmed
    ..The results of these studies allow a reinterpretation of results from earlier analyses of the SD system and serve to limit the possible mechanisms to account for segregation distortion. ..

More Information


  1. Gatti M, Pimpinelli S. Functional elements in Drosophila melanogaster heterochromatin. Annu Rev Genet. 1992;26:239-75 pubmed
  2. Dimitri P. Cytogenetic analysis of the second chromosome heterochromatin of Drosophila melanogaster. Genetics. 1991;127:553-64 pubmed
    ..The l(2)41Aa, l(2)41Ab, rolled (l(2)41Ac) and l(2)41Ad loci are located within the proximal heterochromatin of 2R, while the nine remaining loci in the left arm and two (..
  3. Brittnacher J, Ganetzky B. On the components of segregation distortion in Drosophila melanogaster. IV. Construction and analysis of free duplications for the Responder locus. Genetics. 1989;121:739-50 pubmed
    ..The bearing of these results on present models of segregation distortion are discussed. ..
  4. Dimitri P. Constitutive heterochromatin and transposable elements in Drosophila melanogaster. Genetica. 1997;100:85-93 pubmed
    ..The implications of these findings on the possible impact of heterochromatic TEs on the function and evolution of the host genome are also discussed. ..
  5. Sharp C, Hilliker A, Holm D. Further Characterization of Genetic Elements Associated with the Segregation Distorter Phenomenon in DROSOPHILA MELANOGASTER. Genetics. 1985;110:671-88 pubmed
    ..Moreover, our analysis reveals a probable association of the E(SD) locus with a meiotic drive independent of that caused by Sd. ..
  6. Chew S, Chen P, Link N, GALINDO K, Pogue K, Abrams J. Genome-wide silencing in Drosophila captures conserved apoptotic effectors. Nature. 2009;460:123-7 pubmed publisher
    ..Similarly, the human Tango7 counterpart, PCID1 (also known as EIF3M), impinged on caspase 9, revealing a new regulatory axis affecting the apoptosome. ..