Gene Symbol: turtle
Description: turtle
Alias: CG15426, CG15427, CG15428, CT35489, CT35490, Dmel\CG15427, Tutl, jf4, l(2)01085, l(2)24Df, l(2)jf4, mdcds_7441, turtle, CG15427-PA, CG15427-PC, CG15427-PD, CG15427-PE, CG15427-PF, CG15427-PG, CG15427-PH, CG15427-PI, CG15427-PJ, CG15427-PK, lethal(2)24Df, tutl-PA, tutl-PC, tutl-PD, tutl-PE, tutl-PF, tutl-PG, tutl-PH, tutl-PI, tutl-PJ, tutl-PK
Species: fruit fly

Top Publications

  1. Long H, Ou Y, Rao Y, van Meyel D. Dendrite branching and self-avoidance are controlled by Turtle, a conserved IgSF protein in Drosophila. Development. 2009;136:3475-84 pubmed publisher
    ..The Drosophila transmembrane protein Turtle (Tutl) and its orthologs in other species are conserved members of the immunoglobulin superfamily, the in vivo ..
  2. Ferguson K, Long H, Cameron S, Chang W, Rao Y. The conserved Ig superfamily member Turtle mediates axonal tiling in Drosophila. J Neurosci. 2009;29:14151-9 pubmed publisher
    ..Here, we identify Turtle (Tutl), a member of the conserved Tutl/Dasm1/IgSF9 subfamily of the Ig superfamily, as a key player in regulating ..
  3. Sulkowski M, Iyer S, Kurosawa M, Iyer E, Cox D. Turtle functions downstream of Cut in differentially regulating class specific dendrite morphogenesis in Drosophila. PLoS ONE. 2011;6:e22611 pubmed publisher
    ..However, presently, few genetic pathways regulating dendrite development have been defined. The Drosophila gene turtle belongs to an evolutionarily conserved class of immunoglobulin superfamily members found in the nervous systems of ..
  4. Al Anzi B, Wyman R. The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding. Neural Dev. 2009;4:31 pubmed publisher
    ..The evolutionarily conserved Ig proteins encoded by the turtle/Dasm1 genes are found in Drosophila, Caenorhabditis elegans, and mammals...
  5. Bodily K, Morrison C, Renden R, Broadie K. A novel member of the Ig superfamily, turtle, is a CNS-specific protein required for coordinated motor control. J Neurosci. 2001;21:3113-25 pubmed
    ..describe here the cloning and functional characterization of a neural-specific novel member of the Ig superfamily, turtle (tutl), with a structure of five Ig C2-type domains, two fibronectin type III domains, and one transmembrane ..
  6. Weize Zhang -, Sobolevski A, Bing Li -, Yong Rao -, Xinyu Liu -. A force-controlled robotic micromanipulation system for mechanotransduction studies of Drosophila larvae. Conf Proc IEEE Eng Med Biol Soc. 2014;2014:6526-9 pubmed publisher
    ..5%. This robotic system will greatly facilitate the dissection of mechanotransduction mechanisms of Drosophila larvae at both the molecular and cellular levels. ..
  7. Jordan K, Morgan T, Mackay T. Quantitative trait loci for locomotor behavior in Drosophila melanogaster. Genetics. 2006;174:271-84 pubmed
    ..These data implicate variation in the synthesis of bioamines as a factor contributing to natural variation in locomotor reactivity. ..
  8. Kwon M, Godinho S, Chandhok N, Ganem N, Azioune A, Thery M, et al. Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev. 2008;22:2189-203 pubmed publisher
    ..Thus, morphological features of cancer cells can be linked to unique genetic requirements for survival. ..
  9. Koper A, Schenck A, Prokop A. Analysis of adhesion molecules and basement membrane contributions to synaptic adhesion at the Drosophila embryonic NMJ. PLoS ONE. 2012;7:e36339 pubmed publisher
    ..Therefore, future developmental studies of these synaptic junctions in Drosophila need to consider the important contribution made by BM-dependent mechanisms, in addition to CAM-dependent adhesion. ..

More Information


  1. Zhou Y, Cameron S, Chang W, Rao Y. Control of directional change after mechanical stimulation in Drosophila. Mol Brain. 2012;5:39 pubmed publisher
    ..analysis indicates an important role for the evolutionarily conserved immunoglobulin (Ig) superfamily protein Turtle (Tutl) to regulate touch-initiated directional change...
  2. Hansen M, Walmod P. IGSF9 family proteins. Neurochem Res. 2013;38:1236-51 pubmed publisher
    The Drosophila protein Turtle and the vertebrate proteins immunoglobulin superfamily (IgSF), member 9 (IGSF9/Dasm1) and IGSF9B are members of an evolutionarily ancient protein family...
  3. Robins H, Li Y, Padgett R. Incorporating structure to predict microRNA targets. Proc Natl Acad Sci U S A. 2005;102:4006-9 pubmed
    ..One of these validated genes is mad as a target for bantam. Furthermore, our computational and experimental data suggest that miRNAs have fewer targets than previously reported. ..
  4. Vicente Crespo M, Pascual M, Fernandez Costa J, Garcia Lopez A, Monferrer L, Miranda M, et al. Drosophila muscleblind is involved in troponin T alternative splicing and apoptosis. PLoS ONE. 2008;3:e1613 pubmed publisher
  5. Ma L, Ma J, Xu K. Effect of spaceflight on the circadian rhythm, lifespan and gene expression of Drosophila melanogaster. PLoS ONE. 2015;10:e0121600 pubmed publisher
  6. Nagai T, Mizuno K. Multifaceted roles of Furry proteins in invertebrates and vertebrates. J Biochem. 2014;155:137-46 pubmed publisher
    ..Here, we review current knowledge about the diverse cellular functions and regulation of Fry proteins in invertebrates and vertebrates. ..
  7. Chen Y, Cameron S, Chang W, Rao Y. Turtle interacts with borderless in regulating glial extension and axon ensheathment. Mol Brain. 2017;10:17 pubmed publisher
    ..Here, we present evidence showing that Bdl interacts with the Ig transmembrane protein Turtle (Tutl). Tutl is specifically expressed in photoreceptor axons...
  8. Cameron S, Chang W, Chen Y, Zhou Y, Taran S, Rao Y. Visual circuit assembly requires fine tuning of the novel Ig transmembrane protein Borderless. J Neurosci. 2013;33:17413-21 pubmed publisher
    ..Bdl interacts physically and genetically with the Ig transmembrane protein Turtle, a key regulator of axonal tiling...
  9. Tsubouchi A, Caldwell J, Tracey W. Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae. Curr Biol. 2012;22:2124-34 pubmed publisher
    ..These cells show physiological responses to force. Ion channels in several force-sensing gene families are required for behavioral sensitivity to touch and for the formation of the actin-rich sensory filopodia. ..
  10. Venken K, Schulze K, Haelterman N, Pan H, He Y, Evans Holm M, et al. MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes. Nat Methods. 2011;8:737-43 pubmed
    ..Insertions in coding introns can be exchanged with protein-tag cassettes to create fusion proteins to follow protein expression and perform biochemical experiments. The applications of MiMIC vastly extend the D. melanogaster toolkit. ..