Gene Symbol: tsr
Description: twinstar
Alias: 12/8, ADF, ADF/cofilin, Adf, CG4254, Cadf, D-cof, D61, Dmel\CG4254, Tsr, cofilin, cofilin/ADF, cofilin/actin depolymerizing factor homolog, l(2)03101, l(2)k03101, l(2)k05633, l(2)k13409, ntf, twinstar, ADFcofilin, CG4254-PA, Cofilin/actin depolymerizing factor-like, DCofilin, actin-depolymerizing factor, cofilin, no terminal filament, tsr-PA, twin star
Species: fruit fly

Top Publications

  1. Edwards K, Montague R, Shepard S, Edgar B, Erikson R, Kiehart D. Identification of Drosophila cytoskeletal proteins by induction of abnormal cell shape in fission yeast. Proc Natl Acad Sci U S A. 1994;91:4589-93 pubmed
    ..these defects appear to encode cytoskeletal components: the actin binding proteins profilin and cofilin/actin depolymerizing factor and a membrane-cytoskeleton linker of the ezrin/merlin family...
  2. D Avino P, Savoian M, Glover D. Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy. J Cell Sci. 2005;118:1549-58 pubmed
    ..The same mechanism might be conserved in other organisms. ..
  3. Sansores Garcia L, Bossuyt W, Wada K, Yonemura S, Tao C, Sasaki H, et al. Modulating F-actin organization induces organ growth by affecting the Hippo pathway. EMBO J. 2011;30:2325-35 pubmed publisher
    ..Thus, regulators of F-actin, and in particular Capping proteins, are essential for proper growth control by affecting Hippo signalling. ..
  4. Niwa R, Nagata Ohashi K, Takeichi M, Mizuno K, Uemura T. Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. Cell. 2002;108:233-46 pubmed
    The ADF (actin-depolymerizing factor)/cofilin family is a stimulus-responsive mediator of actin dynamics...
  5. Chen J, Godt D, Gunsalus K, Kiss I, Goldberg M, Laski F. Cofilin/ADF is required for cell motility during Drosophila ovary development and oogenesis. Nat Cell Biol. 2001;3:204-9 pubmed
    ..Here we show that Drosophila cofilin/ADF, which is encoded by the twinstar (tsr) gene, promotes cell movements during ovary development and oogenesis...
  6. Ng J, Luo L. Rho GTPases regulate axon growth through convergent and divergent signaling pathways. Neuron. 2004;44:779-93 pubmed
    ..Here we show that the actin depolymerization factor cofilin is essential for axon growth in Drosophila neurons...
  7. Fernández B, Gaspar P, Bras Pereira C, Jezowska B, Rebelo S, Janody F. Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila. Development. 2011;138:2337-46 pubmed publisher
    ..Reduction of two other actin-regulatory proteins, Cofilin and the cyclase-associated protein Capulet, cause abnormal F-actin accumulation, but only the loss of Capulet, ..
  8. Wang D, Zhang L, Zhao G, Wahlström G, Heino T, Chen J, et al. Drosophila twinfilin is required for cell migration and synaptic endocytosis. J Cell Sci. 2010;123:1546-56 pubmed publisher
    ..Together, our results reveal that twinfilin promotes actin turnover in multiple cellular processes that are highly dependent on actin dynamics. ..
  9. Blair A, Tomlinson A, Pham H, Gunsalus K, Goldberg M, Laski F. Twinstar, the Drosophila homolog of cofilin/ADF, is required for planar cell polarity patterning. Development. 2006;133:1789-97 pubmed
    ..b>Twinstar (Tsr), the Drosophila homolog of Cofilin/ADF (actin depolymerization factor), is a component of the cytoskeleton ..

More Information


  1. Baum B, Perrimon N. Spatial control of the actin cytoskeleton in Drosophila epithelial cells. Nat Cell Biol. 2001;3:883-90 pubmed
    ..We find that profilin and cofilin regulate actin-filament formation throughout the cell cortex...
  2. Baum B, Li W, Perrimon N. A cyclase-associated protein regulates actin and cell polarity during Drosophila oogenesis and in yeast. Curr Biol. 2000;10:964-73 pubmed
    ..As CAP controls the spatial distribution of actin filaments and mRNA determinants in both yeast and Drosophila, we conclude that CAP has an evolutionarily conserved function in the genesis of eukaryotic cell polarity. ..
  3. Jovceva E, Larsen M, Waterfield M, Baum B, Timms J. Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis. J Cell Sci. 2007;120:1888-97 pubmed
    ..approach revealed an increase in the levels of an inactive, phosphorylated form of the actin-severing protein cofilin in cells unable to generate actin-based lamellipodia...
  4. Pham H, Yu H, Laski F. Cofilin/ADF is required for retinal elongation and morphogenesis of the Drosophila rhabdomere. Dev Biol. 2008;318:82-91 pubmed publisher
    ..Here we show that twinstar (tsr), which encodes Drosophila cofilin/ADF (actin-depolymerizing factor), is required for both of these ..
  5. Ohashi K, Hosoya T, Takahashi K, Hing H, Mizuno K. A Drosophila homolog of LIM-kinase phosphorylates cofilin and induces actin cytoskeletal reorganization. Biochem Biophys Res Commun. 2000;276:1178-85 pubmed
    ..In vitro kinase reaction revealed that DLIMK efficiently phosphorylates Drosophila cofilin (twinstar) specifically at Ser-3, the site responsible for inactivation of its actin-depolymerizing activity...
  6. Somma M, Fasulo B, Cenci G, Cundari E, Gatti M. Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells. Mol Biol Cell. 2002;13:2448-60 pubmed
    ..We show that double-stranded RNAs for anillin, acGAP, pavarotti, rho1, pebble, spaghetti squash, syntaxin1A, and twinstar all disrupt cytokinesis in S2 tissue culture cells, causing gene-specific phenotypes...
  7. Fulga T, Elson Schwab I, Khurana V, Steinhilb M, Spires T, Hyman B, et al. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nat Cell Biol. 2007;9:139-48 pubmed
    ..These findings raise the possibility that a direct interaction between tau and actin may be a critical mediator of tau-induced neurotoxicity in Alzheimer's disease and related disorders. ..
  8. Giansanti M, Bonaccorsi S, Williams B, Williams E, Santolamazza C, Goldberg M, et al. Cooperative interactions between the central spindle and the contractile ring during Drosophila cytokinesis. Genes Dev. 1998;12:396-410 pubmed
    ..similar phenotype was seen in testes treated with cytochalasin B and has been noted previously in mutants at the twinstar locus, a gene that encodes a Drosophila member of the cofilin/ADF family of actin-severing proteins...
  9. Delalle I, Pfleger C, Buff E, Lueras P, Hariharan I. Mutations in the Drosophila orthologs of the F-actin capping protein alpha- and beta-subunits cause actin accumulation and subsequent retinal degeneration. Genetics. 2005;171:1757-65 pubmed
    ..In its absence, cells progressively accumulate actin filaments and eventually die. A possible role for their human orthologs in neurodegenerative disease merits further investigation. ..
  10. Gunsalus K, Bonaccorsi S, Williams E, Verni F, Gatti M, Goldberg M. Mutations in twinstar, a Drosophila gene encoding a cofilin/ADF homologue, result in defects in centrosome migration and cytokinesis. J Cell Biol. 1995;131:1243-59 pubmed
    We describe the phenotypic and molecular characterization of twinstar (tsr), an essential gene in Drosophila melanogaster. Two P-element induced alleles of tsr (tsr1 and tsr2) result in late larval or pupal lethality...
  11. Stephan D, Sanchez Soriano N, Loschek L, Gerhards R, Gutmann S, Storchova Z, et al. Drosophila Psidin regulates olfactory neuron number and axon targeting through two distinct molecular mechanisms. J Neurosci. 2012;32:16080-94 pubmed publisher
    ..Together, our data suggest that Psidin plays two independent developmental roles via the acquisition of separate signaling pathways, both of which contribute to the formation of olfactory circuits. ..
  12. von Blume J, Duran J, Forlanelli E, Alleaume A, Egorov M, Polishchuk R, et al. Actin remodeling by ADF/cofilin is required for cargo sorting at the trans-Golgi network. J Cell Biol. 2009;187:1055-69 pubmed publisher
    Knockdown of the actin-severing protein actin-depolymerizing factor (ADF)/cofilin inhibited export of an exogenously expressed soluble secretory protein from Golgi membranes in Drosophila melanogaster and mammalian tissue culture cells...
  13. Johnson R, Seppa M, Cagan R. The Drosophila CD2AP/CIN85 orthologue Cindr regulates junctions and cytoskeleton dynamics during tissue patterning. J Cell Biol. 2008;180:1191-204 pubmed publisher
    ..Together, these data demonstrate that Cindr is involved in dynamic cell rearrangement in an emerging epithelium. ..
  14. Baum B. Winging it--actin on the fly. Dev Cell. 2002;2:125-6 pubmed
    ..New insights may be gained from the recent identification of a conserved cofilin phosphatase, Slingshot, which modulates actin dynamics to help control Drosophila wing hair morphogenesis.
  15. Montell D. Command and control: regulatory pathways controlling invasive behavior of the border cells. Mech Dev. 2001;105:19-25 pubmed
    ..This may contribute to the metastatic effects of steroid hormones on certain cancers and the inhibition of metastasis by steroid hormone antagonists such as tamoxifen. ..
  16. Ojelade S, Acevedo S, Kalahasti G, Rodan A, Rothenfluh A. RhoGAP18B Isoforms Act on Distinct Rho-Family GTPases and Regulate Behavioral Responses to Alcohol via Cofilin. PLoS ONE. 2015;10:e0137465 pubmed publisher
    ..In vivo, a loss-of-function mutation in the cofilin-encoding gene twinstar leads to reduced ethanol-sensitivity and acts in concert with RhoGAP18B...
  17. Rørth P. Initiating and guiding migration: lessons from border cells. Trends Cell Biol. 2002;12:325-31 pubmed
    ..This article discusses the implications of these studies and compares (invasive) migration through a tissue with what is known about cells crawling on a flat substratum. ..
  18. Castellanos E, Dominguez P, Gonzalez C. Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability. Curr Biol. 2008;18:1209-14 pubmed publisher
    ..We propose that such tumors might be caused by impaired asymmetric division of neural stem cells [4]. These results show that centrosome loss, far from being innocuous, is a potentially dangerous condition in flies...
  19. Chen G, Turano B, Ruest P, Hagel M, Settleman J, Thomas S. Regulation of Rho and Rac signaling to the actin cytoskeleton by paxillin during Drosophila development. Mol Cell Biol. 2005;25:979-87 pubmed
    ..cdi belongs to the cofilin kinase family, which includes the downstream Rho target, LIM kinase (LIMK)...
  20. Leyssen M, Ayaz D, Hébert S, Reeve S, De Strooper B, Hassan B. Amyloid precursor protein promotes post-developmental neurite arborization in the Drosophila brain. EMBO J. 2005;24:2944-55 pubmed
    ..Finally, we also found interactions between APP and the JNK stress kinase cascade. Our findings suggest a role for APP in axonal outgrowth after traumatic brain injury. ..
  21. Cervantes Sandoval I, Chakraborty M, Macmullen C, Davis R. Scribble Scaffolds a Signalosome for Active Forgetting. Neuron. 2016;90:1230-1242 pubmed publisher
    ..Scribble interacts physically and genetically with Rac1, Pak3, and Cofilin within MBn, nucleating a forgetting signalosome that is downstream of dopaminergic inputs that regulate ..
  22. Lin C, Lin P, Li Y, Hsu J. Capulet and Slingshot share overlapping functions during Drosophila eye morphogenesis. J Biomed Sci. 2012;19:46 pubmed publisher
    CAP/Capulet (Capt), Slingshot (Ssh) and Cofilin/Twinstar (Tsr) are actin-binding proteins that restrict actin polymerization...
  23. Chu D, Pan H, Wan P, Wu J, Luo J, Zhu H, et al. AIP1 acts with cofilin to control actin dynamics during epithelial morphogenesis. Development. 2012;139:3561-71 pubmed publisher
    ..Here, we report that the actin disassembly factors AIP1 and cofilin are required for remodeling of adherens junctions (AJs) during ommatidial precluster formation in Drosophila eye ..
  24. Dopie J, Skarp K, Rajakylä E, Tanhuanpää K, Vartiainen M. Active maintenance of nuclear actin by importin 9 supports transcription. Proc Natl Acad Sci U S A. 2012;109:E544-52 pubmed publisher
    ..These results demonstrate that cytoplasmic and nuclear actin pools are dynamically connected and identify the nuclear import and export mechanisms of actin. ..
  25. Sutherland J, Witke W. Molecular genetic approaches to understanding the actin cytoskeleton. Curr Opin Cell Biol. 1999;11:142-51 pubmed
    ..Yeast, Dictyostelium, Caenorhabditis elegans, Drosophila, and mice have contributed much in recent years to a better understanding of both the numerous functions and modes of regulation of the actin cytoskeleton. ..
  26. Vierstraete E, Verleyen P, Sas F, Van den Bergh G, De Loof A, Arckens L, et al. The instantly released Drosophila immune proteome is infection-specific. Biochem Biophys Res Commun. 2004;317:1052-60 pubmed
    ..Next to known immune proteins, unannotated proteins were identified such as CG4306 protein, which has homologues with unknown function in all metazoan genome databases available today. ..
  27. Menzel N, Schneeberger D, Raabe T. The Drosophila p21 activated kinase Mbt regulates the actin cytoskeleton and adherens junctions to control photoreceptor cell morphogenesis. Mech Dev. 2007;124:78-90 pubmed
    ..The genetic screen identified the actin depolymerisation factor Twinstar/Cofilin as one target of Mbt signalling. Twinstar/Cofilin becomes phosphorylated upon activation of Mbt...
  28. Sesé M, Corominas M, Stocker H, Heino T, Hafen E, Serras F. The Cdi/TESK1 kinase is required for Sevenless signaling and epithelial organization in the Drosophila eye. J Cell Sci. 2006;119:5047-56 pubmed
    ..human testis-specific kinase 1 (TESK1), a member of the LIM kinases involved in cytoskeleton control through ADF/cofilin phosphorylation...
  29. Grintsevich E, Yesilyurt H, Rich S, Hung R, Terman J, Reisler E. F-actin dismantling through a redox-driven synergy between Mical and cofilin. Nat Cell Biol. 2016;18:876-85 pubmed publisher
    ..The best-characterized disassembly proteins, the ADF (actin-depolymerizing factor)/cofilins (encoded by the twinstar gene in Drosophila), sever filaments and recycle monomers to promote actin assembly...
  30. Kolhekar A, Roberts M, Jiang N, Johnson R, Mains R, Eipper B, et al. Neuropeptide amidation in Drosophila: separate genes encode the two enzymes catalyzing amidation. J Neurosci. 1997;17:1363-76 pubmed
    ..These combined data indicate a fundamental evolutionary divergence in the genes coding for critical neurotransmitter biosynthetic enzymes: in Drosophila, the two enzyme activities of PAM are encoded by separate genes. ..
  31. Reed S, Serio A, Welch M. Rickettsia parkeri invasion of diverse host cells involves an Arp2/3 complex, WAVE complex and Rho-family GTPase-dependent pathway. Cell Microbiol. 2012;14:529-45 pubmed publisher
    ..Our results reveal a key role for the WAVE and Arp2/3 complexes, as well as a higher degree of variation than previously appreciated in actin nucleation pathways activated during Rickettsia invasion...
  32. Sechi S, Frappaolo A, Belloni G, Giansanti M. The roles of the oncoprotein GOLPH3 in contractile ring assembly and membrane trafficking during cytokinesis. Biochem Soc Trans. 2015;43:117-21 pubmed publisher
    ..Because cytokinesis failures have been linked with pre-malignant disease and cancer, the novel connection between GOLPH3 and cytokinesis imposes new fields of investigation in cancer biology and therapy. ..
  33. Ren N, Charlton J, Adler P. The flare gene, which encodes the AIP1 protein of Drosophila, functions to regulate F-actin disassembly in pupal epidermal cells. Genetics. 2007;176:2223-34 pubmed
    ..In Drosophila cofilin is encoded by twinstar (tsr)...
  34. Williams M, Wiklund M, Wikman S, Hultmark D. Rac1 signalling in the Drosophila larval cellular immune response. J Cell Sci. 2006;119:2015-24 pubmed
    ..that actin stabilization is necessary for Rac1-induced hemocyte activation by lowering cofilin (encoded by the twinstar gene tsr) expression in blood cells. Removing Bsk by RNAi suppressed Rac1-induced release of sessile hemocytes...
  35. Zhang D, Zhou W, Yin C, Chen W, Ozawa R, Ang L, et al. Misexpression screen for genes altering the olfactory map in Drosophila. Genesis. 2006;44:189-201 pubmed
    ..Our finding of diverse classes of genes reveals the complexity of the mechanisms that underlie olfactory map development. ..
  36. Wahlstrom G, Vartiainen M, Yamamoto L, Mattila P, Lappalainen P, Heino T. Twinfilin is required for actin-dependent developmental processes in Drosophila. J Cell Biol. 2001;155:787-96 pubmed
    ..We also show that twinfilin and the ADF/cofilin encoding gene twinstar interact genetically in bristle morphogenesis...
  37. Vierstraete E, Verleyen P, Baggerman G, D Hertog W, Van den Bergh G, Arckens L, et al. A proteomic approach for the analysis of instantly released wound and immune proteins in Drosophila melanogaster hemolymph. Proc Natl Acad Sci U S A. 2004;101:470-5 pubmed
    ..Determining the function of all of these immune-induced proteins represents an exciting challenge for increasing our knowledge of insect immunity. ..
  38. Oh S, Kingsley T, Shin H, Zheng Z, Chen H, Chen X, et al. A P-element insertion screen identified mutations in 455 novel essential genes in Drosophila. Genetics. 2003;163:195-201 pubmed
    ..Our mutation collection represents approximately 56% of the second chromosome vital genes and approximately 24% of the total vital Drosophila genes. ..
  39. Piccioli Z, Littleton J. Retrograde BMP signaling modulates rapid activity-dependent synaptic growth via presynaptic LIM kinase regulation of cofilin. J Neurosci. 2014;34:4371-81 pubmed publisher
    ..Limk interfaces with structural plasticity by controlling the activity of the actin depolymerizing protein Cofilin. Expression of constitutively active or inactive Cofilin in motor neurons demonstrates that increased Cofilin ..
  40. Cao J, Albertson R, Riggs B, Field C, Sullivan W. Nuf, a Rab11 effector, maintains cytokinetic furrow integrity by promoting local actin polymerization. J Cell Biol. 2008;182:301-13 pubmed publisher
    ..We propose a model in which RE-derived vesicles promote furrow integrity by regulating the rate of actin polymerization through the RhoGEF2-Rho1 pathway. ..
  41. Zhang S, Yeromin A, Zhang X, Yu Y, Safrina O, Penna A, et al. Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity. Proc Natl Acad Sci U S A. 2006;103:9357-62 pubmed
  42. Ko C, Kim Y, Le T, Choi K. Twinstar/cofilin is required for regulation of epithelial integrity and tissue growth in Drosophila. Oncogene. 2016;35:5144-54 pubmed publisher
    ..However, the role of Twinstar (Tsr), the Drosophila homolog for cofilin/actin depolymerization factor (ADF), in epithelial integrity and Hippo ..
  43. Das A, Shah S, Fan B, Paik D, DiSanto D, Hinman A, et al. Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes. Genetics. 2016;202:61-75 pubmed publisher
    ..In combination our results support a model where the meiotic central spindle and associated proteins are essential for acentrosomal chromosome segregation. ..
  44. Jodoin J, Coravos J, Chanet S, Vasquez C, Tworoger M, Kingston E, et al. Stable Force Balance between Epithelial Cells Arises from F-Actin Turnover. Dev Cell. 2015;35:685-97 pubmed publisher
    ..Our work identifies a critical role for F-actin turnover in connecting actomyosin to intercellular junctions, defining a dynamic process required for the stability of force balance across intercellular contacts in tissues. ..
  45. Mohammad F, Aryal S, Ho J, Stewart J, Norman N, Tan T, et al. Ancient Anxiety Pathways Influence Drosophila Defense Behaviors. Curr Biol. 2016;26:981-6 pubmed publisher
    ..The presence of conserved neurogenetic pathways in the insect brain identifies Drosophila as an attractive genetic model for the study of anxiety and anxiety-related disorders, complementing existing rodent systems. ..
  46. Ratnaparkhi A. Signaling by Folded gastrulation is modulated by mitochondrial fusion and fission. J Cell Sci. 2013;126:5369-76 pubmed publisher
    ..The findings presented here show that mitochondria, through regulation of fusion and fission, function as downstream effectors and modulators of Fog signaling and Fog-dependent cell shape change. ..
  47. Iwasa J, Mullins R. Spatial and temporal relationships between actin-filament nucleation, capping, and disassembly. Curr Biol. 2007;17:395-406 pubmed
    ..In contrast, depletion of cofilin, slingshot, twinfilin, and tropomyosin, all factors that control the stability of actin filaments, dramatically ..
  48. Miller K, Kiehart D. Fly division. J Cell Biol. 1995;131:1-5 pubmed
  49. Pirone L, Xolalpa W, Sigurðsson J, Ramirez J, Pérez C, Gonzalez M, et al. A comprehensive platform for the analysis of ubiquitin-like protein modifications using in vivo biotinylation. Sci Rep. 2017;7:40756 pubmed publisher
    ..Ease of use and the flexibility to modify existing vectors will make the bioUbL system a powerful complement to existing strategies for studying this important mode of protein regulation. ..
  50. Somma M, Fasulo B, Siriaco G, Cenci G. Chromosome condensation defects in barren RNA-interfered Drosophila cells. Genetics. 2003;165:1607-11 pubmed
    ..We have used double-stranded RNA-mediated interference (RNAi) to deplete Barren in Drosophila S2 cells. Our analyses indicate that inactivation of barr leads to extensive chromosome condensation and disrupts chromatid segregation. ..
  51. Lenhart K, Dinardo S. Somatic cell encystment promotes abscission in germline stem cells following a regulated block in cytokinesis. Dev Cell. 2015;34:192-205 pubmed publisher
    ..Through live imaging, we show that a secondary F-actin ring is formed through regulation of Cofilin activity to block cytokinesis progress after contractile ring disassembly...
  52. Shuai Y, Lu B, Hu Y, Wang L, Sun K, Zhong Y. Forgetting is regulated through Rac activity in Drosophila. Cell. 2010;140:579-89 pubmed publisher
    ..We suggest that Rac's role in actin cytoskeleton remodeling may contribute to memory erasure...
  53. Sanchez Soriano N, Gonçalves Pimentel C, Beaven R, Haessler U, Ofner Ziegenfuss L, Ballestrem C, et al. Drosophila growth cones: a genetically tractable platform for the analysis of axonal growth dynamics. Dev Neurobiol. 2010;70:58-71 pubmed publisher
    ..We demonstrate these events to be mediated by the actin-MT linking factor Short stop, thus identifying an essential molecular player in this context. ..
  54. Schober M, Perrimon N. Unconventional ways to travel. Nat Cell Biol. 2002;4:E211-2 pubmed
  55. Janody F, Treisman J. Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium. Development. 2006;133:3349-57 pubmed
    ..Excessive actin filament polymerization is not sufficient to explain this phenotype, as loss of Cofilin or Cyclase-associated protein does not cause cell extrusion or death...
  56. Schottenfeld Roames J, Rosa J, Ghabrial A. Seamless tube shape is constrained by endocytosis-dependent regulation of active Moesin. Curr Biol. 2014;24:1756-64 pubmed publisher
    ..We propose that early endocytosis maintains normal steady-state levels of Crumbs, which recruits apical phosphorylated (active) Moe, which in turn regulates seamless tube shape through modulation of cortical actin filaments. ..
  57. Xu N, Bagumian G, Galiano M, Myat M. Rho GTPase controls Drosophila salivary gland lumen size through regulation of the actin cytoskeleton and Moesin. Development. 2011;138:5415-27 pubmed publisher
    ..Reducing cofilin levels in Rho1 mutant salivary gland cells restored proper distribution of F-actin and phosphorylated Moesin and ..
  58. Schuldiner O, Berdnik D, Levy J, Wu J, Luginbuhl D, Gontang A, et al. piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning. Dev Cell. 2008;14:227-38 pubmed publisher
    ..We also demonstrate a postmitotic role for SMC1 in dendrite targeting of olfactory projection neurons. We suggest that cohesin regulates diverse aspects of neuronal morphogenesis...
  59. Ang L, Chen W, Yao Y, Ozawa R, Tao E, Yonekura J, et al. Lim kinase regulates the development of olfactory and neuromuscular synapses. Dev Biol. 2006;293:178-90 pubmed
    ..in Limk function leads to ectopic glomeruli, a phenotype suppressible by the coexpression of a hyperactive Cofilin gene...
  60. Silverman Gavrila R, Hales K, Wilde A. Anillin-mediated targeting of peanut to pseudocleavage furrows is regulated by the GTPase Ran. Mol Biol Cell. 2008;19:3735-44 pubmed publisher
    ..These data suggest that anillin and Peanut are involved in pseudocleavage furrow ingression in syncytial embryos and that this process is regulated by Ran. ..
  61. Medina P, Worthen R, Forsberg L, Brenman J. The actin-binding protein capulet genetically interacts with the microtubule motor kinesin to maintain neuronal dendrite homeostasis. PLoS ONE. 2008;3:e3054 pubmed publisher
    ..genetic inactivation of capulet and kinesin heavy chain, a microtubule motor protein, produces elongate cofilin-actin rods within dendrites but not axons...
  62. Hempel L, Rathke C, Raja S, Renkawitz Pohl R. In Drosophila, don juan and don juan like encode proteins of the spermatid nucleus and the flagellum and both are regulated at the transcriptional level by the TAF II80 cannonball while translational repression is achieved by distinct elements. Dev Dyn. 2006;235:1053-64 pubmed
    ..Translational repression elements for both mRNAs are localized in the 5' UTR and are capable to form distinct secondary structures in close proximity to the translational initiation codon. ..
  63. Lecuit T. Junctions and vesicular trafficking during Drosophila cellularization. J Cell Sci. 2004;117:3427-33 pubmed
    ..The novel proteins Nullo and Slam, which are specifically induced during cellularization, represent developmental regulators of membrane growth during cellularization. ..
  64. Lamprecht R. The actin cytoskeleton in memory formation. Prog Neurobiol. 2014;117:1-19 pubmed publisher
    ..The actin cytoskeleton may therefore mediate between synaptic transmission during learning and long-term cellular alterations mandatory for memory formation...
  65. Kim J, Cho A, Yin H, Schafer D, Mouneimne G, Simpson K, et al. Psidin, a conserved protein that regulates protrusion dynamics and cell migration. Genes Dev. 2011;25:730-41 pubmed publisher
    ..In vivo, psid mutations exhibited genetic interactions with the genes encoding tropomyosin and cofilin. Border cells overexpressing Psid together with GFP-actin exhibited altered protrusion/retraction dynamics...
  66. Nikitina E, Medvedeva A, Zakharov G, Savvateeva Popova E. Williams syndrome as a model for elucidation of the pathway genes - the brain - cognitive functions: genetics and epigenetics. Acta Naturae. 2014;6:9-22 pubmed
    ..systems to analyze the contribution of both a single gene and the consequences of its epigenetic regulation in the formation of the Williams syndrome's cognitive phenotype? Is it possible to use Drosophila as a simple model system? ..