Gene Symbol: Trpm
Description: Transient receptor potential cation channel, subfamily M
Alias: BcDNA:GH04950, CG16805, CG30078, CG30079, CG34123, CG34187, CG44240, DmTRPM, Dmel\CG44240, Dmel_CG34123, TRPM, TrpM, dTRPM, mdcds_11815, trpm, transient receptor potential cation channel, subfamily M, CG44240-PA, CG44240-PB, CG44240-PD, CG44240-PE, CG44240-PF, CG44240-PG, CG44240-PH, CG44240-PI, CG44240-PJ, Trpm-PA, Trpm-PB, Trpm-PD, Trpm-PE, Trpm-PF, Trpm-PG, Trpm-PH, Trpm-PI, Trpm-PJ, transient receptor potential cation channel, subfamily M ortholog, transient receptor potential channel M
Species: fruit fly

Top Publications

  1. Hofmann T, Chubanov V, Chen X, Dietz A, Gudermann T, Montell C. Drosophila TRPM channel is essential for the control of extracellular magnesium levels. PLoS ONE. 2010;5:e10519 pubmed publisher
    The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans...
  2. Caterina M, Montell C. Take a TRP to beat the heat. Genes Dev. 2005;19:415-8 pubmed
  3. Georgiev P, Okkenhaug H, Drews A, Wright D, Lambert S, Flick M, et al. TRPM channels mediate zinc homeostasis and cellular growth during Drosophila larval development. Cell Metab. 2010;12:386-397 pubmed publisher
    ..We report that the single Drosophila TRPM gene (dTRPM) generates a conductance permeable to divalent cations, especially Zn(2+) and in vivo a loss-of-function mutation ..
  4. Antunes M, Pereira T, Cordeiro J, Almeida L, Jacinto A. Coordinated waves of actomyosin flow and apical cell constriction immediately after wounding. J Cell Biol. 2013;202:365-79 pubmed publisher
    ..concentration increased dramatically immediately after wounding, and down-regulation of transient receptor potential channel M, a stress-activated calcium channel, also impaired the actomyosin flow...
  5. Rosenzweig M, Brennan K, Tayler T, Phelps P, Patapoutian A, Garrity P. The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis. Genes Dev. 2005;19:419-24 pubmed
    ..Our data suggest that thermotaxis relies upon neurons and molecules distinct from those required for high-temperature nociception. We propose dTRPA1 may control thermotaxis by sensing environmental temperature. ..
  6. Montell C. Drosophila TRP channels. Pflugers Arch. 2005;451:19-28 pubmed
    ..As a result, the repertoire of biological roles attributed to Drosophila TRPs has increased considerably and is likely to lead to many additional surprises over the next few years. ..
  7. Razzell W, Evans I, Martin P, Wood W. Calcium flashes orchestrate the wound inflammatory response through DUOX activation and hydrogen peroxide release. Curr Biol. 2013;23:424-9 pubmed publisher
    ..Therefore, calcium represents the earliest signal in the wound inflammatory response. ..
  8. Venkatachalam K, Luo J, Montell C. Evolutionarily conserved, multitasking TRP channels: lessons from worms and flies. Handb Exp Pharmacol. 2014;223:937-62 pubmed publisher
    ..Thus, worms and flies offer the potential to decipher roles for mammalian TRPs, which would otherwise not be suspected. ..
  9. Roos J, DiGregorio P, Yeromin A, Ohlsen K, Lioudyno M, Zhang S, et al. STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol. 2005;169:435-45 pubmed
    ..We propose that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels. ..

More Information


  1. Kwon Y, Shen W, Shim H, Montell C. Fine thermotactic discrimination between the optimal and slightly cooler temperatures via a TRPV channel in chordotonal neurons. J Neurosci. 2010;30:10465-71 pubmed publisher
    ..We conclude that the decision to select the preferred over slightly cooler temperatures requires iav and is achieved by activating chordotonal neurons, which in turn induces repulsive behaviors, due to an increase in high angle turns. ..
  2. Adamson A, Chohan K, Swenson J, Lajeunesse D. A Drosophila model for genetic analysis of influenza viral/host interactions. Genetics. 2011;189:495-506 pubmed publisher
  3. Fowler M, Montell C. Drosophila TRP channels and animal behavior. Life Sci. 2013;92:394-403 pubmed publisher
    ..quot; Drosophila TRPs also function in the sensation of botanically derived insect repellents, and related TRPs in insect pests are potential targets for the development of improved repellents to combat insect-borne diseases. ..
  4. Feng X, Huang Y, Lu Y, Xiong J, Wong C, Yang P, et al. Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane. J Biol Chem. 2014;289:4262-72 pubmed publisher
    ..These features resemble more closely to mammalian TRPML1 than TRPML2 and TRPML3, but with some obvious differences. Together, our data support the use of Drosophila for assessing functional significance of TRPML1 in cell physiology. ..