Gene Symbol: trpl
Description: transient receptor potential-like
Alias: CG1694, CG18345, DmTRPL, Dmel\CG18345, TRP-Like, TRPL, TrpL, Trpl, dTRPL, dTrpL, trp-l, trpL, transient receptor potential-like, CG18345-PA, CG18345-PB, CG18345-PD, TRP-like, transient receptor Potential-Like, trpl-PA, trpl-PB, trpl-PD
Species: fruit fly
Products:     trpl

Top Publications

  1. Obukhov A, Harteneck C, Zobel A, Harhammer R, Kalkbrenner F, Leopoldt D, et al. Direct activation of trpl cation channels by G alpha11 subunits. EMBO J. 1996;15:5833-8 pubmed
    ..The related trp-like (trpl) gene product also forms a Ca(2+)-permeable cation channel, but is not activated by store depletion...
  2. Montell C. New light on TRP and TRPL. Mol Pharmacol. 1997;52:755-63 pubmed
    ..The human TRP-related proteins may mediate many of the store-operated conductances that have been identified previously in a plethora of human cells. ..
  3. Scott K, Zuker C. TRP, TRPL and trouble in photoreceptor cells. Curr Opin Neurobiol. 1998;8:383-8 pubmed
    Calcium influx through the TRP and TRPL light-activated channels triggers a complex regulatory hierarchy resulting in positive and negative feedback regulation of the phototransduction cascade...
  4. Yagodin S, Hardie R, Lansdell S, Millar N, Mason W, Sattelle D. Thapsigargin and receptor-mediated activation of Drosophila TRPL channels stably expressed in a Drosophila S2 cell line. Cell Calcium. 1998;23:219-28 pubmed
    The Drosophila melanogaster genes, transient receptor potential (trp) and transient receptor potential-like (trpl) encode putative plasma membrane cation channels TRP and TRPL, respectively...
  5. Niemeyer B, Suzuki E, Scott K, Jalink K, Zuker C. The Drosophila light-activated conductance is composed of the two channels TRP and TRPL. Cell. 1996;85:651-9 pubmed
    ..The transient receptor potential-like (trpl) gene encodes a protein displaying 40% amino acid identity with TRP...
  6. Xu X, Choudhury A, Li X, Montell C. Coordination of an array of signaling proteins through homo- and heteromeric interactions between PDZ domains and target proteins. J Cell Biol. 1998;142:545-55 pubmed
    ..We also found that a second ion channel, TRPL, bound to INAD. Thus, most of the proteins involved directly in phototransduction appear to bind to INAD...
  7. Hardie R, Raghu P. Visual transduction in Drosophila. Nature. 2001;413:186-93 pubmed
    ..Analysis in Drosophila has revealed many of the underlying molecular strategies, leading to the discovery and characterization of signalling molecules of widespread importance. ..
  8. Chyb S, Raghu P, Hardie R. Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature. 1999;397:255-9 pubmed
    ..fatty acids reversibly activate native light-sensitive channels (transient receptor potential (TRP) and TRP-like (TRPL)) in Drosophila photoreceptors as well as recombinant TRPL channels expressed in Drosophila S2 cells...
  9. Tsunoda S, Sierralta J, Sun Y, Bodner R, Suzuki E, Becker A, et al. A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature. 1997;388:243-9 pubmed
    ..A picture emerges of a highly organized unit of signalling, a 'transduclisome', with PDZ domains functioning as key elements in the organization of transduction complexes in vivo. ..

More Information


  1. Hardie R, Reuss H, Lansdell S, Millar N. Functional equivalence of native light-sensitive channels in the Drosophila trp301 mutant and TRPL cation channels expressed in a stably transfected Drosophila cell line. Cell Calcium. 1997;21:431-40 pubmed
    ..photoreceptors express two putative cation channels encoded by the transient receptor potential (trp) and trp-like (trpl) genes, which represent prototypical members of a novel family of phosphoinositide-regulated calcium influx ..
  2. Harteneck C, Obukhov A, Zobel A, Kalkbrenner F, Schultz G. The Drosophila cation channel trpl expressed in insect Sf9 cells is stimulated by agonists of G-protein-coupled receptors. FEBS Lett. 1995;358:297-300 pubmed
    ..Therefore, the Drosophila photoreceptor channels, trp and trpl, which are assumed to be involved in calcium influx, serve as model system, trpl expressed in Sf9 cells showed ..
  3. Hu Y, Vaca L, Zhu X, Birnbaumer L, Kunze D, Schilling W. Appearance of a novel Ca2+ influx pathway in Sf9 insect cells following expression of the transient receptor potential-like (trpl) protein of Drosophila. Biochem Biophys Res Commun. 1994;201:1050-6 pubmed
    ..Electrophysiological studies suggest that trp and trpl proteins may be important for the light-activated Ca2+ current found in Drosophila photoreceptor cells...
  4. Leung H, Geng C, Pak W. Phenotypes of trpl mutants and interactions between the transient receptor potential (TRP) and TRP-like channels in Drosophila. J Neurosci. 2000;20:6797-803 pubmed
    The trp and trpl genes are thought to encode two classes of light-activated ion channels in Drosophila. A previous report indicated that a null trpl mutant does not display any mutant phenotype...
  5. Bähner M, Frechter S, Da Silva N, Minke B, Paulsen R, Huber A. Light-regulated subcellular translocation of Drosophila TRPL channels induces long-term adaptation and modifies the light-induced current. Neuron. 2002;34:83-93 pubmed
    ..of two classes of cation channels, composed of the channel subunits transient receptor potential (TRP), TRP-like (TRPL), and TRPgamma...
  6. Towers P, Sattelle D. A Drosophila melanogaster cell line (S2) facilitates post-genome functional analysis of receptors and ion channels. Bioessays. 2002;24:1066-73 pubmed
    ..In addition, many useful orthologues of human disease genes are emerging from the Drosophila genome and the study of their functions and interactions is another area for postgenome applications of S2 cell lines. ..
  7. Venkatachalam K, van Rossum D, Patterson R, Ma H, Gill D. The cellular and molecular basis of store-operated calcium entry. Nat Cell Biol. 2002;4:E263-72 pubmed
    ..Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals. ..
  8. Raghu P, Colley N, Webel R, James T, Hasan G, Danin M, et al. Normal phototransduction in Drosophila photoreceptors lacking an InsP(3) receptor gene. Mol Cell Neurosci. 2000;15:429-45 pubmed
    The Drosophila light-sensitive channels TRP and TRPL are prototypical members of an ion channel family responsible for a variety of receptor-mediated Ca(2+) influx phenomena, including store-operated calcium influx...
  9. Kwon Y, Kim S, Ronderos D, Lee Y, Akitake B, Woodward O, et al. Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Curr Biol. 2010;20:1672-8 pubmed publisher
  10. Satoh A, Xia H, Yan L, Liu C, Hardie R, Ready D. Arrestin translocation is stoichiometric to rhodopsin isomerization and accelerated by phototransduction in Drosophila photoreceptors. Neuron. 2010;67:997-1008 pubmed publisher
    ..Our results indicate that Arr2 translocation in Drosophila photoreceptors is driven by diffusion, but profoundly accelerated by phototransduction and Ca2+ influx. ..
  11. Fanning A, Anderson J. Protein modules as organizers of membrane structure. Curr Opin Cell Biol. 1999;11:432-9 pubmed
    ..The organization of these proteins into discreet structures has functional consequences for downstream signaling. ..
  12. Lev S, Katz B, Tzarfaty V, Minke B. Signal-dependent hydrolysis of phosphatidylinositol 4,5-bisphosphate without activation of phospholipase C: implications on gating of Drosophila TRPL (transient receptor potential-like) channel. J Biol Chem. 2012;287:1436-47 pubmed publisher
    ..couples photo-excitation of rhodopsin to the opening of the transient receptor potential (TRP) and TRP-like (TRPL) channels...
  13. Montell C. TRP trapped in fly signaling web. Curr Opin Neurobiol. 1998;8:389-97 pubmed
    ..eye, photoactivation of rhodopsin leads to the opening of the light-sensitive cation influx channels TRP and TRPL. This response is extremely rapid and results in depolarization of the photoreceptor cells followed by Ca(2+)-..
  14. Meyer N, Joel Almagor T, Frechter S, Minke B, Huber A. Subcellular translocation of the eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade. J Cell Sci. 2006;119:2592-603 pubmed
    ..In Drosophila phototransduction the cation channels TRP and TRP-like (TRPL) are the targets of a prototypical G protein-coupled signaling pathway...
  15. Delgado R, Bacigalupo J. Unitary recordings of TRP and TRPL channels from isolated Drosophila retinal photoreceptor rhabdomeres: activation by light and lipids. J Neurophysiol. 2009;101:2372-9 pubmed publisher
    ..We report patch-clamp recordings from intact isolated photoreceptors of wt and mutant flies lacking TRP (trp(343)), TRPL (trpl(302)), or both channels (trp(313); trpl(302))...
  16. Cronin M, Diao F, Tsunoda S. Light-dependent subcellular translocation of Gqalpha in Drosophila photoreceptors is facilitated by the photoreceptor-specific myosin III NINAC. J Cell Sci. 2004;117:4797-806 pubmed
  17. Phillips A, Bull A, Kelly L. Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene. Neuron. 1992;8:631-42 pubmed
    ..We propose the name transient receptor potential-like (trpl) to describe this newly isolated gene...
  18. Kim S, Lee Y, Akitake B, Woodward O, Guggino W, Montell C. Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons. Proc Natl Acad Sci U S A. 2010;107:8440-5 pubmed publisher
    ..Given that mammalian TRPA1 is required for responding to noxious chemicals, many of which cause pain and injury, our analysis underscores the evolutionarily conserved role for TRPA1 channels in chemical avoidance...
  19. Fowler M, Montell C. Drosophila TRP channels and animal behavior. Life Sci. 2013;92:394-403 pubmed publisher
    ..quot; Drosophila TRPs also function in the sensation of botanically derived insect repellents, and related TRPs in insect pests are potential targets for the development of improved repellents to combat insect-borne diseases. ..
  20. Parnas M, Katz B, Minke B. Open channel block by Ca2+ underlies the voltage dependence of drosophila TRPL channel. J Gen Physiol. 2007;129:17-28 pubmed
    The light-activated channels of Drosophila photoreceptors transient receptor potential (TRP) and TRP-like (TRPL) show voltage-dependent conductance during illumination...
  21. Kunze D, Sinkins W, Vaca L, Schilling W. Properties of single Drosophila Trpl channels expressed in Sf9 insect cells. Am J Physiol. 1997;272:C27-34 pubmed
    The transient receptor potential (trp)-like (trpl) gene is thought to encode an ion channel important for signal transduction in Drosophila photoreceptor cells...
  22. Gu Y, Oberwinkler J, Postma M, Hardie R. Mechanisms of light adaptation in Drosophila photoreceptors. Curr Biol. 2005;15:1228-34 pubmed
  23. Warr C, Kelly L. Identification and characterization of two distinct calmodulin-binding sites in the Trpl ion-channel protein of Drosophila melanogaster. Biochem J. 1996;314 ( Pt 2):497-503 pubmed
    ..isolated from Drosophila, encoded by the transient-receptor-potential (trp) and transient-receptor-potential-like (trpl) genes...
  24. Richter D, Katz B, Oberacker T, Tzarfaty V, Belusic G, Minke B, et al. Translocation of the Drosophila transient receptor potential-like (TRPL) channel requires both the N- and C-terminal regions together with sustained Ca2+ entry. J Biol Chem. 2011;286:34234-43 pubmed publisher
    In Drosophila photoreceptors the transient receptor potential-like (TRPL), but not the TRP channels undergo light-dependent translocation between the rhabdomere and cell body...
  25. Parnas M, Peters M, Dadon D, Lev S, Vertkin I, Slutsky I, et al. Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium. 2009;45:300-9 pubmed publisher
    ..cells that carvacrol, a known activator of the thermoTRPs, TRPV3 and TRPA1 is an inhibitor of the Drosophila TRPL channels, which belongs to the TRPC subfamily...
  26. Chevesich J, Kreuz A, Montell C. Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex. Neuron. 1997;18:95-105 pubmed
    ..Furthermore, disruption of this interaction results in retinal degeneration. We propose that the TRP channel is linked to NORPA and RH1 to facilitate feedback regulation of these upstream signaling molecules. ..
  27. Huber A, Sander P, Gobert A, Bahner M, Hermann R, Paulsen R. The transient receptor potential protein (Trp), a putative store-operated Ca2+ channel essential for phosphoinositide-mediated photoreception, forms a signaling complex with NorpA, InaC and InaD. EMBO J. 1996;15:7036-45 pubmed
    ..It is suggested that the organization of signal transducing proteins into a multiprotein complex provides the structural basis for an efficient and fast activation and regulation of Ca2+ entry through the Trp channel. ..
  28. Hardie R, Gu Y, Martin F, Sweeney S, Raghu P. In vivo light-induced and basal phospholipase C activity in Drosophila photoreceptors measured with genetically targeted phosphatidylinositol 4,5-bisphosphate-sensitive ion channels (Kir2.1). J Biol Chem. 2004;279:47773-82 pubmed
    ..were made from mutants lacking both classes of light-sensitive transient receptor potential channels (TRP and TRPL)...
  29. Kwon Y, Shim H, Wang X, Montell C. Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat Neurosci. 2008;11:871-3 pubmed publisher
    ..We propose that activation of TRPA1 through a signaling cascade promotes amplification of small differences in temperature and facilitates adaptation to temperatures within the comfortable range. ..
  30. Rosenzweig M, Kang K, Garrity P. Distinct TRP channels are required for warm and cool avoidance in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2008;105:14668-73 pubmed publisher
    ..Here we identify two TRP channels required for cool avoidance, TRPL and TRP...
  31. Henderson S, Reuss H, Hardie R. Single photon responses in Drosophila photoreceptors and their regulation by Ca2+. J Physiol. 2000;524 Pt 1:179-94 pubmed
    ..Bumps in trpl mutants lacking the second class of light-sensitive channel were very similar to WT bumps, but with slightly slower ..
  32. Zimmer S, Trost C, Wissenbach U, Philipp S, Freichel M, Flockerzi V, et al. Modulation of recombinant transient-receptor-potential-like (TRPL) channels by cytosolic Ca2+. Pflugers Arch. 2000;440:409-17 pubmed
    ..examine the involvement of intracellular Ca2+ in the modulation of recombinant transient-receptor-potential like (TRPL) channels of Drosophila photoreceptor cells...
  33. Xu X, Chien F, Butler A, Salkoff L, Montell C. TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL. Neuron. 2000;26:647-57 pubmed
    TRP and TRPL are two light-sensitive cation channel subunits required for the Drosophila photoresponse; however, our understanding of the identities, subunit composition, and function of the light-responsive channels is incomplete...
  34. Oberegelsbacher C, Schneidler C, Voolstra O, Cerny A, Huber A. The Drosophila TRPL ion channel shares a Rab-dependent translocation pathway with rhodopsin. Eur J Cell Biol. 2011;90:620-30 pubmed publisher
    ..embedded in the rhabdomeres of photoreceptor cells and culminates in the opening of the two ion channels, TRP and TRPL. TRPL translocates from the rhabdomeres to the cell body upon illumination and vice versa when flies are kept in ..
  35. Huang J, Liu C, Hughes S, Postma M, Schwiening C, Hardie R. Activation of TRP channels by protons and phosphoinositide depletion in Drosophila photoreceptors. Curr Biol. 2010;20:189-97 pubmed publisher
    ..phospholipase C (PLC), but how PLC activation leads to the opening of the light-sensitive TRPC channels (TRP and TRPL) remains unresolved...
  36. Reuss H, Mojet M, Chyb S, Hardie R. In vivo analysis of the drosophila light-sensitive channels, TRP and TRPL. Neuron. 1997;19:1249-59 pubmed
    ..conductance with that in mutants lacking one or the other of the putative light-sensitive channel subunits, TRP and TRPL. For a wide range of cations, ionic permeability ratios in wild type were always intermediate between those of trp ..
  37. Wang T, Jiao Y, Montell C. Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel. J Cell Biol. 2005;171:685-94 pubmed
    ..This retinal degeneration was greatly suppressed by elimination of the Na(+)/Ca(2+) exchanger, CalX, indicating that the cell death was due primarily to deficient Ca(2+) entry rather than disruption of the TRP-anchoring function. ..
  38. Raghu P, Usher K, Jonas S, Chyb S, Polyanovsky A, Hardie R. Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA. Neuron. 2000;26:169-79 pubmed rdgA;trp double mutants, lacking TRP channels; however, the less Ca2+-permeable light-sensitive channels (TRPL) were constitutively active instead...
  39. Hardie R, Franze K. Photomechanical responses in Drosophila photoreceptors. Science. 2012;338:260-3 pubmed publisher
    ..leading by an unknown mechanism to activation of the prototypical transient receptor potential (TRP) and TRP-like (TRPL) channels...
  40. Cronin M, Lieu M, Tsunoda S. Two stages of light-dependent TRPL-channel translocation in Drosophila photoreceptors. J Cell Sci. 2006;119:2935-44 pubmed
    ..In Drosophila photoreceptors, TRP-like (TRPL) channels are localized to the signaling compartment, the rhabdomere, in the dark, and undergo light-induced ..
  41. MacPherson M, Pollock V, Kean L, Southall T, Giannakou M, Broderick K, et al. Transient receptor potential-like channels are essential for calcium signaling and fluid transport in a Drosophila epithelium. Genetics. 2005;169:1541-52 pubmed
    ..RT-PCR revealed expression of trp, trpl, and trpgamma in tubules...
  42. Li H, Montell C. TRP and the PDZ protein, INAD, form the core complex required for retention of the signalplex in Drosophila photoreceptor cells. J Cell Biol. 2000;150:1411-22 pubmed
    ..Rather, the primary function of the TRP/ INAD complex is to form the core unit required for localization of the signalplex to the rhabdomeres. ..
  43. Goel M, Garcia R, Estacion M, Schilling W. Regulation of Drosophila TRPL channels by immunophilin FKBP59. J Biol Chem. 2001;276:38762-73 pubmed
    Transient receptor potential and transient receptor potential-like (TRPL) are Ca(2+)-permeable cation channels found in Drosophila photoreceptor cells associated with large multimeric signaling complexes held together by the scaffolding ..
  44. Gillo B, Chorna I, Cohen H, Cook B, Manistersky I, Chorev M, et al. Coexpression of Drosophila TRP and TRP-like proteins in Xenopus oocytes reconstitutes capacitative Ca2+ entry. Proc Natl Acad Sci U S A. 1996;93:14146-51 pubmed
    ..Ca2+ entry mutant designated transient receptor potential (trp) and a Drosophila gene encoding TRP-like protein (trpl)...
  45. Sanxaridis P, Cronin M, Rawat S, Waro G, Acharya U, Tsunoda S. Light-induced recruitment of INAD-signaling complexes to detergent-resistant lipid rafts in Drosophila photoreceptors. Mol Cell Neurosci. 2007;36:36-46 pubmed
    ..Finally, selective recruitment of phosphorylated, and therefore activatable, eye-PKC to DRM rafts suggests that DRM domains are likely to function in signaling, rather than trafficking. ..
  46. Xiang Y, Yuan Q, Vogt N, Looger L, Jan L, Jan Y. Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature. 2010;468:921-6 pubmed publisher
    ..These novel photoreceptors use phototransduction machinery distinct from other photoreceptors in Drosophila and enable larvae to sense light exposure over their entire bodies and move out of danger. ..
  47. Padinjat R, Andrews S. TRP channels at a glance. J Cell Sci. 2004;117:5707-9 pubmed
  48. Xu X, Li H, Guggino W, Montell C. Coassembly of TRP and TRPL produces a distinct store-operated conductance. Cell. 1997;89:1155-64 pubmed
    ..elegans to humans. In vitro studies indicate that TRP is a SOC, but that the related retinal protein, TRPL, is constitutively active...
  49. Agam K, von Campenhausen M, Levy S, Ben Ami H, Cook B, Kirschfeld K, et al. Metabolic stress reversibly activates the Drosophila light-sensitive channels TRP and TRPL in vivo. J Neurosci. 2000;20:5748-55 pubmed ion-selective microelectrodes in eyes of normal and mutant Drosophila to isolate the TRP and TRP-like (TRPL)-dependent currents...
  50. Scott K, Sun Y, Beckingham K, Zuker C. Calmodulin regulation of Drosophila light-activated channels and receptor function mediates termination of the light response in vivo. Cell. 1997;91:375-83 pubmed
    ..function, we demonstrate that the transient phenotype of trp mutants can be explained by CAM regulation of the TRPL channel rather than by the loss of a store-operated conductance leading to depletion of the internal stores...
  51. Lev S, Katz B, Minke B. The activity of the TRP-like channel depends on its expression system. Channels (Austin). 2012;6:86-93 pubmed publisher
    The Drosophila light activated TRP and TRPL channels have been a model for TRPC channel gating. Several gating mechanisms have been proposed following experiments conducted on photoreceptor and tissue cultured cells...
  52. Astorga G, Hartel S, Sanhueza M, Bacigalupo J. TRP, TRPL and cacophony channels mediate Ca2+ influx and exocytosis in photoreceptors axons in Drosophila. PLoS ONE. 2012;7:e44182 pubmed publisher
    In Drosophila photoreceptors Ca(2+)-permeable channels TRP and TRPL are the targets of phototransduction, occurring in photosensitive microvilli and mediated by a phospholipase C (PLC) pathway...
  53. Landry C, Castillo Davis C, Ogura A, Liu J, Hartl D. Systems-level analysis and evolution of the phototransduction network in Drosophila. Proc Natl Acad Sci U S A. 2007;104:3283-8 pubmed
    ..However, one gene encoding the light-induced ion channel TRPL (transient receptor potential-like) shows an excess of expression divergence relative to polymorphism, suggesting a ..
  54. Rosenbaum E, Brehm K, Vasiljevic E, Liu C, Hardie R, Colley N. XPORT-dependent transport of TRP and rhodopsin. Neuron. 2011;72:602-15 pubmed publisher
    ..Our results identify XPORT as a molecular chaperone and provide a mechanistic link between TRP channels and their GPCRs during biosynthesis and transport. ..
  55. Chorna Ornan I, Tzarfaty V, Ankri Eliahoo G, Joel Almagor T, Meyer N, Huber A, et al. Light-regulated interaction of Dmoesin with TRP and TRPL channels is required for maintenance of photoreceptors. J Cell Biol. 2005;171:143-52 pubmed
    ..Thus, our data strongly suggest that the light- and phosphorylation-dependent dynamic association of Dmoesin to membrane channels is involved in maintenance of the photoreceptor cells. ..
  56. Chu B, Liu C, Sengupta S, Gupta A, Raghu P, Hardie R. Common mechanisms regulating dark noise and quantum bump amplification in Drosophila photoreceptors. J Neurophysiol. 2013;109:2044-55 pubmed publisher
    ..By contrast, quantum bump generation is reliable but delayed until sufficient G proteins and PLC are activated to overcome threshold, thereby ensuring generation of full-size bumps with high quantum efficiency. ..