Gene Symbol: Trpgamma
Description: Transient receptor potential cation channel gamma
Alias: CG5996, DmTRPgamma, Dmel\CG5996, TRPgamma, Trp-gamma, dTRPg, dTRPgamma, trp-gamma, trpgamma, transient receptor potential cation channel gamma, CG5996-PA, CG5996-PB, CG5996-PD, Trpgamma-PA, Trpgamma-PB, Trpgamma-PD, trpgamma
Species: fruit fly
Products:     Trpgamma

Top Publications

  1. Xu X, Chien F, Butler A, Salkoff L, Montell C. TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL. Neuron. 2000;26:647-57 pubmed
    ..Here, we identify such a subunit, TRPgamma. We show that TRPgamma is highly enriched in photoreceptor cells and preferentially heteromultimerizes with TRPL ..
  2. Kwon Y, Kim S, Ronderos D, Lee Y, Akitake B, Woodward O, et al. Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Curr Biol. 2010;20:1672-8 pubmed publisher
  3. Kwon Y, Shim H, Wang X, Montell C. Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat Neurosci. 2008;11:871-3 pubmed publisher
    ..We propose that activation of TRPA1 through a signaling cascade promotes amplification of small differences in temperature and facilitates adaptation to temperatures within the comfortable range. ..
  4. MacPherson M, Pollock V, Kean L, Southall T, Giannakou M, Broderick K, et al. Transient receptor potential-like channels are essential for calcium signaling and fluid transport in a Drosophila epithelium. Genetics. 2005;169:1541-52 pubmed
    ..RT-PCR revealed expression of trp, trpl, and trpgamma in tubules...
  5. Kim S, Lee Y, Akitake B, Woodward O, Guggino W, Montell C. Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons. Proc Natl Acad Sci U S A. 2010;107:8440-5 pubmed publisher
    ..Given that mammalian TRPA1 is required for responding to noxious chemicals, many of which cause pain and injury, our analysis underscores the evolutionarily conserved role for TRPA1 channels in chemical avoidance...
  6. Wicher D, Agricola H, Schönherr R, Heinemann S, Derst C. TRPgamma channels are inhibited by cAMP and contribute to pacemaking in neurosecretory insect neurons. J Biol Chem. 2006;281:3227-36 pubmed
    ..pTRPgamma), a protein of 1194 amino acids showing 65% identity to the orthologous Drosophila channel protein dTRPgamma. Heterologous expression of pTRPgamma in HEK293 cells produced a constitutively active, non-selective cation ..
  7. Hardie R. Phototransduction in Drosophila melanogaster. J Exp Biol. 2001;204:3403-9 pubmed
  8. Roos J, DiGregorio P, Yeromin A, Ohlsen K, Lioudyno M, Zhang S, et al. STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol. 2005;169:435-45 pubmed
    ..We propose that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels. ..
  9. Fowler M, Montell C. Drosophila TRP channels and animal behavior. Life Sci. 2013;92:394-403 pubmed publisher
    ..quot; Drosophila TRPs also function in the sensation of botanically derived insect repellents, and related TRPs in insect pests are potential targets for the development of improved repellents to combat insect-borne diseases. ..

More Information


  1. Akitake B, Ren Q, Boiko N, Ni J, Sokabe T, Stockand J, et al. Coordination and fine motor control depend on Drosophila TRPγ. Nat Commun. 2015;6:7288 pubmed publisher
    ..Our findings indicate that TRPγ contributes to fine motor control through mechanical activation in proprioceptive organs, thereby promoting Ca(2+) influx, which is required for function. ..
  2. Venkatachalam K, Luo J, Montell C. Evolutionarily conserved, multitasking TRP channels: lessons from worms and flies. Handb Exp Pharmacol. 2014;223:937-62 pubmed publisher
    ..Thus, worms and flies offer the potential to decipher roles for mammalian TRPs, which would otherwise not be suspected. ..
  3. Zhang Y, Raghuwanshi R, Shen W, Montell C. Food experience-induced taste desensitization modulated by the Drosophila TRPL channel. Nat Neurosci. 2013;16:1468-76 pubmed publisher
    ..We propose that dynamic regulation of taste receptors by ubiquitin-mediated protein degradation comprises an important molecular mechanism that allows an animal to alter its taste behavior in response to a changing food environment. ..
  4. Kain P, Badsha F, Hussain S, Nair A, Hasan G, Rodrigues V. Mutants in phospholipid signaling attenuate the behavioral response of adult Drosophila to trehalose. Chem Senses. 2010;35:663-73 pubmed publisher
    ..These data together with observations from other mutants in phospholipid signaling provide insights into the mechanisms of taste transduction in Drosophila. ..
  5. Ni J, Liu L, Binari R, Hardy R, Shim H, Cavallaro A, et al. A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics. 2009;182:1089-100 pubmed publisher
  6. Jörs S, Kazanski V, Foik A, Krautwurst D, Harteneck C. Receptor-induced activation of Drosophila TRP gamma by polyunsaturated fatty acids. J Biol Chem. 2006;281:29693-702 pubmed
    ..In addition, a third Drosophila TRPC channel, TRPgamma, has been identified and described as an auxiliary subunit of TRPL...
  7. Kwon Y, Shen W, Shim H, Montell C. Fine thermotactic discrimination between the optimal and slightly cooler temperatures via a TRPV channel in chordotonal neurons. J Neurosci. 2010;30:10465-71 pubmed publisher
    ..We conclude that the decision to select the preferred over slightly cooler temperatures requires iav and is achieved by activating chordotonal neurons, which in turn induces repulsive behaviors, due to an increase in high angle turns. ..
  8. Montell C. Drosophila TRP channels. Pflugers Arch. 2005;451:19-28 pubmed
    ..As a result, the repertoire of biological roles attributed to Drosophila TRPs has increased considerably and is likely to lead to many additional surprises over the next few years. ..
  9. Badsha F, Kain P, Prabhakar S, Sundaram S, Padinjat R, Rodrigues V, et al. Mutants in Drosophila TRPC channels reduce olfactory sensitivity to carbon dioxide. PLoS ONE. 2012;7:e49848 pubmed publisher
    ..G?q has recently been implicated in olfactory sensing of carbon dioxide (CO(2)) and other odorants. Here we investigated the role of PLC? and TRPC channels for sensing CO(2) in Drosophila...
  10. Zelhof A, Koundakjian E, Scully A, Hardy R, Pounds L. Mutation of the photoreceptor specific homeodomain gene Pph13 results in defects in phototransduction and rhabdomere morphogenesis. Development. 2003;130:4383-92 pubmed
    ..In addition, we demonstrate that Pph13 exerts its effect by the regulation of photoreceptor specific gene expression. ..
  11. Voets T, Nilius B. TRPs make sense. J Membr Biol. 2003;192:1-8 pubmed
    ..In this review we discuss recent evidence that implicates members of the TRP superfamily in sensory signal transduction. ..
  12. Hardie R, Raghu P. Visual transduction in Drosophila. Nature. 2001;413:186-93 pubmed
    ..Analysis in Drosophila has revealed many of the underlying molecular strategies, leading to the discovery and characterization of signalling molecules of widespread importance. ..