trp

Summary

Gene Symbol: trp
Description: transient receptor potential
Alias: 559, CG7875, DmTRP, Dmel\CG7875, TRP, Trp, dTRP, dTrp, gene B, idl-B, transient receptor potential, CG7875-PA, CG7875-PB, Cosens-Manning mutant, INAD localization-B, transient photreceptor potential, transient receptor potential protein, trp-PA, trp-PB
Species: fruit fly
Products:     trp

Top Publications

  1. Adamski F, Zhu M, Bahiraei F, Shieh B. Interaction of eye protein kinase C and INAD in Drosophila. Localization of binding domains and electrophysiological characterization of a loss of association in transgenic flies. J Biol Chem. 1998;273:17713-9 pubmed
    ..eye-PKC, NORPA (phospholipase Cbeta), and transient-receptor-potential (TRP) (calcium channel) are integral components of a signal transduction complex organized by INAD, a protein containing ..
  2. Chyb S, Raghu P, Hardie R. Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature. 1999;397:255-9 pubmed
    ..Here we show that both of these fatty acids reversibly activate native light-sensitive channels (transient receptor potential (TRP) and TRP-like (TRPL)) in Drosophila photoreceptors as well as recombinant TRPL channels expressed ..
  3. Wes P, Xu X, Li H, Chien F, Doberstein S, Montell C. Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD. Nat Neurosci. 1999;2:447-53 pubmed
    ..Disruption of the NINAC/INAD interaction delayed termination of the photoreceptor response. Thus one role of this signaling complex is in rapid deactivation of the photoresponse. ..
  4. Bähner M, Frechter S, Da Silva N, Minke B, Paulsen R, Huber A. Light-regulated subcellular translocation of Drosophila TRPL channels induces long-term adaptation and modifies the light-induced current. Neuron. 2002;34:83-93 pubmed
    ..results in the opening of two classes of cation channels, composed of the channel subunits transient receptor potential (TRP), TRP-like (TRPL), and TRPgamma...
  5. Hardie R, Gu Y, Martin F, Sweeney S, Raghu P. In vivo light-induced and basal phospholipase C activity in Drosophila photoreceptors measured with genetically targeted phosphatidylinositol 4,5-bisphosphate-sensitive ion channels (Kir2.1). J Biol Chem. 2004;279:47773-82 pubmed
    ..To isolate Kir2.1 currents, recordings were made from mutants lacking both classes of light-sensitive transient receptor potential channels (TRP and TRPL)...
  6. Wang T, Xu H, Oberwinkler J, Gu Y, Hardie R, Montell C. Light activation, adaptation, and cell survival functions of the Na+/Ca2+ exchanger CalX. Neuron. 2005;45:367-78 pubmed
    ..CalX had reciprocal effects and greatly suppressed the retinal degeneration caused by constitutive activity of the TRP channel...
  7. Hardie R. Phototransduction in Drosophila melanogaster. J Exp Biol. 2001;204:3403-9 pubmed
    ..glycerol (DAG), leading to activation of two classes of Ca(2+)-permeable light-sensitive channel, encoded by the trp and trpl genes...
  8. Hardie R, Raghu P, Moore S, Juusola M, Baines R, Sweeney S. Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Neuron. 2001;30:149-59 pubmed
    The trp (transient receptor potential) gene encodes a Ca2+ channel responsible for the major component of the phospholipase C (PLC) mediated light response in Drosophila...
  9. Milligan S, Alb J, Elagina R, Bankaitis V, Hyde D. The phosphatidylinositol transfer protein domain of Drosophila retinal degeneration B protein is essential for photoreceptor cell survival and recovery from light stimulation. J Cell Biol. 1997;139:351-63 pubmed
    ..This in vivo analysis of PITP function in a metazoan system provides further insights into the links between PITP dysfunction and an inherited disease in a higher eukaryote. ..
  10. Chevesich J, Kreuz A, Montell C. Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex. Neuron. 1997;18:95-105 pubmed
    In Drosophila, the store-operated Ca2+ channel, TRP, is required in photoreceptor cells for a sustained response to light...

Detail Information

Publications75

  1. Adamski F, Zhu M, Bahiraei F, Shieh B. Interaction of eye protein kinase C and INAD in Drosophila. Localization of binding domains and electrophysiological characterization of a loss of association in transgenic flies. J Biol Chem. 1998;273:17713-9 pubmed
    ..eye-PKC, NORPA (phospholipase Cbeta), and transient-receptor-potential (TRP) (calcium channel) are integral components of a signal transduction complex organized by INAD, a protein containing ..
  2. Chyb S, Raghu P, Hardie R. Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL. Nature. 1999;397:255-9 pubmed
    ..Here we show that both of these fatty acids reversibly activate native light-sensitive channels (transient receptor potential (TRP) and TRP-like (TRPL)) in Drosophila photoreceptors as well as recombinant TRPL channels expressed ..
  3. Wes P, Xu X, Li H, Chien F, Doberstein S, Montell C. Termination of phototransduction requires binding of the NINAC myosin III and the PDZ protein INAD. Nat Neurosci. 1999;2:447-53 pubmed
    ..Disruption of the NINAC/INAD interaction delayed termination of the photoreceptor response. Thus one role of this signaling complex is in rapid deactivation of the photoresponse. ..
  4. Bähner M, Frechter S, Da Silva N, Minke B, Paulsen R, Huber A. Light-regulated subcellular translocation of Drosophila TRPL channels induces long-term adaptation and modifies the light-induced current. Neuron. 2002;34:83-93 pubmed
    ..results in the opening of two classes of cation channels, composed of the channel subunits transient receptor potential (TRP), TRP-like (TRPL), and TRPgamma...
  5. Hardie R, Gu Y, Martin F, Sweeney S, Raghu P. In vivo light-induced and basal phospholipase C activity in Drosophila photoreceptors measured with genetically targeted phosphatidylinositol 4,5-bisphosphate-sensitive ion channels (Kir2.1). J Biol Chem. 2004;279:47773-82 pubmed
    ..To isolate Kir2.1 currents, recordings were made from mutants lacking both classes of light-sensitive transient receptor potential channels (TRP and TRPL)...
  6. Wang T, Xu H, Oberwinkler J, Gu Y, Hardie R, Montell C. Light activation, adaptation, and cell survival functions of the Na+/Ca2+ exchanger CalX. Neuron. 2005;45:367-78 pubmed
    ..CalX had reciprocal effects and greatly suppressed the retinal degeneration caused by constitutive activity of the TRP channel...
  7. Hardie R. Phototransduction in Drosophila melanogaster. J Exp Biol. 2001;204:3403-9 pubmed
    ..glycerol (DAG), leading to activation of two classes of Ca(2+)-permeable light-sensitive channel, encoded by the trp and trpl genes...
  8. Hardie R, Raghu P, Moore S, Juusola M, Baines R, Sweeney S. Calcium influx via TRP channels is required to maintain PIP2 levels in Drosophila photoreceptors. Neuron. 2001;30:149-59 pubmed
    The trp (transient receptor potential) gene encodes a Ca2+ channel responsible for the major component of the phospholipase C (PLC) mediated light response in Drosophila...
  9. Milligan S, Alb J, Elagina R, Bankaitis V, Hyde D. The phosphatidylinositol transfer protein domain of Drosophila retinal degeneration B protein is essential for photoreceptor cell survival and recovery from light stimulation. J Cell Biol. 1997;139:351-63 pubmed
    ..This in vivo analysis of PITP function in a metazoan system provides further insights into the links between PITP dysfunction and an inherited disease in a higher eukaryote. ..
  10. Chevesich J, Kreuz A, Montell C. Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex. Neuron. 1997;18:95-105 pubmed
    In Drosophila, the store-operated Ca2+ channel, TRP, is required in photoreceptor cells for a sustained response to light...
  11. Liu M, Parker L, Wadzinski B, Shieh B. Reversible phosphorylation of the signal transduction complex in Drosophila photoreceptors. J Biol Chem. 2000;275:12194-9 pubmed
    In the Drosophila visual cascade, the transient receptor potential (TRP) calcium channel, phospholipase Cbeta (no-receptor-potential A), and an eye-specific isoform of protein kinase C (eye-PKC) comprise a multimolecular signaling complex ..
  12. Kosloff M, Elia N, Joel Almagor T, Timberg R, Zars T, Hyde D, et al. Regulation of light-dependent Gqalpha translocation and morphological changes in fly photoreceptors. EMBO J. 2003;22:459-68 pubmed
  13. Hardie R, Franze K. Photomechanical responses in Drosophila photoreceptors. Science. 2012;338:260-3 pubmed publisher
    ..4,5-bisphosphate (PIP(2)), leading by an unknown mechanism to activation of the prototypical transient receptor potential (TRP) and TRP-like (TRPL) channels...
  14. MacPherson M, Pollock V, Kean L, Southall T, Giannakou M, Broderick K, et al. Transient receptor potential-like channels are essential for calcium signaling and fluid transport in a Drosophila epithelium. Genetics. 2005;169:1541-52 pubmed
    ..We demonstrate the first epithelial role, in vivo, for members of the TRP family of calcium channels. RT-PCR revealed expression of trp, trpl, and trpgamma in tubules...
  15. Cronin M, Diao F, Tsunoda S. Light-dependent subcellular translocation of Gqalpha in Drosophila photoreceptors is facilitated by the photoreceptor-specific myosin III NINAC. J Cell Sci. 2004;117:4797-806 pubmed
  16. Sakai T, Sato S, Ishimoto H, Kitamoto T. Significance of the centrally expressed TRP channel painless in Drosophila courtship memory. Learn Mem. 2012;20:34-40 pubmed publisher
    Considerable evidence has demonstrated that transient receptor potential (TRP) channels play vital roles in sensory neurons, mediating responses to various environmental stimuli...
  17. Xu X, Li H, Guggino W, Montell C. Coassembly of TRP and TRPL produces a distinct store-operated conductance. Cell. 1997;89:1155-64 pubmed
    The Drosophila retinal-specific protein, TRP (transient receptor potential), is the founding member of a family of store-operated channels (SOCs) conserved from C. elegans to humans...
  18. Satoh A, O Tousa J, Ozaki K, Ready D. Rab11 mediates post-Golgi trafficking of rhodopsin to the photosensitive apical membrane of Drosophila photoreceptors. Development. 2005;132:1487-97 pubmed
    ..Furthermore, Rab11 is required for transport of TRP, another rhabdomeric protein, and for development of specialized membrane structures within Garland cells...
  19. Fanning A, Anderson J. Protein modules as organizers of membrane structure. Curr Opin Cell Biol. 1999;11:432-9 pubmed
    ..The organization of these proteins into discreet structures has functional consequences for downstream signaling. ..
  20. Reuss H, Mojet M, Chyb S, Hardie R. In vivo analysis of the drosophila light-sensitive channels, TRP and TRPL. Neuron. 1997;19:1249-59 pubmed
    ..conductance with that in mutants lacking one or the other of the putative light-sensitive channel subunits, TRP and TRPL...
  21. Kwon Y, Shim H, Wang X, Montell C. Control of thermotactic behavior via coupling of a TRP channel to a phospholipase C signaling cascade. Nat Neurosci. 2008;11:871-3 pubmed publisher
    ..We propose that activation of TRPA1 through a signaling cascade promotes amplification of small differences in temperature and facilitates adaptation to temperatures within the comfortable range. ..
  22. Kim S, Lee Y, Akitake B, Woodward O, Guggino W, Montell C. Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons. Proc Natl Acad Sci U S A. 2010;107:8440-5 pubmed publisher
    ..Given that mammalian TRPA1 is required for responding to noxious chemicals, many of which cause pain and injury, our analysis underscores the evolutionarily conserved role for TRPA1 channels in chemical avoidance...
  23. Rosenbaum E, Brehm K, Vasiljevic E, Liu C, Hardie R, Colley N. XPORT-dependent transport of TRP and rhodopsin. Neuron. 2011;72:602-15 pubmed publisher
    b>TRP channels have emerged as key biological sensors in vision, taste, olfaction, hearing, and touch. Despite their importance, virtually nothing is known about the folding and transport of TRP channels during biosynthesis...
  24. Scott K, Sun Y, Beckingham K, Zuker C. Calmodulin regulation of Drosophila light-activated channels and receptor function mediates termination of the light response in vivo. Cell. 1997;91:375-83 pubmed
    ..Contrary to current models of excitation and TRP channel function, we demonstrate that the transient phenotype of trp mutants can be explained by CAM regulation of ..
  25. Liu C, Plaçais P, Yamagata N, Pfeiffer B, Aso Y, Friedrich A, et al. A subset of dopamine neurons signals reward for odour memory in Drosophila. Nature. 2012;488:512-6 pubmed publisher
    ..Dopamine in insects is known to mediate aversive reinforcement signals. Our results highlight the cellular specificity underlying the various roles of dopamine and the importance of spatially segregated local circuits within the MBs. ..
  26. Gu Y, Oberwinkler J, Postma M, Hardie R. Mechanisms of light adaptation in Drosophila photoreceptors. Curr Biol. 2005;15:1228-34 pubmed
    ..in Drosophila is mediated by a phospholipase C (PLC) cascade culminating in activation of transient receptor potential (TRP) channels...
  27. Lee S, Montell C. Suppression of constant-light-induced blindness but not retinal degeneration by inhibition of the rhodopsin degradation pathway. Curr Biol. 2004;14:2076-85 pubmed
    ..Our results support a model in which visual impairment caused by continuous illumination occurs through an arrestin-dependent pathway that promotes degradation of rhodopsin. ..
  28. Huang J, Liu C, Hughes S, Postma M, Schwiening C, Hardie R. Activation of TRP channels by protons and phosphoinositide depletion in Drosophila photoreceptors. Curr Biol. 2010;20:189-97 pubmed publisher
    ..phospholipase C (PLC), but how PLC activation leads to the opening of the light-sensitive TRPC channels (TRP and TRPL) remains unresolved...
  29. Voolstra O, Beck K, Oberegelsbacher C, Pfannstiel J, Huber A. Light-dependent phosphorylation of the drosophila transient receptor potential ion channel. J Biol Chem. 2010;285:14275-84 pubmed publisher
    The Drosophila phototransduction cascade terminates in the opening of an ion channel, designated transient receptor potential (TRP)...
  30. Shieh B, Zhu M. Regulation of the TRP Ca2+ channel by INAD in Drosophila photoreceptors. Neuron. 1996;16:991-8 pubmed
    ..We report that anti-INAD antibodies coimmunoprecipitate TRP, identified by its electrophoretic mobility, cross reactivity with anti-TRP antibody, and absence in a null allele ..
  31. Leung H, Geng C, Pak W. Phenotypes of trpl mutants and interactions between the transient receptor potential (TRP) and TRP-like channels in Drosophila. J Neurosci. 2000;20:6797-803 pubmed
    ..This lack of detectable mutant phenotypes made it difficult to suggest functions for the transient receptor potential-like (TRPL) channel in photoreceptor responses...
  32. Montell C, Rubin G. Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron. 1989;2:1313-23 pubmed
    ..that the fly uses the inositol lipid signaling system for visual excitation and that the Drosophila transient receptor potential (trp) mutation disrupts this process subsequent to the production of IP3...
  33. Paetkau D, Elagin V, Sendi L, Hyde D. Isolation and characterization of Drosophila retinal degeneration B suppressors. Genetics. 1999;151:713-24 pubmed
    ..This demonstrates that TRP activity, but not INAC, is required for rapid rdgB-dependent degeneration.
  34. LaLonde M, Janssens H, Rosenbaum E, Choi S, Gergen J, Colley N, et al. Regulation of phototransduction responsiveness and retinal degeneration by a phospholipase D-generated signaling lipid. J Cell Biol. 2005;169:471-9 pubmed
    ..Altogether, these findings suggest that Pld facilitates phototransduction by maintaining adequate levels of PIP2 and by protecting the visual system from metarhodopsin-induced, low light degeneration. ..
  35. Sengupta S, Barber T, Xia H, Ready D, Hardie R. Depletion of PtdIns(4,5)P? underlies retinal degeneration in Drosophila trp mutants. J Cell Sci. 2013;126:1247-59 pubmed publisher
    The prototypical transient receptor potential (TRP) channel is the major light-sensitive, and Ca(2+)-permeable channel in the microvillar photoreceptors of Drosophila...
  36. Hardie R, Peretz A, Suss Toby E, Rom Glas A, Bishop S, Selinger Z, et al. Protein kinase C is required for light adaptation in Drosophila photoreceptors. Nature. 1993;363:634-7 pubmed
    ..Furthermore, we show that in the absence of PKC individual bumps fail to terminate normally, an effect that can account for the pleiotropic manifestations of the inaC phenotype. ..
  37. Sanxaridis P, Cronin M, Rawat S, Waro G, Acharya U, Tsunoda S. Light-induced recruitment of INAD-signaling complexes to detergent-resistant lipid rafts in Drosophila photoreceptors. Mol Cell Neurosci. 2007;36:36-46 pubmed
    ..Mutations affecting INAD and TRP showed that PDZ4 and PDZ5 domains of INAD, as well as the INAD-TRP interaction, are required for translocation of ..
  38. Delgado R, Bacigalupo J. Unitary recordings of TRP and TRPL channels from isolated Drosophila retinal photoreceptor rhabdomeres: activation by light and lipids. J Neurophysiol. 2009;101:2372-9 pubmed publisher
    b>Transient receptor potential (TRP) channels play key roles in sensory transduction...
  39. Garcia Murillas I, Pettitt T, Macdonald E, Okkenhaug H, Georgiev P, Trivedi D, et al. lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction. Neuron. 2006;49:533-46 pubmed
    ..PI(4,5)P2 by phospholipase Cbeta (PLCbeta) to generate a second messenger that opens the light-activated channels TRP and TRPL...
  40. Voolstra O, Bartels J, Oberegelsbacher C, Pfannstiel J, Huber A. Phosphorylation of the Drosophila transient receptor potential ion channel is regulated by the phototransduction cascade and involves several protein kinases and phosphatases. PLoS ONE. 2013;8:e73787 pubmed publisher
    ..We previously reported the light-dependent phosphorylation of the Drosophila transient receptor potential (TRP) ion channel at multiple sites...
  41. Cosens D, Perry M. The fine structure of the eye of a visual mutant, A-type of Drosophila melanogaster. J Insect Physiol. 1972;18:1773-86 pubmed
  42. Peretz A, Sandler C, Kirschfeld K, Hardie R, Minke B. Genetic dissection of light-induced Ca2+ influx into Drosophila photoreceptors. J Gen Physiol. 1994;104:1057-77 pubmed
    ..changes of Ca2+ [delta Ca2+]o in Drosophila retina using Ca(2+)-selective microelectrodes in both the transient receptor potential (trp) mutant, in which the calcium permeability of the light-sensitive channels is greatly diminished ..
  43. Tsunoda S, Sierralta J, Sun Y, Bodner R, Suzuki E, Becker A, et al. A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade. Nature. 1997;388:243-9 pubmed
    ..A picture emerges of a highly organized unit of signalling, a 'transduclisome', with PDZ domains functioning as key elements in the organization of transduction complexes in vivo. ..
  44. Hardie R, Minke B. Phosphoinositide-mediated phototransduction in Drosophila photoreceptors: the role of Ca2+ and trp. Cell Calcium. 1995;18:256-74 pubmed
    ..The light-activated conductance in Drosophila is normally highly permeable to Ca2+, but in null mutants of the trp gene Ca2+ permeability is greatly reduced...
  45. Henderson S, Reuss H, Hardie R. Single photon responses in Drosophila photoreceptors and their regulation by Ca2+. J Physiol. 2000;524 Pt 1:179-94 pubmed
    ..Quantum bumps in trp mutants lacking the major class of light-sensitive channel were reduced in size (mean 3...
  46. Montell C. TRP trapped in fly signaling web. Curr Opin Neurobiol. 1998;8:389-97 pubmed
    ..the Drosophila eye, photoactivation of rhodopsin leads to the opening of the light-sensitive cation influx channels TRP and TRPL...
  47. Meyer N, Joel Almagor T, Frechter S, Minke B, Huber A. Subcellular translocation of the eGFP-tagged TRPL channel in Drosophila photoreceptors requires activation of the phototransduction cascade. J Cell Sci. 2006;119:2592-603 pubmed
    Signal-mediated translocation of transient receptor potential (TRP) channels is a novel mechanism to fine tune a variety of signaling pathways including neuronal path finding and Drosophila photoreception...
  48. Xiang Y, Yuan Q, Vogt N, Looger L, Jan L, Jan Y. Light-avoidance-mediating photoreceptors tile the Drosophila larval body wall. Nature. 2010;468:921-6 pubmed publisher
    ..These novel photoreceptors use phototransduction machinery distinct from other photoreceptors in Drosophila and enable larvae to sense light exposure over their entire bodies and move out of danger. ..
  49. Mecklenburg K, Takemori N, Komori N, Chu B, Hardie R, Matsumoto H, et al. Retinophilin is a light-regulated phosphoprotein required to suppress photoreceptor dark noise in Drosophila. J Neurosci. 2010;30:1238-49 pubmed publisher
    ..We propose that RTP is a light-regulated phosphoprotein that organizes rhabdomeric components to suppress random activation of the phototransduction cascade and thus increases the signaling fidelity of dark-adapted photoreceptors. ..
  50. Oberegelsbacher C, Schneidler C, Voolstra O, Cerny A, Huber A. The Drosophila TRPL ion channel shares a Rab-dependent translocation pathway with rhodopsin. Eur J Cell Biol. 2011;90:620-30 pubmed publisher
    ..is embedded in the rhabdomeres of photoreceptor cells and culminates in the opening of the two ion channels, TRP and TRPL...
  51. Richter D, Katz B, Oberacker T, Tzarfaty V, Belusic G, Minke B, et al. Translocation of the Drosophila transient receptor potential-like (TRPL) channel requires both the N- and C-terminal regions together with sustained Ca2+ entry. J Biol Chem. 2011;286:34234-43 pubmed publisher
    In Drosophila photoreceptors the transient receptor potential-like (TRPL), but not the TRP channels undergo light-dependent translocation between the rhabdomere and cell body...
  52. Pollock J, Assaf A, Peretz A, Nichols C, Mojet M, Hardie R, et al. TRP, a protein essential for inositide-mediated Ca2+ influx is localized adjacent to the calcium stores in Drosophila photoreceptors. J Neurosci. 1995;15:3747-60 pubmed
    The Drosophila transient receptor potential (trp) gene product (TRP) shows some structural similarity to vertebrate voltage-gated Ca2+ channels...
  53. Wang T, Jiao Y, Montell C. Dissecting independent channel and scaffolding roles of the Drosophila transient receptor potential channel. J Cell Biol. 2005;171:685-94 pubmed
    Drosophila transient receptor potential (TRP) serves dual roles as a cation channel and as a molecular anchor for the PDZ protein, INAD (inactivation no afterpotential D)...
  54. Georgiev P, Garcia Murillas I, Ulahannan D, Hardie R, Raghu P. Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant. J Cell Sci. 2005;118:1373-84 pubmed
    The TRP family of ion channels mediates a wide range of calcium-influx phenomena in eukaryotic cells...
  55. Parnas M, Peters M, Dadon D, Lev S, Vertkin I, Slutsky I, et al. Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium. 2009;45:300-9 pubmed publisher
    b>Transient receptor potential (TRP) channels are essential components of biological sensors that detect changes in the environment in response to a myriad of stimuli...
  56. Raghu P, Usher K, Jonas S, Chyb S, Polyanovsky A, Hardie R. Constitutive activity of the light-sensitive channels TRP and TRPL in the Drosophila diacylglycerol kinase mutant, rdgA. Neuron. 2000;26:169-79 pubmed
    ..Whole-cell recordings revealed that light-sensitive Ca2+ channels encoded by the trp gene were constitutively active in rdgA photoreceptors...
  57. Niemeyer B, Suzuki E, Scott K, Jalink K, Zuker C. The Drosophila light-activated conductance is composed of the two channels TRP and TRPL. Cell. 1996;85:651-9 pubmed
    ..The Drosophila light-activated conductance is constituted in part by the transient receptor potential (trp) ion channel, yet trp mutants still display a robust response demonstrating the presence of ..
  58. Liu C, Wang T, Postma M, Obukhov A, Montell C, Hardie R. In vivo identification and manipulation of the Ca2+ selectivity filter in the Drosophila transient receptor potential channel. J Neurosci. 2007;27:604-15 pubmed
    Null mutations in the transient receptor potential (trp) gene eliminate the major, Ca2+-selective component of the light-sensitive conductance in Drosophila photoreceptors...
  59. Peng L, Popescu D, Wang N, Shieh B. Anchoring TRP to the INAD macromolecular complex requires the last 14 residues in its carboxyl terminus. J Neurochem. 2008;104:1526-35 pubmed
    Drosophila transient-receptor-potential (TRP) is a Ca2+ channel responsible for the light-dependent depolarization of photoreceptors. TRP is anchored to a macromolecular complex by tethering to inactivation-no-afterpotential D (INAD)...
  60. Shieh B, Zhu M, Lee J, Kelly I, Bahiraei F. Association of INAD with NORPA is essential for controlled activation and deactivation of Drosophila phototransduction in vivo. Proc Natl Acad Sci U S A. 1997;94:12682-7 pubmed
    ..a G protein-coupled phospholipase C-mediated process that leads to depolarization via activation of the transient receptor potential (TRP) calcium channel...
  61. Xu X, Chien F, Butler A, Salkoff L, Montell C. TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL. Neuron. 2000;26:647-57 pubmed
    b>TRP and TRPL are two light-sensitive cation channel subunits required for the Drosophila photoresponse; however, our understanding of the identities, subunit composition, and function of the light-responsive channels is incomplete...
  62. Hardie R, Raghu P. Visual transduction in Drosophila. Nature. 2001;413:186-93 pubmed
    ..Analysis in Drosophila has revealed many of the underlying molecular strategies, leading to the discovery and characterization of signalling molecules of widespread importance. ..
  63. Rosenzweig M, Kang K, Garrity P. Distinct TRP channels are required for warm and cool avoidance in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2008;105:14668-73 pubmed publisher
    ..At the molecular level, members of the transient receptor potential (TRP) family of cation channels contribute to thermosensory behaviors in animals from flies to humans...
  64. Hardie R, Minke B. The trp gene is essential for a light-activated Ca2+ channel in Drosophila photoreceptors. Neuron. 1992;8:643-51 pubmed
    ..In the transient receptor potential (trp) mutant, one of the most intensively studied transduction mutants of Drosophila, the light ..
  65. Xu X, Wes P, Chen H, Li H, Yu M, Morgan S, et al. Retinal targets for calmodulin include proteins implicated in synaptic transmission. J Biol Chem. 1998;273:31297-307 pubmed
    ..calmodulin appear to be mediated, at least in part, by four previously identified calmodulin-binding proteins: the TRP and TRPL ion channels, NINAC and INAD...
  66. Lee S, Xu H, Kang L, Amzel L, Montell C. Light adaptation through phosphoinositide-regulated translocation of Drosophila visual arrestin. Neuron. 2003;39:121-32 pubmed
    ..Since phospholipase C activity is required for activation of Drosophila phototransduction, these data point to a dual role of PIs in phototransduction. ..
  67. Satoh A, Xia H, Yan L, Liu C, Hardie R, Ready D. Arrestin translocation is stoichiometric to rhodopsin isomerization and accelerated by phototransduction in Drosophila photoreceptors. Neuron. 2010;67:997-1008 pubmed publisher
    ..of key phototransduction proteins, including phospholipase C (PLC), Gq, and the light-sensitive Ca2+-permeable TRP channels, slows translocation by 10- to 100-fold...
  68. Huber A, Sander P, Gobert A, Bahner M, Hermann R, Paulsen R. The transient receptor potential protein (Trp), a putative store-operated Ca2+ channel essential for phosphoinositide-mediated photoreception, forms a signaling complex with NorpA, InaC and InaD. EMBO J. 1996;15:7036-45 pubmed
    The transient receptor potential protein (Trp) is a putative capacitative Ca2+ entry channel present in fly photoreceptors, which use the inositol 1,4,5-trisphosphate (InsP3) signaling pathway for phototransduction...
  69. Hiesinger P, Zhai R, Zhou Y, Koh T, Mehta S, Schulze K, et al. Activity-independent prespecification of synaptic partners in the visual map of Drosophila. Curr Biol. 2006;16:1835-43 pubmed
    ..analysis of photoreceptor synapses in mutants affecting the generation of electrical potentials (norpA, trp;trpl), neurotransmitter release (hdc, syt), vesicle endocytosis (synj), the trafficking of specific guidance ..
  70. Peretz A, Suss Toby E, Rom Glas A, Arnon A, Payne R, Minke B. The light response of Drosophila photoreceptors is accompanied by an increase in cellular calcium: effects of specific mutations. Neuron. 1994;12:1257-67 pubmed
    ..In Calcium Green-5N-loaded trp mutants, which lack a large fraction of the Ca2+ permeability underlying the light-evoked inward current, the Ca2+ ..
  71. Fowler M, Montell C. Drosophila TRP channels and animal behavior. Life Sci. 2013;92:394-403 pubmed publisher
    ..Among the many classes of ion channels, Transient Receptor Potential (TRP) cation channels are notable in contributing to virtually every sensory modality, and in ..
  72. Padinjat R, Andrews S. TRP channels at a glance. J Cell Sci. 2004;117:5707-9 pubmed
  73. Phillips A, Bull A, Kelly L. Identification of a Drosophila gene encoding a calmodulin-binding protein with homology to the trp phototransduction gene. Neuron. 1992;8:631-42 pubmed
    ..of amino acid sequence and tissue-specific expression are observed between this gene and the transient receptor potential (trp) gene...