Gene Symbol: Traf4
Description: TNF-receptor-associated factor 4
Alias: CG3048, DTRAF, DTRAF1, Dmel\CG3048, TRAF, TRAF1, TRAF4, Traf1, dTRAF, dTRAF1, dTraf1, dTraf4, dtraf1, traf-4, traf1, traf4, TNF-receptor-associated factor 4, CG3048-PA, CG3048-PE, TNF receptor associated factor 1, TNF-receptor-associated factor 1, Traf4-PA, Traf4-PE
Species: fruit fly

Top Publications

  1. Cha G, Cho K, Lee J, Kim M, Kim E, Park J, et al. Discrete functions of TRAF1 and TRAF2 in Drosophila melanogaster mediated by c-Jun N-terminal kinase and NF-kappaB-dependent signaling pathways. Mol Cell Biol. 2003;23:7982-91 pubmed
    Two Drosophila tumor necrosis factor receptor-associated factors (TRAF), DTRAF1 and DTRAF2, are proposed to have similar functions with their mammalian counterparts as a signal mediator of cell surface receptors...
  2. Igaki T, Pagliarini R, Xu T. Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol. 2006;16:1139-46 pubmed
    ..Similar oncogenic cooperation mediated through these evolutionarily conserved signaling pathways could contribute to human cancer progression. ..
  3. Xue L, Igaki T, Kuranaga E, Kanda H, Miura M, Xu T. Tumor suppressor CYLD regulates JNK-induced cell death in Drosophila. Dev Cell. 2007;13:446-54 pubmed
    ..These data provide a molecular mechanism for the tumor suppressor function of this evolutionary conserved molecule by indicating that dCYLD plays a critical role in modulating TNF-JNK-mediated cell death. ..
  4. Griciuc A, Roux M, Merl J, Giangrande A, Hauck S, Aron L, et al. Proteomic survey reveals altered energetic patterns and metabolic failure prior to retinal degeneration. J Neurosci. 2014;34:2797-812 pubmed publisher
    ..Genetic inactivation of the endoplasmic reticulum stress-induced JNK/TRAF1 axis as well as the APAF-1/caspase-9 axis, activated by damaged mitochondria, dramatically suppressed Rh1(P37H)-..
  5. Varfolomeev E, Ashkenazi A. Tumor necrosis factor: an apoptosis JuNKie?. Cell. 2004;116:491-7 pubmed
    ..Here, we review recent data on the role of JNK in the regulation of TNF-dependent apoptosis and discuss what is known so far about how cells decide whether to live or die in response to TNF. ..
  6. Wang H, Cai Y, Chia W, Yang X. Drosophila homologs of mammalian TNF/TNFR-related molecules regulate segregation of Miranda/Prospero in neuroblasts. EMBO J. 2006;25:5783-93 pubmed
    ..demonstrate that the Drosophila homolog of the mammalian tumor-necrosis factor (TNF) receptor-associated factor (DTRAF1) and Eiger (Egr), the homolog of the mammalian TNF, are required for telophase rescue of Mira/Pros...
  7. Zapata J, Matsuzawa S, Godzik A, Leo E, Wasserman S, Reed J. The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with Pelle and regulates NFkappaB activity. J Biol Chem. 2000;275:12102-7 pubmed
    A member of the tumor necrosis factor (TNF) receptor-associated factor (TRAF) family was identified in Drosophila. DTRAF1 contains 7 zinc finger domains followed by a TRAF domain, similar to mammalian TRAFs and other members of the family ..
  8. Aderem A, Ulevitch R. Toll-like receptors in the induction of the innate immune response. Nature. 2000;406:782-7 pubmed
    ..This reflects a remarkable conservation of function and it is therefore not surprising that studies of the mechanism by which they act has revealed new and important insights into host defence. ..
  9. Preiss A, Johannes B, Nagel A, Maier D, Peters N, Wajant H. Dynamic expression of Drosophila TRAF1 during embryogenesis and larval development. Mech Dev. 2001;100:109-13 pubmed
    ..Two TRAF homologues are present in the genome of Drosophila melanogaster, DTRAF1 and DTRAF2 (also known as DTRAF6) and both have been implicated in the Toll-receptor pathways leading to the ..

More Information


  1. Liu H, Su Y, Becker E, Treisman J, Skolnik E. A Drosophila TNF-receptor-associated factor (TRAF) binds the ste20 kinase Misshapen and activates Jun kinase. Curr Biol. 1999;9:101-4 pubmed
    ..We have identified a Drosophila TNF-receptor-associated factor, DTRAF1, by screening for Msn-interacting proteins using the yeast two-hybrid system...
  2. Pirooznia S, Sarthi J, Johnson A, Toth M, Chiu K, Koduri S, et al. Tip60 HAT activity mediates APP induced lethality and apoptotic cell death in the CNS of a Drosophila Alzheimer's disease model. PLoS ONE. 2012;7:e41776 pubmed publisher
  3. Mallik M, Lakhotia S. The developmentally active and stress-inducible noncoding hsromega gene is a novel regulator of apoptosis in Drosophila. Genetics. 2009;183:831-52 pubmed publisher
    ..These observations add to the diversity of regulatory functions that the large noncoding RNAs carry out in the cells' life. ..
  4. Geuking P, Narasimamurthy R, Basler K. A genetic screen targeting the tumor necrosis factor/Eiger signaling pathway: identification of Drosophila TAB2 as a functionally conserved component. Genetics. 2005;171:1683-94 pubmed
    ..Genetic epistasis and biochemical protein-protein interaction assays assign an adaptor role to dTAB2, linking dTRAF1 to the JNKKK dTAK1, demonstrating a conserved mechanism of TNF signal transduction in mammals and Drosophila...
  5. Lu T, MacDonald J, Neukomm L, Sheehan A, Bradshaw R, Logan M, et al. Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling. Nat Commun. 2017;8:14355 pubmed publisher
    ..We identify TNF receptor associated factor 4 (TRAF4) as a novel Draper binding partner that is required for reporter activation and phagocytosis ..
  6. Zhang M, Zhang Y, Xu Z. POSH is involved in Eiger-Basket (TNF-JNK) signaling and embryogenesis in Drosophila. J Genet Genomics. 2010;37:605-19 pubmed publisher
  7. Wu H, Arron J. TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. Bioessays. 2003;25:1096-105 pubmed
    ..It is a member of a group of six closely related TRAF proteins, which serve as adapter molecules, coupling the TNF receptor (TNFR) superfamily to intracellular signaling ..
  8. Vicente Crespo M, Pascual M, Fernandez Costa J, Garcia Lopez A, Monferrer L, Miranda M, et al. Drosophila muscleblind is involved in troponin T alternative splicing and apoptosis. PLoS ONE. 2008;3:e1613 pubmed publisher
    ..Drosophila CUG-BP1 homolog aret, exon junction complex components tsunagi and Aly, and pro-apoptotic genes Traf1 and reaper. We further investigated Muscleblind implication in apoptosis and splicing regulation...
  9. Marchal C, Vinatier G, Sanial M, Plessis A, Pret A, Limbourg Bouchon B, et al. The HIV-1 Vpu protein induces apoptosis in Drosophila via activation of JNK signaling. PLoS ONE. 2012;7:e34310 pubmed publisher
    ..Our results in the fly thus provide the first functional evidence linking Vpu pro-apoptotic effects to activation of the conserved JNK pathway. ..
  10. Nechaev S, Fargo D, dos Santos G, Liu L, Gao Y, Adelman K. Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in Drosophila. Science. 2010;327:335-8 pubmed publisher
    ..These results indicate that the intrinsic efficiency of early elongation can greatly affect gene expression. ..
  11. Mathew S, Rembold M, Leptin M. Role for Traf4 in polarizing adherens junctions as a prerequisite for efficient cell shape changes. Mol Cell Biol. 2011;31:4978-93 pubmed publisher
    ..A Twist target gene encoding a member of the tumor necrosis factor (TNF) receptor-associated factor (TRAF) family, Traf4, is involved in this process...
  12. Cannavò E, Khoueiry P, Garfield D, Geeleher P, Zichner T, Gustafson E, et al. Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks. Curr Biol. 2016;26:38-51 pubmed publisher
    ..simple situation of having only two shadow enhancers-often there are three (rols), four (CadN and ade5), or five (Traf1), at least one of which can be deleted with no obvious phenotypic effects...
  13. Kuranaga E, Kanuka H, Igaki T, Sawamoto K, Ichijo H, Okano H, et al. Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila. Nat Cell Biol. 2002;4:705-10 pubmed
    ..a genetic screen that a mutant of Drosophila melanogaster tumour-necrosis factor receptor-associated factor 1 (DTRAF1) is a dominant suppressor of Reaper-induced cell death...
  14. Kang M, Chung J, Ryoo H. CDK5 and MEKK1 mediate pro-apoptotic signalling following endoplasmic reticulum stress in an autosomal dominant retinitis pigmentosa model. Nat Cell Biol. 2012;14:409-15 pubmed publisher
    ..These findings establish a previously unrecognized branch of ER-stress response signalling involved in degenerative diseases. ..
  15. Cha G, Kim S, Park J, Lee E, Kim M, Lee S, et al. Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila. Proc Natl Acad Sci U S A. 2005;102:10345-50 pubmed
  16. van Bergeijk P, Heimiller J, Uyetake L, Su T. Genome-wide expression analysis identifies a modulator of ionizing radiation-induced p53-independent apoptosis in Drosophila melanogaster. PLoS ONE. 2012;7:e36539 pubmed publisher
    ..These and other results support the emerging notion that there is not a single dominant mechanism but that both positive and negative inputs collaborate to induce p53-independent apoptosis in response to IR in Drosophila larvae. ..
  17. Tiwari A, Roy J. Mutation in Rab11 results in abnormal organization of ommatidial cells and activation of JNK signaling in the Drosophila eye. Eur J Cell Biol. 2009;88:445-60 pubmed publisher
  18. Berkey C, Blow N, Watnick P. Genetic analysis of Drosophila melanogaster susceptibility to intestinal Vibrio cholerae infection. Cell Microbiol. 2009;11:461-74 pubmed publisher
  19. Clavier A, Rincheval Arnold A, Baillet A, Mignotte B, Guénal I. Two different specific JNK activators are required to trigger apoptosis or compensatory proliferation in response to Rbf1 in Drosophila. Cell Cycle. 2016;15:283-94 pubmed publisher
    ..e. Rac1-dTak1-dMekk1-JNK pathway) and in proliferation in response to Rbf1-induced apoptosis (i.e., dTRAF1-Slipper-JNK pathway)...
  20. Grech A, Quinn R, Srinivasan D, Badoux X, Brink R. Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants. Mol Immunol. 2000;37:721-34 pubmed
    ..The Drosophila genome was found to contain three TRAF family genes: dTRAF1, dTRAF6 (dTRAF2) and a previously undescribed member we have designated dTRAF3...
  21. Ozdemir A, Fisher Aylor K, Pepke S, Samanta M, Dunipace L, McCue K, et al. High resolution mapping of Twist to DNA in Drosophila embryos: Efficient functional analysis and evolutionary conservation. Genome Res. 2011;21:566-77 pubmed publisher
    ..Our results show that high resolution in vivo occupancy data can be used to drive efficient discovery and dissection of global and local cis-regulatory logic. ..
  22. Balakireva M, Rosse C, Langevin J, Chien Y, Gho M, Gonzy Treboul G, et al. The Ral/exocyst effector complex counters c-Jun N-terminal kinase-dependent apoptosis in Drosophila melanogaster. Mol Cell Biol. 2006;26:8953-63 pubmed
    ..We propose that the exocyst complex is Ral executioner in the JNK pathway and that a cascade from Ral to the exocyst to HGK would be a molecular basis of Ral action on JNK. ..
  23. Wu Y, Zhuang Y, Han M, Xu T, Deng K. Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye. BMC Dev Biol. 2009;9:53 pubmed publisher
    ..Thus, in addition to its requirement for cell viability, Ras appears to mediate different biological roles depending on the developmental context and on the level of its expression. ..
  24. Sun H, Bristow B, Qu G, Wasserman S. A heterotrimeric death domain complex in Toll signaling. Proc Natl Acad Sci U S A. 2002;99:12871-6 pubmed
    ..Furthermore, functional assays confirm that the formation of this heterotrimer is critical for signal transduction by the Toll pathway. ..
  25. Tang H, Liao H, Peng W, Lin H, Chen C, Chen G. Atg9 interacts with dTRAF2/TRAF6 to regulate oxidative stress-induced JNK activation and autophagy induction. Dev Cell. 2013;27:489-503 pubmed publisher
    ..Our findings indicate a dual role for Atg9 in the regulation of JNK signaling and autophagy under oxidative stress conditions. ..