Gene Symbol: Traf-like
Description: TNF-receptor-associated factor-like
Alias: CG4394, Dmel\CG4394, TRAF3, Traf-related, Traf3, dTRAF3, TNF-receptor-associated factor-like, CG4394-PA, CG4394-PB, CG4394-PC, CG4394-PD, CG4394-PE, CG4394-PF, CG4394-PG, Traf-like-PA, Traf-like-PB, Traf-like-PC, Traf-like-PD, Traf-like-PE, Traf-like-PF, Traf-like-PG, Traf3
Species: fruit fly

Top Publications

  1. Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway C, et al. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Genes Dev. 1999;13:2059-71 pubmed
    ..These results indicate an important role for ECSIT in signaling to NF-kappaB and suggest that processing of MEKK-1 is required for its function in the Toll/IL-1 pathway. ..
  2. Grech A, Quinn R, Srinivasan D, Badoux X, Brink R. Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants. Mol Immunol. 2000;37:721-34 pubmed contain three TRAF family genes: dTRAF1, dTRAF6 (dTRAF2) and a previously undescribed member we have designated dTRAF3. TRAF-C domain homology indicated that dTRAF3 is likely to have derived from the common precursor for the TRAF 1, ..
  3. Sun H, Bristow B, Qu G, Wasserman S. A heterotrimeric death domain complex in Toll signaling. Proc Natl Acad Sci U S A. 2002;99:12871-6 pubmed
    ..Furthermore, functional assays confirm that the formation of this heterotrimer is critical for signal transduction by the Toll pathway. ..
  4. Doumanis J, Wada K, Kino Y, Moore A, Nukina N. RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. PLoS ONE. 2009;4:e7275 pubmed publisher
    ..Newly identified modifiers including genes related to nuclear transport, nucleotide processes, and signaling, may be involved in polyglutamine aggregate formation and Huntington disease cascades. ..
  5. Hill Burns E, Clark A. X-linked variation in immune response in Drosophila melanogaster. Genetics. 2009;183:1477-91 pubmed publisher
    ..Many of the associations act in a sex-specific or sexually antagonistic manner, supporting the theory that with the selective pressures facing genes on the X chromosome, sexually antagonistic variation may be more easily maintained. ..
  6. Wu H, Arron J. TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. Bioessays. 2003;25:1096-105 pubmed
    ..By virtue of its many signaling roles, TRAF6 represents an important target in the regulation of many disease processes, including immunity, inflammation and osteoporosis. ..