Gene Symbol: TpnC73F
Description: Troponin C at 73F
Alias: CG7930, DmTnC3, DmTpnC73F, DmTpnCIa, Dmel\CG7930, TNC, TNC73F, TnC, TnC73F, Tnc2, TpnC Ia, TpnCIa, tpnC73F, troponin C at 73F, CG7930-PA, CG7930-PC, TpnC73F-PA, TpnC73F-PC, TroponinC73F, troponin C, troponin C73F
Species: fruit fly

Top Publications

  1. Herranz R, Díaz Castillo C, Nguyen T, Lovato T, Cripps R, Marco R. Expression patterns of the whole troponin C gene repertoire during Drosophila development. Gene Expr Patterns. 2004;4:183-90 pubmed
    ..This is the case of the Troponin C gene repertoire in Drosophila melanogaster...
  2. Herranz R, Mateos J, Marco R. Diversification and independent evolution of troponin C genes in insects. J Mol Evol. 2005;60:31-44 pubmed publisher
    b>Troponin C (TpnC), the calcium-binding subunit of the troponin regulatory complex in the muscle thin filament, is encoded by multiple genes in insects...
  3. Nongthomba U, Clark S, Cummins M, Ansari M, Stark M, Sparrow J. Troponin I is required for myofibrillogenesis and sarcomere formation in Drosophila flight muscle. J Cell Sci. 2004;117:1795-805 pubmed
  4. Qiu F, Lakey A, Agianian B, Hutchings A, Butcher G, Labeit S, et al. Troponin C in different insect muscle types: identification of two isoforms in Lethocerus, Drosophila and Anopheles that are specific to asynchronous flight muscle in the adult insect. Biochem J. 2003;371:811-21 pubmed
    ..Lethocerus and Drosophila have an unusual isoform of the Ca(2+)-binding subunit of troponin, troponin C (TnC), with a single Ca(2+)-binding site near the C-terminus (domain IV); this isoform is only in IFMs, together ..
  5. Díaz Castillo C, Golic K. Evolution of gene sequence in response to chromosomal location. Genetics. 2007;177:359-74 pubmed
    ..Consequently, such sequences are subject to rapid evolutionary change. By examining the Troponin C gene family of Drosophila melanogaster, which has euchromatic and heterochromatic members, we find that protein-..
  6. Baker D, Meadows L, Wang J, Dow J, Russell S. Variable sexually dimorphic gene expression in laboratory strains of Drosophila melanogaster. BMC Genomics. 2007;8:454 pubmed
    ..Much of this variation reflects sex-specific challenges associated with divergent physiological trade-offs, morphology and regulatory pathways operating within males and females. ..
  7. Fyrberg C, Parker H, Hutchison B, Fyrberg E. Drosophila melanogaster genes encoding three troponin-C isoforms and a calmodulin-related protein. Biochem Genet. 1994;32:119-35 pubmed
    ..Our report is the first to describe insect troponin-C isoforms and further avails genetic methods for investigating the in vivo functions of the troponin-C/myosin light-chain/calmodulin protein superfamily. ..
  8. Vigoreaux J. Genetics of the Drosophila flight muscle myofibril: a window into the biology of complex systems. Bioessays. 2001;23:1047-63 pubmed
  9. Rui Y, Bai J, Perrimon N. Sarcomere formation occurs by the assembly of multiple latent protein complexes. PLoS Genet. 2010;6:e1001208 pubmed publisher
    ..Thus, sarcomere formation occurs by the coordinated assembly of multiple latent protein complexes, as opposed to sequential assembly. ..

More Information


  1. Hornbruch Freitag C, Griemert B, Buttgereit D, Renkawitz Pohl R. Drosophila Swiprosin-1/EFHD2 accumulates at the prefusion complex stage during Drosophila myoblast fusion. J Cell Sci. 2011;124:3266-78 pubmed publisher
    ..Therefore, we hypothesise that Drosophila Swip-1 participates in the breakdown of the prefusion complex during the progression of myoblast fusion. ..