Gene Symbol: TpnC41C
Description: Troponin C at 41C
Alias: CG2981, DmTnC1, DmTpnC41C, DmTpnCIIIa, Dmel\CG2981, TNC41C, TPNC, TnC, TnC1, TnC41C, Tnc1, TpnC IIIa, TpnC41, TpnCIIIa, troponin C at 41C, CG2981-PA, CG2981-PB, TpnC41C-PA, TpnC41C-PB, TroponinC at 41C, troponin C, troponin-C
Species: fruit fly

Top Publications

  1. Fyrberg C, Parker H, Hutchison B, Fyrberg E. Drosophila melanogaster genes encoding three troponin-C isoforms and a calmodulin-related protein. Biochem Genet. 1994;32:119-35 pubmed
    ..Our report is the first to describe insect troponin-C isoforms and further avails genetic methods for investigating the in vivo functions of the troponin-C/myosin light-chain/calmodulin protein superfamily. ..
  2. Nongthomba U, Clark S, Cummins M, Ansari M, Stark M, Sparrow J. Troponin I is required for myofibrillogenesis and sarcomere formation in Drosophila flight muscle. J Cell Sci. 2004;117:1795-805 pubmed
  3. Bryantsev A, Duong S, Brunetti T, Chechenova M, Lovato T, Nelson C, et al. Extradenticle and homothorax control adult muscle fiber identity in Drosophila. Dev Cell. 2012;23:664-73 pubmed publisher
    ..Because mammalian orthologs of exd and hth also contribute to muscle gene regulation, our studies suggest that an evolutionarily conserved genetic pathway determines muscle fiber differentiation. ..
  4. Schönbauer C, Distler J, Jährling N, Radolf M, Dodt H, Frasch M, et al. Spalt mediates an evolutionarily conserved switch to fibrillar muscle fate in insects. Nature. 2011;479:406-9 pubmed publisher
    ..We propose that Spalt proteins switch myofibres from tubular to fibrillar fate during development, a function potentially conserved in the vertebrate heart--a stretch-activated muscle sharing features with insect flight muscle. ..
  5. Eldred C, Katzemich A, Patel M, Bullard B, Swank D. The roles of troponin C isoforms in the mechanical function of Drosophila indirect flight muscle. J Muscle Res Cell Motil. 2014;35:211-23 pubmed publisher
    ..The highly stretch-activated Drosophila IFMs express two isoforms of the Ca(2+)-binding subunit of troponin (TnC). TnC1 (TnC-F2 in Lethocerus IFM) has two calcium binding sites, while an unusual isoform, TnC4 (TnC-F1 in Lethocerus IFM),..
  6. Herranz R, Mateos J, Marco R. Diversification and independent evolution of troponin C genes in insects. J Mol Evol. 2005;60:31-44 pubmed publisher
    b>Troponin C (TpnC), the calcium-binding subunit of the troponin regulatory complex in the muscle thin filament, is encoded by multiple genes in insects...
  7. Vikhorev P, Vikhoreva N, Cammarato A, Sparrow J. In vitro motility of native thin filaments from Drosophila indirect flight muscles reveals that the held-up 2 TnI mutation affects calcium activation. J Muscle Res Cell Motil. 2010;31:171-9 pubmed publisher
    ..This is discussed with respect to calcium dependent regulation of held-up-2 thin filaments in in vitro motility. ..
  8. Rui Y, Bai J, Perrimon N. Sarcomere formation occurs by the assembly of multiple latent protein complexes. PLoS Genet. 2010;6:e1001208 pubmed publisher
    ..Thus, sarcomere formation occurs by the coordinated assembly of multiple latent protein complexes, as opposed to sequential assembly. ..
  9. Vigoreaux J. Genetics of the Drosophila flight muscle myofibril: a window into the biology of complex systems. Bioessays. 2001;23:1047-63 pubmed

More Information


  1. Firdaus H, Mohan J, Naz S, Arathi P, Ramesh S, Nongthomba U. A cis-regulatory mutation in troponin-I of Drosophila reveals the importance of proper stoichiometry of structural proteins during muscle assembly. Genetics. 2015;200:149-65 pubmed publisher
  2. Spletter M, Schnorrer F. Transcriptional regulation and alternative splicing cooperate in muscle fiber-type specification in flies and mammals. Exp Cell Res. 2014;321:90-8 pubmed publisher
    ..Thus, research in Drosophila can provide important mechanistic insight into muscle fiber specification, which is relevant to homologous processes in mammals and to the pathology of muscle diseases. ..
  3. Coulthard A, Alm C, Cealiac I, Sinclair D, Honda B, Rossi F, et al. Essential loci in centromeric heterochromatin of Drosophila melanogaster. I: the right arm of chromosome 2. Genetics. 2010;185:479-95 pubmed publisher
  4. Díaz Castillo C, Golic K. Evolution of gene sequence in response to chromosomal location. Genetics. 2007;177:359-74 pubmed
    ..Consequently, such sequences are subject to rapid evolutionary change. By examining the Troponin C gene family of Drosophila melanogaster, which has euchromatic and heterochromatic members, we find that protein-..
  5. Qiu F, Lakey A, Agianian B, Hutchings A, Butcher G, Labeit S, et al. Troponin C in different insect muscle types: identification of two isoforms in Lethocerus, Drosophila and Anopheles that are specific to asynchronous flight muscle in the adult insect. Biochem J. 2003;371:811-21 pubmed
    ..Lethocerus and Drosophila have an unusual isoform of the Ca(2+)-binding subunit of troponin, troponin C (TnC), with a single Ca(2+)-binding site near the C-terminus (domain IV); this isoform is only in IFMs, together ..
  6. Herranz R, Díaz Castillo C, Nguyen T, Lovato T, Cripps R, Marco R. Expression patterns of the whole troponin C gene repertoire during Drosophila development. Gene Expr Patterns. 2004;4:183-90 pubmed
    ..This is the case of the Troponin C gene repertoire in Drosophila melanogaster...
  7. Singh S, Kumar P, Ramachandra N, Nongthomba U. Roles of the troponin isoforms during indirect flight muscle development in Drosophila. J Genet. 2014;93:379-88 pubmed
    ..the troponin subunits are required for normal myofibril assembly and flight, except for the troponin-C isoform 1 (TnC1)...
  8. Chechenova M, Maes S, Cripps R. Expression of the Troponin C at 41C Gene in Adult Drosophila Tubular Muscles Depends upon Both Positive and Negative Regulatory Inputs. PLoS ONE. 2015;10:e0144615 pubmed publisher
    ..fate remain incompletely understood, therefore we chose to analyze the transcriptional regulation of TpnC41C, a Troponin C gene expressed in the tubular jump muscles, but not in the fibrillar flight muscles...