Gene Symbol: TotM
Description: Turandot M
Alias: CG14027, Dmel\CG14027, TOTM, Tot M, tot, totM, turandot M, CG14027-PA, CG14027-PB, TotM-PA, TotM-PB, turandot
Species: fruit fly

Top Publications

  1. Kleino A, Myllymäki H, Kallio J, Vanha aho L, Oksanen K, Ulvila J, et al. Pirk is a negative regulator of the Drosophila Imd pathway. J Immunol. 2008;180:5413-22 pubmed
    ..Furthermore, pirk-overexpressing flies were more susceptible to Gram-negative bacterial infection than wild-type flies. We conclude that Pirk is a negative regulator of the Imd pathway. ..
  2. Gordon M, Ayres J, Schneider D, Nusse R. Pathogenesis of listeria-infected Drosophila wntD mutants is associated with elevated levels of the novel immunity gene edin. PLoS Pathog. 2008;4:e1000111 pubmed publisher
    ..These results are consistent with a model in which the regulation of host factors, including edin, must be tightly controlled to avoid the detrimental consequences of having too much or too little activity...
  3. Ekengren S, Hultmark D. A family of Turandot-related genes in the humoral stress response of Drosophila. Biochem Biophys Res Commun. 2001;284:998-1003 pubmed
    The Drosophila Turandot A (TotA) gene was recently shown to encode a stress-induced humoral factor which gives increased resistance to the lethal effects of high temperature...
  4. Kallio J, Myllymäki H, Grönholm J, Armstrong M, Vanha aho L, Mäkinen L, et al. Eye transformer is a negative regulator of Drosophila JAK/STAT signaling. FASEB J. 2010;24:4467-79 pubmed publisher
    ..In conclusion, we have identified ET as a novel negative regulator of the Drosophila JAK/STAT pathway both in vitro and in vivo, and it functions in regulating Stat92E phosphorylation. ..
  5. Shokal U, Yadav S, Atri J, Accetta J, Kenney E, Banks K, et al. Effects of co-occurring Wolbachia and Spiroplasma endosymbionts on the Drosophila immune response against insect pathogenic and non-pathogenic bacteria. BMC Microbiol. 2016;16:16 pubmed publisher
    ..Results from such studies are important for understanding the molecular basis of the interactions between endosymbiotic bacteria of insects and exogenous microbes. ..
  6. Kim K, Lin Y, Park Y. Enhancement of stress resistances and downregulation of Imd pathway by lower developmental temperature in Drosophila melanogaster. Exp Gerontol. 2010;45:984-7 pubmed publisher
    ..We also showed that development at a lower temperature represented by 18°C significantly downregulates anti-microbial peptide genes, AttA and DptB, of Imd pathway. ..
  7. Wang L, Sexton T, Venard C, Giedt M, Guo Q, Chen Q, et al. Pleiotropy of the Drosophila JAK pathway cytokine Unpaired 3 in development and aging. Dev Biol. 2014;395:218-31 pubmed publisher
    ..Thus the upd region serves as a genetically tractable model for coordinate regulation of tandemly duplicated gene families that are commonly found in higher eukaryotes. ..
  8. Zhong W, McClure C, Evans C, Mlynski D, Immonen E, Ritchie M, et al. Immune anticipation of mating in Drosophila: Turandot M promotes immunity against sexually transmitted fungal infections. Proc Biol Sci. 2013;280:20132018 pubmed publisher
    ..melanogaster, specifically upregulate two members of the Turandot family of immune and stress response genes, Turandot M and Turandot C (TotM and TotC), when they hear male courtship song...
  9. Dong S, Zhang H, Chen X, Stanley D, Yu X, Song Q. The neuropeptide bursicon acts in cuticle metabolism. Arch Insect Biochem Physiol. 2015;89:87-97 pubmed publisher
    ..We report that burs β-β and bursicon act in cuticle synthesis and degradation by regulating the expression of cuticular protein and chitin metabolizing related genes. ..

More Information


  1. McClure C, Zhong W, Hunt V, Chapman F, Hill F, Priest N. Hormesis results in trade-offs with immunity. Evolution. 2014;68:2225-33 pubmed publisher
    ..benefits of pathogen challenge are greater in lines that lack key components of antifungal immunity (Dif and Turandot M)...
  2. Chakrabarti S, Dudzic J, Li X, Collas E, Boquete J, Lemaitre B. Remote Control of Intestinal Stem Cell Activity by Haemocytes in Drosophila. PLoS Genet. 2016;12:e1006089 pubmed publisher
    ..It also reveals that release of Upds by haemocytes coordinates the wound-healing program in multiple tissues, including the gut, an organ whose integrity is critical to fly survival. ..
  3. Chamilos G, Lewis R, Hu J, Xiao L, Zal T, Gilliet M, et al. Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Proc Natl Acad Sci U S A. 2008;105:9367-72 pubmed publisher
    ..Our results provide insights into the factors that mediate host-pathogen interactions in zygomycosis and establish D. melanogaster as a promising model to study this important mycosis...
  4. Vanha aho L, Kleino A, Kaustio M, Ulvila J, Wilke B, Hultmark D, et al. Functional characterization of the infection-inducible peptide Edin in Drosophila melanogaster. PLoS ONE. 2012;7:e37153 pubmed publisher
    ..faecalis infection via an uncharacterized mechanism. Further studies are still required to elucidate the exact role of Edin in the Drosophila immune response. ..
  5. Castillo J, Shokal U, Eleftherianos I. Immune gene transcription in Drosophila adult flies infected by entomopathogenic nematodes and their mutualistic bacteria. J Insect Physiol. 2013;59:179-85 pubmed publisher
    ..These results suggest that Heterorhabditis nematodes and their associated Photorhabdus bacteria employ distinct strategies to evade the Drosophila immune response and establish infection. ..
  6. Szuplewski S, Terracol R. The cyclope gene of Drosophila encodes a cytochrome c oxidase subunit VIc homolog. Genetics. 2001;158:1629-43 pubmed
    ..A search in the Genome Annotation Database of Drosophila revealed the absence of subunit VIIb and the presence of 9 putative nuclear cytochrome c oxidase subunits with high identity scores when compared to the 10 human subunits. ..
  7. Moskalev A, Zhikrivetskaya S, Krasnov G, Shaposhnikov M, Proshkina E, Borisoglebsky D, et al. A comparison of the transcriptome of Drosophila melanogaster in response to entomopathogenic fungus, ionizing radiation, starvation and cold shock. BMC Genomics. 2015;16 Suppl 13:S8 pubmed publisher
    ..Studied doses of stress treatments deleteriously affect the organism's viability and lead to different changes of both general and specific cellular stress response mechanisms. ..
  8. Ip Y. Drosophila innate immunity goes viral. Nat Immunol. 2005;6:863-4 pubmed
  9. Agaisse H, Perrimon N. The roles of JAK/STAT signaling in Drosophila immune responses. Immunol Rev. 2004;198:72-82 pubmed
    ..We present the JAK/STAT-dependent humoral factors, such as the thioester-containing proteins and the Tot peptides, produced by the fat body in response to septic injury...
  10. Hultmark D, Ekengren S. A cytokine in the Drosophila stress response. Dev Cell. 2003;5:360-1 pubmed
    ..However, in this issue of Developmental Cell, show that cytokines do play a role in mediating an acute phase response in this organism. ..
  11. An S, Dong S, Wang Q, Li S, Gilbert L, Stanley D, et al. Insect neuropeptide bursicon homodimers induce innate immune and stress genes during molting by activating the NF-?B transcription factor Relish. PLoS ONE. 2012;7:e34510 pubmed publisher
    ..prophylactic innate immunity during molting via induced expression of genes encoding AMPs and genes of the Turandot family. Turandot genes are also up-regulated by a broader range of extreme insults...
  12. Grönholm J, Kaustio M, Myllymäki H, Kallio J, Saarikettu J, Kronhamn J, et al. Not4 enhances JAK/STAT pathway-dependent gene expression in Drosophila and in human cells. FASEB J. 2012;26:1239-50 pubmed publisher
    ..reporter gene activation in S2 cells; and in flies, Not4 overexpression resulted in an 8-fold increase in Turandot M (TotM) and in a 4-fold increase in Turandot A (TotA) stress gene activation when compared to wild-type flies...