Tollo

Summary

Gene Symbol: Tollo
Description: tollo
Alias: CG6890, CT21344, Dmel\CG6890, TOLL 8, Tl-8, Toll-8, dTLR8, dToll8, toll, tollo, tollo/toll-8, tollo, CG6890-PA, Toll-8, Tollo-PA, toll receptor
Species: fruit fly

Top Publications

  1. Ayyar S, Pistillo D, Calleja M, Brookfield A, Gittins K, Goldstone C, et al. NF-kappaB/Rel-mediated regulation of the neural fate in Drosophila. PLoS ONE. 2007;2:e1178 pubmed
    ..Second, genetic evidence suggests that the receptor Toll-8, Relish, Dif and Dorsal, and the caspase Dredd pathway are active over the entire imaginal disc epithelium, but ..
  2. Kim S, Chung S, Yoon J, Choi K, Yim J. Ectopic expression of Tollo/Toll-8 antagonizes Dpp signaling and induces cell sorting in the Drosophila wing. Genesis. 2006;44:541-9 pubmed
    ..Here, we report that Tollo/Toll-8, a member of Toll family transmembrane proteins, is also expressed proximal to the wing domain...
  3. Kambris Z, Hoffmann J, Imler J, Capovilla M. Tissue and stage-specific expression of the Tolls in Drosophila embryos. Gene Expr Patterns. 2002;2:311-7 pubmed
    The Drosophila transmembrane receptor Toll plays a key role in specifying the dorsoventral axis of the embryo. At later stages of development, it controls the immune response of the fly to fungal and Gram-positive bacterial infections...
  4. Seppo A, Matani P, Sharrow M, Tiemeyer M. Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila Toll-like receptor expressed in non-neural cells. Development. 2003;130:1439-48 pubmed
    ..Genetic and molecular mapping of the relevant locus reveals that Tollo/Toll-8, a member of the Toll-like receptor family, is altered on the TM3 chromosome...
  5. Tauszig S, Jouanguy E, Hoffmann J, Imler J. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Proc Natl Acad Sci U S A. 2000;97:10520-5 pubmed
    ..of the regulation of the antifungal peptide drosomycin has demonstrated a key role for the transmembrane receptor Toll, which prompted the search for mammalian homologs...
  6. Wagner C, Isermann K, Fehrenbach H, Roeder T. Molecular architecture of the fruit fly's airway epithelial immune system. BMC Genomics. 2008;9:446 pubmed publisher
    ..Although vital parts of the Toll-pathway are missing, dorsal and dif, the NF-kappaB factors dedicated to this signalling system, are present...
  7. Aoki K, Perlman M, Lim J, Cantu R, Wells L, Tiemeyer M. Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo. J Biol Chem. 2007;282:9127-42 pubmed
    ..The activity of a Toll-like receptor, called Tollo/Toll-8, induces a pattern of incompletely defined, but neural specific, glycan expression in the Drosophila embryo...
  8. Ooi J, Yagi Y, Hu X, Ip Y. The Drosophila Toll-9 activates a constitutive antimicrobial defense. EMBO Rep. 2002;3:82-7 pubmed
    The Toll family of transmembrane proteins participates in signaling infection during the innate immune response. We analyzed the nine Drosophila Toll proteins and found that wild-type Toll-9 behaves similar to gain-of-function Toll-1...
  9. Tauszig Delamasure S, Bilak H, Capovilla M, Hoffmann J, Imler J. Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections. Nat Immunol. 2002;3:91-7 pubmed
    ..DmMyD88 combines a Toll-IL-1R homology (TIR) domain and a death domain...

More Information

Publications27

  1. Yagi Y, Nishida Y, Ip Y. Functional analysis of Toll-related genes in Drosophila. Dev Growth Differ. 2010;52:771-83 pubmed publisher
    The Drosophila genome encodes a total of nine Toll and related proteins...
  2. Baas S, Sharrow M, Kotu V, Middleton M, Nguyen K, Flanagan Steet H, et al. Sugar-free frosting, a homolog of SAD kinase, drives neural-specific glycan expression in the Drosophila embryo. Development. 2011;138:553-63 pubmed publisher
    ..Furthermore, neuronal sff expression is dependent on transcellular signaling through a non-neural toll-like receptor, linking neural-specific glycan expression to a kinase activity that is induced in response to ..
  3. Neyen C, Lemaitre B. Different flavors of Toll guide olfaction. Trends Immunol. 2015;36:439-41 pubmed publisher
    b>Toll-like receptors are historically linked to immunity across animal phyla, but accumulating evidence suggests they play additional roles in neuronal networks and in cell-cell interactions...
  4. Paré A, Vichas A, Fincher C, Mirman Z, Farrell D, Mainieri A, et al. A positional Toll receptor code directs convergent extension in Drosophila. Nature. 2014;515:523-7 pubmed publisher
    ..strongly reduces actomyosin-driven junctional remodelling and axis elongation, and an ectopic stripe of Toll receptor expression is sufficient to induce planar polarized actomyosin contractility...
  5. Moy R, Gold B, Molleston J, Schad V, Yanger K, Salzano M, et al. Antiviral autophagy restrictsRift Valley fever virus infection and is conserved from flies to mammals. Immunity. 2014;40:51-65 pubmed publisher
    ..In Drosophila, Toll-7 limited RVFV replication and mortality through activation of autophagy...
  6. Samaraweera S, O Keefe L, Price G, Venter D, Richards R. Distinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases. Hum Mol Genet. 2013;22:2811-9 pubmed publisher
    ..Our results show that Drosophila rCAG.rCUG?100 RNA toxicity is dependent upon Toll signaling and sensitive to autophagy, further implicating innate immune activation...
  7. Theisen J, Lim C, Kadonaga J. Three key subregions contribute to the function of the downstream RNA polymerase II core promoter. Mol Cell Biol. 2010;30:3471-9 pubmed publisher
    ..These studies have thus revealed a tripartite organization of key subregions in the downstream core promoter. ..
  8. Xu J, Grant G, Sabin L, Gordesky Gold B, Yasunaga A, Tudor M, et al. Transcriptional pausing controls a rapid antiviral innate immune response in Drosophila. Cell Host Microbe. 2012;12:531-43 pubmed publisher
    ..upon arbovirus infection, including components of antiviral pathways (RNA silencing, autophagy, JAK/STAT, Toll, and Imd) and various Toll receptors...
  9. Akhouayri I, Turc C, Royet J, Charroux B. Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium. PLoS Pathog. 2011;7:e1002319 pubmed publisher
    ..AMP activation is antagonized by a constitutively active signalling module involving the receptor Toll-8/Tollo, the ligand Spätzle2/DNT1 and Ect-4, the Drosophila ortholog of the human Sterile alpha and HEAT/ARMadillo motif (..
  10. Chen L, Wang J, Hyvert Y, Lin H, Perrimon N, Imler J, et al. Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo. Curr Biol. 2006;16:1183-93 pubmed
    The Drosophila Toll pathway takes part in both establishment of the embryonic dorsoventral axis and induction of the innate immune response in adults...
  11. Lavine M, Strand M. Insect hemocytes and their role in immunity. Insect Biochem Mol Biol. 2002;32:1295-309 pubmed
    ..Cross-talk between the immune and nervous system may also play a role in regulating inflammation-like responses in insects during infection. ..
  12. Luo C, Zheng L. Independent evolution of Toll and related genes in insects and mammals. Immunogenetics. 2000;51:92-8 pubmed
    b>Toll and Toll-related proteins play an important role in antibacterial innate immunity in insect, plants, and mammals. We present the first comprehensive phylogenetic analyses of Toll-related genes from both insects and mammals...
  13. Meyer S, Amoyel M, Bergantiños C, de la Cova C, Schertel C, Basler K, et al. An ancient defense system eliminates unfit cells from developing tissues during cell competition. Science. 2014;346:1258236 pubmed publisher
    ..We find that Toll-related receptors (TRRs) and the cytokine Spätzle (Spz) lead to NFκB-dependent apoptosis...
  14. Ward A, Hong W, Favaloro V, Luo L. Toll receptors instruct axon and dendrite targeting and participate in synaptic partner matching in a Drosophila olfactory circuit. Neuron. 2015;85:1013-28 pubmed publisher
    ..Here we show that Toll-6 and Toll-7, members of the Toll receptor family best known for functions in innate immunity and embryonic patterning, cell autonomously instruct the ..
  15. Nakamoto M, Moy R, Xu J, Bambina S, Yasunaga A, Shelly S, et al. Virus recognition by Toll-7 activates antiviral autophagy in Drosophila. Immunity. 2012;36:658-67 pubmed publisher
    ..These data uncover an evolutionarily conserved role for a second Drosophila Toll receptor that links viral recognition to autophagy and defense and suggest that other Drosophila Tolls may restrict ..
  16. Janssens S, Beyaert R. A universal role for MyD88 in TLR/IL-1R-mediated signaling. Trends Biochem Sci. 2002;27:474-82 pubmed
    The MyD88 adapter protein links members of the toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily to the downstream activation of nuclear factor-kappaB and mitogen-activated protein kinases...
  17. Ballard S, Miller D, Ganetzky B. Retrograde neurotrophin signaling through Tollo regulates synaptic growth in Drosophila. J Cell Biol. 2014;204:1157-72 pubmed publisher
    ..Here, we demonstrate that the TLR Tollo positively regulates growth of the Drosophila melanogaster larval neuromuscular junction (NMJ)...
  18. Lim C, Santoso B, Boulay T, Dong E, Ohler U, Kadonaga J. The MTE, a new core promoter element for transcription by RNA polymerase II. Genes Dev. 2004;18:1606-17 pubmed
    ..In addition, the MTE exhibits strong synergism with the TATA-box as well as the DPE. These findings indicate that the MTE is a novel downstream core promoter element that is important for transcription by RNA polymerase II. ..