Toll 9

Summary

Gene Symbol: Toll 9
Description: Toll-9
Alias: CG5528, CT17508, Dm Toll-9, Dmel\CG5528, TOLL 9, Tak/Toll-like, Tl-5, Tl-9, Toll 9, dTLR9, dToll9, toll, Toll-9, CG5528-PA, CG5528-PB, CG5528-PC, Toll-9-PA, Toll-9-PB, Toll-9-PC, toll receptor
Species: fruit fly

Top Publications

  1. Ooi J, Yagi Y, Hu X, Ip Y. The Drosophila Toll-9 activates a constitutive antimicrobial defense. EMBO Rep. 2002;3:82-7 pubmed
    The Toll family of transmembrane proteins participates in signaling infection during the innate immune response. We analyzed the nine Drosophila Toll proteins and found that wild-type Toll-9 behaves similar to gain-of-function Toll-1...
  2. Yagi Y, Nishida Y, Ip Y. Functional analysis of Toll-related genes in Drosophila. Dev Growth Differ. 2010;52:771-83 pubmed publisher
    The Drosophila genome encodes a total of nine Toll and related proteins...
  3. Tauszig S, Jouanguy E, Hoffmann J, Imler J. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Proc Natl Acad Sci U S A. 2000;97:10520-5 pubmed
    ..of the regulation of the antifungal peptide drosomycin has demonstrated a key role for the transmembrane receptor Toll, which prompted the search for mammalian homologs...
  4. Kambris Z, Hoffmann J, Imler J, Capovilla M. Tissue and stage-specific expression of the Tolls in Drosophila embryos. Gene Expr Patterns. 2002;2:311-7 pubmed
    The Drosophila transmembrane receptor Toll plays a key role in specifying the dorsoventral axis of the embryo. At later stages of development, it controls the immune response of the fly to fungal and Gram-positive bacterial infections...
  5. Janssens S, Beyaert R. A universal role for MyD88 in TLR/IL-1R-mediated signaling. Trends Biochem Sci. 2002;27:474-82 pubmed
    The MyD88 adapter protein links members of the toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily to the downstream activation of nuclear factor-kappaB and mitogen-activated protein kinases...
  6. Chen L, Wang J, Hyvert Y, Lin H, Perrimon N, Imler J, et al. Weckle is a zinc finger adaptor of the toll pathway in dorsoventral patterning of the Drosophila embryo. Curr Biol. 2006;16:1183-93 pubmed
    The Drosophila Toll pathway takes part in both establishment of the embryonic dorsoventral axis and induction of the innate immune response in adults...
  7. Meyer S, Amoyel M, Bergantiños C, de la Cova C, Schertel C, Basler K, et al. An ancient defense system eliminates unfit cells from developing tissues during cell competition. Science. 2014;346:1258236 pubmed publisher
    ..We find that Toll-related receptors (TRRs) and the cytokine Spätzle (Spz) lead to NFκB-dependent apoptosis...
  8. Narbonne Reveau K, Charroux B, Royet J. Lack of an antibacterial response defect in Drosophila Toll-9 mutant. PLoS ONE. 2011;6:e17470 pubmed publisher
    b>Toll and Toll-like receptors represent families of receptors involved in mediating innate immunity response in insects and mammals...
  9. Nakamoto M, Moy R, Xu J, Bambina S, Yasunaga A, Shelly S, et al. Virus recognition by Toll-7 activates antiviral autophagy in Drosophila. Immunity. 2012;36:658-67 pubmed publisher
    ..These data uncover an evolutionarily conserved role for a second Drosophila Toll receptor that links viral recognition to autophagy and defense and suggest that other Drosophila Tolls may restrict ..

More Information

Publications12

  1. Samaraweera S, O Keefe L, Price G, Venter D, Richards R. Distinct roles for Toll and autophagy pathways in double-stranded RNA toxicity in a Drosophila model of expanded repeat neurodegenerative diseases. Hum Mol Genet. 2013;22:2811-9 pubmed publisher
    ..Our results show that Drosophila rCAG.rCUG?100 RNA toxicity is dependent upon Toll signaling and sensitive to autophagy, further implicating innate immune activation...
  2. Moy R, Gold B, Molleston J, Schad V, Yanger K, Salzano M, et al. Antiviral autophagy restrictsRift Valley fever virus infection and is conserved from flies to mammals. Immunity. 2014;40:51-65 pubmed publisher
    ..In Drosophila, Toll-7 limited RVFV replication and mortality through activation of autophagy...
  3. Ward A, Hong W, Favaloro V, Luo L. Toll receptors instruct axon and dendrite targeting and participate in synaptic partner matching in a Drosophila olfactory circuit. Neuron. 2015;85:1013-28 pubmed publisher
    ..Here we show that Toll-6 and Toll-7, members of the Toll receptor family best known for functions in innate immunity and embryonic patterning, cell autonomously instruct the ..