Gene Symbol: tmod
Description: tropomodulin
Alias: 1309/10, CG11493, CG1539, CG15540, CT3919, CT41421, Dmel\CG1539, E42, Tmod, l(3)00848, l(3)S130910, spdo, tropomodulin, CG1539-PA, CG1539-PB, CG1539-PC, CG1539-PD, CG1539-PE, CG1539-PF, CG1539-PG, CG1539-PH, CG1539-PI, CG1539-PJ, CG1539-PK, CG1539-PL, CG1539-PM, CG1539-PN, CG1539-PO, CG1539-PP, CG1539-PQ, sanpodo, tmod-PA, tmod-PB, tmod-PC, tmod-PD, tmod-PE, tmod-PF, tmod-PG, tmod-PH, tmod-PI, tmod-PJ, tmod-PK, tmod-PL, tmod-PM, tmod-PN, tmod-PO, tmod-PP, tmod-PQ, tropmodulin
Species: fruit fly

Top Publications

  1. Bai J, Hartwig J, Perrimon N. SALS, a WH2-domain-containing protein, promotes sarcomeric actin filament elongation from pointed ends during Drosophila muscle growth. Dev Cell. 2007;13:828-42 pubmed myofibrils reveals that the full length of thin filaments is achieved in a two-step process, and that SALS is required for the second elongation phase, most likely because it antagonizes the pointed-end capping protein Tropomodulin.
  2. Dye C, Lee J, Atkinson R, Brewster R, Han P, Bellen H. The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein. Development. 1998;125:1845-56 pubmed
    ..Genetic interaction studies show that sanpodo is epistatic to numb. sanpodo encodes a homolog of tropomodulin, an actin/tropomyosin-associated protein...
  3. Katzemich A, Kreisköther N, Alexandrovich A, Elliott C, Schock F, Leonard K, et al. The function of the M-line protein obscurin in controlling the symmetry of the sarcomere in the flight muscle of Drosophila. J Cell Sci. 2012;125:3367-79 pubmed publisher
    ..We conclude that obscurin in the IFM is necessary for the development of a symmetrical sarcomere in Drosophila IFM...
  4. Mardahl Dumesnil M, Fowler V. Thin filaments elongate from their pointed ends during myofibril assembly in Drosophila indirect flight muscle. J Cell Biol. 2001;155:1043-53 pubmed
    b>Tropomodulin (Tmod) is an actin pointed-end capping protein that regulates actin dynamics at thin filament pointed ends in striated muscle...
  5. Irion U. Drosophila muscleblind codes for proteins with one and two tandem zinc finger motifs. PLoS ONE. 2012;7:e34248 pubmed publisher
    ..1), are not muscle-specific but expressed mainly in epidermal cells, indicating a function for mbl not only in muscles and the nervous system. ..
  6. Mohammad F, Aryal S, Ho J, Stewart J, Norman N, Tan T, et al. Ancient Anxiety Pathways Influence Drosophila Defense Behaviors. Curr Biol. 2016;26:981-6 pubmed publisher
    ..The presence of conserved neurogenetic pathways in the insect brain identifies Drosophila as an attractive genetic model for the study of anxiety and anxiety-related disorders, complementing existing rodent systems. ..
  7. Roegiers F, Jan L, Jan Y. Regulation of membrane localization of Sanpodo by lethal giant larvae and neuralized in asymmetrically dividing cells of Drosophila sensory organs. Mol Biol Cell. 2005;16:3480-7 pubmed function as an antagonist of Notch signaling and also as a negative regulator of the membrane localization of Sanpodo, a four-pass transmembrane protein required for Notch signaling during asymmetric cell division in the CNS...
  8. Ong S, Tan C. Germline cyst formation and incomplete cytokinesis during Drosophila melanogaster oogenesis. Dev Biol. 2010;337:84-98 pubmed publisher
    ..This work establishes a foundation for identifying genes specific for IC and for elucidating the molecular mechanism underlying this aspect of germline cyst formation. ..
  9. Kaushik G, Zambon A, Fuhrmann A, Bernstein S, Bodmer R, Engler A, et al. Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic dysfunction. J Cell Mol Med. 2012;16:1656-62 pubmed publisher
    ..By using powerful Drosophila genetic tools, we aim to efficiently alter changes observed in factors that contribute to diastolic dysfunction to understand how one might improve diastolic performance at advanced ages in humans. ..

More Information


  1. Sevdali M, Kumar V, Peckham M, Sparrow J. Human congenital myopathy actin mutants cause myopathy and alter Z-disc structure in Drosophila flight muscle. Neuromuscul Disord. 2013;23:243-55 pubmed publisher
    ..No differences in levels of sarcomeric protein expression were observed, but tropomodulin staining was somewhat disrupted in D164N, V163L, G15R and V163M heterozygotes...
  2. Molnar I, Migh E, Szikora S, Kalmar T, Végh A, Deak F, et al. DAAM is required for thin filament formation and Sarcomerogenesis during muscle development in Drosophila. PLoS Genet. 2014;10:e1004166 pubmed publisher
    ..the initial assembly of thin filaments, and subsequently it promotes filament elongation by assembling short actin polymers that anneal to the pointed end of the growing filaments, and by antagonizing the capping protein Tropomodulin.
  3. O Connor Giles K, Skeath J. Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila. Dev Cell. 2003;5:231-43 pubmed
    ..Here we focus on the only genes known to function specifically to regulate Notch-dependent asymmetric divisions: sanpodo and numb...
  4. Lighthouse D, Buszczak M, Spradling A. New components of the Drosophila fusome suggest it plays novel roles in signaling and transport. Dev Biol. 2008;317:59-71 pubmed publisher
    ..A significant number of fusome components are dispensable, because genetic disruption of tropomodulin, ferritin-1 heavy chain, or scribble, does not alter fusome structure or female fertility...
  5. Ong S, Foote C, Tan C. Mutations of DMYPT cause over constriction of contractile rings and ring canals during Drosophila germline cyst formation. Dev Biol. 2010;346:161-9 pubmed publisher
    ..Our results suggest that there may be two parallel mechanisms to prevent the contractile rings from being completely closed, physical resistance and inhibition of myosin II activity via DMYPT. ..