tipE

Summary

Gene Symbol: tipE
Description: temperature-induced paralytic E
Alias: CG1232, Dmel\CG1232, TipE, tip-E, CG1232-PA, CG1232-PB, temperature-induced paralysis locus E, temperature-induced-paralytic-E, tipE-PA, tipE-PB
Species: fruit fly

Top Publications

  1. ncbi Four novel sequences in Drosophila melanogaster homologous to the auxiliary Para sodium channel subunit TipE
    Christian Derst
    Center for Anatomy, Charite Berlin, Philippstr 12, 10115 Berlin, Germany
    Biochem Biophys Res Commun 339:939-48. 2006
  2. ncbi Voltage-clamp analysis of sodium channels in wild-type and mutant Drosophila neurons
    D K O'Dowd
    Department of Neurobiology, Stanford University School of Medicine, California 94305
    J Neurosci 8:3633-43. 1988
  3. pmc Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology
    J W Warmke
    Department of Genetics and Molecular Biology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Gen Physiol 110:119-33. 1997
  4. ncbi The tip-E mutation of Drosophila decreases saxitoxin binding and interacts with other mutations affecting nerve membrane excitability
    F R Jackson
    J Neurogenet 3:1-17. 1986
  5. ncbi Neurogenetic analysis of Drosophila mutations affecting sodium channels: synergistic effects on viability and nerve conduction in double mutants involving tip-E
    B Ganetzky
    J Neurogenet 3:19-31. 1986
  6. ncbi Cloning and functional analysis of TipE, a novel membrane protein that enhances Drosophila para sodium channel function
    G Feng
    Department of Biochemical Pharmacology, State University of New York at Buffalo 14260 1200, USA
    Cell 82:1001-11. 1995
  7. ncbi The molecular biology of knockdown resistance to pyrethroid insecticides
    D M Soderlund
    Department of Entomology, New York State Agricultural Experiment Station, Cornell University, Geneva, NY 14456, USA
    Insect Biochem Mol Biol 33:563-77. 2003
  8. ncbi Domain 2 of Drosophila para voltage-gated sodium channel confers insect properties to a rat brain channel
    Iris Shichor
    Department of Physiology, Sackler School of Medicine and Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, 69978 Ramat Aviv, Israel
    J Neurosci 22:4364-71. 2002
  9. ncbi tipE regulates Na+-dependent repetitive firing in Drosophila neurons
    Dianne D Hodges
    Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697 1280, USA
    Mol Cell Neurosci 19:402-16. 2002
  10. pmc Cytogenetic and molecular localization of tipE: a gene affecting sodium channels in Drosophila melanogaster
    G Feng
    State University of New York at Buffalo, Department of Biochemical Pharmacology 14260 1200, USA
    Genetics 139:1679-88. 1995

Research Grants

  1. Insecticide Action at the Local Anesthetic Receptor
    DAVID SODERLUND; Fiscal Year: 2007
  2. Molecular Determinants of Pyrethroid Neurotoxicity
    DAVID SODERLUND; Fiscal Year: 2007
  3. Insecticide Action at the Local Anesthetic Receptor
    DAVID SODERLUND; Fiscal Year: 2009
  4. Molecular Determinants of Pyrethroid Neurotoxicity
    DAVID SODERLUND; Fiscal Year: 2009
  5. Molecular Determinants of Pyrethroid Neurotoxicity
    David M Soderlund; Fiscal Year: 2010
  6. Insecticide Action at the Local Anesthetic Receptor
    David M Soderlund; Fiscal Year: 2011

Scientific Experts

  • P N R Usherwood
  • J M Gleason
  • Shunyi Zhu
  • Malgorzata Lagisz
  • Louise Parker
  • D M Soderlund
  • E Zlotkin
  • Ralph J Greenspan
  • Lior Cohen
  • Jia Li
  • Mark J Burton
  • Huiqiong He
  • Robert A Carrillo
  • Elena Repnikova
  • Rachel O Donnell Olson
  • Christian Derst
  • Zhiqi Liu
  • Yoshiko Nomura
  • Ke Dong
  • Dianne D Hodges
  • Jianguo Tan
  • Iris Shichor
  • Bangqian Dong
  • Ian R Mellor
  • T G Emyr Davies
  • Robert M Waterhouse
  • Linda M Field
  • Martin S Williamson
  • Jingjing Zhou
  • Xueqin Shu
  • ZhiRui Liu
  • Yonghua Ji
  • Ian R Duce
  • Evgeny M Zdobnov
  • Jianwei Zhang
  • Kate Koles
  • B Ganetzky
  • Mark J Zoran
  • Haig Keshishian
  • Apoorva Ambavane
  • Kenneth S Yoon
  • Vladislav M Panin
  • Jared Pitts
  • Haiwen Li
  • Michiko Nakamura
  • Douglas P Olsen
  • G Feng
  • Weizhong Song
  • Stefan H Heinemann
  • Rudiger W Veh
  • Dieter Wicher
  • Christian Walther
  • A A Peixoto
  • J T Littleton
  • J W Warmke
  • Walter Stuhmer
  • A Morgan
  • Daewoo Lee
  • Kevin Boswell
  • Charles F Preston
  • Dalia Gordon
  • Alan L Goldin
  • Ilana Lotan
  • Linda M Hall
  • Nitza Ilan
  • DIANE K O'DOWD
  • Dodo Chikashvili
  • L M Hall
  • J Jarecki
  • P Deak
  • J C Hall
  • M B Garment
  • S D Carlson
  • R Kreber
  • E R Chapman
  • S J Kulkarni
  • R A Reenan
  • L H Van der Ploeg
  • P Wang
  • J Wang
  • S Qian
  • J P Arena
  • C J Cohen
  • K Liu
  • D Wunderler
  • G J Kaczorowski
  • F R Jackson
  • D P Kasbekar
  • D W Gil
  • M Chopra

Detail Information

Publications33

  1. ncbi Four novel sequences in Drosophila melanogaster homologous to the auxiliary Para sodium channel subunit TipE
    Christian Derst
    Center for Anatomy, Charite Berlin, Philippstr 12, 10115 Berlin, Germany
    Biochem Biophys Res Commun 339:939-48. 2006
    b>TipE is an auxiliary subunit of the Drosophila Para sodium channel...
  2. ncbi Voltage-clamp analysis of sodium channels in wild-type and mutant Drosophila neurons
    D K O'Dowd
    Department of Neurobiology, Stanford University School of Medicine, California 94305
    J Neurosci 8:3633-43. 1988
    ..These results indicate that both the tip-E and sei loci are important in regulation of sodium current density in embryonic neurons...
  3. pmc Functional expression of Drosophila para sodium channels. Modulation by the membrane protein TipE and toxin pharmacology
    J W Warmke
    Department of Genetics and Molecular Biology, Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Gen Physiol 110:119-33. 1997
    The Drosophila para sodium channel alpha subunit was expressed in Xenopus oocytes alone and in combination with tipE, a putative Drosophila sodium channel accessory subunit...
  4. ncbi The tip-E mutation of Drosophila decreases saxitoxin binding and interacts with other mutations affecting nerve membrane excitability
    F R Jackson
    J Neurogenet 3:1-17. 1986
    ..We postulate that either the structure of sodium channels or their microenvironment is altered in tip-E mutants resulting in an increased liability of binding sites in vitro...
  5. ncbi Neurogenetic analysis of Drosophila mutations affecting sodium channels: synergistic effects on viability and nerve conduction in double mutants involving tip-E
    B Ganetzky
    J Neurogenet 3:19-31. 1986
    ..The results of these studies suggest that tip-E shares related function with para and nap. It is proposed that tip-E, like para and nap exerts an effect at some level on the structure, function, or stability of sodium channels...
  6. ncbi Cloning and functional analysis of TipE, a novel membrane protein that enhances Drosophila para sodium channel function
    G Feng
    Department of Biochemical Pharmacology, State University of New York at Buffalo 14260 1200, USA
    Cell 82:1001-11. 1995
    ..Here we report that tipE, a gene defined by a temperature-sensitive paralytic mutation in Drosophila, encodes a novel integral membrane ..
  7. ncbi The molecular biology of knockdown resistance to pyrethroid insecticides
    D M Soderlund
    Department of Entomology, New York State Agricultural Experiment Station, Cornell University, Geneva, NY 14456, USA
    Insect Biochem Mol Biol 33:563-77. 2003
    ..These results also provide new insight into the mechanisms by which pyrethroids modify the function of voltage-sensitive sodium channels...
  8. ncbi Domain 2 of Drosophila para voltage-gated sodium channel confers insect properties to a rat brain channel
    Iris Shichor
    Department of Physiology, Sackler School of Medicine and Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, 69978 Ramat Aviv, Israel
    J Neurosci 22:4364-71. 2002
    ..rBIIA, were sensitive to scorpion alpha-toxins and regulated by the auxiliary subunit beta(1) but not by the insect TipE. Notably, like Drosophila Para/TipE, but unlike rBIIA/beta(1), the chimera gained sensitivity to AahIT, indicating ..
  9. ncbi tipE regulates Na+-dependent repetitive firing in Drosophila neurons
    Dianne D Hodges
    Department of Anatomy and Neurobiology, University of California at Irvine, Irvine, California 92697 1280, USA
    Mol Cell Neurosci 19:402-16. 2002
    The tipE gene, originally identified by a temperature-sensitive paralytic mutation in Drosophila, encodes a transmembrane protein that dramatically influences sodium channel expression in Xenopus oocytes...
  10. pmc Cytogenetic and molecular localization of tipE: a gene affecting sodium channels in Drosophila melanogaster
    G Feng
    State University of New York at Buffalo, Department of Biochemical Pharmacology 14260 1200, USA
    Genetics 139:1679-88. 1995
    ..One such mutation is temperature-induced paralysis locus E (tipE), which has been shown by electrophysiology and ligand binding studies to reduce sodium channel numbers...
  11. ncbi Mutations and natural genetic variation in the courtship song of Drosophila
    Jennifer M Gleason
    Department of Ecology and Evolutionary Biology, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS, USA
    Behav Genet 35:265-77. 2005
    ..With many new tools in genetic analysis and the multiple Drosophila genome projects currently underway, the ability to relate mutational and quantitative analyses will improve...
  12. pmc Sialyltransferase regulates nervous system function in Drosophila
    Elena Repnikova
    Department of Biochemistry and Biophysics, Texas A and M University, College Station, Texas 77843, USA
    J Neurosci 30:6466-76. 2010
    ..Thus, our data shed light on one of the most ancient functions of sialic acids in metazoan organisms and suggest a possibility that this function is evolutionarily conserved between flies and mammals...
  13. doi Drosotoxin, a selective inhibitor of tetrodotoxin-resistant sodium channels
    Shunyi Zhu
    Group of Animal Innate Immunity, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing 100101, China
    Biochem Pharmacol 80:1296-302. 2010
    ..showed no activity on K(+), Ca(2+) and TTX-sensitive (TTX-S) Na(+) channels in rat DRG neurons and Drosophila para/tipE channels at micromolar concentrations...
  14. pmc Presynaptic activity and CaMKII modulate retrograde semaphorin signaling and synaptic refinement
    Robert A Carrillo
    Pharmacology Department, Yale School of Medicine, New Haven, CT 06520, USA
    Neuron 68:32-44. 2010
    ..1 calcium channel (cac), or the voltage-gated Na(v)1 sodium channel (mle(nap-ts);tipE) each result in ectopic neuromuscular contacts. Sema-2a interacts genetically with both of the channel mutations...
  15. pmc Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures
    Louise Parker
    Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720, USA
    Genetics 187:523-34. 2011
    ....
  16. pmc Localization of receptor site on insect sodium channel for depressant β-toxin BmK IT2
    Huiqiong He
    Lab of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai, People s Republic of China
    PLoS ONE 6:e14510. 2011
    ..Combined with molecular approach, the receptor site of BmK IT2 was further localized...
  17. doi Differential resistance of insect sodium channels with kdr mutations to deltamethrin, permethrin and DDT
    Mark J Burton
    School of Biology, University of Nottingham, University Park, Nottingham NG72RD, UK
    Insect Biochem Mol Biol 41:723-32. 2011
    ..We conclude that L1014H and L1014S may have arisen through heavy exposure to specific pyrethroids and DDT respectively...
  18. pmc A remarkably stable TipE gene cluster: evolution of insect Para sodium channel auxiliary subunits
    Jia Li
    Department of Genetic Medicine and Development, University of Geneva Medical School, Rue Michel Servet 1, 1211 Geneva, Switzerland
    BMC Evol Biol 11:337. 2011
    First identified in fruit flies with temperature-sensitive paralysis phenotypes, the Drosophila melanogaster TipE locus encodes four voltage-gated sodium (NaV) channel auxiliary subunits...
  19. pmc Two distinct genomic regions, harbouring the period and fruitless genes, affect male courtship song in Drosophila montana
    M Lagisz
    Department of Animal and Plant Sciences, University of Sheffield, Sheffield, UK
    Heredity (Edinb) 108:602-8. 2012
    ..In previous studies, the pulse train traits have been found to vary substantially between Drosophila species, and so are potential species recognition signals, while the pulse traits may be more important in intra-specific mate choice...
  20. pmc Drosomycin, an innate immunity peptide of Drosophila melanogaster, interacts with the fly voltage-gated sodium channel
    Lior Cohen
    Department of Plant Sciences, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    J Biol Chem 284:23558-63. 2009
    ..As for drosomycin, we discuss the intriguing possibility that it has additional functions in the fly, as implied by its tight interaction with DmNa(v)1...
  21. pmc Molecular and functional characterization of voltage-gated sodium channel variants from Drosophila melanogaster
    Rachel O Donnell Olson
    Department of Entomology, Neuroscience Program and Genetics Program, Michigan State University, East Lansing, MI 48824, USA
    Insect Biochem Mol Biol 38:604-10. 2008
    ....
  22. ncbi Mutations in DIIS5 and the DIIS4-S5 linker of Drosophila melanogaster sodium channel define binding domains for pyrethroids and DDT
    P N R Usherwood
    School of Biology, The University of Nottingham, University Park, Nottingham, UK
    FEBS Lett 581:5485-92. 2007
    ..DDT potency was unaffected by M918T, but abolished by T929I and reduced by L925I, L932F and I936V, suggesting that DIIS5 contains at least part of the DDT binding domain. The data support a computer model of pyrethroid and DDT binding...
  23. ncbi Sensitivity of the Drosophila para sodium channel to DDT is not lowered by the super-kdr mutation M918T on the IIS4-S5 linker that profoundly reduces sensitivity to permethrin and deltamethrin
    P N R Usherwood
    School of Biology, The University of Nottingham, Nottingham, NG7 2RD, UK
    FEBS Lett 579:6317-25. 2005
    ..We conclude that DDT binds either to or in the region of L1014 on IIS6 but only weakly to M918 on the IIS4-S5 linker, which is part of a high-affinity binding site for permethrin and deltamethrin...
  24. ncbi Conduction in the giant nerve fiber pathway in temperature-sensitive paralytic mutants of Drosophila
    T Elkins
    Department of Zoology, University of Wisconsin, Madison 53706
    J Neurogenet 6:207-19. 1990
    ..In the mutants tipE, napts and parats, conduction in certain neurons presynaptic to the CGF failed at about the same temperature at ..
  25. ncbi Drosophila GABAergic systems. II. Mutational analysis of chromosomal segment 64AB, a region containing the glutamic acid decarboxylase gene
    S J Kulkarni
    Neurobiology Group, Worcester Foundation for Experimental Biology, Shrewsbury, MA 01545
    Mol Gen Genet 243:555-64. 1994
    ..Both of these rearrangements are associated with embryonic lethality and decreased GAD enzymatic activity...
  26. ncbi Role of neural activity during synaptogenesis in Drosophila
    J Jarecki
    Department of Genetics, Yale University, New Haven, Connecticut 06511, USA
    J Neurosci 15:8177-90. 1995
    ..Our experiments suggest that neural activity may function during development by preventing inappropriate connections and thereby maintaining the precise connectivity achieved during nerve outgrowth and target selection...
  27. ncbi Classic clues to NSF function
    A Morgan
    Nature 382:680. 1996
  28. pmc Analysis of temperature-sensitive mutants reveals new genes involved in the courtship song of Drosophila
    A A Peixoto
    Department of Biology, Brandeis University, Waltham, Massachusetts 02254, USA
    Genetics 148:827-38. 1998
    ..The implications of these findings from the perspective of interspecific lovesong variations in Drosophila are discussed...
  29. ncbi Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly
    J T Littleton
    Laboratory of Genetics, University of Wisconsin, Madison 53706, USA
    Neuron 21:401-13. 1998
    ..These results provide in vivo evidence that cycles of assembly and disassembly of SNARE complexes drive membrane trafficking at synapses...
  30. ncbi The pharmacological flexibility of the insect voltage gated sodium channel: toxicity of AaIT to knockdown resistant (kdr) flies
    E Zlotkin
    Merck Research Laboratories, Rahway, NJ, USA
    Insect Biochem Mol Biol 29:849-53. 1999
    ..The above data are interpreted in terms of the pharmacological diversity and flexibility ("allosteric coupling") of voltage gated sodium channels and their implications for the management of pesticide resistance are discussed...
  31. pmc Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels
    Jianguo Tan
    Department of Entomology and Neuroscience Program, Michigan State University, East Lansing, Michigan 48824, USA
    J Neurosci 22:5300-9. 2002
    ..Exon swapping partially reversed the channel sensitivity to deltamethrin. Our results therefore provide the first evidence that alternative splicing of a sodium channel gene produces pharmacologically distinct channels...
  32. ncbi The varieties of selectional experience in behavioral genetics
    Ralph J Greenspan
    The Neurosciences Institute, San Diego, CA 92121, USA
    J Neurogenet 17:241-70. 2003
  33. ncbi Neurogenetic studies of ion channels in Drosophila
    C F Wu
    Department of Biology, University of Iowa, Iowa City 52242
    Ion Channels 3:261-314. 1992

Research Grants9

  1. Insecticide Action at the Local Anesthetic Receptor
    DAVID SODERLUND; Fiscal Year: 2007
    ..This research will provide new insight into the structure of the local anesthetic receptor and its role in the neurotoxic actions of PTIs. ..
  2. Molecular Determinants of Pyrethroid Neurotoxicity
    DAVID SODERLUND; Fiscal Year: 2007
    ....
  3. Insecticide Action at the Local Anesthetic Receptor
    DAVID SODERLUND; Fiscal Year: 2009
    ..This research will provide new insight into the structure of the local anesthetic receptor and its role in the neurotoxic actions of PTIs. ..
  4. Molecular Determinants of Pyrethroid Neurotoxicity
    DAVID SODERLUND; Fiscal Year: 2009
    ....
  5. Molecular Determinants of Pyrethroid Neurotoxicity
    David M Soderlund; Fiscal Year: 2010
    ....
  6. Insecticide Action at the Local Anesthetic Receptor
    David M Soderlund; Fiscal Year: 2011
    ..This research will provide new insight into the structure of the local anesthetic receptor and its role in the neurotoxic actions of PTIs. ..