Gene Symbol: tin
Description: tinman
Alias: CG7895, DROHOXHK4, DROHOXNK4, DmNK-4, Dmel\CG7895, HOX, NK-4, NK-4/msh-2, NK4, NK4/msh-2, NKX2.5, TIN, Tin, msh-2, msh2, tin/NK4, tinman, CG7895-PA, muscle-specific-homeodomain-2, tin-PA
Species: fruit fly
Products:     tin

Top Publications

  1. Grigorian M, Mandal L, Hakimi M, Ortiz I, Hartenstein V. The convergence of Notch and MAPK signaling specifies the blood progenitor fate in the Drosophila mesoderm. Dev Biol. 2011;353:105-18 pubmed publisher
  2. Clark I, Boyd J, Hamilton G, Finnegan D, Jarman A. D-six4 plays a key role in patterning cell identities deriving from the Drosophila mesoderm. Dev Biol. 2006;294:220-31 pubmed
    ..For the dorsoventral axis, the homeodomain gene, tinman, is a key patterning mediator for dorsal mesodermal fates like the heart...
  3. Jakobsen J, Braun M, Astorga J, Gustafson E, Sandmann T, Karzynski M, et al. Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network. Genes Dev. 2007;21:2448-60 pubmed
    ..The regulatory connection of a number of Biniou target genes is conserved in mice, suggesting an ancient wiring of this developmental program. ..
  4. Han Z, Fujioka M, Su M, Liu M, Jaynes J, Bodmer R. Transcriptional integration of competence modulated by mutual repression generates cell-type specificity within the cardiogenic mesoderm. Dev Biol. 2002;252:225-40 pubmed
  5. Chartier A, Zaffran S, Astier M, Semeriva M, Gratecos D. Pericardin, a Drosophila type IV collagen-like protein is involved in the morphogenesis and maintenance of the heart epithelium during dorsal ectoderm closure. Development. 2002;129:3241-53 pubmed
    ..Our results support, for the first time, the function of a collagen-like protein in the coordinated migration of dorsal ectoderm and heart cells. ..
  6. Formaz Preston A, Ryu J, Svendsen P, Brook W. The Tbx20 homolog Midline represses wingless in conjunction with Groucho during the maintenance of segment polarity. Dev Biol. 2012;369:319-29 pubmed publisher
    ..Mutating these sequences in transgenic reporter constructs results in ectopic reporter expression in the midline-expression domain, consistent with wingless being a direct target of Midline repression. ..
  7. Kremser T, Gajewski K, Schulz R, Renkawitz Pohl R. Tinman regulates the transcription of the beta3 tubulin gene (betaTub60D) in the dorsal vessel of Drosophila. Dev Biol. 1999;216:327-39 pubmed
    ..The homeodomain protein Tinman is also expressed in these cardioblasts, implying that Tinman might be a key regulator of the beta3 tubulin gene...
  8. Ghazi A, VijayRaghavan K. Developmental biology. Control by combinatorial codes. Nature. 2000;408:419-20 pubmed
  9. Lilly B, Zhao B, Ranganayakulu G, Paterson B, Schulz R, Olson E. Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila. Science. 1995;267:688-93 pubmed
    ..These results demonstrate that different muscle cell types share a common myogenic differentiation program controlled by MEF2. ..

More Information


  1. Zhu X, Ahmad S, Aboukhalil A, Busser B, Kim Y, Tansey T, et al. Differential regulation of mesodermal gene expression by Drosophila cell type-specific Forkhead transcription factors. Development. 2012;139:1457-66 pubmed publisher
  2. Yarnitzky T, Volk T. Laminin is required for heart, somatic muscles, and gut development in the Drosophila embryo. Dev Biol. 1995;169:609-18 pubmed
    ..These studies indicate that the primary function of laminin is to provide structural support for the various cell types, thereby enabling their proper organization into the various organs. ..
  3. Ryu J, Najand N, Brook W. Tinman is a direct activator of midline in the Drosophila dorsal vessel. Dev Dyn. 2011;240:86-95 pubmed publisher
    ..5, GATA and T-box family transcription factors. In Drosophila melanogaster, the Nkx2.5 gene tinman acts upstream of many cardiac genes including the Tbx20 homolog midline, a critical regulator of heart development ..
  4. Zaffran S, Reim I, Qian L, Lo P, Bodmer R, Frasch M. Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila. Development. 2006;133:4073-83 pubmed
    The NK homeobox gene tinman (tin) is required for the specification of the cardiac, visceral muscle and somatic muscle progenitors in the early dorsal mesoderm of Drosophila. Like its vertebrate counterpart Nkx2...
  5. Miskolczi McCallum C, Scavetta R, Svendsen P, Soanes K, Brook W. The Drosophila melanogaster T-box genes midline and H15 are conserved regulators of heart development. Dev Biol. 2005;278:459-72 pubmed
    ..of midline and H15 in the dorsal vessel is dependent on Wingless signaling and the transcription factors tinman and pannier...
  6. Gajewski K, Kim Y, Choi C, Schulz R. Combinatorial control of Drosophila mef2 gene expression in cardiac and somatic muscle cell lineages. Dev Genes Evol. 1998;208:382-92 pubmed
    ..D-mef2 transcription in cardiac and adult muscle precursor cells have been identified and their regulation by the Tinman and Twist myogenic factors have been demonstrated...
  7. Qian L, Mohapatra B, Akasaka T, Liu J, Ocorr K, Towbin J, et al. Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease. Proc Natl Acad Sci U S A. 2008;105:19833-8 pubmed publisher
    ..Along with other known congenital heart disease genes, including tinman/Nkx2-5, dorsocross/Tbx5/6, and pannier/Gata4/6, they are important for specification and morphogenesis of the ..
  8. Zaffran S, Kuchler A, Lee H, Frasch M. biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut morphogenesis in Drosophila. Genes Dev. 2001;15:2900-15 pubmed
    ..biniou expression is activated in the trunk visceral mesoderm primordia downstream of dpp, tinman, and bagpipe and is maintained in all types of developing gut muscles...
  9. Qian L, Liu J, Bodmer R. Neuromancer Tbx20-related genes (H15/midline) promote cell fate specification and morphogenesis of the Drosophila heart. Dev Biol. 2005;279:509-24 pubmed
    ..causing an expansion of cardiac lbe expression, as well as ectopic mesodermal expression of the homeobox gene tinman. In addition, nmr mutants with less severe penetrance exhibit cell alignment defects of the myocardium at the ..
  10. Aboukhalil A, Bulyk M. LOESS correction for length variation in gene set-based genomic sequence analysis. Bioinformatics. 2012;28:1446-54 pubmed publisher
    ..Source code and compiled code are available from http://thebrain.bwh.harvard.edu/LM_LOESS/ ..
  11. Guruharsha K, Ruiz Gomez M, Ranganath H, Siddharthan R, Vijayraghavan K. The complex spatio-temporal regulation of the Drosophila myoblast attractant gene duf/kirre. PLoS ONE. 2009;4:e6960 pubmed publisher
    ..Our results and the bioinformatics tools developed provide a basis for the study of the transcriptional regulation of other complex genes. ..
  12. Akasaka T, Klinedinst S, Ocorr K, Bustamante E, Kim S, Bodmer R. The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman. Proc Natl Acad Sci U S A. 2006;103:11999-2004 pubmed
    The homeobox transcription factor Tinman plays an important role in the initiation of heart development. Later functions of Tinman, including the target genes involved in cardiac physiology, are less well studied...
  13. Choi C, Lee Y, Kim Y, Park T, Jeon B, Schulz R, et al. The homeodomain transcription factor NK-4 acts as either a transcriptional activator or repressor and interacts with the p300 coactivator and the Groucho corepressor. J Biol Chem. 1999;274:31543-52 pubmed
    NK-4 (tinman) encodes an NK-2 class homeodomain transcription factor that is required for development of the Drosophila dorsal mesoderm, including heart...
  14. Jagla T, Bidet Y, Da Ponte J, Dastugue B, Jagla K. Cross-repressive interactions of identity genes are essential for proper specification of cardiac and muscular fates in Drosophila. Development. 2002;129:1037-47 pubmed
    ..The cross-repressive interactions of identity genes are likely to ensure their localised expression over time, thus providing an essential element in establishing cell identity. ..
  15. Alvarez A, Shi W, Wilson B, Skeath J. pannier and pointedP2 act sequentially to regulate Drosophila heart development. Development. 2003;130:3015-26 pubmed
  16. Furlong E. Integrating transcriptional and signalling networks during muscle development. Curr Opin Genet Dev. 2004;14:343-50 pubmed
    ..The combination of a common set of mesoderm autonomous transcription factors (e.g. Tinman and Twist) and spatially restricted inductive signals (e.g...
  17. Cripps R, Zhao B, Olson E. Transcription of the myogenic regulatory gene Mef2 in cardiac, somatic, and visceral muscle cell lineages is regulated by a Tinman-dependent core enhancer. Dev Biol. 1999;215:420-30 pubmed
    ..The core of this enhancer contains two evolutionarily conserved binding sites for the homeodomain protein Tinman (Tin), expressed in developing cardiac, somatic, and visceral muscle lineages...
  18. Zaffran S, Astier M, Gratecos D, Guillen A, Semeriva M. Cellular interactions during heart morphogenesis in the Drosophila embryo. Biol Cell. 1995;84:13-24 pubmed
    ..We show that an extracellular matrix component is specifically expressed at the surface of the dorsal vessel and could participate in the interaction between the dorsalmost ectodermal cells and the heart during this migration step. ..
  19. Berger M, Badis G, Gehrke A, Talukder S, Philippakis A, Pena Castillo L, et al. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell. 2008;133:1266-76 pubmed publisher
    ..Our results provide an unprecedented level of resolution in the analysis of this simple domain structure and suggest that variation in sequence recognition may be a factor in its functional diversity and evolutionary success. ..
  20. Jagla T, Bellard F, Lutz Y, Dretzen G, Bellard M, Jagla K. ladybird determines cell fate decisions during diversification of Drosophila somatic muscles. Development. 1998;125:3699-708 pubmed
    ..Altogether our results provide new insights into the genetic control of diversification of muscle precursors and indicate a further similarity between the myogenic and neurogenic pathways. ..
  21. Riechmann V, Rehorn K, Reuter R, Leptin M. The genetic control of the distinction between fat body and gonadal mesoderm in Drosophila. Development. 1998;125:713-23 pubmed
    ..We suggest a model in which tinman, engrailed and wingless are necessary to permit somatic gonadal develoment, while serpent counteracts the effects ..
  22. LaBeau E, Trujillo D, Cripps R. Bithorax complex genes control alary muscle patterning along the cardiac tube of Drosophila. Mech Dev. 2009;126:478-86 pubmed publisher
    ..These studies demonstrate an additional facet of muscle development that depends upon the Hox genes, and define for the first time mechanisms that impact development of this important subset of muscles.
  23. Albrecht S, Wang S, Holz A, Bergter A, Paululat A. The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster. Mech Dev. 2006;123:372-87 pubmed
    ..Our data presented herein suggest that Kuzbanian acts during lateral inhibition within the cardiac primordium. Furthermore we discuss a second function of Kuzbanian in heart cell morphogenesis. ..
  24. Popichenko D, Sellin J, Bartkuhn M, Paululat A. Hand is a direct target of the forkhead transcription factor Biniou during Drosophila visceral mesoderm differentiation. BMC Dev Biol. 2007;7:49 pubmed
    ..This leads to the activation of the key regulators Tinman, Bagpipe and Biniou that are crucial for specification of the circular visceral muscles...
  25. Reim I, Mohler J, Frasch M. Tbx20-related genes, mid and H15, are required for tinman expression, proper patterning, and normal differentiation of cardioblasts in Drosophila. Mech Dev. 2005;122:1056-69 pubmed
    ..However, the expression of tinman (tin), which normally occurs in four out of six cardioblasts in each hemisegment of the dorsal vessel, is almost ..
  26. Sellin J, Drechsler M, Nguyen H, Paululat A. Antagonistic function of Lmd and Zfh1 fine tunes cell fate decisions in the Twi and Tin positive mesoderm of Drosophila melanogaster. Dev Biol. 2009;326:444-55 pubmed publisher
    ..to the reduction of Zfh1 positive cell types, thereby restricting the number of Odd-skipped (Odd) positive and Tinman (Tin) positive pericardial cells in the dorsal mesoderm...
  27. Sellin J, Albrecht S, Kölsch V, Paululat A. Dynamics of heart differentiation, visualized utilizing heart enhancer elements of the Drosophila melanogaster bHLH transcription factor Hand. Gene Expr Patterns. 2006;6:360-75 pubmed
  28. Taghli Lamallem O, Akasaka T, Hogg G, Nudel U, Yaffe D, Chamberlain J, et al. Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype. Aging Cell. 2008;7:237-49 pubmed publisher
    ..Our results illustrate the utility of Drosophila as a model system to study dilated cardiomyopathy and other muscular-dystrophy-associated phenotypes. ..
  29. Ward E, Skeath J. Characterization of a novel subset of cardiac cells and their progenitors in the Drosophila embryo. Development. 2000;127:4959-69 pubmed
    ..Furthermore, we demonstrate that numb and sanpodo mediate the asymmetric divisions of the two mixed-lineage heart progenitors noted above. ..
  30. Reim I, Frasch M. The Dorsocross T-box genes are key components of the regulatory network controlling early cardiogenesis in Drosophila. Development. 2005;132:4911-25 pubmed
    ..In an early step, the Dorsocross genes act in parallel with tinman to activate the expression of pannier, a cardiogenic gene encoding a Gata factor...
  31. Yin Z, Xu X, Frasch M. Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development. Development. 1997;124:4971-82 pubmed
    The Drosophila tinman homeobox gene has a major role in early mesoderm patterning and determines the formation of visceral mesoderm, heart progenitors, specific somatic muscle precursors and glia-like mesodermal cells...
  32. Lee H, Frasch M. Nuclear integration of positive Dpp signals, antagonistic Wg inputs and mesodermal competence factors during Drosophila visceral mesoderm induction. Development. 2005;132:1429-42 pubmed
    ..Dpp signals are required in cooperation with the mesoderm-specific NK homeodomain transcription factor Tinman (Tin) to induce all dorsal mesodermal tissue derivatives, which include dorsal somatic muscles, the dorsal vessel ..
  33. Gorczyca M, Phillis R, Budnik V. The role of tinman, a mesodermal cell fate gene, in axon pathfinding during the development of the transverse nerve in Drosophila. Development. 1994;120:2143-52 pubmed
    ..In this paper, we examine the role of the mesodermal cell determination gene tinman on cells that provide pathfinding cues in Drosophila...
  34. Busser B, Huang D, Rogacki K, Lane E, Shokri L, Ni T, et al. Integrative analysis of the zinc finger transcription factor Lame duck in the Drosophila myogenic gene regulatory network. Proc Natl Acad Sci U S A. 2012;109:20768-73 pubmed publisher
    ..Collectively, these findings provide insights into the transcriptional codes regulating muscle gene expression and offer a generalizable approach for similar studies in other systems. ..
  35. Gisselbrecht S, Skeath J, Doe C, Michelson A. heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo. Genes Dev. 1996;10:3003-17 pubmed
    ..These studies establish that Htl signaling provides a vital connection between initial formation of the embryonic mesoderm in Drosophila and subsequent cell-fate specification within this germ layer. ..
  36. Ryan K, Hendren J, Helander L, Cripps R. The NK homeodomain transcription factor Tinman is a direct activator of seven-up in the Drosophila dorsal vessel. Dev Biol. 2007;302:694-702 pubmed
    ..other mesodermal derivatives, and we show that this enhancer is initially activated by the NK homeodomain factor Tinman (Tin) via two conserved Tin binding sites...
  37. Zinzen R, Girardot C, Gagneur J, Braun M, Furlong E. Combinatorial binding predicts spatio-temporal cis-regulatory activity. Nature. 2009;462:65-70 pubmed publisher
    ..This data-driven approach does not require previous knowledge of transcription factor sequence affinity, function or expression, making it widely applicable. ..
  38. Kölsch V, Paululat A. The highly conserved cardiogenic bHLH factor Hand is specifically expressed in circular visceral muscle progenitor cells and in all cell types of the dorsal vessel during Drosophila embryogenesis. Dev Genes Evol. 2002;212:473-85 pubmed
    ..g. Tinman and Bagpipe, suggesting a role of Hand in differentiation rather than in tissue determination...
  39. Gajewski K, Kim Y, Lee Y, Olson E, Schulz R. D-mef2 is a target for Tinman activation during Drosophila heart development. EMBO J. 1997;16:515-22 pubmed
    The NK-type homeobox gene tinman and the MADS box gene D-mef2 encode transcription factors required for the development and differentiation of the Drosophila heart, and closely related genes regulate cardiogenesis in vertebrates...
  40. Xu X, Yin Z, Hudson J, Ferguson E, Frasch M. Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes Dev. 1998;12:2354-70 pubmed
    ..by Dpp is, at least in part, effected through the transcriptional activation and function of the homeobox gene tinman in dorsal mesodermal cells during early embryogenesis...
  41. Halfon M, Carmena A, Gisselbrecht S, Sackerson C, Jimenez F, Baylies M, et al. Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors. Cell. 2000;103:63-74 pubmed
    ..and Pointed-functioning in the Wg, Dpp, and Ras/MAPK pathways, respectively) and two tissue-restricted (Twist and Tinman) transcription factors on a progenitor identity gene enhancer...
  42. Gajewski K, Zhang Q, Choi C, Fossett N, Dang A, Kim Y, et al. Pannier is a transcriptional target and partner of Tinman during Drosophila cardiogenesis. Dev Biol. 2001;233:425-36 pubmed
    During Drosophila embryogenesis, the homeobox gene tinman is expressed in the dorsal mesoderm where it functions in the specification of precursor cells of the heart, visceral, and dorsal body wall muscles...
  43. Lockwood W, Bodmer R. The patterns of wingless, decapentaplegic, and tinman position the Drosophila heart. Mech Dev. 2002;114:13-26 pubmed
    ..progressively to the elaboration of the expression pattern of the mesoderm-specific homeobox-containing gene tinman (tin), and that the overlap of wg and dpp at an early stage (9) as well as at a later stage (11) in the presence ..
  44. Han Z, Bodmer R. Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division. Development. 2003;130:3039-51 pubmed
    ..In addition, we provide evidence that whether or not Suppressor-of-Hairless can become a transcriptional activator is the key switch for the Numb/Notch activity in determining a myocardial versus pericardial cell fate. ..
  45. Lilly B, Galewsky S, Firulli A, Schulz R, Olson E. D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis. Proc Natl Acad Sci U S A. 1994;91:5662-6 pubmed
    ..D-mef2 is dependent on the mesodermal determinants twist and snail but independent of the homeobox-containing gene tinman, which is required for visceral muscle and heart development...
  46. Haag T, Haag N, Lekven A, Hartenstein V. The role of cell adhesion molecules in Drosophila heart morphogenesis: faint sausage, shotgun/DE-cadherin, and laminin A are required for discrete stages in heart development. Dev Biol. 1999;208:56-69 pubmed
    ..We discuss our findings in light of recent results that elucidate the function of different adhesion systems in vertebrate heart development. ..
  47. Lo P, Frasch M. A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila. Mech Dev. 2001;104:49-60 pubmed
    The Drosophila gene tinman is essential for dorsal vessel (heart) formation and is structurally and functionally conserved in vertebrates...
  48. Liu J, Qian L, Wessells R, Bidet Y, Jagla K, Bodmer R. Hedgehog and RAS pathways cooperate in the anterior-posterior specification and positioning of cardiac progenitor cells. Dev Biol. 2006;290:373-85 pubmed
    ..Thus, the spatial precision of cell type specification within an organ depends on multiple phases of inductive interaction between the ectoderm and the mesoderm. ..
  49. Wang J, Tao Y, Reim I, Gajewski K, Frasch M, Schulz R. Expression, regulation, and requirement of the toll transmembrane protein during dorsal vessel formation in Drosophila melanogaster. Mol Cell Biol. 2005;25:4200-10 pubmed
    ..The Toll dorsal vessel enhancer has been characterized, with its activity controlled by Dorsocross and Tinman transcription factors...
  50. Wu X, Golden K, Bodmer R. Heart development in Drosophila requires the segment polarity gene wingless. Dev Biol. 1995;169:619-28 pubmed
    ..The homeobox gene, tinman, has been shown to be crucial for heart formation in Drosophila...
  51. Frasch M. Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo. Nature. 1995;374:464-7 pubmed
    ..An early and important event in the regional subdivision of the mesoderm is the restriction of tinman expression to dorsal mesodermal cells...
  52. Broihier H, Moore L, Van Doren M, Newman S, Lehmann R. zfh-1 is required for germ cell migration and gonadal mesoderm development in Drosophila. Development. 1998;125:655-66 pubmed
    ..Finally, through analysis of a tinman zfh-1 double mutant, we show that zfh-1 acts in conjunction with tinman, another homeodomain protein, in the ..
  53. Staehling Hampton K, Hoffmann F, Baylies M, Rushton E, Bate M. dpp induces mesodermal gene expression in Drosophila. Nature. 1994;372:783-6 pubmed
    ..Here we show, by expressing dpp ectopically in the ectoderm and mesoderm and by examining dpp null mutant embryos, that dpp regulates expression of mesodermal genes. ..
  54. Baylies M, Bate M. twist: a myogenic switch in Drosophila. Science. 1996;272:1481-4 pubmed
    ..Vertebrate homologs of twist may also participate in the subdivision of mesoderm. ..
  55. Han Z, Olson E. Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis. Development. 2005;132:3525-36 pubmed
    ..The homeodomain protein Tinman and the GATA factors Pannier and Serpent directly activate Hand in these cell types through a minimal enhancer, ..
  56. Venkatesh T, Park M, Ocorr K, Nemaceck J, Golden K, Wemple M, et al. Cardiac enhancer activity of the homeobox gene tinman depends on CREB consensus binding sites in Drosophila. Genesis. 2000;26:55-66 pubmed
    The Drosophila homeobox gene tinman plays a critical role in subdividing the early mesoderm. In particular, tinman is absolutely required for formation of the heart and visceral mesoderm...
  57. Kremser T, Hasenpusch Theil K, Wagner E, Buttgereit D, Renkawitz Pohl R. Expression of the beta3 tubulin gene (beta Tub60D) in the visceral mesoderm of Drosophila is dependent on a complex enhancer that binds Tinman and UBX. Mol Gen Genet. 1999;262:643-58 pubmed
    ..Gel-retardation and footprint analysis identified a binding site for the homeodomain protein Tinman, which is essential for the specification of the dorsal mesoderm, within e7...
  58. Hendren J, Shah A, Arguelles A, Cripps R. Cardiac expression of the Drosophila Sulphonylurea receptor gene is regulated by an intron enhancer dependent upon the NK homeodomain factor Tinman. Mech Dev. 2007;124:416-26 pubmed
    ..In Drosophila, the NK homeodomain transcription factor Tinman is critical to cardiac specification and development via the activation of a number of key regulatory genes which ..
  59. Busser B, Shokri L, Jaeger S, Gisselbrecht S, Singhania A, Berger M, et al. Molecular mechanism underlying the regulatory specificity of a Drosophila homeodomain protein that specifies myoblast identity. Development. 2012;139:1164-74 pubmed publisher
    ..Collectively, these studies provide new insights into the roles of individual HD TFs in determining cellular identity, and suggest that the diversity of HD binding preferences can confer regulatory specificity. ..
  60. Jagla K, Georgel P, Bellard F, Dretzen G, Bellard M. A novel homeobox nkch4 gene from the Drosophila 93E region. Gene. 1993;127:165-71 pubmed
    ..Low levels of nkch4 transcripts were detected during late stages of embryogenesis as well as in third instar larvae and pupae. In late embryos nkch4 is expressed in the developing CNS. ..
  61. Azpiazu N, Frasch M. tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev. 1993;7:1325-40 pubmed
    ..Here, we describe two homeo box genes, tinman (tin) and bagpipe (bap), which spatially subdivide the mesoderm and determine cell fates in the dorsal mesoderm...
  62. Klinedinst S, Bodmer R. Gata factor Pannier is required to establish competence for heart progenitor formation. Development. 2003;130:3027-38 pubmed
    ..from the ectoderm to the underlying mesoderm induces cardiac-specific differentiation in the presence of Tinman, a mesoderm-specific homeobox transcription factor...
  63. Park M, Lewis C, Turbay D, Chung A, Chen J, Evans S, et al. Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes. Proc Natl Acad Sci U S A. 1998;95:9366-71 pubmed
    b>tinman, a mesodermal NK2-type homeobox gene, is absolutely required for the subdivision of the early Drosophila mesoderm and for the formation of the heart as well as the visceral muscle primordia...
  64. Tögel M, Pass G, Paululat A. The Drosophila wing hearts originate from pericardial cells and are essential for wing maturation. Dev Biol. 2008;318:29-37 pubmed publisher
    ..undescribed subset of the Even-skipped positive pericardial cells (EPC) and are characterized by the early loss of tinman expression in contrast to the continuously Tinman positive classical EPCs...
  65. Lawrence P, Bodmer R, Vincent J. Segmental patterning of heart precursors in Drosophila. Development. 1995;121:4303-8 pubmed
    ..We conclude that the mesoderm is segmented in some way not dependent on the distribution of Wingless, suggesting a more permissive and less instructive role for the protein in this instance. ..
  66. De Graeve F, Jagla T, Daponte J, Rickert C, Dastugue B, Urban J, et al. The ladybird homeobox genes are essential for the specification of a subpopulation of neural cells. Dev Biol. 2004;270:122-34 pubmed
  67. Nguyen H, Xu X. Drosophila mef2 expression during mesoderm development is controlled by a complex array of cis-acting regulatory modules. Dev Biol. 1998;204:550-66 pubmed
  68. Zaffran S, Astier M, Gratecos D, Semeriva M. The held out wings (how) Drosophila gene encodes a putative RNA-binding protein involved in the control of muscular and cardiac activity. Development. 1997;124:2087-98 pubmed
    ..The properties of the how gene described herein suggest that this gene participates in the control of expression of as yet unidentified target mRNAs coding for proteins essential to cardiac and muscular activity. ..
  69. Zaffran S, Frasch M. The homeodomain of Tinman mediates homo- and heterodimerization of NK proteins. Biochem Biophys Res Commun. 2005;334:361-9 pubmed
    ..One of these factors, encoded by the homeobox gene tinman (tin), is essential for the specification of all cardiac cells in Drosophila...
  70. Jin H, Stojnic R, Adryan B, Ozdemir A, Stathopoulos A, Frasch M. Genome-wide screens for in vivo Tinman binding sites identify cardiac enhancers with diverse functional architectures. PLoS Genet. 2013;9:e1003195 pubmed publisher
    The NK homeodomain factor Tinman is a crucial regulator of early mesoderm patterning and, together with the GATA factor Pannier and the Dorsocross T-box factors, serves as one of the key cardiogenic factors during specification and ..
  71. Bodmer R, Jan L, Jan Y. A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila. Development. 1990;110:661-9 pubmed
    ..H2.0, a homeo-box-containing gene specifically expressed in visceral mesoderm, is not transcribed in the mesoderm in 93C-F deficiency embryos.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  72. Maggert K, Levine M, Frasch M. The somatic-visceral subdivision of the embryonic mesoderm is initiated by dorsal gradient thresholds in Drosophila. Development. 1995;121:2107-16 pubmed
    ..These results also suggest that the dorsal regulatory gradient defines the limits of inductive interactions between germ layers after gastrulation. We discuss the parallels between the subdivision of the mesoderm and dorsal ectoderm. ..