tin

Summary

Gene Symbol: tin
Description: tinman
Alias: CG7895, DROHOXHK4, DROHOXNK4, DmNK-4, Dmel\CG7895, HOX, NK-4, NK-4/msh-2, NK4, NK4/msh-2, NKX2.5, TIN, Tin, msh-2, msh2, tin/NK4, CG7895-PA, muscle-specific-homeodomain-2, tin-PA
Species: fruit fly

Top Publications

  1. ncbi The gene tinman is required for specification of the heart and visceral muscles in Drosophila
    R Bodmer
    Department of Biology, University of Michigan, Ann Arbor 48109 1048
    Development 118:719-29. 1993
  2. ncbi Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors
    M S Halfon
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cell 103:63-74. 2000
  3. ncbi tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila
    N Azpiazu
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029
    Genes Dev 7:1325-40. 1993
  4. ncbi The Dorsocross T-box genes are key components of the regulatory network controlling early cardiogenesis in Drosophila
    Ingolf Reim
    Brookdale Department of Molecular, Cell and Developmental Biology, Box 1020, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 132:4911-25. 2005
  5. ncbi Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development
    Z Yin
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 124:4971-82. 1997
  6. ncbi The beta 3 tubulin gene is a direct target of bagpipe and biniou in the visceral mesoderm of Drosophila
    Stephane Zaffran
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, Box 1020, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mech Dev 114:85-93. 2002
  7. pmc D-mef2 is a target for Tinman activation during Drosophila heart development
    K Gajewski
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    EMBO J 16:515-22. 1997
  8. doi Tinman is a direct activator of midline in the Drosophila dorsal vessel
    Jae Ryeon Ryu
    Genes and Development Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada
    Dev Dyn 240:86-95. 2011
  9. ncbi Tbx20-related genes, mid and H15, are required for tinman expression, proper patterning, and normal differentiation of cardioblasts in Drosophila
    Ingolf Reim
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, Box 1020, One Gustave L Levy Pl, New York, NY 10029, USA
    Mech Dev 122:1056-69. 2005
  10. pmc Transcriptional integration of competence modulated by mutual repression generates cell-type specificity within the cardiogenic mesoderm
    Zhe Han
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 252:225-40. 2002

Scientific Experts

Detail Information

Publications107 found, 100 shown here

  1. ncbi The gene tinman is required for specification of the heart and visceral muscles in Drosophila
    R Bodmer
    Department of Biology, University of Michigan, Ann Arbor 48109 1048
    Development 118:719-29. 1993
    ....
  2. ncbi Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors
    M S Halfon
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA
    Cell 103:63-74. 2000
    ..The integration of Pointed with the combinatorial effects of dTCF, Mad, Twist, and Tinman determines inductive Ras signaling specificity in muscle and heart development...
  3. ncbi tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila
    N Azpiazu
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029
    Genes Dev 7:1325-40. 1993
    ..Here, we describe two homeo box genes, tinman (tin) and bagpipe (bap), which spatially subdivide the mesoderm and determine cell fates in the dorsal mesoderm...
  4. ncbi The Dorsocross T-box genes are key components of the regulatory network controlling early cardiogenesis in Drosophila
    Ingolf Reim
    Brookdale Department of Molecular, Cell and Developmental Biology, Box 1020, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 132:4911-25. 2005
    ..The integration of this new information with previous findings has allowed us to draw a more complete pathway of regulatory events during cardiac induction and differentiation in Drosophila...
  5. ncbi Regulation of the twist target gene tinman by modular cis-regulatory elements during early mesoderm development
    Z Yin
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 124:4971-82. 1997
    ....
  6. ncbi The beta 3 tubulin gene is a direct target of bagpipe and biniou in the visceral mesoderm of Drosophila
    Stephane Zaffran
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, Box 1020, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Mech Dev 114:85-93. 2002
    ..Together, these observations suggest that Bagpipe and Biniou serve as direct, partially redundant, and tissue-specific activators of the terminal differentiation gene beta 3Tub60D in the visceral mesoderm...
  7. pmc D-mef2 is a target for Tinman activation during Drosophila heart development
    K Gajewski
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    EMBO J 16:515-22. 1997
    ..These results define the only known in vivo target for transcriptional activation by Tinman and demonstrate that D-mef2 lies directly downstream of tinman in the genetic cascade controlling heart formation in Drosophila...
  8. doi Tinman is a direct activator of midline in the Drosophila dorsal vessel
    Jae Ryeon Ryu
    Genes and Development Research Group, Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada
    Dev Dyn 240:86-95. 2011
    ..7 kb subfragment that drives reporter expression in mid-expressing heart cells that maintain tin expression...
  9. ncbi Tbx20-related genes, mid and H15, are required for tinman expression, proper patterning, and normal differentiation of cardioblasts in Drosophila
    Ingolf Reim
    Brookdale Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, Box 1020, One Gustave L Levy Pl, New York, NY 10029, USA
    Mech Dev 122:1056-69. 2005
    ..However, the expression of tinman (tin), which normally occurs in four out of six cardioblasts in each hemisegment of the dorsal vessel, is almost ..
  10. pmc Transcriptional integration of competence modulated by mutual repression generates cell-type specificity within the cardiogenic mesoderm
    Zhe Han
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Dev Biol 252:225-40. 2002
    ....
  11. ncbi Pannier is a transcriptional target and partner of Tinman during Drosophila cardiogenesis
    K Gajewski
    Department of Biochemistry and Molecular Biology, Graduate Program in Genes and Development, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Biol 233:425-36. 2001
    ..Together, these results provide important insights into the genetic mechanisms controlling heart formation in the Drosophila model system...
  12. ncbi Nuclear integration of positive Dpp signals, antagonistic Wg inputs and mesodermal competence factors during Drosophila visceral mesoderm induction
    Hsiu Hsiang Lee
    Brookdale Department of Molecular, Cell and Developmental Biology, Box 1026, Mount Sinai School of Medicine, New York, NY 10029, USA
    Development 132:1429-42. 2005
    ..Dpp signals are required in cooperation with the mesoderm-specific NK homeodomain transcription factor Tinman (Tin) to induce all dorsal mesodermal tissue derivatives, which include dorsal somatic muscles, the dorsal vessel and ..
  13. ncbi The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila
    K Gajewski
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Development 126:5679-88. 1999
    ..The related GATA4 protein of mice likewise functions as a cardiogenic factor in Drosophila, demonstrating an evolutionarily conserved function between Pannier and GATA4 in heart development...
  14. pmc Molecular mechanism underlying the regulatory specificity of a Drosophila homeodomain protein that specifies myoblast identity
    Brian W Busser
    Laboratory of Developmental Systems Biology, Genetics and Developmental Biology Center, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Development 139:1164-74. 2012
    ..Collectively, these studies provide new insights into the roles of individual HD TFs in determining cellular identity, and suggest that the diversity of HD binding preferences can confer regulatory specificity...
  15. ncbi Drosophila mef2 expression during mesoderm development is controlled by a complex array of cis-acting regulatory modules
    H T Nguyen
    Department of Medicine, Division of Cardiology, Forchheimer G42, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, 10461, USA
    Dev Biol 204:550-66. 1998
    ....
  16. ncbi heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo
    S Gisselbrecht
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Dev 10:3003-17. 1996
    ..These studies establish that Htl signaling provides a vital connection between initial formation of the embryonic mesoderm in Drosophila and subsequent cell-fate specification within this germ layer...
  17. ncbi A role for the COUP-TF-related gene seven-up in the diversification of cardioblast identities in the dorsal vessel of Drosophila
    P C Lo
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029, USA
    Mech Dev 104:49-60. 2001
    ..We also describe the tinman cis sequences that mediate tinman repression by seven-up and examine whether Seven-up can bind these sequences to directly inhibit tinman...
  18. ncbi Regulation and function of tinman during dorsal mesoderm induction and heart specification in Drosophila
    Z Yin
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Dev Genet 22:187-200. 1998
    ..It is likely that some of these functional and regulatory properties of tinman are shared by tinman-related genes from vertebrates that have similarly important roles in embryonic heart development...
  19. ncbi The NK homeodomain transcription factor Tinman is a direct activator of seven-up in the Drosophila dorsal vessel
    Kathryn M Ryan
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Dev Biol 302:694-702. 2007
    ..mesodermal derivatives, and we show that this enhancer is initially activated by the NK homeodomain factor Tinman (Tin) via two conserved Tin binding sites...
  20. pmc The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis
    Tabea Mann
    Institute for Biochemistry and Molecular Biology, University of Ulm, Albert Einstein Allee 11, 89081 Ulm, Germany
    Development 136:317-26. 2009
    ..Indeed, tup mutants are characterized by a reduction of the essential early cardiac transcription factors Tin, Pnr and Dorsocross1-3 (Doc)...
  21. ncbi pannier and pointedP2 act sequentially to regulate Drosophila heart development
    Alejandra D Alvarez
    Department of Genetics, Washington University School of Medicine, 4566 Scott Avenue, St Louis, MO 63110, USA
    Development 130:3015-26. 2003
    ....
  22. ncbi Hand is a direct target of Tinman and GATA factors during Drosophila cardiogenesis and hematopoiesis
    Zhe Han
    Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Development 132:3525-36. 2005
    ....
  23. ncbi Characterization of a novel subset of cardiac cells and their progenitors in the Drosophila embryo
    E J Ward
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 127:4959-69. 2000
    ..Furthermore, we demonstrate that numb and sanpodo mediate the asymmetric divisions of the two mixed-lineage heart progenitors noted above...
  24. ncbi Tinman regulates the transcription of the beta3 tubulin gene (betaTub60D) in the dorsal vessel of Drosophila
    T Kremser
    Fachbereich Biologie, Entwicklungsbiologie, Philipps Universitat Marburg, Marburg, 35032, Germany
    Dev Biol 216:327-39. 1999
    ..The BS(Tin-1460) site is absolutely required for expression in cardioblasts, while BS(Tin-1425) is needed for high-level ..
  25. ncbi Gata factor Pannier is required to establish competence for heart progenitor formation
    Susan L Klinedinst
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Development 130:3027-38. 2003
    ..In support, we find that manipulation of pannier activity in either germ layer affects cardiac specification, suggesting that its function is required in both the mesoderm and the ectoderm...
  26. ncbi Neuromancer Tbx20-related genes (H15/midline) promote cell fate specification and morphogenesis of the Drosophila heart
    Li Qian
    The Burnham Institute, Center for Neuroscienes and Aging, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Dev Biol 279:509-24. 2005
    ..We propose that nmr is another determinant of cardiogenesis, along with tinman and pannier...
  27. ncbi The homeodomain transcription factor NK-4 acts as either a transcriptional activator or repressor and interacts with the p300 coactivator and the Groucho corepressor
    C Y Choi
    Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 274:31543-52. 1999
    ..Together, our results indicate that NK-4 can act as either a transcriptional activator or repressor and provide the first evidence of NK-4 interactions with the p300 coactivator and the Groucho corepressor...
  28. pmc Differential rescue of visceral and cardiac defects in Drosophila by vertebrate tinman-related genes
    M Park
    Department of Biology, University of Michigan, 830 N University, Ann Arbor, MI 48109 1048, USA
    Proc Natl Acad Sci U S A 95:9366-71. 1998
    ....
  29. ncbi Expression of the beta3 tubulin gene (beta Tub60D) in the visceral mesoderm of Drosophila is dependent on a complex enhancer that binds Tinman and UBX
    T Kremser
    Fachbereich Biologie, Entwicklungsbiologie, Philipps Universitat Marburg, Germany
    Mol Gen Genet 262:643-58. 1999
    ..Thus the vm1 enhancer of the beta3 tubulin gene contains a complex array of elements that are involved in transactivation by a combination of tissue- and position-specific factors including Tinman and UBX...
  30. pmc Hand is a direct target of the forkhead transcription factor Biniou during Drosophila visceral mesoderm differentiation
    Dmitry Popichenko
    Department of Biology, University of Osnabruck, Zoology, Osnabruck, Germany
    BMC Dev Biol 7:49. 2007
    ..In our report we focus on the analysis of the transcriptional control of the highly conserved transcription factor Hand in circular visceral muscle cells, providing evidence that the hand gene is a direct target of Biniou...
  31. ncbi dpp induces mesodermal gene expression in Drosophila
    K Staehling-Hampton
    McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706
    Nature 372:783-6. 1994
    ..Here we show, by expressing dpp ectopically in the ectoderm and mesoderm and by examining dpp null mutant embryos, that dpp regulates expression of mesodermal genes...
  32. pmc Tinman/Nkx2-5 acts via miR-1 and upstream of Cdc42 to regulate heart function across species
    Li Qian
    Development and Aging Program, NASCR Center, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 193:1181-96. 2011
    ..We conclude that Cdc42 plays a conserved role in regulating heart function and is an indirect target of Tinman/Nkx2-5 via miR-1...
  33. pmc Cardiac expression of the Drosophila Sulphonylurea receptor gene is regulated by an intron enhancer dependent upon the NK homeodomain factor Tinman
    Jill D Hendren
    Department of Biology, University of New Mexico, Albuquerque, NM 87131, USA
    Mech Dev 124:416-26. 2007
    ..an intron enhancer which first becomes active at stage 12 of embryogenesis, and whose function is restricted to the Tin cardial cells by the end of embryogenesis...
  34. ncbi Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila
    Stephane Zaffran
    Brookdale Department of Molecular, Cell and Developmental Biology, Box 1020, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Development 133:4073-83. 2006
    The NK homeobox gene tinman (tin) is required for the specification of the cardiac, visceral muscle and somatic muscle progenitors in the early dorsal mesoderm of Drosophila. Like its vertebrate counterpart Nkx2...
  35. ncbi The held out wings (how) Drosophila gene encodes a putative RNA-binding protein involved in the control of muscular and cardiac activity
    S Zaffran
    Laboratoire de Genetique et Physiologie du Developpement, UMR 9943 CNRS Université, IBDM CNRS INSERM, Universite de la Mediterranee, Campus de Luminy Case, Marseille, France
    Development 124:2087-98. 1997
    ..The properties of the how gene described herein suggest that this gene participates in the control of expression of as yet unidentified target mRNAs coding for proteins essential to cardiac and muscular activity...
  36. pmc Expression, regulation, and requirement of the toll transmembrane protein during dorsal vessel formation in Drosophila melanogaster
    Jianbo Wang
    Department of Biochemistry and Molecular Biology, Box 117, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cell Biol 25:4200-10. 2005
    ..Such findings implicate Toll as a critical cell adhesion molecule in the alignment and migration of cardioblasts during dorsal vessel morphogenesis...
  37. pmc biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut morphogenesis in Drosophila
    S Zaffran
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Genes Dev 15:2900-15. 2001
    ....
  38. pmc Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm
    X Xu
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029 USA
    Genes Dev 12:2354-70. 1998
    ..Thus, integration of positive and negative regulators on enhancers of target genes appears to be an important mechanism in tissue-specific induction by TGF-beta molecules...
  39. pmc The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman
    Takeshi Akasaka
    Del E Webb Center for Neurosciences and Aging, The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 103:11999-2004. 2006
    ..dSUR provides a model for addressing how embryonic regulators of myocardial cell commitment can contribute to the establishment and maintenance of cardiac performance...
  40. ncbi The role of tinman, a mesodermal cell fate gene, in axon pathfinding during the development of the transverse nerve in Drosophila
    M G Gorczyca
    Department of Biology, University of Massachusetts, Amherst 01003
    Development 120:2143-52. 1994
    ..Our results support the hypothesis that the exit glia have a mesodermal origin and that glia play an essential role in determining transverse nerve axon pathways...
  41. ncbi bagpipe-Dependent expression of vimar, a novel Armadillo-repeats gene, in Drosophila visceral mesoderm
    P C Lo
    Brookdale Center for Developmental and Molecular Biology, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029, USA
    Mech Dev 72:65-75. 1998
    ..These results, together with the observed lethality of vimar mutations, indicate that vimar is one of the bagpipe target genes that are required for normal development and differentiation of the midgut visceral mesoderm...
  42. ncbi Heart development in Drosophila requires the segment polarity gene wingless
    X Wu
    Department of Biology, University of Michigan, Ann Arbor 48109 1048, USA
    Dev Biol 169:619-28. 1995
    ..This developmental requirement of wg for cardiac organogenesis is distinct from its function in segmentation and neurogenesis. We conclude that wg signaling is a crucial component of heart formation...
  43. ncbi The patterns of wingless, decapentaplegic, and tinman position the Drosophila heart
    Wendy K Lockwood
    Department of Cell, Developmental and Neural Biology, University of Michigan, 830 N University, Ann Arbor, MI 48109 1048, USA
    Mech Dev 114:13-26. 2002
    ..to the elaboration of the expression pattern of the mesoderm-specific homeobox-containing gene tinman (tin), and that the overlap of wg and dpp at an early stage (9) as well as at a later stage (11) in the presence of tin-..
  44. ncbi Cross-repressive interactions of identity genes are essential for proper specification of cardiac and muscular fates in Drosophila
    Teresa Jagla
    INSERM U 384, Faculte de Medecine, 28, Place Henri Dunant, 63001 Clermont Ferrand, France
    Development 129:1037-47. 2002
    ..The cross-repressive interactions of identity genes are likely to ensure their localised expression over time, thus providing an essential element in establishing cell identity...
  45. pmc Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease
    Li Qian
    Development and Aging Program, Del E Webb Neuroscience, Aging and Stem Cell Research Center NASCR, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:19833-8. 2008
    ..These findings suggest that the fly heart might serve as an identifier of candidate genes involved in human heart disease...
  46. ncbi Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division
    Zhe Han
    Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Development 130:3039-51. 2003
    ..In addition, we provide evidence that whether or not Suppressor-of-Hairless can become a transcriptional activator is the key switch for the Numb/Notch activity in determining a myocardial versus pericardial cell fate...
  47. pmc D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis
    B Lilly
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030
    Proc Natl Acad Sci U S A 91:5662-6. 1994
    ..Its temporal and spatial expression patterns suggest that D-mef2 may play an important role in commitment of mesoderm to myogenic lineages...
  48. ncbi ladybird determines cell fate decisions during diversification of Drosophila somatic muscles
    T Jagla
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, CU de Strasbourg, France
    Development 125:3699-708. 1998
    ..Altogether our results provide new insights into the genetic control of diversification of muscle precursors and indicate a further similarity between the myogenic and neurogenic pathways...
  49. ncbi The ADAM metalloprotease Kuzbanian is crucial for proper heart formation in Drosophila melanogaster
    Stefanie Albrecht
    Universitat Osnabruck, Fachbereich Biologie chemie, Zoologie, Barbarastrasse 11, D 49069 Osnabruck, Germany
    Mech Dev 123:372-87. 2006
    ..Our data presented herein suggest that Kuzbanian acts during lateral inhibition within the cardiac primordium. Furthermore we discuss a second function of Kuzbanian in heart cell morphogenesis...
  50. ncbi ladybird, a new component of the cardiogenic pathway in Drosophila required for diversification of heart precursors
    K Jagla
    Institut de Genetique et de Biologie Moleculaire et Cellulaire CNRS INSERM ULP, College de France, CU de Strasbourg
    Development 124:3471-9. 1997
    ..These events result in a diversification of heart cell identities within each segment...
  51. ncbi The wingless signaling pathway is directly involved in Drosophila heart development
    M Park
    Department of Biology, University of Michigan, Ann Arbor, Michigan, 48109 1048, USA
    Dev Biol 177:104-16. 1996
    ..In particular, overexpression of dsh can restore heart formation in the absence of wg function. We discuss the possibility that Wg signaling is part of a combinatorial mechanism to specify the cardiac mesoderm...
  52. ncbi D-six4 plays a key role in patterning cell identities deriving from the Drosophila mesoderm
    Ivan B N Clark
    Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Dev Biol 294:220-31. 2006
    ..At stage 10, the mesodermal expression patterns of D-six4 and tin are complementary, being restricted to the dorsal and non-dorsal regions respectively...
  53. pmc Dystrophin deficiency in Drosophila reduces lifespan and causes a dilated cardiomyopathy phenotype
    Ouarda Taghli-Lamallem
    Development and Aging Program, Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, Building 7, Room 7125, La Jolla, CA 92037, USA
    Aging Cell 7:237-49. 2008
    ..Our results illustrate the utility of Drosophila as a model system to study dilated cardiomyopathy and other muscular-dystrophy-associated phenotypes...
  54. ncbi Laminin is required for heart, somatic muscles, and gut development in the Drosophila embryo
    T Yarnitzky
    Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel
    Dev Biol 169:609-18. 1995
    ..These studies indicate that the primary function of laminin is to provide structural support for the various cell types, thereby enabling their proper organization into the various organs...
  55. ncbi Dynamics of heart differentiation, visualized utilizing heart enhancer elements of the Drosophila melanogaster bHLH transcription factor Hand
    Julia Sellin
    Universitat Osnabruck, Fachbereich Biologie Chemie Zoologie, Barbarastrasse 11, 49069 Osnabruck, Germany
    Gene Expr Patterns 6:360-75. 2006
    ....
  56. ncbi Segmental patterning of heart precursors in Drosophila
    P A Lawrence
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, UK
    Development 121:4303-8. 1995
    ..We conclude that the mesoderm is segmented in some way not dependent on the distribution of Wingless, suggesting a more permissive and less instructive role for the protein in this instance...
  57. pmc Temporal ChIP-on-chip reveals Biniou as a universal regulator of the visceral muscle transcriptional network
    Janus S Jakobsen
    European Molecular Biology Laboratory, D 69117 Heidelberg, Germany
    Genes Dev 21:2448-60. 2007
    ..The regulatory connection of a number of Biniou target genes is conserved in mice, suggesting an ancient wiring of this developmental program...
  58. ncbi Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo
    M Frasch
    Brookdale Center for Molecular Biology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Nature 374:464-7. 1995
    ..This demonstrates that the spatial expression of dpp in the ectoderm determines which cells of the mesoderm become competent to develop into visceral mesoderm and the heart...
  59. ncbi A new homeobox-containing gene, msh-2, is transiently expressed early during mesoderm formation of Drosophila
    R Bodmer
    Howard Hughes Medical Institute, San Francisco, CA
    Development 110:661-9. 1990
    ..H2.0, a homeo-box-containing gene specifically expressed in visceral mesoderm, is not transcribed in the mesoderm in 93C-F deficiency embryos.(ABSTRACT TRUNCATED AT 250 WORDS)..
  60. ncbi The highly conserved cardiogenic bHLH factor Hand is specifically expressed in circular visceral muscle progenitor cells and in all cell types of the dorsal vessel during Drosophila embryogenesis
    Verena Kölsch
    Universitat Marburg, Fachbereich Biologie Entwicklungsbiologie, Karl von Frisch Strasse, 35032 Marburg, Germany
    Dev Genes Evol 212:473-85. 2002
    ..In many aspects the expression pattern of Drosophila hand resembles the patterns of its vertebrates orthologues, for instance in cardiac tissues. We assume that Hand proteins might play a highly conserved role throughout evolution...
  61. ncbi Combinatorial control of Drosophila mef2 gene expression in cardiac and somatic muscle cell lineages
    K Gajewski
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Dev Genes Evol 208:382-92. 1998
    ..The analysis of D-mef2-lacZ fusion genes in mutant embryos revealed that the specification of the muscle precursor cells involved the wingless gene and the activation of a receptor tyrosine kinase signaling pathway...
  62. ncbi zfh-1 is required for germ cell migration and gonadal mesoderm development in Drosophila
    H T Broihier
    Skirball Institute, New York University Medical Center, NY, NY 10016, USA
    Development 125:655-66. 1998
    ..Finally, through analysis of a tinman zfh-1 double mutant, we show that zfh-1 acts in conjunction with tinman, another homeodomain protein, in the specification of lateral mesodermal derivatives, including the gonadal mesoderm...
  63. ncbi Regulation of muscle differentiation by the MEF2 family of MADS box transcription factors
    E N Olson
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 172:2-14. 1995
  64. ncbi Vertebrate homologs of tinman and bagpipe: roles of the homeobox genes in cardiovascular development
    M Tanaka
    Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    Dev Genet 22:239-49. 1998
    ..In this paper, we discuss molecular mechanisms of cardiovascular development with particular emphasis on roles of transcription factors...
  65. ncbi Mosaic and regulative development: two faces of one coin
    Peter A Lawrence
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Biol 16:R236-9. 2006
  66. ncbi Gene regulatory networks and the evolution of animal body plans
    Eric H Davidson
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Science 311:796-800. 2006
    ..Conservation of phyletic body plans may have been due to the retention since pre-Cambrian time of GRN kernels, which underlie development of major body parts...
  67. ncbi Hedgehog and RAS pathways cooperate in the anterior-posterior specification and positioning of cardiac progenitor cells
    Jiandong Liu
    The Burnham Institute, Center for Neurosciences and Aging, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Dev Biol 290:373-85. 2006
    ..Thus, the spatial precision of cell type specification within an organ depends on multiple phases of inductive interaction between the ectoderm and the mesoderm...
  68. ncbi Subdivision and developmental fate of the head mesoderm in Drosophila melanogaster
    Begona De Velasco
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Dev Genes Evol 216:39-51. 2006
    ..The lSHM contributes hemocytes, as well as the nephrocytes forming the subesophageal body, also called garland cells...
  69. ncbi Dual functions of the heartless fibroblast growth factor receptor in development of the Drosophila embryonic mesoderm
    A M Michelson
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Dev Genet 22:212-29. 1998
    ..pathway act downstream of Htl, and 3) establish a functional relationship between the Ras pathway and Tinman (Tin), a homeodomain factor that is essential for specifying some of the same dorsal mesodermal cells that are dependent ..
  70. pmc The engrailed story
    A Garcia-Bellido
    Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    Genetics 148:539-44. 1998
  71. ncbi Wingless effects mesoderm patterning and ectoderm segmentation events via induction of its downstream target sloppy paired
    H H Lee
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Development 127:5497-508. 2000
    ..We also propose that in wg-expressing ectodermal cells, slp is an integral component in an autocrine feedback loop of Wg signaling...
  72. pmc Defective decapentaplegic signaling results in heart overgrowth and reduced cardiac output in Drosophila
    Aaron N Johnson
    School of Life Sciences, Arizona State University, Tempe, Arizona 85287 4501, USA
    Genetics 176:1609-24. 2007
    During germ-band extension, Decapentaplegic (Dpp) signals from the dorsal ectoderm to maintain Tinman (Tin) expression in the underlying mesoderm. This signal specifies the cardiac field, and homologous genes (BMP2/4 and Nkx2...
  73. ncbi Twist-mediated activation of the NK-4 homeobox gene in the visceral mesoderm of Drosophila requires two distinct clusters of E-box regulatory elements
    Y M Lee
    Laboratory of Molecular Cardiology, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 272:17531-41. 1997
    NK-4, also called msh2 and tinman, encodes a homeodomain transcription factor that is required for the development of the dorsal mesoderm and its derivatives in the Drosophila embryo...
  74. pmc Identification of novel genes in Drosophila reveals the complex regulation of early gene activity in the mesoderm
    J Casal
    Max Planck Institut fur Entwicklungsbiologie, Tubingen, Germany
    Proc Natl Acad Sci U S A 93:10327-32. 1996
    ..These novel genes show a variety of expression patterns and also differ in their dependence on twist and snail functions. This indicates that the regulation of early gene activity in the mesoderm is more complex than previously thought...
  75. ncbi Gene expression analysis in post-embryonic pericardial cells of Drosophila
    Debjani Das
    Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur PO, Bangalore 560064, India
    Gene Expr Patterns 8:199-205. 2008
    ..Embryonic PCs belong to three distinct genetic classes based on Odd-skipped (Odd), Even-skipped (Eve) and Tinman (Tin) expression...
  76. ncbi NK-2 homeobox genes and heart development
    R P Harvey
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia
    Dev Biol 178:203-16. 1996
    ..Signaling pathways that establish the tin expression domain also appear to be conserved in vertebrates...
  77. doi The Drosophila wing hearts originate from pericardial cells and are essential for wing maturation
    Markus Tögel
    Department of Biology, University of Osnabruck, Zoology Developmental Biology, Barbarastrasse 11, D 49069 Osnabruck, Germany
    Dev Biol 318:29-37. 2008
    ..This indicates that wing hearts are required for proper wing morphogenesis and functionality...
  78. ncbi The pioneer gene, apontic, is required for morphogenesis and function of the Drosophila heart
    M T Su
    Department of Biology, University of Michigan, Ann Arbor 48109 1048, USA
    Mech Dev 80:125-32. 1999
    ..These cardiac defects may be the cause of death of these mutants during late embryonic or early larval stages...
  79. ncbi Homeotic selector genes control the patterning of seven-up expressing cells in the Drosophila dorsal vessel
    Kathryn M Ryan
    Department of Biology, University of New Mexico, Albuquerque, NM 87131 1091, USA
    Mech Dev 122:1023-33. 2005
    ..In Drosophila, the Hox segmentation gene abdominal-A (abd-A) is required for the specification of a functionally distinct heart region at ..
  80. ncbi Regulation of Smad signalling by protein associations and signalling crosstalk
    Y Zhang
    Depts of Growth and Development, and Anatomy, Programs in Cell Biology and Developmental Biology, University of California at San Francisco, San Francisco, CA 94143 0640, USA
    Trends Cell Biol 9:274-9. 1999
    ..This signalling crosstalk might explain the complexity of the responses to TGF-beta and related factors...
  81. ncbi Jelly belly: a Drosophila LDL receptor repeat-containing signal required for mesoderm migration and differentiation
    J B Weiss
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center B300, 279 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305, USA
    Cell 107:387-98. 2001
    ..jeb reveals a signaling process in which somatic muscle precursors support the proper migration and differentiation of visceral muscle cells. Later in embryogenesis, jeb is transcribed in neurons and Jeb protein is found in axons...
  82. ncbi Combinatorial expression of GATA4, Nkx2-5, and serum response factor directs early cardiac gene activity
    Jorge L Sepulveda
    Department of Pathology, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    J Biol Chem 277:25775-82. 2002
    ..The combinatorial expression of SRF, a MADS box factor Nkx2-5 (a NK4 homeodomain), and/or GATA4, a dual C4 zinc finger protein, in heterologous CV1 fibroblasts and Schneider 2 insect ..
  83. ncbi Angiotensin-converting enzyme 2 is an essential regulator of heart function
    Michael A Crackower
    Amgen Research Institute Ontario Cancer Institute and Department of Medical Biophysics and Immunology, University of Toronto, University Avenue, Toronto, Ontario M5G 2M9, Canada
    Nature 417:822-8. 2002
    ..But disruption of ACER, a Drosophila ACE2 homologue, results in a severe defect of heart morphogenesis. These genetic data for ACE2 show that it is an essential regulator of heart function in vivo...
  84. ncbi Receptor tyrosine kinases: specific outcomes from general signals
    M A Simon
    Department of Biological Sciences, Stanford University, California 94305, USA
    Cell 103:13-5. 2000
  85. ncbi Genetics of heart development
    J N Chen
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Trends Genet 16:383-8. 2000
    ..Mutational analysis in mice and, as particular focus of this review, in zebrafish, reveals the additional genes brought into play to fashion these evolutionarily 'new' organotypic components...
  86. ncbi The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel
    TyAnna L Lovato
    Department of Biology, University of New Mexico, Albuquerque 87131 1091, USA
    Development 129:5019-27. 2002
    ..These findings for the first time demonstrate a specific involvement for Hox genes in patterning the muscular circulatory system, and suggest a mechanism of broad relevance for animal heart ..
  87. ncbi Regulation of BMP/Dpp signaling during embryonic development
    T Nakayama
    Department of Cell and Developmental Biology, School of Medicine, Oregon Health Sciences University, Portland 97201 3098, USA
    Cell Mol Life Sci 57:943-56. 2000
    ..Recent studies have shown that the BMP signal transduction cascade can be modulated at every step of this process...
  88. ncbi Posterior migration of the salivary gland requires an intact visceral mesoderm and integrin function
    Pamela L Bradley
    Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Dev Biol 257:249-62. 2003
    ..These findings suggest that salivary tube dimensions may be an intrinsic property of salivary gland cells...
  89. pmc The multitype zinc-finger protein U-shaped functions in heart cell specification in the Drosophila embryo
    N Fossett
    Department of Biochemistry and Molecular Biology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 97:7348-53. 2000
    ..Taken together, these results demonstrate a critical role for the Ush transcriptional regulator in several diverse processes of mesoderm differentiation and heart formation...
  90. pmc Nucleotide variation in the tinman and bagpipe homeobox genes of Drosophila melanogaster
    Evgeniy S Balakirev
    Department of Ecology and Evolutionary Biology, University of California, Irvine, California 92697 2525, USA
    Genetics 166:1845-56. 2004
    The tinman (tin) and bagpipe (bap) genes are members of the NK homeobox gene family of Drosophila, so that tin occupies a higher position than bap in the regulatory hierarchy...
  91. pmc Transcriptional control by the TGF-beta/Smad signaling system
    J Massague
    Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    EMBO J 19:1745-54. 2000
  92. ncbi Evidence for a fruit fly hemangioblast and similarities between lymph-gland hematopoiesis in fruit fly and mammal aorta-gonadal-mesonephros mesoderm
    Lolitika Mandal
    Department of Molecular Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    Nat Genet 36:1019-23. 2004
    ..In addition, the GATA factor gene pannier (pnr) and the homeobox gene tinman (tin), which are controlled by the convergence of Decapentaplegic (Dpp), fibroblast growth factor (FGF), Wingless (Wg) ..
  93. ncbi Ectoderm induces muscle-specific gene expression in Drosophila embryos
    R Baker
    Department of Genetics, University of Washington, Seattle 98195, USA
    Development 121:1387-98. 1995
    ..Our findings suggest that muscle determination in Drosophila is regulated by induction between germ layers during gastrulation...
  94. ncbi The Drosophila schnurri gene acts in the Dpp/TGF beta signaling pathway and encodes a transcription factor homologous to the human MBP family
    K Arora
    Department of Molecular Biology and Biochemistry, University of California, Irvine 92717, USA
    Cell 81:781-90. 1995
    ..Genetic interactions and the strikingly similar phenotypes of mutations in shn and the dpp receptors encoded by thick veins and punt suggest that shn plays a downstream role in dpp signaling...
  95. ncbi Molecular cloning and embryonic expression of dFKBP59, a novel Drosophila FK506-binding protein
    S Zaffran
    Department of Biochemistry and Molecular Biology, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Gene 246:103-9. 2000
    ..Finally, I have mapped an enhancer trap element within the 5' region of dFKBP59 which may help in future studies to address the question of its function during Drosophila development...
  96. ncbi Epithelium formation in the Drosophila midgut depends on the interaction of endoderm and mesoderm
    U Tepass
    Department of Biology, University of California Los Angeles 90024 1606
    Development 120:579-90. 1994
    ....
  97. doi Antagonistic function of Lmd and Zfh1 fine tunes cell fate decisions in the Twi and Tin positive mesoderm of Drosophila melanogaster
    Julia Sellin
    Universitat Osnabruck, Fachbereich Biologie Chemie Zoologie Entwicklungsbiologie, Osnabruck, Germany
    Dev Biol 326:444-55. 2009
    ..the reduction of Zfh1 positive cell types, thereby restricting the number of Odd-skipped (Odd) positive and Tinman (Tin) positive pericardial cells in the dorsal mesoderm...
  98. ncbi Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice
    G Ranganayakulu
    Department of Molecular Biology and Oncology, The University of Texas Southwestern Medical Center, Dallas, TX 75235 9148, USA
    Development 125:3037-48. 1998
    ..In Drosophila, the NK-2 class homeobox gene tinman (tin) is expressed in cardiac and visceral mesodermal progenitors and is essential for their specification...
  99. ncbi Steroid-dependent modification of Hox function drives myocyte reprogramming in the Drosophila heart
    Bruno Monier
    Laboratoire de Genetique et Physiologie du Developpement, UMR 6545 CNRS Université, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Development 132:5283-93. 2005
    In the Drosophila larval cardiac tube, aorta and heart differentiation are controlled by the Hox genes Ultrabithorax (Ubx) and abdominal A (abdA), respectively...
  100. pmc Quantitative trait loci for sexual isolation between Drosophila simulans and D. mauritiana
    Amanda J Moehring
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Genetics 167:1265-74. 2004
    ..The observation of a few QTL with moderate to large effects will facilitate positional cloning of genes underlying sexual isolation...
  101. ncbi Heart tube patterning in Drosophila requires integration of axial and segmental information provided by the Bithorax Complex genes and hedgehog signaling
    Romina Ponzielli
    Laboratoire de Genetique et Physiologie du Developpement, UMR 6545 CNRS Université, IBDM CNRS INSERM Université de la Méditerranée, Campus de Luminy, Case 907, 13288 Marseille Cedex 09, France
    Development 129:4509-21. 2002
    ..In combination with the axial information furnished by abd-A, the segmental hh-dependent information leads to the differentiation of the six pairs of svp-expressing cells into functional ostiae...

Research Grants67

  1. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric H Davidson; Fiscal Year: 2010
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  2. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2006
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  3. Biology and biochemistry of Jelly belly signaling
    Joseph Weiss; Fiscal Year: 2007
    ..Analysis of the phenotype of Ptn/Mk mutants in Drosophila will clarify the signaling function of these molecules both with respect to the pathways in which they participate and their functions in those pathways. ..
  4. Computational Model of Gene Regulatory Program
    Eric Davidson; Fiscal Year: 2007
    ..abstract_text> ..
  5. Regulatory Genomics: BAC-GFP Library of Control Genes
    Eric Davidson; Fiscal Year: 2007
    ..Numerous letters from outside investigators attesting interest in this facility are included as an Appendix to this application. ..
  6. Patterning of the Primitive Heart Tube in Zebrafish
    Jau Nian Chen; Fiscal Year: 2007
    ..The combination of cellular, molecular and genetic studies proposed in this project will provide new and in-depth insight into mechanisms of primitive heart tube morphogenesis. ..
  7. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2005
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  8. Organogenesis Screen Using Tissue-Specific Zebrafish
    Jau Nian Chen; Fiscal Year: 2005
    ..Mutations identified from this screen will provide entry points to dissect genetic and molecular pathways involved in vertebrate organogenesis. ..
  9. GLOBAL GENE REGULATORY NETWORKS FOR SPECIFIC CELL TYPES OF THE SEA URCHIN EMBRYO
    Eric H Davidson; Fiscal Year: 2010
    ..Our practice must get beyond struggling to ameliorate effects rather than altering causes. This research shows the way to discovery of structure and function in causal genomic control systems. ..
  10. TGF-BETA FAMILY REGULATION OF EPITHELIAL MORPHOGENESIS
    Laurel Raftery; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Protein signals move between cells to coordinate decisions. We study how these signals make cells do the right thing at the right time. ..
  11. Computational Model of Gene Regulatory Program
    Eric Davidson; Fiscal Year: 2009
    ..abstract_text> ..
  12. Elucidating the molecular mechanisms regulating embryonic cardiac rhythmicity
    Jau Nian Chen; Fiscal Year: 2010
    ..The studies in this proposal will help elucidate cellular and molecular mechanisms underlying cardiac fibrillation and ultimately contribute to the development of new preventive and therapeutic approaches. ..
  13. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2009
    ..And we present the bioinformatics tools and databases of genomic sequence collections to the experimentalist. All of the individual goals detailed above are direct responses to this view. ..
  14. Computational Model of Gene Regulatory Program
    Eric H Davidson; Fiscal Year: 2010
    ....
  15. Patterning of the Primitive Heart Tube in Zebrafish
    Jau Nian Chen; Fiscal Year: 2010
    ..The combination of cellular, molecular and genetic studies proposed in this project will provide new and in-depth insight into mechanisms of primitive heart tube morphogenesis. ..
  16. TGF-BETA FAMILY REGULATION OF EPITHELIAL MORPHOGENESIS
    Laurel Raftery; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Protein signals move between cells to coordinate decisions. We study how these signals make cells do the right thing at the right time. ..
  17. HOMOZYGOUS SEA URCHIN AS A POTENTIAL RESEARCH RESOURCE
    Eric Davidson; Fiscal Year: 1993
    ....
  18. REGULATORS OF MUSCLE DIFFERENTIATION
    Hanh Nguyen; Fiscal Year: 2004
    ..Some of the principles arising from studies in the muscle system may also be applicable to other developmental systems, and thus will potentially contribute to our understanding of other developmental defects in humans. ..
  19. GENE LIBRARY RESOURCE FOR SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2004
    ..abstract_text> ..
  20. TGF-BETA FAMILY REGULATION OF EPITHELIAL MORPHOGENESIS
    Laurel Raftery; Fiscal Year: 2004
    ....
  21. GENE LIBRARY RESOURCE FOR THE SEA URCHIN S. PURPURATUS
    Eric Davidson; Fiscal Year: 2003
    ..In addition, the investigators need to carry out several unique computational analyses that reflect the particular features of the S. purpuratus genome. ..
  22. TGF-BETA FAMILY REGULATION OF EPITHELIAL MORPHOGENESIS
    Laurel Raftery; Fiscal Year: 2007
    ..abstract_text> ..
  23. Transforming Growth Factor-Beta Signal Transduction
    Joan Massague; Fiscal Year: 2007
    ..Through this proposed work, we wish to furnish the field with a better understanding of the role of the TGFb/Smad pathway in physiology and a better ability to manage this pathway in tumor progression, metastasis and other disorders. ..