Gene Symbol: Tep4
Description: Thioester-containing protein 4
Alias: CG10363, CT29102, Dmel\CG10363, TEP IV, TEP4, TEP4mel, TEPIV, Tep IV, TepIV, dTEPIV, tep4, tepIV, Thioester-containing protein 4, CG10363-PA, CG10363-PB, CG10363-PC, CG10363-PD, TEP, Tep4-PA, Tep4-PB, Tep4-PC, Tep4-PD, thioester containing protein IV, thiolester containing protein IV
Species: fruit fly

Top Publications

  1. Krzemien J, Dubois L, Makki R, Meister M, Vincent A, Crozatier M. Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre. Nature. 2007;446:325-8 pubmed
  2. Shokal U, Eleftherianos I. The Drosophila Thioester containing Protein-4 participates in the induction of the cellular immune response to the pathogen Photorhabdus. Dev Comp Immunol. 2017;76:200-208 pubmed publisher
    ..Recently, we showed the involvement of TEP4 in the activation of humoral and phenoloxidase immune responses of Drosophila against the pathogenic bacteria ..
  3. Shokal U, Eleftherianos I. Thioester-Containing Protein-4 Regulates the Drosophila Immune Signaling and Function against the Pathogen Photorhabdus. J Innate Immun. 2017;9:83-93 pubmed publisher
    ..melanogaster immune system. Here, we investigated the role of TEP4 in the regulation and function of D...
  4. Doroszuk A, Jonker M, Pul N, Breit T, Zwaan B. Transcriptome analysis of a long-lived natural Drosophila variant: a prominent role of stress- and reproduction-genes in lifespan extension. BMC Genomics. 2012;13:167 pubmed publisher
    ..The results suggest that natural genetic variation for SR and lifespan can operate through similar transcriptional mechanisms as those of dietary restriction and life-extending mutations. ..
  5. Kocks C, Maehr R, Overkleeft H, Wang E, Iyer L, Lennon Dumenil A, et al. Functional proteomics of the active cysteine protease content in Drosophila S2 cells. Mol Cell Proteomics. 2003;2:1188-97 pubmed
    ..Among them was thiol-ester motif-containing protein (TEP) 4 which is involved in insect innate immunity and shares structural and functional similarities with the mammalian ..
  6. Stofanko M, Kwon S, Badenhorst P. Lineage tracing of lamellocytes demonstrates Drosophila macrophage plasticity. PLoS ONE. 2010;5:e14051 pubmed publisher
    ..Taken together, our data suggest that lamellocytes arise from plasmatocytes and that plasmatocytes may be inherently plastic, possessing the ability to differentiate further into lamellocytes upon appropriate challenge. ..
  7. Lagueux M, Perrodou E, Levashina E, Capovilla M, Hoffmann J. Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila. Proc Natl Acad Sci U S A. 2000;97:11427-32 pubmed
    ..We also observe a constitutive expression in gain-of-function Toll mutants. We discuss the possible roles of these novel complement-like proteins in the Drosophila host defense. ..
  8. Igboin C, Tordoff K, Moeschberger M, Griffen A, Leys E. Porphyromonas gingivalis-host interactions in a Drosophila melanogaster model. Infect Immun. 2011;79:449-58 pubmed publisher
    ..Drosophila thiol-ester protein II (Tep II) and Tep IV and the tumor necrosis factor (TNF) homolog Eiger were also involved in the immune response against P...
  9. Bou Aoun R, Hetru C, Troxler L, Doucet D, Ferrandon D, Matt N. Analysis of thioester-containing proteins during the innate immune response of Drosophila melanogaster. J Innate Immun. 2011;3:52-64 pubmed publisher
    ..This expression pattern is consistent with a role in innate immunity. However, we find that TEP1, TEP2, and TEP4 are not strictly required in the body cavity to fight several bacterial and fungal infections...

More Information


  1. Wong Z, Hedges L, Brownlie J, Johnson K. Wolbachia-mediated antibacterial protection and immune gene regulation in Drosophila. PLoS ONE. 2011;6:e25430 pubmed publisher
    ..RC flies which are naturally infected with Wolbachia showed no upregulation of the antibacterial immune genes TepIV, Defensin, Diptericin B, PGRP-SD, Cecropin A1 and Attacin D compared to paired flies without Wolbachia...
  2. Bras S, Martin Lannerée S, Gobert V, Augé B, Breig O, Sanial M, et al. Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis. Proc Natl Acad Sci U S A. 2012;109:4986-91 pubmed publisher
    ..Thus, we propose that the regulation of RUNX protein levels is a conserved feature of MLF family members that could be critical for normal and pathological blood cell development. ..
  3. Benmimoun B, Polesello C, Waltzer L, Haenlin M. Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila. Development. 2012;139:1713-7 pubmed publisher
    ..Hence, our study highlights the role of the IIS/TOR pathways in orchestrating hematopoietic progenitor fate and links blood cell fate to nutritional status. ..
  4. Jiggins F, Kim K. Contrasting evolutionary patterns in Drosophila immune receptors. J Mol Evol. 2006;63:769-80 pubmed
    ..In contrast to the Tep genes, the GNBP genes are highly conserved...
  5. Makki R, Meister M, Pennetier D, Ubeda J, Braun A, Daburon V, et al. A short receptor downregulates JAK/STAT signalling to control the Drosophila cellular immune response. PLoS Biol. 2010;8:e1000441 pubmed publisher
  6. Heger A, Ponting C. Evolutionary rate analyses of orthologs and paralogs from 12 Drosophila genomes. Genome Res. 2007;17:1837-49 pubmed
    ..Duplications were significantly more frequent among trypsin-like proteases and DM8 putative lipid-binding domain proteins. ..
  7. Erturk Hasdemir D, Silverman N. Eater: a big bite into phagocytosis. Cell. 2005;123:190-2 pubmed
    ..In this issue of Cell, Kocks et al. (2005) demonstrate that Eater, a scavenger receptor, plays an important role in the recognition and phagocytosis of bacteria in the fruit fly Drosophila. ..
  8. Giardina T, Beavis A, Clark A, Fiumera A. Female influence on pre- and post-copulatory sexual selection and its genetic basis in Drosophila melanogaster. Mol Ecol. 2011;20:4098-108 pubmed publisher
    ..05. Several other associations, including those impacting both fertility and female remating rate suggest that sperm storage might be an important factor mitigating female influence on sexual selection. ..