Tep2

Summary

Gene Symbol: Tep2
Description: Thioester-containing protein 2
Alias: 145970_at, 145971_at, CG18589, CG7052, Dmel\CG7052, T13, TEP II, TEP2, TEP2mel, Tep 2, Tep II, TepII, dTEPII, tepII, Thioester-containing protein 2, CG7052-PA, CG7052-PB, CG7052-PD, CG7052-PF, CG7052-PG, TEP, Tep2-PA, Tep2-PB, Tep2-PD, Tep2-PF, Tep2-PG, thioester containing protein II, thiolester containing protein II
Species: fruit fly

Top Publications

  1. Nakahara K, Kim K, Sciulli C, Dowd S, Minden J, Carthew R. Targets of microRNA regulation in the Drosophila oocyte proteome. Proc Natl Acad Sci U S A. 2005;102:12023-8 pubmed
    ..The preponderance of genes that control global protein abundance suggests this process is under tight control by miRNAs at the onset of fertilization. ..
  2. Lagueux M, Perrodou E, Levashina E, Capovilla M, Hoffmann J. Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila. Proc Natl Acad Sci U S A. 2000;97:11427-32 pubmed
    ..We also observe a constitutive expression in gain-of-function Toll mutants. We discuss the possible roles of these novel complement-like proteins in the Drosophila host defense. ..
  3. Ye Y, Chenoweth S, McGraw E. Effective but costly, evolved mechanisms of defense against a virulent opportunistic pathogen in Drosophila melanogaster. PLoS Pathog. 2009;5:e1000385 pubmed publisher
    ..aeruginosa infection than previously reported. This work reveals novel pathways by which Drosophila can survive infection with a virulent pathogen that may be rare in wild populations, however, due to their cost. ..
  4. Sackton T, Clark A. Comparative profiling of the transcriptional response to infection in two species of Drosophila by short-read cDNA sequencing. BMC Genomics. 2009;10:259 pubmed publisher
    ..virilis hemolymph and validate our transcriptional data. These results suggest that the acquisition of novel components of the immune system, and particularly novel effector proteins, may be a common evolutionary phenomenon. ..
  5. Vierstraete E, Verleyen P, Sas F, Van den Bergh G, De Loof A, Arckens L, et al. The instantly released Drosophila immune proteome is infection-specific. Biochem Biophys Res Commun. 2004;317:1052-60 pubmed
    ..Next to known immune proteins, unannotated proteins were identified such as CG4306 protein, which has homologues with unknown function in all metazoan genome databases available today. ..
  6. Heger A, Ponting C. Evolutionary rate analyses of orthologs and paralogs from 12 Drosophila genomes. Genome Res. 2007;17:1837-49 pubmed
    ..Duplications were significantly more frequent among trypsin-like proteases and DM8 putative lipid-binding domain proteins. ..
  7. Vierstraete E, Verleyen P, Baggerman G, D Hertog W, Van den Bergh G, Arckens L, et al. A proteomic approach for the analysis of instantly released wound and immune proteins in Drosophila melanogaster hemolymph. Proc Natl Acad Sci U S A. 2004;101:470-5 pubmed
    ..Determining the function of all of these immune-induced proteins represents an exciting challenge for increasing our knowledge of insect immunity. ..
  8. Erturk Hasdemir D, Silverman N. Eater: a big bite into phagocytosis. Cell. 2005;123:190-2 pubmed
    ..In this issue of Cell, Kocks et al. (2005) demonstrate that Eater, a scavenger receptor, plays an important role in the recognition and phagocytosis of bacteria in the fruit fly Drosophila. ..
  9. Igboin C, Tordoff K, Moeschberger M, Griffen A, Leys E. Porphyromonas gingivalis-host interactions in a Drosophila melanogaster model. Infect Immun. 2011;79:449-58 pubmed publisher
    ..Drosophila thiol-ester protein II (Tep II) and Tep IV and the tumor necrosis factor (TNF) homolog Eiger were also involved in the immune response against P...

More Information

Publications15

  1. An S, Dong S, Wang Q, Li S, Gilbert L, Stanley D, et al. Insect neuropeptide bursicon homodimers induce innate immune and stress genes during molting by activating the NF-?B transcription factor Relish. PLoS ONE. 2012;7:e34510 pubmed publisher
    ..From these data we infer that CNS-generated bursicon homodimers mediate innate prophylactic immunity to both stress and infection during the vulnerable molting cycle. ..
  2. Xu J, Grant G, Sabin L, Gordesky Gold B, Yasunaga A, Tudor M, et al. Transcriptional pausing controls a rapid antiviral innate immune response in Drosophila. Cell Host Microbe. 2012;12:531-43 pubmed publisher
    ..Thus, transcriptional pausing primes virally induced genes to facilitate rapid gene induction and robust antiviral responses. ..
  3. Shin S, Kokoza V, Bian G, Cheon H, Kim Y, Raikhel A. REL1, a homologue of Drosophila dorsal, regulates toll antifungal immune pathway in the female mosquito Aedes aegypti. J Biol Chem. 2005;280:16499-507 pubmed
    ..bassiana. These results indicate that the homologue of Dl, but not that of Dif, is a key regulator of the Toll antifungal immune pathway in A. aegypti female mosquitoes. ..
  4. Jiggins F, Kim K. Contrasting evolutionary patterns in Drosophila immune receptors. J Mol Evol. 2006;63:769-80 pubmed
    ..report that two of these three Drosophila genes evolve rapidly under positive selection and that, in both TepI and TepII, the "bait-like region" (also known as the variable region) shows the strongest signature of positive ..
  5. Bou Aoun R, Hetru C, Troxler L, Doucet D, Ferrandon D, Matt N. Analysis of thioester-containing proteins during the innate immune response of Drosophila melanogaster. J Innate Immun. 2011;3:52-64 pubmed publisher
    ..This expression pattern is consistent with a role in innate immunity. However, we find that TEP1, TEP2, and TEP4 are not strictly required in the body cavity to fight several bacterial and fungal infections...
  6. Ye Y, McGraw E. Adult Drosophila melanogaster evolved for antibacterial defense invest in infection-induced expression of both humoral and cellular immunity genes. BMC Res Notes. 2011;4:305 pubmed publisher
    ..The similarity in fold change increase across all immunity genes may suggest a shared mechanism for the evolution of increased transcription in small, discrete units such as duplication of cis-regulatory elements. ..