Tep1

Summary

Gene Symbol: Tep1
Description: Thioester-containing protein 1
Alias: BG:DS00365.2, CG18096, Dmel\CG18096, TEP1, TEP1mel, Tep 1, Tep I, Tep-1, TepI, dTEPI, tep1, Thioester-containing protein 1, CG18096-PA, TEP, Tep1-PA, thioester containing protein I, thiolester containing protein I
Species: fruit fly

Top Publications

  1. Lagueux M, Perrodou E, Levashina E, Capovilla M, Hoffmann J. Constitutive expression of a complement-like protein in toll and JAK gain-of-function mutants of Drosophila. Proc Natl Acad Sci U S A. 2000;97:11427-32 pubmed
    ..We also observe a constitutive expression in gain-of-function Toll mutants. We discuss the possible roles of these novel complement-like proteins in the Drosophila host defense. ..
  2. Agaisse H, Perrimon N. The roles of JAK/STAT signaling in Drosophila immune responses. Immunol Rev. 2004;198:72-82 pubmed
  3. Ip Y. Drosophila innate immunity goes viral. Nat Immunol. 2005;6:863-4 pubmed
  4. Erturk Hasdemir D, Silverman N. Eater: a big bite into phagocytosis. Cell. 2005;123:190-2 pubmed
    ..In this issue of Cell, Kocks et al. (2005) demonstrate that Eater, a scavenger receptor, plays an important role in the recognition and phagocytosis of bacteria in the fruit fly Drosophila. ..
  5. An S, Dong S, Wang Q, Li S, Gilbert L, Stanley D, et al. Insect neuropeptide bursicon homodimers induce innate immune and stress genes during molting by activating the NF-?B transcription factor Relish. PLoS ONE. 2012;7:e34510 pubmed publisher
    ..From these data we infer that CNS-generated bursicon homodimers mediate innate prophylactic immunity to both stress and infection during the vulnerable molting cycle. ..
  6. Badenhorst P, Voas M, Rebay I, Wu C. Biological functions of the ISWI chromatin remodeling complex NURF. Genes Dev. 2002;16:3186-98 pubmed
    ..Finally, mutants in NURF subunits exhibit neoplastic transformation of larval blood cells that causes melanotic tumors to form. ..
  7. Jiggins F, Kim K. Contrasting evolutionary patterns in Drosophila immune receptors. J Mol Evol. 2006;63:769-80 pubmed
    ..We report that two of these three Drosophila genes evolve rapidly under positive selection and that, in both TepI and TepII, the "bait-like region" (also known as the variable region) shows the strongest signature of ..
  8. Ye Y, Chenoweth S, McGraw E. Effective but costly, evolved mechanisms of defense against a virulent opportunistic pathogen in Drosophila melanogaster. PLoS Pathog. 2009;5:e1000385 pubmed publisher
    ..aeruginosa infection than previously reported. This work reveals novel pathways by which Drosophila can survive infection with a virulent pathogen that may be rare in wild populations, however, due to their cost. ..
  9. Bou Aoun R, Hetru C, Troxler L, Doucet D, Ferrandon D, Matt N. Analysis of thioester-containing proteins during the innate immune response of Drosophila melanogaster. J Innate Immun. 2011;3:52-64 pubmed publisher
    ..In Drosophila, the Tep family is composed of 6 genes named Tep1-Tep6...

More Information

Publications11

  1. Stofanko M, Kwon S, Badenhorst P. Lineage tracing of lamellocytes demonstrates Drosophila macrophage plasticity. PLoS ONE. 2010;5:e14051 pubmed publisher
    ..Taken together, our data suggest that lamellocytes arise from plasmatocytes and that plasmatocytes may be inherently plastic, possessing the ability to differentiate further into lamellocytes upon appropriate challenge. ..
  2. Yamamoto Hino M, Muraoka M, Kondo S, Ueda R, Okano H, Goto S. Dynamic regulation of innate immune responses in Drosophila by Senju-mediated glycosylation. Proc Natl Acad Sci U S A. 2015;112:5809-14 pubmed publisher