Gene Symbol: tej
Alias: CG8589, Dmel\CG8589, Tej, anon-EST:fe1D11, tejas, CG8589-PA, anon-fast-evolving-1D11, tej-PA
Species: fruit fly
Patil V, Kai T. Repression of retroelements in Drosophila germline via piRNA pathway by the Tudor domain protein Tejas. Curr Biol. 2010;20:724-30 pubmed publisher
..Here we report a conserved yet uncharacterized component of the germline piRNA pathway, Tejas (Tej), which localizes to nuage...
Arkov A, Ramos A. Building RNA-protein granules: insight from the germline. Trends Cell Biol. 2010;20:482-90 pubmed publisher
..These data suggest a widespread use of several protein motifs in germline development and further our understanding of other ribonucleoprotein structures, for example, processing bodies and neuronal granules. ..
Olivieri D, Sykora M, Sachidanandam R, Mechtler K, Brennecke J. An in vivo RNAi assay identifies major genetic and cellular requirements for primary piRNA biogenesis in Drosophila. EMBO J. 2010;29:3301-17 pubmed publisher
..Loss of Zucchini leads to an accumulation of Piwi and Armitage in Yb bodies, indicating that Yb bodies are sites of primary piRNA biogenesis. ..
Anand A, Kai T. The tudor domain protein kumo is required to assemble the nuage and to generate germline piRNAs in Drosophila. EMBO J. 2012;31:870-82 pubmed publisher
..Our data suggest that kumo facilitates germline piRNA production by promoting piRNA cluster transcription in the nucleus and piRNA processing at the nuage. ..
Gao M, Arkov A. Next generation organelles: structure and role of germ granules in the germline. Mol Reprod Dev. 2013;80:610-23 pubmed publisher
Webster A, Li S, Hur J, Wachsmuth M, Bois J, Perkins E, et al
. Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper. Mol Cell. 2015;59:564-75 pubmed publisher
..Our study reveals a multi-step process responsible for the assembly and function of nuage complexes in piRNA-guided transposon repression. ..
Pane A, Jiang P, Zhao D, Singh M, Schupbach T. The Cutoff protein regulates piRNA cluster expression and piRNA production in the Drosophila germline. EMBO J. 2011;30:4601-15 pubmed publisher
..Our results unveil a link between Cuff activity, heterochromatin assembly and piRNA cluster expression, which is critical for stem-cell and germ-cell development in Drosophila. ..
Molla Herman A, VallÃ©s A, Ganem Elbaz C, Antoniewski C, Huynh J. tRNA processing defects induce replication stress and Chk2-dependent disruption of piRNA transcription. EMBO J. 2015;34:3009-27 pubmed publisher
..Our data thus link tRNA processing, DNA replication, and genome defense by small RNAs. This unexpected connection reveals constraints that could shape genome organization during evolution. ..
Meisel R. Evolutionary dynamics of recently duplicated genes: Selective constraints on diverging paralogs in the Drosophila pseudoobscura genome. J Mol Evol. 2009;69:81-93 pubmed publisher
..Therefore, the relative position of paralogs and the mechanism of duplication indirectly affect whether a duplicated gene is retained or pseudogenized. ..