Gene Symbol: Tehao
Description: tehao
Alias: CG7121, CT22017, Dmel\CG7121, Tho, Tl-5, Toll 5, Toll-5, dTLR5, dToll5, tehao, toll, tehao, CG7121-PA, CG7121-PB, Tehao-PA, Tehao-PB, Toll-5, toll receptor
Species: fruit fly

Top Publications

  1. Tauszig Delamasure S, Bilak H, Capovilla M, Hoffmann J, Imler J. Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections. Nat Immunol. 2002;3:91-7 pubmed
    ..DmMyD88 combines a Toll-IL-1R homology (TIR) domain and a death domain...
  2. Tauszig S, Jouanguy E, Hoffmann J, Imler J. Toll-related receptors and the control of antimicrobial peptide expression in Drosophila. Proc Natl Acad Sci U S A. 2000;97:10520-5 pubmed
    ..of the regulation of the antifungal peptide drosomycin has demonstrated a key role for the transmembrane receptor Toll, which prompted the search for mammalian homologs...
  3. Janssens S, Beyaert R. A universal role for MyD88 in TLR/IL-1R-mediated signaling. Trends Biochem Sci. 2002;27:474-82 pubmed
    The MyD88 adapter protein links members of the toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) superfamily to the downstream activation of nuclear factor-kappaB and mitogen-activated protein kinases...
  4. Lavine M, Strand M. Insect hemocytes and their role in immunity. Insect Biochem Mol Biol. 2002;32:1295-309 pubmed
    ..Cross-talk between the immune and nervous system may also play a role in regulating inflammation-like responses in insects during infection. ..
  5. Lazzaro B, Sceurman B, Clark A. Genetic basis of natural variation in D. melanogaster antibacterial immunity. Science. 2004;303:1873-6 pubmed
    ..Variation in these genes, therefore, seems to drive variability in immunocompetence among wild Drosophila. ..
  6. Schlenke T, Begun D. Linkage disequilibrium and recent selection at three immunity receptor loci in Drosophila simulans. Genetics. 2005;169:2013-22 pubmed publisher
    ..In this study, we focus on three D. simulans immunity loci, Hmu, Sr-CI/Sr-CIII, and Tehao, for which the polymorphic sites are in nearly perfect linkage disequilibrium, an unusual finding even with ..
  7. Ward A, Hong W, Favaloro V, Luo L. Toll receptors instruct axon and dendrite targeting and participate in synaptic partner matching in a Drosophila olfactory circuit. Neuron. 2015;85:1013-28 pubmed publisher
    ..Here we show that Toll-6 and Toll-7, members of the Toll receptor family best known for functions in innate immunity and embryonic patterning, cell autonomously instruct the ..
  8. Luo C, Zheng L. Independent evolution of Toll and related genes in insects and mammals. Immunogenetics. 2000;51:92-8 pubmed
    ..Drosophila melanogaster contains Toll and a highly homologous gene, Tehao. The protein, Dm Tehao, comprises 795 amino acid residues and its cytoplasmic domain shares a striking 61% ..
  9. Kim J, Orr Weaver T. Analysis of a Drosophila amplicon in follicle cells highlights the diversity of metazoan replication origins. Proc Natl Acad Sci U S A. 2011;108:16681-6 pubmed publisher
    ..Intriguingly, the final round of origin activation at DAFC-34B occurs in the absence of detectable ORC, although MCMs are present, suggesting a new amplification initiation mechanism. ..

More Information


  1. Nakamoto M, Moy R, Xu J, Bambina S, Yasunaga A, Shelly S, et al. Virus recognition by Toll-7 activates antiviral autophagy in Drosophila. Immunity. 2012;36:658-67 pubmed publisher
    ..These data uncover an evolutionarily conserved role for a second Drosophila Toll receptor that links viral recognition to autophagy and defense and suggest that other Drosophila Tolls may restrict ..
  2. Meyer S, Amoyel M, Bergantiños C, de la Cova C, Schertel C, Basler K, et al. An ancient defense system eliminates unfit cells from developing tissues during cell competition. Science. 2014;346:1258236 pubmed publisher
    ..We find that Toll-related receptors (TRRs) and the cytokine Spätzle (Spz) lead to NFκB-dependent apoptosis...
  3. Ooi J, Yagi Y, Hu X, Ip Y. The Drosophila Toll-9 activates a constitutive antimicrobial defense. EMBO Rep. 2002;3:82-7 pubmed
    The Toll family of transmembrane proteins participates in signaling infection during the innate immune response. We analyzed the nine Drosophila Toll proteins and found that wild-type Toll-9 behaves similar to gain-of-function Toll-1...
  4. Luo C, Shen B, Manley J, Zheng L. Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity. Insect Mol Biol. 2001;10:457-64 pubmed
    ..In Drosophila melanogaster, Tehao shares a striking similarity in its intracellular domain with Toll...
  5. Kambris Z, Hoffmann J, Imler J, Capovilla M. Tissue and stage-specific expression of the Tolls in Drosophila embryos. Gene Expr Patterns. 2002;2:311-7 pubmed
    The Drosophila transmembrane receptor Toll plays a key role in specifying the dorsoventral axis of the embryo. At later stages of development, it controls the immune response of the fly to fungal and Gram-positive bacterial infections...
  6. Lazzaro B, Sackton T, Clark A. Genetic variation in Drosophila melanogaster resistance to infection: a comparison across bacteria. Genetics. 2006;174:1539-54 pubmed
    ..We find that molecular variation in some genes, such as Tehao, contributes to phenotypic variation in the suppression of only a subset of the pathogens...
  7. Yagi Y, Nishida Y, Ip Y. Functional analysis of Toll-related genes in Drosophila. Dev Growth Differ. 2010;52:771-83 pubmed publisher
    The Drosophila genome encodes a total of nine Toll and related proteins...