tefu

Summary

Gene Symbol: tefu
Description: telomere fusion
Alias: ATM, Atm, CG6535, Dmel\CG6535, Tefu, atm, atm/tefu, dATM, tef, telomere fusion, A-T mutated, CG6535-PB, ataxia telangiectasia mutated, ataxia telengiesctasia mutated, ataxia-telangiectasia mutated, drosophila ATM, tefu-PB
Species: fruit fly

Top Publications

  1. Laurencon A, Purdy A, Sekelsky J, Hawley R, Su T. Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR. Genetics. 2003;164:589-601 pubmed
    ..Here we report the generation of a null allele of mei-41, Drosophila ATM/ATR homolog, and the use of it to document a semidominant effect on a larval mitotic checkpoint and methyl ..
  2. Musarò M, Ciapponi L, Fasulo B, Gatti M, Cenci G. Unprotected Drosophila melanogaster telomeres activate the spindle assembly checkpoint. Nat Genet. 2008;40:362-6 pubmed publisher
    ..was alleviated by mutations in mei-41 (encoding ATR), mus304 (ATRIP), grp (Chk1) and rad50 but not by mutations in tefu (ATM)...
  3. Queiroz Machado J, Perdigao J, Simões Carvalho P, Herrmann S, Sunkel C. tef: a mutation that causes telomere fusion and severe genome rearrangements in Drosophila melanogaster. Chromosoma. 2001;110:10-23 pubmed
    ..The gene is essential for normal cell proliferation and mutant tissue shows significant apoptosis. Our analysis suggests that the function encoded by the mutant gene is required to protect the linear ends of chromosomes. ..
  4. Bi X, Gong M, Srikanta D, Rong Y. Drosophila ATM and Mre11 are essential for the G2/M checkpoint induced by low-dose irradiation. Genetics. 2005;171:845-7 pubmed
    Others have suggested recently that the conserved ATM checkpoint kinase is minimally involved in controlling the G(2)/M checkpoint in Drosophila that serves to prevent mitotic entry in the presence of DNA damage...
  5. Joyce E, Pedersen M, Tiong S, White Brown S, Paul A, Campbell S, et al. Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair. J Cell Biol. 2011;195:359-67 pubmed publisher
    Ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-related (ATR) kinases are conserved regulators of cellular responses to double strand breaks (DSBs)...
  6. Silva E, Tiong S, Pedersen M, Homola E, Royou A, Fasulo B, et al. ATM is required for telomere maintenance and chromosome stability during Drosophila development. Curr Biol. 2004;14:1341-7 pubmed
    ..Here, we show that Drosophila ATM function is essential for normal adult development...
  7. Sekelsky J, Brodsky M, Burtis K. DNA repair in Drosophila: insights from the Drosophila genome sequence. J Cell Biol. 2000;150:F31-6 pubmed
  8. Rickmyre J, Dasgupta S, Ooi D, Keel J, Lee E, Kirschner M, et al. The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. J Cell Sci. 2007;120:3565-77 pubmed
    ..Finally, brains of mcph1 adult male flies have defects in mushroom body structure, suggesting an evolutionarily conserved role for MCPH1 in brain development. ..
  9. Bi X, Srikanta D, Fanti L, Pimpinelli S, Badugu R, Kellum R, et al. Drosophila ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance. Proc Natl Acad Sci U S A. 2005;102:15167-72 pubmed
    In higher eukaryotes, the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) checkpoint kinases play distinct, but partially overlapping, roles in DNA damage response...

More Information

Publications65

  1. Cenci G, Ciapponi L, Gatti M. The mechanism of telomere protection: a comparison between Drosophila and humans. Chromosoma. 2005;114:135-45 pubmed
    ..the Rad50 and Mre11 DNA repair proteins that are required for HOAP and HP1 localization at telomeres, and the ATM kinase...
  2. Bi X, Wei S, Rong Y. Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance. Curr Biol. 2004;14:1348-53 pubmed
    ..We conducted genetic and cytological studies on Drosophila atm and mre11 knockout mutants and discovered a telomere defect that was more severe than in any of the non-..
  3. Raffa G, Cenci G, Siriaco G, Goldberg M, Gatti M. The putative Drosophila transcription factor woc is required to prevent telomeric fusions. Mol Cell. 2005;20:821-31 pubmed
    ..To characterize the role of woc in telomere maintenance, we analyzed its relationships with Su(var)205, cav, atm, and rad50, four genes that prevent telomeric fusions; Su(var)205 and cav encode HP1 and HP1/ORC Associated Protein ..
  4. Gao G, Walser J, Beaucher M, Morciano P, Wesolowska N, Chen J, et al. HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner. EMBO J. 2010;29:819-29 pubmed publisher
    ..and HOAP are both rapidly evolving proteins yet their telomeric deposition is under the control of the conserved ATM and Mre11-Rad50-Nbs (MRN) proteins that modulate DNA structures at telomeres and at DSBs...
  5. Oikemus S, McGinnis N, Queiroz Machado J, Tukachinsky H, Takada S, Sunkel C, et al. Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect. Genes Dev. 2004;18:1850-61 pubmed
    ..In mammals, Ataxia Telangiectasia Mutated (ATM) is activated by DNA damage and acts through an unknown, telomerase-independent mechanism to ..
  6. Oikemus S, Queiroz Machado J, Lai K, McGinnis N, Sunkel C, Brodsky M. Epigenetic telomere protection by Drosophila DNA damage response pathways. PLoS Genet. 2006;2:e71 pubmed
    ..The telomere fusion phenotype of nbs is consistent with defects in each of these activities...
  7. Raffa G, Ciapponi L, Cenci G, Gatti M. Terminin: a protein complex that mediates epigenetic maintenance of Drosophila telomeres. Nucleus. 2011;2:383-91 pubmed publisher
    ..we call terminin, which includes HOAP, HipHop, Moi and Ver; these are fast-evolving proteins that prevent telomere fusion, directly interact with each other, and appear to localize and function only at telomeres...
  8. Moskalev A, Plyusnina E, Shaposhnikov M. Radiation hormesis and radioadaptive response in Drosophila melanogaster flies with different genetic backgrounds: the role of cellular stress-resistance mechanisms. Biogerontology. 2011;12:253-63 pubmed publisher
    ..were observed in flies with mutations in autophagy genes (atg7, atg8a) but absent in flies with mutations in FOXO, ATM, ATR, and p53 homologues. The hormetic effect was revealed in Sirt2 mutant males but not in females...
  9. Klovstad M, Abdu U, Schupbach T. Drosophila brca2 is required for mitotic and meiotic DNA repair and efficient activation of the meiotic recombination checkpoint. PLoS Genet. 2008;4:e31 pubmed publisher
    ..In addition, Brca2 co-immunoprecipitates with the checkpoint protein Rad9, suggesting a direct role for Brca2 in the transduction of the meiotic recombination checkpoint signal. ..
  10. Beaucher M, Zheng X, Amariei F, Rong Y. Multiple pathways suppress telomere addition to DNA breaks in the Drosophila germline. Genetics. 2012;191:407-17 pubmed publisher
    ..Interestingly, partial disruption of factors that normally regulate telomere protection (ATM or NBS) also led to higher frequencies of telomere formation, suggesting that these proteins have opposing roles in ..
  11. Pedersen M, Tiong S, Campbell S. Molecular genetic characterization of Drosophila ATM conserved functional domains. Genome. 2010;53:778-86 pubmed publisher
    ..The gene encoding Drosophila ATM kinase (dATM) was originally designated tefu because of the telomere fusion defects observed in atm mutants...
  12. Chiolo I, Minoda A, Colmenares S, Polyzos A, Costes S, Karpen G. Double-strand breaks in heterochromatin move outside of a dynamic HP1a domain to complete recombinational repair. Cell. 2011;144:732-44 pubmed publisher
    ..We propose that the spatial and temporal control of DSB repair in heterochromatin safeguards genome stability by preventing aberrant exchanges between repeats. ..
  13. Rong Y. Loss of the histone variant H2A.Z restores capping to checkpoint-defective telomeres in Drosophila. Genetics. 2008;180:1869-75 pubmed publisher
    ..chromatin-remodeling protein, suppressed the fusion of telomeres that lacked the protection of checkpoint proteins: ATM, ATR, and the Mre11-Rad50-NBS complex. Loss of H2A...
  14. Rong Y. Telomere capping in Drosophila: dealing with chromosome ends that most resemble DNA breaks. Chromosoma. 2008;117:235-42 pubmed publisher
    ..I review recent progress in Drosophila telomere studies, and challenge the notion that Drosophila may not be a relevant model for the study of telomere maintenance. ..
  15. Wells B, Yoshida E, Johnston L. Compensatory proliferation in Drosophila imaginal discs requires Dronc-dependent p53 activity. Curr Biol. 2006;16:1606-15 pubmed
    ..Our data suggest that dp53 may carry out an ancestral function that promotes animal survival through the coordination of responses leading to compensatory growth after tissue damage. ..
  16. Ciapponi L, Cenci G, Gatti M. The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability. Genetics. 2006;173:1447-54 pubmed
    ..It has been previously shown that mutations in the Drosophila mre11 and rad50 genes cause both telomere fusion and chromosome breakage...
  17. Song Y, Mirey G, Betson M, Haber D, Settleman J. The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development. Curr Biol. 2004;14:1354-9 pubmed
    ..Unlike mei-41 mutants, flies deficient for the true ATM ortholog, dATM, die as pupae or eclose with eye and wing abnormalities...
  18. Mitchell J, Friesen P. Baculoviruses modulate a proapoptotic DNA damage response to promote virus multiplication. J Virol. 2012;86:13542-53 pubmed publisher
    ..Replication of vDNA activated DDR kinases, as evidenced by ATM-driven phosphorylation of the Drosophila histone H2AX homolog (H2Av), a critical regulator of the DDR...
  19. Li X, Zhuo R, Tiong S, Di Cara F, King Jones K, Hughes S, et al. The Smc5/Smc6/MAGE complex confers resistance to caffeine and genotoxic stress in Drosophila melanogaster. PLoS ONE. 2013;8:e59866 pubmed publisher
    ..to identify mutations that confer reduced resistance to the genotoxic effects of caffeine, which inhibits the ATM and ATR DNA damage response proteins...
  20. Cantera R, Barrio R. Do the genes of the innate immune response contribute to neuroprotection in Drosophila?. J Innate Immun. 2015;7:3-10 pubmed publisher
    ..This review opens this debate in Drosophila, which could thus be used as an instrumental model to elucidate this question. ..
  21. Lu W, Chapo J, Roig I, Abrams J. Meiotic recombination provokes functional activation of the p53 regulatory network. Science. 2010;328:1278-81 pubmed publisher
    ..Our findings establish a physiological role for p53 in meiosis and suggest that tumor-suppressive functions may have been co-opted from primordial activities linked to recombination. ..
  22. Guan D, Mo F, Han Y, Gu W, Zhang M. Digital gene expression profiling (DGE) of cadmium-treated Drosophila melanogaster. Environ Toxicol Pharmacol. 2015;39:300-6 pubmed publisher
    ..five differentially expressed genes (confirmed by real-time PCR) involved in all three processes: Ald, Cdc2, skpA, tefu, and Pvr...
  23. Klattenhoff C, Bratu D, McGinnis Schultz N, Koppetsch B, Cook H, Theurkauf W. Drosophila rasiRNA pathway mutations disrupt embryonic axis specification through activation of an ATR/Chk2 DNA damage response. Dev Cell. 2007;12:45-55 pubmed
    ..We conclude that rasiRNA-based gene silencing is not required for axis specification, and that the critical developmental function for this pathway is to suppress DNA damage signaling in the germline. ..
  24. Bilak A, Uyetake L, Su T. Dying cells protect survivors from radiation-induced cell death in Drosophila. PLoS Genet. 2014;10:e1004220 pubmed publisher
    ..If conserved in mammals, a phenomenon in which dying cells make the rest harder to kill by IR could have implications for treatments that involve the sequential use of cytotoxic agents and radiation therapy. ..
  25. Petersen A, Katzenberger R, Wassarman D. The innate immune response transcription factor relish is necessary for neurodegeneration in a Drosophila model of ataxia-telangiectasia. Genetics. 2013;194:133-42 pubmed publisher
    ..is a hallmark of the human disease ataxia-telangiectasia (A-T) that is caused by mutation of the A-T mutated (ATM) gene...
  26. Katzenberger R, Marengo M, Wassarman D. ATM and ATR pathways signal alternative splicing of Drosophila TAF1 pre-mRNA in response to DNA damage. Mol Cell Biol. 2006;26:9256-67 pubmed
    ..that ionizing-radiation-induced upregulation of TAF1-3 and TAF1-4 splicing in S2 cells was mediated by the ATM (ataxia-telangiectasia mutated) DNA damage response kinase and checkpoint kinase 2 (CHK2), a known ATM substrate...
  27. Hong S, Choi K. TCTP directly regulates ATM activity to control genome stability and organ development in Drosophila melanogaster. Nat Commun. 2013;4:2986 pubmed publisher
    ..We identify Drosophila ATM (dATM) as a direct binding partner of dTCTP and describe a mechanistic basis for dATM activation by dTCTP...
  28. Castellanos E, Dominguez P, Gonzalez C. Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability. Curr Biol. 2008;18:1209-14 pubmed publisher
    ..We propose that such tumors might be caused by impaired asymmetric division of neural stem cells [4]. These results show that centrosome loss, far from being innocuous, is a potentially dangerous condition in flies...
  29. Morciano P, Carrisi C, Capobianco L, Mannini L, Burgio G, Cestra G, et al. A conserved role for the mitochondrial citrate transporter Sea/SLC25A1 in the maintenance of chromosome integrity. Hum Mol Genet. 2009;18:4180-8 pubmed publisher
    ..This study therefore provides an intriguing and unexpected link between intermediary metabolism and epigenetic control of genome stability. ..
  30. Mengoli V, Bucciarelli E, Lattao R, Piergentili R, Gatti M, Bonaccorsi S. The analysis of mutant alleles of different strength reveals multiple functions of topoisomerase 2 in regulation of Drosophila chromosome structure. PLoS Genet. 2014;10:e1004739 pubmed publisher
    ..Thus, our results suggest that the previously observed discrepancies in the chromosomal phenotypes elicited by Topo II downregulation in vertebrates might depend on slight differences in Topo II concentration and/or activity. ..
  31. Hing H, Bangalore L, Sun X, Artavanis Tsakonas S. Mutations in the heatshock cognate 70 protein (hsc4) modulate Notch signaling. Eur J Cell Biol. 1999;78:690-7 pubmed
    ..We discuss how hsc4, a gene thought to be involved in subcellular trafficking, may affect the number of functional Notch receptors on the cell surface. ..
  32. Bronk P, Wenniger J, Dawson Scully K, Guo X, Hong S, Atwood H, et al. Drosophila Hsc70-4 is critical for neurotransmitter exocytosis in vivo. Neuron. 2001;30:475-88 pubmed
    ..We suggest that Hsc4 and CSP cooperatively augment the probability of release by increasing the Ca(2+) sensitivity of vesicle fusion. ..
  33. Miranda Saavedra D, Barton G. Classification and functional annotation of eukaryotic protein kinases. Proteins. 2007;68:893-914 pubmed
    ..The application of the Library facilitates the annotation of kinomes and has provided novel insights on the early evolution and subsequent adaptations of the various protein kinase families in eukaryotes. ..
  34. Frydrychova R, Mason J, Archer T. HP1 is distributed within distinct chromatin domains at Drosophila telomeres. Genetics. 2008;180:121-31 pubmed publisher
    ..Chromatin immunoprecipitation to identify other heterochromatic proteins indicates that TAS and the HTT array may be distinct from either heterochromatin or euchromatin. ..
  35. Lu X, Mattis V, Wang N, Al Ramahi I, van den Berg N, Fratantoni S, et al. Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease. Sci Transl Med. 2014;6:268ra178 pubmed publisher
    ..One attractive gene is that encoding the ataxia-telangiectasia mutated (ATM) protein, a kinase involved in the DNA damage response, apoptosis, and cellular homeostasis...
  36. Lee E, Trinh T, Shim H, Park S, Nguyen T, Kim M, et al. Drosophila Claspin is required for the G2 arrest that is induced by DNA replication stress but not by DNA double-strand breaks. DNA Repair (Amst). 2012;11:741-52 pubmed publisher
    ..and a hyperphosphorylated form of Claspin was generated only after HU treatment in mei-41/ATR-dependent and tefu/ATM-independent way...
  37. Morciano P, Zhang Y, Cenci G, Rong Y. A hypomorphic mutation reveals a stringent requirement for the ATM checkpoint protein in telomere protection during early cell division in Drosophila. G3 (Bethesda). 2013;3:1043-8 pubmed publisher
    Using Drosophila as a model system, we identified a stringent requirement for the conserved function of Ataxia Telangiectasia Mutated (ATM) in telomere protection during early embryonic development...
  38. Baehrecke E. Growth control: p53, the guardian angel of compensatory proliferation. Curr Biol. 2006;16:R840-2 pubmed
    ..Recent work has revealed a new role for Drosophila p53 in the compensatory proliferation of cells that are needed to repair damaged tissues, a role that requires the non-apoptotic function of the caspase protease Dronc. ..
  39. Wang Y, Wang Z, Joshi B, Puri R, Stultz B, Yuan Q, et al. The tumor suppressor Caliban regulates DNA damage-induced apoptosis through p53-dependent and -independent activity. Oncogene. 2013;32:3857-66 pubmed publisher
    ..We conclude that Caliban is a regulator of DNA damage-induced apoptosis, functioning as a tumor suppressor in both p53-dependent and -independent pathways. ..
  40. Park J, Na H, Pyo J, Jeon H, Kim Y, Yoo M. Requirement of ATR for maintenance of intestinal stem cells in aging Drosophila. Aging (Albany NY). 2015;7:307-18 pubmed
    ..This study was focused on the role of two major DDR-related factors, ataxia telangiectasia-mutated (ATM) and ATM- and RAD3-related (ATR) kinases, in the maintenance of intestinal stem cells (ISCs) in the adultDrosophila ..
  41. Derive N, Landmann C, Montembault E, Claverie M, Pierre Elies P, Goutte Gattat D, et al. Bub3-BubR1-dependent sequestration of Cdc20Fizzy at DNA breaks facilitates the correct segregation of broken chromosomes. J Cell Biol. 2015;211:517-32 pubmed publisher
    ..We therefore propose that the Bub3-BubR1 complex on broken DNA inhibits the APC/C locally via the sequestration of Cdc20, thus promoting proper transmission of broken chromosomes. ..
  42. Komonyi O, Schauer T, Papai G, Deak P, Boros I. A product of the bicistronic Drosophila melanogaster gene CG31241, which also encodes a trimethylguanosine synthase, plays a role in telomere protection. J Cell Sci. 2009;122:769-74 pubmed publisher
    ..In contrast to ATR kinase, mutations of ATM (ataxia telangiectasia mutated) kinase, which acts in a partially overlapping pathway of telomere protection, do not suppress ..
  43. Rimkus S, Katzenberger R, Trinh A, Dodson G, Tibbetts R, Wassarman D. Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia. Genes Dev. 2008;22:1205-20 pubmed publisher
    Mutations in ATM (Ataxia telangiectasia mutated) result in Ataxia telangiectasia (A-T), a disorder characterized by progressive neurodegeneration...
  44. Higa L, Mihaylov I, Banks D, Zheng J, Zhang H. Radiation-mediated proteolysis of CDT1 by CUL4-ROC1 and CSN complexes constitutes a new checkpoint. Nat Cell Biol. 2003;5:1008-15 pubmed
    ..We show that radiation-mediated CDT1 proteolysis is independent of ATM and CHK2 and can occur in G1-phase cells...
  45. Petersen A, Rimkus S, Wassarman D. ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila. Proc Natl Acad Sci U S A. 2012;109:E656-64 pubmed publisher
    ..Mutation of the C-terminal amino acid in Drosophila ATM inhibited the kinase activity and caused neuron and glial cell death in the adult brain and a reduction in ..
  46. Sopko R, Foos M, Vinayagam A, Zhai B, Binari R, Hu Y, et al. Combining genetic perturbations and proteomics to examine kinase-phosphatase networks in Drosophila embryos. Dev Cell. 2014;31:114-27 pubmed publisher
    ..Further, we show how correlative phosphorylation at the site level can indicate function, as exemplified by Sterile20-like kinase-dependent regulation of Stat92E. ..
  47. Ida H, Suyari O, Shimamura M, Tien Tai T, Yamaguchi M, Taketani S. Genetic link between heme oxygenase and the signaling pathway of DNA damage in Drosophila melanogaster. Tohoku J Exp Med. 2013;231:117-25 pubmed
    ..frequently induces DNA lesions that are recognized by damage sensors, including ataxia-telangiectasia mutated (ATM) and ataxia-telangiectasia and rad3-related (ATR) proteins...
  48. Yamasaki S, Yagishita N, Sasaki T, Nakazawa M, Kato Y, Yamadera T, et al. Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J. 2007;26:113-22 pubmed
    ..Our results provide novel insights into p53 signaling mediated by Synoviolin. ..
  49. Purdy A, Su T. Telomeres: not all breaks are equal. Curr Biol. 2004;14:R613-4 pubmed
    ATM, Rad50 and Mre11 have been shown to prevent telomere fusion in Drosophila, thereby extending the protective role of DNA damage checkpoint proteins to non-canonical telomeres formed without telomerase...
  50. Singer A, Gall J. An inducible nuclear body in the Drosophila germinal vesicle. Nucleus. 2011;2:403-9 pubmed publisher
    ..We suggest that their behavior serves as a useful model for self-assembly of nuclear bodies in general, and we discuss the possibility that similar bodies may occur normally in cells of other organisms. ..
  51. Raffa G, Cenci G, Ciapponi L, Gatti M. Organization and Evolution of Drosophila Terminin: Similarities and Differences between Drosophila and Human Telomeres. Front Oncol. 2013;3:112 pubmed publisher
    ..Other proteins required to prevent end-to-end fusion in flies include HP1, Eff/UbcD1, ATM, the components of the Mre11-Rad50-Nbs (MRN) complex, and the Woc transcription factor...
  52. Cipressa F, Romano S, Centonze S, zur Lage P, Vernì F, Dimitri P, et al. Effete, a Drosophila chromatin-associated ubiquitin-conjugating enzyme that affects telomeric and heterochromatic position effect variegation. Genetics. 2013;195:147-58 pubmed publisher
    ..Surprisingly, only a few of the genes required to prevent telomere fusion have been tested for their effect on TPE...
  53. Chen Z, Robin C, Damiano J, Lydall J, Lumb C, Smith K, et al. Positional cloning of a cyromazine resistance gene in Drosophila melanogaster. Insect Mol Biol. 2006;15:181-6 pubmed
    ..In mammals Smg1 phosphorylates P53 in response to DNA damage. This finding supports the hypothesis that cyromazine interferes with nucleic acid metabolism. ..
  54. Zhang H, Stallock J, Ng J, Reinhard C, Neufeld T. Regulation of cellular growth by the Drosophila target of rapamycin dTOR. Genes Dev. 2000;14:2712-24 pubmed
    ..Our results suggest that dTOR regulates growth during animal development by coupling growth factor signaling to nutrient availability. ..
  55. Mehrotra S, Maqbool S, Kolpakas A, Murnen K, Calvi B. Endocycling cells do not apoptose in response to DNA rereplication genotoxic stress. Genes Dev. 2008;22:3158-71 pubmed publisher
    ..Similar mechanisms may operate during vertebrate development, with implications for cancer predisposition in certain tissues. ..
  56. Pedersen K, Kristensen T, Loeschcke V, Petersen B, Duus J, Nielsen N, et al. Metabolomic signatures of inbreeding at benign and stressful temperatures in Drosophila melanogaster. Genetics. 2008;180:1233-43 pubmed publisher