Gene Symbol: Taf12L
Description: TBP-associated factor 30kD subunit alpha-2
Alias: CG15632, Dmel\CG15632, Rye, TAF, TAF12L, TAF30alpha-2, TAF[[II]], TFIID, Taf30alpha-2, dTAF12, dTAF12L, dTAF[[II]]30a, dTAF[[II]]30alpha-2, dmTAF12L, dmTAF12b, rye, TBP-associated factor 30kD subunit alpha-2, CG15632-PA, TBP-associated factor, TBP-associated factor subunit alpha-2, Taf12L-PA, ryan express
Species: fruit fly

Top Publications

  1. Tora L. A unified nomenclature for TATA box binding protein (TBP)-associated factors (TAFs) involved in RNA polymerase II transcription. Genes Dev. 2002;16:673-5 pubmed
  2. Hiller M, Chen X, Pringle M, Suchorolski M, Sancak Y, Viswanathan S, et al. Testis-specific TAF homologs collaborate to control a tissue-specific transcription program. Development. 2004;131:5297-308 pubmed
    ..tissue-specific TAFs: nht (homolog of dTAF4), mia (homolog of dTAF6), sa (homolog of dTAF8) and rye (homolog of dTAF12)...
  3. Metcalf C, Wassarman D. Nucleolar colocalization of TAF1 and testis-specific TAFs during Drosophila spermatogenesis. Dev Dyn. 2007;236:2836-43 pubmed
    ..tTAFs are paralogs of generally expressed TAF subunits of transcription factor IID (TFIID)...
  4. Goodrich J, Tjian R. Unexpected roles for core promoter recognition factors in cell-type-specific transcription and gene regulation. Nat Rev Genet. 2010;11:549-58 pubmed publisher
    ..Furthermore, new roles for components of these complexes have been identified beyond development; for example, in mediating interactions with chromatin and in maintaining active gene expression across cell divisions. ..
  5. Chen X, Hiller M, Sancak Y, Fuller M. Tissue-specific TAFs counteract Polycomb to turn on terminal differentiation. Science. 2005;310:869-72 pubmed
    ..Here we show that testis-specific TAF (TBP-associated factor) homologs required for terminal differentiation of male germ cells may activate target gene ..
  6. Boutanaev A, Mikhaylova L, Nurminsky D. Up-regulation of the Ku heterodimer in Drosophila testicular cyst cells. FEBS Lett. 2007;581:1707-15 pubmed
    ..Abundance of Ku in the cyst cell cytoplasm suggests the role for Ku subunits in the regulation of sperm individualization. ..
  7. Li V, Davis J, Lenkov K, Bolival B, Fuller M, Petrov D. Molecular evolution of the testis TAFs of Drosophila. Mol Biol Evol. 2009;26:1103-16 pubmed publisher
    ..of the Drosophila testis TAFs (TBP-associated factors), paralogs of TAFs from the basal transcription factor TFIID that are essential for normal transcription during spermatogenesis of a large set of specific genes involved in ..
  8. Chen X, Lu C, Morillo Prado J, Eun S, Fuller M. Sequential changes at differentiation gene promoters as they become active in a stem cell lineage. Development. 2011;138:2441-50 pubmed publisher
    ..Together, the action of the tMAC and tTAF cell type-specific chromatin and transcription machinery leads to loss of Polycomb and release of stalled Pol II from the terminal differentiation gene promoters, allowing robust transcription. ..
  9. Katzenberger R, Rach E, Anderson A, Ohler U, Wassarman D. The Drosophila Translational Control Element (TCE) is required for high-level transcription of many genes that are specifically expressed in testes. PLoS ONE. 2012;7:e45009 pubmed publisher
    ..Finally, mutation of testis-specific TFIID (tTFIID) subunits significantly reduced the transcription of a subset of endogenous TCE-containing but not TCE-..

More Information


  1. Hochheimer A, Tjian R. Diversified transcription initiation complexes expand promoter selectivity and tissue-specific gene expression. Genes Dev. 2003;17:1309-20 pubmed
  2. Sorourian M, Kunte M, Domingues S, Gallach M, Ozdil F, Río J, et al. Relocation facilitates the acquisition of short cis-regulatory regions that drive the expression of retrogenes during spermatogenesis in Drosophila. Mol Biol Evol. 2014;31:2170-80 pubmed publisher
    ..As a consequence we infer that positive selection will play a role in the evolution of these regulatory regions and can often act from the moment of the retrocopy insertion. ..
  3. Theofel I, Bartkuhn M, Hundertmark T, Boettger T, Gärtner S, Leser K, et al. tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family. PLoS ONE. 2014;9:e108267 pubmed publisher