Gene Symbol: Taf1
Description: TBP-associated factor 1
Alias: BG:DS00004.13, CG17603, Dmel\CG17603, EfW1, SR3-5, TAF, TAF1, TAF200, TAF230, TAF250, TAF250/230, TAFII-250, TAFII250, TAF[II]250, TAF[[II]], TAF[[II]]230, TAF[[II]]250, TAF[[II]]250/230, TFIID, TFIID TAF250, Taf1p, Taf200, Taf230, Taf250, Taf[[II]]250, cel, cell, d230, dTAF1, dTAF230, dTAF250, dTAFII250, dTAF[[II]]230, dTAF[[II]]250, dmTAF1, dmTAF[[II]]230, l(3)84Ab, p230, TBP-associated factor 1, CG17603-PA, CG17603-PB, CG17603-PC, CG17603-PD, CG17603-PE, CG17603-PF, TATA-associated factor 250, TBP-associated factor, TBP-associated factor 250, TBP-associated factor 250kD, TFIID 230 kda subunit, Taf1-PA, Taf1-PB, Taf1-PC, Taf1-PD, Taf1-PE, Taf1-PF, cell lethal, suppressor of Ras85D 3-5
Species: fruit fly

Top Publications

  1. Vorobyeva N, Soshnikova N, Nikolenko J, Kuzmina J, Nabirochkina E, Georgieva S, et al. Transcription coactivator SAYP combines chromatin remodeler Brahma and transcription initiation factor TFIID into a single supercomplex. Proc Natl Acad Sci U S A. 2009;106:11049-54 pubmed publisher
    ..consisting of the chromatin-remodeling factor Brahma (SWI/SNF) and the transcription initiation factor TFIID, named BTFly (Brahma and TFIID in one assembly)...
  2. Metcalf C, Wassarman D. Nucleolar colocalization of TAF1 and testis-specific TAFs during Drosophila spermatogenesis. Dev Dyn. 2007;236:2836-43 pubmed
    ..tTAFs are paralogs of generally expressed TAF subunits of transcription factor IID (TFIID)...
  3. Jeanmougin F, Wurtz J, Le Douarin B, Chambon P, Losson R. The bromodomain revisited. Trends Biochem Sci. 1997;22:151-3 pubmed
  4. Vorobyeva N, Soshnikova N, Kuzmina J, Kopantseva M, Nikolenko J, Nabirochkina E, et al. The novel regulator of metazoan development SAYP organizes a nuclear coactivator supercomplex. Cell Cycle. 2009;8:2152-6 pubmed
    ..is related to the conserved domain SAY, which assembles a nuclear supercomplex BTFly consisting of Brahma and TFIID coactivators...
  5. Wassarman D, Aoyagi N, Pile L, Schlag E. TAF250 is required for multiple developmental events in Drosophila. Proc Natl Acad Sci U S A. 2000;97:1154-9 pubmed
    ..Studies in unicellular systems indicate that TAF250 is required for progression through G(1)/S of the cell cycle and repression of apoptosis...
  6. Vorobyeva N, Nikolenko J, Krasnov A, Kuzmina J, Panov V, Nabirochkina E, et al. SAYP interacts with DHR3 nuclear receptor and participates in ecdysone-dependent transcription regulation. Cell Cycle. 2011;10:1821-7 pubmed
    ..interacts with DHR3 nuclear receptor and activates the corresponding genes by recruiting the BTFly (Brahma and TFIID) coactivator supercomplex. The knockdown of SAYP leads to a decrease in the level of DHR3-activated transcription...
  7. Metcalf C, Wassarman D. DNA binding properties of TAF1 isoforms with two AT-hooks. J Biol Chem. 2006;281:30015-23 pubmed publisher
    TATA-binding protein-associated factor 1 (TAF1) is an essential component of the general transcription factor IID (TFIID), which nucleates assembly of the preinitiation complex for transcription by RNA polymerase II...
  8. Yokomori K, Admon A, Goodrich J, Chen J, Tjian R. Drosophila TFIIA-L is processed into two subunits that are associated with the TBP/TAF complex. Genes Dev. 1993;7:2235-45 pubmed
    ..While characterizing the Drosophila TFIID complex, we discovered that a 30-kD protein that cofractionated with dTFIID was homologous to the previously ..
  9. Yokomori K, Chen J, Admon A, Zhou S, Tjian R. Molecular cloning and characterization of dTAFII30 alpha and dTAFII30 beta: two small subunits of Drosophila TFIID. Genes Dev. 1993;7:2587-97 pubmed
    ..Both dTAFII30 alpha and dTAFII30 beta are associated with TFIID via interactions with other TAFs, including dTAFII250, dTAFII150, and dTAFII110. In addition, dTAFII30 alpha also contacts dTBP...

More Information


  1. Kokubo T, Gong D, Roeder R, Horikoshi M, Nakatani Y. The Drosophila 110-kDa transcription factor TFIID subunit directly interacts with the N-terminal region of the 230-kDa subunit. Proc Natl Acad Sci U S A. 1993;90:5896-900 pubmed
    Transcription initiation factor TFIID is a multimeric protein complex that plays a central role in transcriptional regulation by facilitating promoter responses to various activators...
  2. Wu C, Madabusi L, Nishioka H, Emanuel P, Sypes M, Arkhipova I, et al. Analysis of core promoter sequences located downstream from the TATA element in the hsp70 promoter from Drosophila melanogaster. Mol Cell Biol. 2001;21:1593-602 pubmed
    ..In contrast, the initiator cross-linked exclusively to dTAF230. Remarkably, dTAF230 cross-links approximately 10 times more efficiently to the nontranscribed strand than to the ..
  3. Chen J, Attardi L, Verrijzer C, Yokomori K, Tjian R. Assembly of recombinant TFIID reveals differential coactivator requirements for distinct transcriptional activators. Cell. 1994;79:93-105 pubmed
    ..A minimal complex containing TBP and TAFII250 directs basal but not activator-responsive transcription...
  4. Kokubo T, Gong D, Yamashita S, Horikoshi M, Roeder R, Nakatani Y. Drosophila 230-kD TFIID subunit, a functional homolog of the human cell cycle gene product, negatively regulates DNA binding of the TATA box-binding subunit of TFIID. Genes Dev. 1993;7:1033-46 pubmed
    A Drosophila cDNA encoding the largest TFIID subunit (p230) was isolated using a degenerate oligodeoxynucleotide probe based on an amino acid sequence of the purified protein...
  5. Marengo M, Wassarman D. A DNA damage signal activates and derepresses exon inclusion in Drosophila TAF1 alternative splicing. RNA. 2008;14:1681-95 pubmed publisher
    ..A model to address this issue is alternative splicing of Drosophila TAF1 pre-mRNA in response to camptothecin (CPT)-induced DNA damage signals...
  6. Park J, Werner J, Kim J, Lis J, Kim Y. Mediator, not holoenzyme, is directly recruited to the heat shock promoter by HSF upon heat shock. Mol Cell. 2001;8:9-19 pubmed
    ..Therefore, the activator-Mediator interaction likely underlies the initiation of signal transfer from enhancer-bound activators to the basal transcription machinery. ..
  7. Zhou J, Zwicker J, Szymanski P, Levine M, Tjian R. TAFII mutations disrupt Dorsal activation in the Drosophila embryo. Proc Natl Acad Sci U S A. 1998;95:13483-8 pubmed
    In this study, we present evidence that the Dorsal activator interacts with limiting amounts of the TFIID complex in the Drosophila embryo...
  8. Weissman J, Brown J, Howcroft T, Hwang J, Chawla A, Roche P, et al. HIV-1 tat binds TAFII250 and represses TAFII250-dependent transcription of major histocompatibility class I genes. Proc Natl Acad Sci U S A. 1998;95:11601-6 pubmed
    ..We now show that repression results from the interaction of Tat with the TAFII250 component of the general transcription factor, TFIID...
  9. Smoyer L, Dorer D, Nickerson K, Christensen A. Phenotype of the Triplo-lethal locus of Drosophila melanogaster and its suppression by hyperoxia. Genet Res. 2003;82:163-70 pubmed
    ..We have examined Tpl-aneuploid embryos and find that, in both trisomics and monosomics, the midgut shows extensive cell death and the tracheae are abnormal. Shortly thereafter, all tissues die...
  10. Leibovitch B, Lu Q, Benjamin L, Liu Y, Gilmour D, Elgin S. GAGA factor and the TFIID complex collaborate in generating an open chromatin structure at the Drosophila melanogaster hsp26 promoter. Mol Cell Biol. 2002;22:6148-57 pubmed
    ..we have created flies with an hsp26/lacZ transgene wherein the entire DNA segment known to interact with the TFIID complex has been replaced by a random sequence...
  11. Wright K, Tjian R. Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivo. Proc Natl Acad Sci U S A. 2009;106:55-60 pubmed publisher
    Understanding the diverse activities of the multisubunit core promoter recognition complex TFIID in vivo requires knowledge of how individual subunits contribute to overall functions of this TATA box-binding protein (TBP)/TBP-associated ..
  12. Liénard M, Araripe L, Hartl D. Neighboring genes for DNA-binding proteins rescue male sterility in Drosophila hybrids. Proc Natl Acad Sci U S A. 2016;113:E4200-7 pubmed publisher
    ..DNA-binding proteins, agt for an alkyl-cysteine-S-alkyltransferase and Taf1 for a subunit of transcription factor TFIID that serves as a multifunctional transcriptional regulator...
  13. Kennett S, Moorefield K, Horowitz J. Sp3 represses gene expression via the titration of promoter-specific transcription factors. J Biol Chem. 2002;277:9780-9 pubmed
    ..Regions of M2 required for physical interactions with five TATA box-associated factors (TAF(II)s) were mapped, and mutations that disrupt the interaction of M2 with two of these proteins, TAF(II)70 and TAF(..
  14. Pereira L, van der Knaap J, Van Den Boom V, van den Heuvel F, Timmers H. TAF(II)170 interacts with the concave surface of TATA-binding protein to inhibit its DNA binding activity. Mol Cell Biol. 2001;21:7523-34 pubmed
    The human RNA polymerase II transcription factor B-TFIID consists of TATA-binding protein (TBP) and the TBP-associated factor (TAF) TAF(II)170 and can rapidly redistribute over promoter DNA...
  15. Verrijzer C, Yokomori K, Chen J, Tjian R. Drosophila TAFII150: similarity to yeast gene TSM-1 and specific binding to core promoter DNA. Science. 1994;264:933-41 pubmed
    ..Both the product of TSM-1 and dTAFII150 bind directly to TBP and dTAFII250, demonstrating a functional similarity between human and yeast TAFs...
  16. Muratoglu S, Georgieva S, Papai G, Scheer E, Enunlu I, Komonyi O, et al. Two different Drosophila ADA2 homologues are present in distinct GCN5 histone acetyltransferase-containing complexes. Mol Cell Biol. 2003;23:306-21 pubmed
    ..Furthermore, in vivo the two dADA2 proteins showed different localizations on polytene X chromosomes. These results, taken together, suggest that the two Drosophila ADA2 homologues are present in distinct GCN5-containing HAT complexes. ..
  17. Veenstra J. What the loss of the hormone neuroparsin in the melanogaster subgroup of Drosophila can tell us about its function. Insect Biochem Mol Biol. 2010;40:354-61 pubmed publisher
    ..Perhaps the combination of the development of a complete metamorphosis and a redundant role in reproduction made neuroparsin dispensable in some Drosophila species. ..
  18. Roy S, Jiang N, Hart C. Lack of the Drosophila BEAF insulator proteins alters regulation of genes in the Antennapedia complex. Mol Genet Genomics. 2011;285:113-23 pubmed publisher
    ..A control gene, Dref, was not affected. A full understanding of the regulation of ANT-C genes during development will have to take the role of BEAF into account. ..
  19. Yang X. The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. Nucleic Acids Res. 2004;32:959-76 pubmed
  20. Kokubo T, Takada R, Yamashita S, Gong D, Roeder R, Horikoshi M, et al. Identification of TFIID components required for transcriptional activation by upstream stimulatory factor. J Biol Chem. 1993;268:17554-8 pubmed
    A TATA box-binding initiation factor, TFIID, plays a central role in the transcriptional regulation by activators...
  21. Katzenberger R, Marengo M, Wassarman D. ATM and ATR pathways signal alternative splicing of Drosophila TAF1 pre-mRNA in response to DNA damage. Mol Cell Biol. 2006;26:9256-67 pubmed
    ..TAF1 encodes a subunit of TFIID, which is broadly required for RNA polymerase II transcription...
  22. Rabenstein M, Zhou S, Lis J, Tjian R. TATA box-binding protein (TBP)-related factor 2 (TRF2), a third member of the TBP family. Proc Natl Acad Sci U S A. 1999;96:4791-6 pubmed
    ..These findings suggest that metazoans have evolved multiple TBPs to accommodate the vast increase in genes and expression patterns during development and cellular differentiation. ..
  23. Georgieva S, Kirschner D, Jagla T, Nabirochkina E, Hanke S, Schenkel H, et al. Two novel Drosophila TAF(II)s have homology with human TAF(II)30 and are differentially regulated during development. Mol Cell Biol. 2000;20:1639-48 pubmed
    b>TFIID is a multiprotein complex composed of the TATA binding protein (TBP) and TBP-associated factors (TAF(II)s)...
  24. Pennington K, Marr S, Chirn G, Marr M. Holo-TFIID controls the magnitude of a transcription burst and fine-tuning of transcription. Proc Natl Acad Sci U S A. 2013;110:7678-83 pubmed publisher
    ..Recent evidence suggests that the role and composition of TFIID are more diverse than previously understood...
  25. Wright K, Marr M, Tjian R. TAF4 nucleates a core subcomplex of TFIID and mediates activated transcription from a TATA-less promoter. Proc Natl Acad Sci U S A. 2006;103:12347-52 pubmed
    Activator-dependent recruitment of TFIID initiates formation of the transcriptional preinitiation complex...
  26. Wakimoto B, Turner F, Kaufman T. Defects in embryogenesis in mutants associated with the antennapedia gene complex of Drosophila melanogaster. Dev Biol. 1984;102:147-72 pubmed
    ..The mutant phenotypes suggest, in addition to ensuring proper segment identity, the wild-type alleles of the 84A-84B1,2 genes are necessary for normal segmentation and elongation of the germ band and normal head involution. ..
  27. Mizzen C, Yang X, Kokubo T, Brownell J, Bannister A, Owen Hughes T, et al. The TAF(II)250 subunit of TFIID has histone acetyltransferase activity. Cell. 1996;87:1261-70 pubmed
    The transcription initiation factor TFIID is a multimeric protein complex composed of TATA box-binding protein (TBP) and many TBP-associated factors (TAF(II)s)...
  28. Damania B, Alwine J. TAF-like function of SV40 large T antigen. Genes Dev. 1996;10:1369-81 pubmed
    ..to epitope-tagged TBP, endogenous TBP, hTAF(II)100, hTAF(II)130, and hTAF(II)250, under conditions where holo-TFIID would be precipitated...
  29. Usakin L, Abad J, Vagin V, de Pablos B, Villasante A, Gvozdev V. Transcription of the 1.688 satellite DNA family is under the control of RNA interference machinery in Drosophila melanogaster ovaries. Genetics. 2007;176:1343-9 pubmed
    ..The spn-E(1) mutation causes an increase of the H3-AcK9 mark and TAF1 (a component of the polymerase II transcriptional complex) occupancy in the chromatin of autosomal pericentromeric ..
  30. Farmer G, Colgan J, Nakatani Y, Manley J, Prives C. Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo. Mol Cell Biol. 1996;16:4295-304 pubmed
    The transcriptional activator p53 is known to interact with components of the general transcription factor TFIID in vitro...
  31. Read R, Fenton T, Gomez G, Wykosky J, VandenBerg S, Babic I, et al. A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. PLoS Genet. 2013;9:e1003253 pubmed publisher
    ..Conversely, reduced expression of RIOK1 or RIOK2 disrupted Akt signaling and caused cell cycle exit, apoptosis, and chemosensitivity in glioblastoma cells by inducing p53 activity through the RpL11-..
  32. Mizzen C, Allis C. Transcription. New insights into an old modification. Science. 2000;289:2290-1 pubmed
  33. Sauer F, Hansen S, Tjian R. Multiple TAFIIs directing synergistic activation of transcription. Science. 1995;270:1783-8 pubmed
    ..A quadruple complex containing TATA binding protein (TBP), TAFII250, TAFII110, and TAFII60 mediated transcriptional synergism by BCD and HB, whereas triple TBP-TAFII complexes ..
  34. Schock F, Sauer F, Jackle H, Purnell B. Drosophila head segmentation factor buttonhead interacts with the same TATA box-binding protein-associated factors and in vivo DNA targets as human Sp1 but executes a different biological program. Proc Natl Acad Sci U S A. 1999;96:5061-5 pubmed
  35. Kasahara K, Kawaichi M, Kokubo T. In vivo synthesis of Taf1p lacking the TAF N-terminal domain using alternative transcription or translation initiation sites. Genes Cells. 2004;9:709-21 pubmed
    ..of yeast TAND1 or TAND2 with the equivalent domain from a Drosophila homologue leads to accumulation of truncated Taf1p in yeast. This study demonstrates that these truncated Taf1p derivatives lack TAND...
  36. Liu D, Ishima R, Tong K, Bagby S, Kokubo T, Muhandiram D, et al. Solution structure of a TBP-TAF(II)230 complex: protein mimicry of the minor groove surface of the TATA box unwound by TBP. Cell. 1998;94:573-83 pubmed
    General transcription factor TFIID consists of TATA box-binding protein (TBP) and TBP-associated factors (TAF(II)s), which together play a central role in both positive and negative regulation of transcription...
  37. Weinzierl R, Ruppert S, Dynlacht B, Tanese N, Tjian R. Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID. EMBO J. 1993;12:5303-9 pubmed
    ..Recombinant TAFII60/70 binds weakly to TBP and tightly to the largest subunit of TFIID, TAFII250. In the presence of TAFII60/70, TBP and TAFII250, a stable ternary complex is formed...
  38. Hansen S, Tjian R. TAFs and TFIIA mediate differential utilization of the tandem Adh promoters. Cell. 1995;82:565-75 pubmed
    ..We propose a mechanism for regulating differential promoter utilization during Drosophila development that involves the recognition of specific initiator elements by TAFs in the TFIID complex.
  39. Hoey T, Weinzierl R, Gill G, Chen J, Dynlacht B, Tjian R. Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Cell. 1993;72:247-60 pubmed
    The general transcription factor TFIID is a multiprotein complex containing the TATA-binding protein and several associated factors (TAFs), some of which may function as coactivators that are essential for activated, but not basal, ..
  40. Lewis R, Wakimoto B, Denell R, Kaufman T. Genetic Analysis of the Antennapedia Gene Complex (Ant-C) and Adjacent Chromosomal Regions of DROSOPHILA MELANOGASTER. II. Polytene Chromosome Segments 84A-84B1,2. Genetics. 1980;95:383-97 pubmed
    ..Three have been demonstrated to be homoeotic in nature. The specific homoeotic transformations thus far observed suggest that these loci are critical for normal development of adult labial, maxillary and thoracic structures. ..
  41. Weinzierl R, Dynlacht B, Tjian R. Largest subunit of Drosophila transcription factor IID directs assembly of a complex containing TBP and a coactivator. Nature. 1993;362:511-7 pubmed
    ..Here we report the cloning of Drosophila TAFII250 and the assembly of a partial complex containing recombinant TBP, TAFII110 and the C-terminal domain of TAFII250...
  42. Jones K, Kadonaga J. Exploring the transcription-chromatin interface. Genes Dev. 2000;14:1992-6 pubmed
  43. Albright S, Tjian R. TAFs revisited: more data reveal new twists and confirm old ideas. Gene. 2000;242:1-13 pubmed
    ..Coordinating the interaction of these proteins is the basal transcription factor TFIID, which recognizes the core promoter and supplies a scaffolding upon which the rest of the transcriptional ..
  44. Xie G, Yu Z, Jia D, Jiao R, Deng W. E(y)1/TAF9 mediates the transcriptional output of Notch signaling in Drosophila. J Cell Sci. 2014;127:3830-9 pubmed publisher
    ..Here, we report that E(y)1/TAF9, a component of the transcription factor TFIID complex, interacts specifically with the NICD-Su(H)-Mam complex to facilitate the transcriptional output of Notch ..
  45. Niessing D, Rivera Pomar R, La Rosée A, Hader T, Schock F, Purnell B, et al. A cascade of transcriptional control leading to axis determination in Drosophila. J Cell Physiol. 1997;173:162-7 pubmed
  46. Georgieva S, Nabirochkina E, Dilworth F, Eickhoff H, Becker P, Tora L, et al. The novel transcription factor e(y)2 interacts with TAF(II)40 and potentiates transcription activation on chromatin templates. Mol Cell Biol. 2001;21:5223-31 pubmed
    ..studies demonstrate that the major complex, including both proteins, appears to be distinct from TFIID. Furthermore, we provide genetic evidence suggesting that the carboxy terminus of dTAF(II)40 is important for ..
  47. Leser K, Awe S, Barckmann B, Renkawitz Pohl R, Rathke C. The bromodomain-containing protein tBRD-1 is specifically expressed in spermatocytes and is essential for male fertility. Biol Open. 2012;1:597-606 pubmed publisher
    ..on several translationally repressed and stored mRNAs that are often expressed exclusively in the testis through a cell type specific transcriptional program...
  48. Kotani T, Miyake T, Tsukihashi Y, Hinnebusch A, Nakatani Y, Kawaichi M, et al. Identification of highly conserved amino-terminal segments of dTAFII230 and yTAFII145 that are functionally interchangeable for inhibiting TBP-DNA interactions in vitro and in promoting yeast cell growth in vivo. J Biol Chem. 1998;273:32254-64 pubmed
    b>TFIID is a multiprotein complex composed of TBP and several TAFIIs...
  49. Scheuermann J, de Ayala Alonso A, Oktaba K, Ly Hartig N, McGinty R, Fraterman S, et al. Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature. 2010;465:243-7 pubmed publisher
    Polycomb group (PcG) proteins are transcriptional repressors that control processes ranging from the maintenance of cell fate decisions and stem cell pluripotency in animals to the control of flowering time in plants...
  50. Saha N, Liu M, Gajan A, Pile L. Genome-wide studies reveal novel and distinct biological pathways regulated by SIN3 isoforms. BMC Genomics. 2016;17:111 pubmed publisher
    ..We established a Drosophila S2 cell culture model system in which cells predominantly express either SIN3 187 or SIN3 220...
  51. Yokomori K, Zeidler M, Chen J, Verrijzer C, Mlodzik M, Tjian R. Drosophila TFIIA directs cooperative DNA binding with TBP and mediates transcriptional activation. Genes Dev. 1994;8:2313-23 pubmed
    ..These results suggest that dTFIIA is a multifunctional transcription factor capable of influencing DNA binding as well as interactions with the basal machinery, thereby enhancing activator-dependent transcription. ..
  52. Araripe L, Montenegro H, Lemos B, Hartl D. Fine-scale genetic mapping of a hybrid sterility factor between Drosophila simulans and D. mauritiana: the varied and elusive functions of "speciation genes". BMC Evol Biol. 2010;10:385 pubmed publisher
    ..Gene Taf1 is partially contained in the region, but yet shows high polymorphism with four fixed non-synonymous substitutions ..
  53. Merrill V, Diederich R, Turner F, Kaufman T. A genetic and developmental analysis of mutations in labial, a gene necessary for proper head formation in Drosophila melanogaster. Dev Biol. 1989;135:376-91 pubmed
    ..Mutations in lab, like those in the Deformed and proboscipedia loci of the ANT-C, reveal a homoeotic phenotype only in the adult stage of the life cycle. ..
  54. Kenyon K, Li D, Clouser C, Tran S, Pignoni F. Fly SIX-type homeodomain proteins Sine oculis and Optix partner with different cofactors during eye development. Dev Dyn. 2005;234:497-504 pubmed publisher
  55. Kokubo T, Yamashita S, Horikoshi M, Roeder R, Nakatani Y. Interaction between the N-terminal domain of the 230-kDa subunit and the TATA box-binding subunit of TFIID negatively regulates TATA-box binding. Proc Natl Acad Sci U S A. 1994;91:3520-4 pubmed
    Transcription initiation factor TFIID plays a central role in transcriptional regulation. Drosophila TFIID is a multimeric protein consisting of the TATA box-binding polypeptide (TBP) and a number of tightly associated polypeptides...
  56. Karim F, Chang H, Therrien M, Wassarman D, Laverty T, Rubin G. A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics. 1996;143:315-29 pubmed
    b>Cell-fate specification of the R7 photoreceptor cell is controlled by the sevenless receptor tyrosine kinase (SevRTK) and Ras1, the Drosophila homologue of mammalian H-ras, K-ras and N-ras oncogenes...
  57. Bagby S, Mal T, Liu D, Raddatz E, Nakatani Y, Ikura M. TFIIA-TAF regulatory interplay: NMR evidence for overlapping binding sites on TBP. FEBS Lett. 2000;468:149-54 pubmed
    ..Transcription factor IIA (TFIIA) stabilizes the TBP-promoter complex whereas the N-terminal domain of the largest TAF(II) inhibits TBP-promoter interaction...
  58. Berk A. TBP-like factors come into focus. Cell. 2000;103:5-8 pubmed
  59. Cutler G, Perry K, Tjian R. Adf-1 is a nonmodular transcription factor that contains a TAF-binding Myb-like motif. Mol Cell Biol. 1998;18:2252-61 pubmed
    ..Like many transcriptional activators, Adf-1 contains a TFIID-binding domain that can interact with specific TAF subunits...
  60. Feller C, Forné I, Imhof A, Becker P. Global and specific responses of the histone acetylome to systematic perturbation. Mol Cell. 2015;57:559-71 pubmed publisher
    ..Conceivably, the acetylation level is adjusted to maintain the global charge neutralization of chromatin and the stability of nuclei. ..
  61. Vorobyeva N, Soshnikova N, Nikolenko Y, Nabirochkina E, Georgieva S, Shidlovskii Y. A new evolutionarily conserved protein domain is capable of transcription activation. Dokl Biochem Biophys. 2008;423:349-51 pubmed
  62. Lebedeva L, Nabirochkina E, Kurshakova M, Robert F, Krasnov A, Evgen ev M, et al. Occupancy of the Drosophila hsp70 promoter by a subset of basal transcription factors diminishes upon transcriptional activation. Proc Natl Acad Sci U S A. 2005;102:18087-92 pubmed
    ..TATA-binding protein (TBP) and several TBP-associated factors (TAFs), TFIIB, TFIIF (RAP30), TFIIH (XPB), TBP-free/TAF-containg complex (GCN5 and TRRAP), and the Mediator complex subunit 13 before heat shock...
  63. Santoso B, Kadonaga J. Reconstitution of chromatin transcription with purified components reveals a chromatin-specific repressive activity of p300. Nat Struct Mol Biol. 2006;13:131-9 pubmed
    ..Hence, the mechanism of transcriptional repression by p300 is distinct from that of histone H1, PARP-1 or Sir2. These findings reveal a novel chromatin-specific repressive function of p300. ..
  64. Klenov M, Lavrov S, Stolyarenko A, Ryazansky S, Aravin A, Tuschl T, et al. Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline. Nucleic Acids Res. 2007;35:5430-8 pubmed
    ..Our results provide evidence that germinal Piwi-associated short RNAs induce chromatin modifications of their targets. ..
  65. Kokubo T, Gong D, Wootton J, Horikoshi M, Roeder R, Nakatani Y. Molecular cloning of Drosophila TFIID subunits. Nature. 1994;367:484-7 pubmed
    Transcription initiation factor TFIID is a multisubunit complex containing a TATA-box-binding factor (TFIID tau/TBP) and associated polypeptide factors (TAFs) with sizes ranging from M(r) approximately 20,000 to > 200,000...
  66. Goodrich J, Hoey T, Thut C, Admon A, Tjian R. Drosophila TAFII40 interacts with both a VP16 activation domain and the basal transcription factor TFIIB. Cell. 1993;75:519-30 pubmed
    Enhancement of RNA polymerase II transcription by the viral transactivator VP16 requires the TFIID complex, which consists of the TATA-binding protein (TBP) and TBP-associated factors (TAFs)...
  67. Pham A, Sauer F. Ubiquitin-activating/conjugating activity of TAFII250, a mediator of activation of gene expression in Drosophila. Science. 2000;289:2357-60 pubmed
    ..A biochemical approach identified the Drosophila coactivator TAFII250, the central subunit within the general transcription factor TFIID, as a histone-specific ubiquitin-activating/..
  68. Roy S, Tan Y, Hart C. A genetic screen supports a broad role for the Drosophila insulator proteins BEAF-32A and BEAF-32B in maintaining patterns of gene expression. Mol Genet Genomics. 2007;277:273-86 pubmed
    ..Because it is unlikely that insulator function is limited to eye development, the present results support the hypothesis that insulators play a widespread role in maintaining global transcription programs. ..
  69. Barnes V, Bhat A, Unnikrishnan A, Heydari A, Arking R, Pile L. SIN3 is critical for stress resistance and modulates adult lifespan. Aging (Albany NY). 2014;6:645-60 pubmed
    ..Taken together, the data support a model whereby SIN3 regulates a gene expression program required for proper mitochondrial function and effective stress response during adulthood. ..
  70. Duttke S. Evolution and diversification of the basal transcription machinery. Trends Biochem Sci. 2015;40:127-9 pubmed publisher
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    The transcription initiation factor TFIID, consisting of the TATA box-binding protein (TBP) and many TBP-associated factors (TAFs), plays a central role in both basal and activated transcription...