Gene Symbol: Syx6
Description: Syntaxin 6
Alias: CG7736, CT23545, Dm Syx6, DmSyx6, Dmel\CG7736, SYN6, SYX6/10, Syx, syntaxin 6, CG7736-PB, CG7736-PD, CG7736-PE, Syx6-PB, Syx6-PD, Syx6-PE, syntaxin
Species: fruit fly
Schneider C, Will C, BROSIUS J, Frilander M, Luhrmann R. Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila. Proc Natl Acad Sci U S A. 2004;101:9584-9 pubmed
..A comparison of U11 snRNAs that we have identified from vertebrates, plants, and insects, suggests that an evolutionarily divergent U11 snRNA may be unique to Drosophila and not characteristic of insects in general. ..
Otake L, Scamborova P, Hashimoto C, Steitz J. The divergent U12-type spliceosome is required for pre-mRNA splicing and is essential for development in Drosophila. Mol Cell. 2002;9:439-46 pubmed
..Thus, we demonstrate the requirement for the U12 spliceosome in the development of a metazoan organism. ..
Dumstrei K, Wang F, Hartenstein V. Role of DE-cadherin in neuroblast proliferation, neural morphogenesis, and axon tract formation in Drosophila larval brain development. J Neurosci. 2003;23:3325-35 pubmed
..We conclude that DE-cadherin plays a pivotal role in larval brain proliferation, brain cortex morphogenesis, and axon growth. ..
Pereanu W, Shy D, Hartenstein V. Morphogenesis and proliferation of the larval brain glia in Drosophila. Dev Biol. 2005;283:191-203 pubmed
..This increase results from mitosis of differentiated glia, but, more significantly, from the proliferation of neuroblasts. ..
Wagh D, Rasse T, Asan E, Hofbauer A, Schwenkert I, Dürrbeck H, et al
. Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila. Neuron. 2006;49:833-44 pubmed
..We propose that BRP is critical for intact AZ structure and normal-evoked neurotransmitter release at chemical synapses of Drosophila. ..
Lin C, Mount S, Jarmołowski A, Makałowski W. Evolutionary dynamics of U12-type spliceosomal introns. BMC Evol Biol. 2010;10:47 pubmed publisher
..Loss of U12 introns or the genes containing them is more common than conversion to the U2-type. The degeneracy of U12-type terminal dinucleotides among natural U12-type introns is higher than previously thought. ..
Littleton J, Pallanck L, Ganetzky B. Mechanisms of neurotransmitter release. Int Rev Neurobiol. 1999;43:139-61 pubmed
Pereanu W, Hartenstein V. Neural lineages of the Drosophila brain: a three-dimensional digital atlas of the pattern of lineage location and projection at the late larval stage. J Neurosci. 2006;26:5534-53 pubmed
..Third, the atlas can serve as a repository for genes expressed in lineage-specific patterns. ..
Praveen K, Wen Y, Matera A. A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects. Cell Rep. 2012;1:624-31 pubmed publisher
..These findings have major implications for SMA etiology because they show that SMN's role in snRNP biogenesis can be uncoupled from the organismal viability and locomotor defects. ..