Gene Symbol: Syt1
Description: Synaptotagmin 1
Alias: CG3139, D. Syt I, DSYT, DSYT2, DSypt, DSyt, DSyt1, Dmel\CG3139, Droso1, Dsyt2, STY1, SYT, SYT I, SYT1, Syt, Syt 1, Syt I, Syt-1, SytI, dSYT, dSyt1, dsyt1, dsytI, l(2)23AB1, l(2)23Ba, l(2)k05909, syt, syt 1, syt I, syt-1, syt1, sytI, synaptotagmin 1, CG3139-PA, CG3139-PB, CG3139-PC, CG3139-PE, CG3139-PF, CG3139-PG, CG3139-PH, CG3139-PI, Synaptotagmin-1, Synaptotagmin-I, Synaptotagmin1, SynaptotagminI, Syt1-PA, Syt1-PB, Syt1-PC, Syt1-PE, Syt1-PF, Syt1-PG, Syt1-PH, Syt1-PI, synaptoptagmin 1, synaptotagmin, synaptotagmin I
Species: fruit fly
Products:     Syt1

Top Publications

  1. Robinson I, Ranjan R, Schwarz T. Synaptotagmins I and IV promote transmitter release independently of Ca(2+) binding in the C(2)A domain. Nature. 2002;418:336-40 pubmed
    ..The most extensively studied candidate for the Ca(2+)-sensing trigger is synaptotagmin I, whose Ca(2+)-dependent interactions with acidic phospholipids and syntaxin have largely been ascribed to its ..
  2. Pennetta G, Hiesinger P, Fabian Fine R, Meinertzhagen I, Bellen H. Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner. Neuron. 2002;35:291-306 pubmed
    ..We propose that a DVAP-33A-mediated interaction between microtubules and presynaptic membrane plays a pivotal role during bouton budding. ..
  3. Yoshihara M, Littleton J. Synaptotagmin I functions as a calcium sensor to synchronize neurotransmitter release. Neuron. 2002;36:897-908 pubmed
    To characterize Ca(2+)-mediated synaptic vesicle fusion, we analyzed Drosophila synaptotagmin I mutants deficient in specific interactions mediated by its two Ca(2+) binding C2 domains...
  4. McCabe B, Marques G, Haghighi A, Fetter R, Crotty M, Haerry T, et al. The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction. Neuron. 2003;39:241-54 pubmed
    ..These experiments reveal that a muscle-derived BMP retrograde signal participates in coordinating neuromuscular synapse development and growth. ..
  5. Adolfsen B, Saraswati S, Yoshihara M, Littleton J. Synaptotagmins are trafficked to distinct subcellular domains including the postsynaptic compartment. J Cell Biol. 2004;166:249-60 pubmed
    The synaptotagmin family has been implicated in calcium-dependent neurotransmitter release, although Synaptotagmin 1 is the only isoform demonstrated to control synaptic vesicle fusion...
  6. Gonzalez Gaitan M, Jackle H. Role of Drosophila alpha-adaptin in presynaptic vesicle recycling. Cell. 1997;88:767-76 pubmed
    ..Our results suggest an alpha-adaptin-dependent control of the vesicle cycle that maintains the balance between the amount of vesicle- and surface-associated membranes. ..
  7. Littleton J, Chapman E, Kreber R, Garment M, Carlson S, Ganetzky B. Temperature-sensitive paralytic mutations demonstrate that synaptic exocytosis requires SNARE complex assembly and disassembly. Neuron. 1998;21:401-13 pubmed
    ..These results provide in vivo evidence that cycles of assembly and disassembly of SNARE complexes drive membrane trafficking at synapses. ..
  8. Martin M, Iyadurai S, Gassman A, Gindhart J, Hays T, Saxton W. Cytoplasmic dynein, the dynactin complex, and kinesin are interdependent and essential for fast axonal transport. Mol Biol Cell. 1999;10:3717-28 pubmed
    ..The shared bidirectional disruption phenotypes and the dominant genetic interactions demonstrate that cytoplasmic dynein, the dynactin complex, and conventional kinesin are interdependent in fast axonal transport. ..
  9. Rohrbough J, Grotewiel M, Davis R, Broadie K. Integrin-mediated regulation of synaptic morphology, transmission, and plasticity. J Neurosci. 2000;20:6868-78 pubmed
    ..Our results provide direct evidence that Volado regulates functional synaptic plasticity processes and support recent findings implicating integrins in rapid changes in synaptic efficacy and in memory formation. ..

More Information

Publications101 found, 100 shown here

  1. Narayanan R, Kramer H, Ramaswami M. Drosophila endosomal proteins hook and deep orange regulate synapse size but not synaptic vesicle recycling. J Neurobiol. 2000;45:105-19 pubmed
    ..Our observations suggest a model in which Hook and Dor function in later stages of endocytosis is essential for regulating synaptic plasma membrane composition but not synaptic vesicle recycling. ..
  2. Aberle H, Haghighi A, Fetter R, McCabe B, Magalhaes T, Goodman C. wishful thinking encodes a BMP type II receptor that regulates synaptic growth in Drosophila. Neuron. 2002;33:545-58 pubmed
    ..The NMJ phenotype is specifically rescued by transgenic expression of Wit only in motoneurons. Thus, Wit appears to function as a presynaptic receptor that regulates synaptic size at the Drosophila NMJ. ..
  3. Bao H, Daniels R, MacLeod G, Charlton M, Atwood H, Zhang B. AP180 maintains the distribution of synaptic and vesicle proteins in the nerve terminal and indirectly regulates the efficacy of Ca2+-triggered exocytosis. J Neurophysiol. 2005;94:1888-903 pubmed
    ..Consistent with this hypothesis, three vesicle proteins critical for calcium-mediated exocytosis, synaptotagmin I, cysteine-string protein, and neuronal synaptobrevin, are all mislocalized to the extrasynaptic axonal ..
  4. Pack Chung E, Kurshan P, Dickman D, Schwarz T. A Drosophila kinesin required for synaptic bouton formation and synaptic vesicle transport. Nat Neurosci. 2007;10:980-9 pubmed
    ..Our data thus indicate that Imac transports components required for synaptic maturation and provide insight into presynaptic maturation as a process that can be differentiated from axon outgrowth and targeting. ..
  5. Barber C, Jorquera R, Melom J, Littleton J. Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains. J Cell Biol. 2009;187:295-310 pubmed publisher
    ..Although the role of presynaptic Ca(2+) in triggering vesicle fusion though the Ca(2+) sensor synaptotagmin 1 (Syt 1) is established, molecular mechanisms that underlie responses to postsynaptic Ca(2+) influx remain ..
  6. Banovic D, Khorramshahi O, Owald D, Wichmann C, Riedt T, Fouquet W, et al. Drosophila neuroligin 1 promotes growth and postsynaptic differentiation at glutamatergic neuromuscular junctions. Neuron. 2010;66:724-38 pubmed publisher
    ..Instead, other signaling components are likely involved in DNlg1 transsynaptic functions, with essential interactions organized by the DNlg1 extracellular domain but also by the cytoplasmic domain. ..
  7. Bate M, Broadie K. Wiring by fly: the neuromuscular system of the Drosophila embryo. Neuron. 1995;15:513-25 pubmed
  8. Landgraf M, Roy S, Prokop A, Vijayraghavan K, Bate M. even-skipped determines the dorsal growth of motor axons in Drosophila. Neuron. 1999;22:43-52 pubmed
    ..Thus, even-skipped complements the function of islet, and together these two genes constitute a bimodal switch regulating axonal growth and directing motor axons to ventral or to dorsal regions of the muscle field. ..
  9. Mackler J, Drummond J, Loewen C, Robinson I, Reist N. The C(2)B Ca(2+)-binding motif of synaptotagmin is required for synaptic transmission in vivo. Nature. 2002;418:340-4 pubmed
    b>Synaptotagmin is a synaptic vesicle protein that is postulated to be the Ca(2+) sensor for fast, evoked neurotransmitter release...
  10. Trotta N, Orso G, Rossetto M, Daga A, Broadie K. The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function. Curr Biol. 2004;14:1135-47 pubmed
    ..The role of Spastin in regulating neuronal microtubule stability suggests therapeutic targets for HSP treatment and may provide insight into neurological disorders linked to microtubule dysfunction. ..
  11. Hiesinger P, Zhai R, Zhou Y, Koh T, Mehta S, Schulze K, et al. Activity-independent prespecification of synaptic partners in the visual map of Drosophila. Curr Biol. 2006;16:1835-43 pubmed mutants affecting the generation of electrical potentials (norpA, trp;trpl), neurotransmitter release (hdc, syt), vesicle endocytosis (synj), the trafficking of specific guidance molecules during photoreceptor targeting (sec15),..
  12. Ratnaparkhi A, Lawless G, Schweizer F, GOLSHANI P, Jackson G. A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism. PLoS ONE. 2008;3:e2334 pubmed publisher
    ..This new fly model of ALS, with its robust pathological phenotypes, should for the first time allow the power of unbiased screens in Drosophila to be applied to study of motor neuron diseases. ..
  13. Mao Z, Davis R. Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity. Front Neural Circuits. 2009;3:5 pubmed publisher
    ..Differences in functional response properties of these neurons suggest that they are involved in different behavioral processes. ..
  14. Lai J, Lo S, Dickson B, Chiang A. Auditory circuit in the Drosophila brain. Proc Natl Acad Sci U S A. 2012;109:2607-12 pubmed publisher
    ..Our findings delineate an auditory processing pathway involving AMMC?IVLP?VLP in the Drosophila brain. ..
  15. Wan H, DiAntonio A, Fetter R, Bergstrom K, Strauss R, Goodman C. Highwire regulates synaptic growth in Drosophila. Neuron. 2000;26:313-29 pubmed
    ..Within presynaptic terminals, HIW is localized to the periactive zone surrounding active zones; Fasciclin II (Fas II), which also controls synaptic growth, is found at the same location. ..
  16. Verstreken P, Kjaerulff O, Lloyd T, Atkinson R, Zhou Y, Meinertzhagen I, et al. Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release. Cell. 2002;109:101-12 pubmed
    ..We propose that kiss-and-run maintains neurotransmission at active zones of the larval NMJ in endophilin animals. ..
  17. Hiesinger P, Fayyazuddin A, Mehta S, Rosenmund T, Schulze K, Zhai R, et al. The v-ATPase V0 subunit a1 is required for a late step in synaptic vesicle exocytosis in Drosophila. Cell. 2005;121:607-620 pubmed publisher
    ..Our data suggest that Vha100-1 functions downstream of SNAREs in synaptic vesicle fusion. ..
  18. Pielage J, Fetter R, Davis G. A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction. J Cell Biol. 2006;175:491-503 pubmed
    ..We propose a model in which a postsynaptic Spectrin-actin lattice acts as an organizing scaffold upon which pre- and postsynaptic development are arranged. ..
  19. Chou Y, Spletter M, Yaksi E, Leong J, Wilson R, Luo L. Diversity and wiring variability of olfactory local interneurons in the Drosophila antennal lobe. Nat Neurosci. 2010;13:439-49 pubmed publisher
    ..Our results reveal an unexpected degree of complexity and individual variation in an invertebrate neural circuit, a result that creates challenges for solving the Drosophila connectome. ..
  20. Torroja L, Chu H, Kotovsky I, White K. Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport. Curr Biol. 1999;9:489-92 pubmed
  21. Krishnan K, Rikhy R, Rao S, Shivalkar M, Mosko M, Narayanan R, et al. Nucleoside diphosphate kinase, a source of GTP, is required for dynamin-dependent synaptic vesicle recycling. Neuron. 2001;30:197-210 pubmed
    ..This connection between NDK and membrane internalization further strengthens an emerging hypothesis that endocytosis, probably of activated growth factor receptors, is an important tumor suppressor activity in vivo. ..
  22. Featherstone D, Davis W, Dubreuil R, Broadie K. Drosophila alpha- and beta-spectrin mutations disrupt presynaptic neurotransmitter release. J Neurosci. 2001;21:4215-24 pubmed
  23. Chang K, MIN K. Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome. Proc Natl Acad Sci U S A. 2009;106:17117-22 pubmed publisher
    ..These findings imply that restoring the level of any one of these genes may reduce endocytic defects seen in DS. ..
  24. Lloyd T, Machamer J, O Hara K, Kim J, Collins S, Wong M, et al. The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic termini. Neuron. 2012;74:344-60 pubmed publisher
    ..Therefore, the p150(Glued) CAP-Gly domain regulates dynein-mediated retrograde transport at synaptic termini, and this function of dynactin is disrupted by a mutation that causes motor neuron disease. ..
  25. Littleton J, Stern M, Perin M, Bellen H. Calcium dependence of neurotransmitter release and rate of spontaneous vesicle fusions are altered in Drosophila synaptotagmin mutants. Proc Natl Acad Sci U S A. 1994;91:10888-92 pubmed
    ..b>Synaptotagmin is an integral membrane protein of synaptic vesicles that contains two copies of a domain known to be involved ..
  26. DiAntonio A, Parfitt K, Schwarz T. Synaptic transmission persists in synaptotagmin mutants of Drosophila. Cell. 1993;73:1281-90 pubmed
    b>Synaptotagmin is one of the major integral membrane proteins of synaptic vesicles...
  27. Littleton J, Serano T, Rubin G, Ganetzky B, Chapman E. Synaptic function modulated by changes in the ratio of synaptotagmin I and IV. Nature. 1999;400:757-60 pubmed
    ..Genetic and biochemical evidence indicates that synaptotagmin I may function as a Ca2+ sensor in neuronal exocytosis because it can bind Ca2+ and penetrate into lipid ..
  28. Zhang Y, Bailey A, Matthies H, Renden R, Smith M, Speese S, et al. Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell. 2001;107:591-603 pubmed
    ..dfxr futsch double mutants restore normal synaptic structure and function. We propose that dFXR acts as a translational repressor of Futsch to regulate microtubule-dependent synaptic growth and function. ..
  29. Collins C, Wairkar Y, Johnson S, DiAntonio A. Highwire restrains synaptic growth by attenuating a MAP kinase signal. Neuron. 2006;51:57-69 pubmed
    ..In addition to controlling synaptic growth, Highwire promotes synaptic function through a separate pathway that does not require wallenda. ..
  30. Loewen C, Lee S, Shin Y, Reist N. C2B polylysine motif of synaptotagmin facilitates a Ca2+-independent stage of synaptic vesicle priming in vivo. Mol Biol Cell. 2006;17:5211-26 pubmed
    b>Synaptotagmin I, a synaptic vesicle protein required for efficient synaptic transmission, contains a highly conserved polylysine motif necessary for function...
  31. Mohrmann R, Matthies H, Woodruff E, Broadie K. Stoned B mediates sorting of integral synaptic vesicle proteins. Neuroscience. 2008;153:1048-63 pubmed publisher
    ..In support of such role of STNB, synaptic levels of the vesicular glutamate transporter (vGLUT) and synaptotagmin-1 are strongly reduced with diminishing STNB function, while other synaptic proteins are largely unaffected...
  32. Liu C, Plaçais P, Yamagata N, Pfeiffer B, Aso Y, Friedrich A, et al. A subset of dopamine neurons signals reward for odour memory in Drosophila. Nature. 2012;488:512-6 pubmed publisher
    ..Dopamine in insects is known to mediate aversive reinforcement signals. Our results highlight the cellular specificity underlying the various roles of dopamine and the importance of spatially segregated local circuits within the MBs. ..
  33. Eddison M, Guarnieri D, Cheng L, Liu C, Moffat K, Davis G, et al. arouser reveals a role for synapse number in the regulation of ethanol sensitivity. Neuron. 2011;70:979-90 pubmed publisher
    ..We thus show that a developmental abnormality affecting synapse number and ethanol sensitivity is not permanent and can be reversed by manipulating the environment of the adult fly. ..
  34. Petersen S, Fetter R, Noordermeer J, Goodman C, DiAntonio A. Genetic analysis of glutamate receptors in Drosophila reveals a retrograde signal regulating presynaptic transmitter release. Neuron. 1997;19:1237-48 pubmed
    ..Thus, a decrease in postsynaptic receptors leads to an increase in presynaptic transmitter release, indicating that postsynaptic activity controls a retrograde signal that regulates presynaptic function. ..
  35. Roos J, Hummel T, Ng N, Klämbt C, Davis G. Drosophila Futsch regulates synaptic microtubule organization and is necessary for synaptic growth. Neuron. 2000;26:371-82 pubmed
    ..These data suggest a common microtubule-based growth mechanism at the synapse and growth cone. ..
  36. Littleton J, Bai J, Vyas B, Desai R, Baltus A, Garment M, et al. synaptotagmin mutants reveal essential functions for the C2B domain in Ca2+-triggered fusion and recycling of synaptic vesicles in vivo. J Neurosci. 2001;21:1421-33 pubmed
    b>Synaptotagmin has been proposed to function as a Ca(2+) sensor that regulates synaptic vesicle exocytosis, whereas the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is thought to form the core of a ..
  37. Kaufmann N, DeProto J, Ranjan R, Wan H, Van Vactor D. Drosophila liprin-alpha and the receptor phosphatase Dlar control synapse morphogenesis. Neuron. 2002;34:27-38 pubmed
    ..These data suggest a model where Dliprin-alpha and Dlar cooperate to regulate the formation and/or maintenance of a network of presynaptic proteins. ..
  38. Acharya U, Edwards M, Jorquera R, Silva H, Nagashima K, Labarca P, et al. Drosophila melanogaster Scramblases modulate synaptic transmission. J Cell Biol. 2006;173:69-82 pubmed
    ..The lack of phenotypes related to failure of scrambling and the neurophysiological analysis lead us to propose that Scramblases play a modulatory role in the process of neurotransmission. ..
  39. Kasprowicz J, Kuenen S, Miskiewicz K, Habets R, Smitz L, Verstreken P. Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake. J Cell Biol. 2008;182:1007-16 pubmed publisher
    ..Our data not only indicate that chc is critical for synaptic vesicle recycling but they also show that in the absence of the protein, bulk retrieval mediates massive synaptic membrane internalization. ..
  40. Yoshihara M, Rheuben M, Kidokoro Y. Transition from growth cone to functional motor nerve terminal in Drosophila embryos. J Neurosci. 1997;17:8408-26 pubmed
    ..b>Synaptotagmin immunoreactive clusters form concurrently...
  41. Dickman D, Lu Z, Meinertzhagen I, Schwarz T. Altered synaptic development and active zone spacing in endocytosis mutants. Curr Biol. 2006;16:591-8 pubmed
    ..Mutants in endophilin, synaptojanin, dynamin, AP180, and synaptotagmin all show increases in supernumerary bouton structures...
  42. Nunes P, Haines N, Kuppuswamy V, Fleet D, Stewart B. Synaptic vesicle mobility and presynaptic F-actin are disrupted in a N-ethylmaleimide-sensitive factor allele of Drosophila. Mol Biol Cell. 2006;17:4709-19 pubmed
    ..Our data are consistent with a model in which actin filaments promote vesicle mobility and suggest that NSF participates in establishing or maintaining this population of actin. ..
  43. Jepson J, Reenan R. Adenosine-to-inosine genetic recoding is required in the adult stage nervous system for coordinated behavior in Drosophila. J Biol Chem. 2009;284:31391-400 pubmed publisher
  44. Seabrooke S, Qiu X, Stewart B. Nonmuscle Myosin II helps regulate synaptic vesicle mobility at the Drosophila neuromuscular junction. BMC Neurosci. 2010;11:37 pubmed publisher
    ..This work begins to reveal the process by which synaptic vesicles traverse within the bouton. ..
  45. Nicolaï L, Ramaekers A, Raemaekers T, Drozdzecki A, Mauss A, Yan J, et al. Genetically encoded dendritic marker sheds light on neuronal connectivity in Drosophila. Proc Natl Acad Sci U S A. 2010;107:20553-8 pubmed publisher
    ..We show that DenMark is a powerful tool for revealing novel aspects of the neuroanatomy of developing dendrites, identifying previously unknown dendritic arbors, and elucidating neuronal connectivity. ..
  46. Prokop A, Martin Bermudo M, Bate M, Brown N. Absence of PS integrins or laminin A affects extracellular adhesion, but not intracellular assembly, of hemiadherens and neuromuscular junctions in Drosophila embryos. Dev Biol. 1998;196:58-76 pubmed
    ..We suggest that neuromuscular contact in part requires basement membrane adhesion to the general muscle surface, and this form of adhesion is completely abolished in the absence of laminin A. ..
  47. Zhang B, Koh Y, Beckstead R, Budnik V, Ganetzky B, Bellen H. Synaptic vesicle size and number are regulated by a clathrin adaptor protein required for endocytosis. Neuron. 1998;21:1465-75 pubmed
    ..These results provide novel insights into the molecular mechanism of endocytosis and reveal a role for AP180 in regulating vesicle size through a clathrin-dependent reassembly process. ..
  48. Fergestad T, Broadie K. Interaction of stoned and synaptotagmin in synaptic vesicle endocytosis. J Neurosci. 2001;21:1218-27 pubmed
    ..We have documented previously a highly specific synaptic mislocalization and degradation of Synaptotagmin I in stoned mutants...
  49. Parnas D, Haghighi A, Fetter R, Kim S, Goodman C. Regulation of postsynaptic structure and protein localization by the Rho-type guanine nucleotide exchange factor dPix. Neuron. 2001;32:415-24 pubmed
    ..Many, but not all, dpix defects are mediated through dPak, a member of the family of Cdc42/Rac1-activated kinases. Thus, a Rho-type GEF and Rho-type effector kinase regulate postsynaptic structure. ..
  50. Babcock M, Stowers R, Leither J, Goodman C, Pallanck L. A genetic screen for synaptic transmission mutants mapping to the right arm of chromosome 3 in Drosophila. Genetics. 2003;165:171-83 pubmed
    ..Given the tools available for investigation of synaptic function in Drosophila, these mutants represent a valuable resource for future analysis of synapse development and function. ..
  51. Sanchez Soriano N, Bottenberg W, Fiala A, Haessler U, Kerassoviti A, Knust E, et al. Are dendrites in Drosophila homologous to vertebrate dendrites?. Dev Biol. 2005;288:126-38 pubmed
    ..Implications of these findings for studies of dendrite development, neuronal polarity, transport and evolution are discussed. ..
  52. Mahr A, Aberle H. The expression pattern of the Drosophila vesicular glutamate transporter: a marker protein for motoneurons and glutamatergic centers in the brain. Gene Expr Patterns. 2006;6:299-309 pubmed
    ..become concentrated at neuromuscular junctions (NMJs), where they colocalize with the synaptic vesicle marker synaptotagmin. We find that the DVGLUT-specific antibodies are valuable tools for the identification of motoneurons and ..
  53. Iyengar B, Chou C, Sharma A, Atwood H. Modular neuropile organization in the Drosophila larval brain facilitates identification and mapping of central neurons. J Comp Neurol. 2006;499:583-602 pubmed
    ..Thus, in the Drosophila larval brain, modular neuropiles can be used as a framework for systematically identifying, mapping, and classifying interneurons; understanding their roles in behavior can then be pursued further. ..
  54. Tamura T, Hou J, Reist N, Kidokoro Y. Nerve-evoked synchronous release and high K+ -induced quantal events are regulated separately by synaptotagmin I at Drosophila neuromuscular junctions. J Neurophysiol. 2007;97:540-9 pubmed
    The distal Ca(2+)-binding domain of synaptotagmin I (Syt I), C2B, has two Ca(2+)-binding sites...
  55. Busch S, Selcho M, Ito K, Tanimoto H. A map of octopaminergic neurons in the Drosophila brain. J Comp Neurol. 2009;513:643-67 pubmed publisher
    ..The map may provide an anatomical framework for the functional constitution of the octopaminergic system. It also serves as a model for the single-cell organization of a particular neurotransmitter in the brain. ..
  56. Littleton J, Bellen H, Perin M. Expression of synaptotagmin in Drosophila reveals transport and localization of synaptic vesicles to the synapse. Development. 1993;118:1077-88 pubmed
    b>Synaptotagmin is a synaptic vesicle-specific integral membrane protein that has been suggested to play a key role in synaptic vesicle docking and fusion...
  57. O Brien M, Taghert P. A peritracheal neuropeptide system in insects: release of myomodulin-like peptides at ecdysis. J Exp Biol. 1998;201:193-209 pubmed
    ..These data suggest that peritracheal cells release MM-like peptides as part of a conserved feature of the endocrine regulation of insect ecdysis. ..
  58. Nie Z, Ranjan R, Wenniger J, Hong S, Bronk P, Zinsmaier K. Overexpression of cysteine-string proteins in Drosophila reveals interactions with syntaxin. J Neurosci. 1999;19:10270-9 pubmed
  59. Koon A, Ashley J, Barria R, Dasgupta S, Brain R, Waddell S, et al. Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling. Nat Neurosci. 2011;14:190-9 pubmed publisher
    ..Our results provide a mechanism for global regulation of excitatory synapses, presumably to maintain synaptic and behavioral plasticity in a dynamic range. ..
  60. Christiansen F, Zube C, Andlauer T, Wichmann C, Fouquet W, Owald D, et al. Presynapses in Kenyon cell dendrites in the mushroom body calyx of Drosophila. J Neurosci. 2011;31:9696-707 pubmed publisher
    ..The newly identified KC-derived presynapses in the calyx are, inter alia, candidate sites for the formation of memory traces during olfactory learning. ..
  61. Gindhart J, Desai C, Beushausen S, Zinn K, Goldstein L. Kinesin light chains are essential for axonal transport in Drosophila. J Cell Biol. 1998;141:443-54 pubmed
    ..Cell 64:1093-1102; Hurd, D.D., and W.M. Saxton. 1996. Genetics 144: 1075-1085) mutant phenotypes indicates that KLC is essential for kinesin function, perhaps by tethering KHC to intracellular cargos or by activating the kinesin motor. ..
  62. Stowers R, Schwarz T. A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype. Genetics. 1999;152:1631-9 pubmed
    ..We illustrate the utility of the method by applying it to lethal mutations in the synaptic transmission genes synaptotagmin and syntaxin.
  63. Poskanzer K, Marek K, Sweeney S, Davis G. Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo. Nature. 2003;426:559-63 pubmed
    Neurotransmission requires a balance of synaptic vesicle exocytosis and endocytosis. Synaptotagmin I (Syt I) is widely regarded as the primary calcium sensor for synaptic vesicle exocytosis...
  64. Glater E, Megeath L, Stowers R, Schwarz T. Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent. J Cell Biol. 2006;173:545-57 pubmed
    ..Thus, milton and miro are likely to form an essential protein complex that links KHC to mitochondria for light chain-independent, anterograde transport of mitochondria. ..
  65. Davis G, Schuster C, Goodman C. Genetic analysis of the mechanisms controlling target selection: target-derived Fasciclin II regulates the pattern of synapse formation. Neuron. 1997;19:561-73 pubmed
    ..Changing the relative levels of Fas II on neighboring muscles leads to dramatic shifts in target selection. ..
  66. Stimson D, Estes P, Smith M, Kelly L, Ramaswami M. A product of the Drosophila stoned locus regulates neurotransmitter release. J Neurosci. 1998;18:9638-49 pubmed
    ..Remarkably, almost all phenotypes of stoned mutants are similar to those previously described for mutants of synaptotagmin, a protein postulated to regulate both exocytosis and the recycling of synaptic vesicles...
  67. Billeter J, Goodwin S. Characterization of Drosophila fruitless-gal4 transgenes reveals expression in male-specific fruitless neurons and innervation of male reproductive structures. J Comp Neurol. 2004;475:270-87 pubmed
  68. Rohrbough J, Rushton E, Woodruff E, Fergestad T, Vigneswaran K, Broadie K. Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation. Genes Dev. 2007;21:2607-28 pubmed
    ..These findings suggest that MTG is secreted from the presynaptic terminal to shape the extracellular synaptic cleft domain, and that the cleft domain functions to mediate transsynaptic signals required for post-synaptic development. ..
  69. Ting C, Herman T, Yonekura S, Gao S, Wang J, Serpe M, et al. Tiling of r7 axons in the Drosophila visual system is mediated both by transduction of an activin signal to the nucleus and by mutual repulsion. Neuron. 2007;56:793-806 pubmed
    ..We propose that dActivin is an autocrine signal that restricts R7 growth cone motility, and we demonstrate that it acts in parallel with a paracrine signal that mediates repulsion between R7 terminals. ..
  70. Jepson J, Savva Y, Yokose C, Sugden A, Sahin A, Reenan R. Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets. J Biol Chem. 2011;286:8325-37 pubmed publisher
    ..Our data demonstrate that network-wide temporal and spatial regulation of ADAR activity can tune the complex system of RNA-editing sites and modulate multiple ethologically relevant behavioral modalities. ..
  71. Davis G, Schuster C, Goodman C. Genetic dissection of structural and functional components of synaptic plasticity. III. CREB is necessary for presynaptic functional plasticity. Neuron. 1996;17:669-79 pubmed
    ..Expression of dCREB2-a in a FasII mutant background genetically reconstitutes this cAMP-dependent plasticity. Thus, cAMP initiates parallel changes in CREB and Fas II to achieve long-term synaptic enhancement. ..
  72. Hurd D, Saxton W. Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila. Genetics. 1996;144:1075-85 pubmed
    ..These phenotypes parallel the pathologies of some vertebrate motor neuron diseases, including some forms of amyotrophic lateral sclerosis (ALS), and suggest that impaired fast axonal transport is a key element in these diseases. ..
  73. Adolfsen B, Littleton J. Genetic and molecular analysis of the synaptotagmin family. Cell Mol Life Sci. 2001;58:393-402 pubmed
    ..It is within this local synaptic trafficking pathway that the synaptotagmin family of calcium-binding synaptic vesicle proteins has been postulated to function...
  74. Phillips A, Ramaswami M, Kelly L. Stoned. Traffic. 2010;11:16-24 pubmed publisher
    ..In this review, we examine the published literature on stoned and comment on the available data, conclusions from these analyses and how they may relate to alternative models of vesicle cycling. ..
  75. Maldonado C, Alicea D, Gonzalez M, Bykhovskaia M, Marie B. Adar is essential for optimal presynaptic function. Mol Cell Neurosci. 2013;52:173-80 pubmed publisher
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