Gene Symbol: sun
Alias: ATP5E, ATPE, ATPsynepsilon, BcDNA:RE19513, BcDNA:RH48911, CG9032, Dmel\CG9032, Sun, l(1)13Fe, l(1)XV, stunted, ATP synthase epsilon chain, ATP synthase, epsilon subunit, CG9032-PA, CG9032-PB, F0/F1 ATP synthase epsilon, sun-PA, sun-PB
Species: fruit fly
Balaban R, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005;120:483-95 pubmed
..Here we review the evidence that both supports and conflicts with the free radical theory and examine the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging. ..
Kidd T, Abu Shumays R, Katzen A, Sisson J, Jiménez G, Pinchin S, et al
. The epsilon-subunit of mitochondrial ATP synthase is required for normal spindle orientation during the Drosophila embryonic divisions. Genetics. 2005;170:697-708 pubmed
..phenotypes of null mutations in the Drosophila gene for the epsilon-subunit of mitochondrial ATP synthase, stunted (sun)...
Ja W, Carvalho G, Madrigal M, Roberts R, Benzer S. The Drosophila G protein-coupled receptor, Methuselah, exhibits a promiscuous response to peptides. Protein Sci. 2009;18:2203-8 pubmed publisher
..Previously, Stunted (Sun) was identified as a peptide agonist of Mth...
Aspden J, Eyre Walker Y, Phillips R, Amin U, Mumtaz M, Brocard M, et al
. Extensive translation of small Open Reading Frames revealed by Poly-Ribo-Seq. elife. 2014;3:e03528 pubmed publisher
..Our findings indicate that thousands of smORFs are translated in metazoan genomes, reinforcing the idea that smORFs are an abundant and fundamental genome component. ..
Katzen A, Bishop J. myb provides an essential function during Drosophila development. Proc Natl Acad Sci U S A. 1996;93:13955-60 pubmed
..Examination of the mutant phenotype revealed that Drosophila myb is important for both embryonic and imaginal development and that myb serves a role in the development of many tissues and during oogenesis. ..
Cvejic S, Zhu Z, Felice S, Berman Y, Huang X. The endogenous ligand Stunted of the GPCR Methuselah extends lifespan in Drosophila. Nat Cell Biol. 2004;6:540-6 pubmed
..we report the identification and characterization of two endogenous peptide ligands of Methuselah, designated Stunted A and B...
Teixeira F, Sanchez C, Hurd T, Seifert J, Czech B, Preall J, et al
. ATP synthase promotes germ cell differentiation independent of oxidative phosphorylation. Nat Cell Biol. 2015;17:689-96 pubmed publisher
..Taken together, our results suggest that ATP synthase-dependent crista maturation is a key developmental process required for differentiation independent of oxidative phosphorylation. ..
Delanoue R, Meschi E, Agrawal N, Mauri A, Tsatskis Y, McNeill H, et al
. Drosophila insulin release is triggered by adipose Stunted ligand to brain Methuselah receptor. Science. 2016;353:1553-1556 pubmed
..We further show, using genetic and ex vivo organ culture experiments, that the Mth ligand Stunted (Sun) is a circulating insulinotropic peptide produced by fat cells...