Gene Symbol: sub
Description: subito
Alias: CG12298, DmKlp54E, DmSub, Dmel\CG12298, Dub, KIF 20A, KIF20A/B, Mklp2, SUB, Sub, mei-1794, subito, CG12298-PA, CG12298-PB, Kinesin_A, double or nothing, double-or-nothing, sub-PA, sub-PB
Species: fruit fly

Top Publications

  1. Swan A, Schupbach T. The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila. Development. 2007;134:891-9 pubmed
  2. Das A, Shah S, Fan B, Paik D, DiSanto D, Hinman A, et al. Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes. Genetics. 2016;202:61-75 pubmed publisher
    ..The Drosophila kinesin-6 protein Subito, although nonessential for mitotic spindle assembly, is required to organize a bipolar meiotic spindle and ..
  3. Afonso O, Matos I, Pereira A, Aguiar P, Lampson M, Maiato H. Feedback control of chromosome separation by a midzone Aurora B gradient. Science. 2014;345:332-336 pubmed publisher
    ..This allows the correction and reintegration of lagging chromosomes in the main nuclei before completion of NER...
  4. Mohr S, Gelbart W. Using the P[wHy] hybrid transposable element to disrupt genes in region 54D-55B in Drosophila melanogaster. Genetics. 2002;162:165-76 pubmed
    ..Thus, the P[wHy] method provides an efficient method for systematically determining the phenotypes of genes in a given region of the fly genome. ..
  5. Ji J, Crest J, Schubiger G. Genetic interactions between Cdk1-CyclinB and the Separase complex in Drosophila. Development. 2005;132:1875-84 pubmed
  6. Radford S, Hoang T, GÅ‚uszek A, Ohkura H, McKim K. Lateral and End-On Kinetochore Attachments Are Coordinated to Achieve Bi-orientation in Drosophila Oocytes. PLoS Genet. 2015;11:e1005605 pubmed publisher
    ..Together, these results demonstrate that, in oocytes, kinetochore-dependent and -independent chromosome-microtubule attachments work together to promote the accurate segregation of chromosomes. ..
  7. Puerma E, Orengo D, Aguade M. Evidence for a gene involved in multiple and diverse rearrangements in the Drosophila genus. Mol Biol Evol. 2014;31:2998-3001 pubmed publisher
    ..The level of reorganization and the evidence for breakpoint reuse vary both between and within elements. The subito gene stands out as a gene involved in multiple rearrangements both because of its active single-gene transposition ..
  8. Radford S, Jang J, McKim K. The chromosomal passenger complex is required for meiotic acentrosomal spindle assembly and chromosome biorientation. Genetics. 2012;192:417-29 pubmed publisher
    ..Furthermore, chromosome biorientation and the localization of the central spindle kinesin-6 protein Subito, which is required for spindle bipolarity, depend on the CPC components Aurora B and Incenp...
  9. Dagenbach E, Endow S. A new kinesin tree. J Cell Sci. 2004;117:3-7 pubmed

More Information


  1. Carpenter A. Chiasma function. Cell. 1994;77:957-62 pubmed
  2. Cesario J, McKim K. RanGTP is required for meiotic spindle organization and the initiation of embryonic development in Drosophila. J Cell Sci. 2011;124:3797-810 pubmed publisher
    ..Around the chromosomes, however, RanGTP might be redundant with other factors such as the chromosome passenger complex. ..
  3. Colombié N, Cullen C, Brittle A, Jang J, Earnshaw W, Carmena M, et al. Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis. Development. 2008;135:3239-46 pubmed publisher
    ..Our analysis suggests that Subito, a kinesin-6 protein, cooperates with Incenp for this latter function, but not in microtubule assembly...
  4. Jang J, Rahman T, Kober V, Cesario J, McKim K. Misregulation of the kinesin-like protein Subito induces meiotic spindle formation in the absence of chromosomes and centrosomes. Genetics. 2007;177:267-80 pubmed
    ..An important contributor to this process is Subito, which is a kinesin-6 protein that is required for bundling interpolar microtubules located within the central ..
  5. Jang J, Rahman T, McKim K. The kinesinlike protein Subito contributes to central spindle assembly and organization of the meiotic spindle in Drosophila oocytes. Mol Biol Cell. 2005;16:4684-94 pubmed
    ..b>Subito mutants are characterized by the formation of tripolar or monopolar spindles and nondisjunction of homologous ..
  6. Hirai K, Toyohira S, Ohsako T, Yamamoto M. Isolation and cytogenetic characterization of male meiotic mutants of Drosophila melanogaster. Genetics. 2004;166:1795-806 pubmed
    ..mei(2)yh92 predominantly induced nondisjunction at meiosis I that appeared to be the consequence of failure of the separation of paired homologous chromosomes...
  7. Philip A. Mitotic sister-chromatid separation: what Drosophila mutants can tell us. Trends Cell Biol. 1998;8:150 pubmed
  8. Williams B, Gatti M, Goldberg M. Bipolar spindle attachments affect redistributions of ZW10, a Drosophila centromere/kinetochore component required for accurate chromosome segregation. J Cell Biol. 1996;134:1127-40 pubmed
    ..We propose that ZW10 acts as part of, or immediately downstream of, a tension-sensing mechanism that regulates chromosome separation or movement at anaphase onset. ..
  9. Orr Weaver T. Meiosis in Drosophila: seeing is believing. Proc Natl Acad Sci U S A. 1995;92:10443-9 pubmed
    ..Additional advances in understanding Drosophila meiosis are the delineation of a functional centromere by using minichromosome derivatives and the identification of several regulatory genes for the meiotic cell cycle. ..
  10. Radford S, Harrison A, McKim K. Microtubule-depolymerizing kinesin KLP10A restricts the length of the acentrosomal meiotic spindle in Drosophila females. Genetics. 2012;192:431-40 pubmed publisher
  11. Wu C, Singaram V, McKim K. mei-38 is required for chromosome segregation during meiosis in Drosophila females. Genetics. 2008;180:61-72 pubmed publisher
    ..We suggest MEI-38 is required for the stability of parallel microtubules, including the kinetochore microtubules. ..
  12. Barth T, Schade G, Schmidt A, Vetter I, Wirth M, Heun P, et al. Identification of novel Drosophila centromere-associated proteins. Proteomics. 2014;14:2167-78 pubmed publisher
    ..All MS data have been deposited in the ProteomeXchange with identifier PXD000758 ( ..
  13. Cesario J, Jang J, Redding B, Shah N, Rahman T, McKim K. Kinesin 6 family member Subito participates in mitotic spindle assembly and interacts with mitotic regulators. J Cell Sci. 2006;119:4770-80 pubmed
    Drosophila Subito is a kinesin 6 family member and ortholog of mitotic kinesin-like protein (MKLP2) in mammalian cells...
  14. Giunta K, Jang J, Manheim E, Subramanian G, McKim K. subito encodes a kinesin-like protein required for meiotic spindle pole formation in Drosophila melanogaster. Genetics. 2002;160:1489-501 pubmed
    ..We have identified a second Drosophila kinesin-like protein, SUB, that is required for meiotic spindle function...
  15. Moore D, Miyazaki W, Tomkiel J, Orr Weaver T. Double or nothing: a Drosophila mutation affecting meiotic chromosome segregation in both females and males. Genetics. 1994;136:953-64 pubmed
    We describe a Drosophila mutation, Double or nothing (Dub), that causes meiotic nondisjunction in a conditional, dominant manner...
  16. Tomkiel J. Chromosomally-induced meiotic drive in Drosophila males: checkpoint or fallout?. Genetica. 2000;109:95-103 pubmed
    ..We discuss how this hypothesis may account for previously described examples chromosomal causes of meiotic drive and sterility in Drosophila. ..