Su(var)205

Summary

Gene Symbol: Su(var)205
Description: Suppressor of variegation 205
Alias: CBX5, CG8409, DmHP-1, DmHP1, Dmel\CG8409, E(var)29, E(var)29A, FBgn0003607, HP-1, HP1, HP1-VS, HP1A, HP1a, HP1alpha, Hp1, Hp1a, SU(VAR)205, Su(Var)2-5, Su(var), Su(var)2-05, Su(var)2-5, Su(var)2-501, Su(var)29A, Su(var)[205], Su-var(2)5, Su[Var]205, Su[var]205, Suvar(2)5, Suvar2-5, dHP-1a, dHP1, hp1, hp1a, su(var)205, C1A9-nuclear-antigen, CG8409-PA, CG8409-PB, Su(var)2-5, Su(var)205-PA, Su(var)205-PB, heterochromatic protein, heterochromatic protein 1a, heterochromatin protein 1, heterochromatin protein 1A, heterochromatin protein-1, heterochromatin-binding protein, heterochromatin-protein-1, histone protein 1, suppressor of variegation 205
Species: fruit fly

Top Publications

  1. pmc Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome
    Michaela Schwaiger
    Friedrich Miescher Institute for Biomedical Research, CH 4058 Basel, Switzerland
    Genome Res 20:771-80. 2010
  2. pmc Plasticity in patterns of histone modifications and chromosomal proteins in Drosophila heterochromatin
    Nicole C Riddle
    Department of Biology, Washington University St Louis, Missouri 63130, USA
    Genome Res 21:147-63. 2011
  3. pmc HP1 recruitment in the absence of argonaute proteins in Drosophila
    Nellie Moshkovich
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 6:e1000880. 2010
  4. pmc A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster
    Hang Yin
    Yale Stem Cell Center and Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut, United States of America
    PLoS Genet 7:e1002380. 2011
  5. doi Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2
    Sameer Phalke
    Institute of Biology, Developmental Genetics, Martin Luther University Halle, Halle, Germany
    Nat Genet 41:696-702. 2009
  6. ncbi The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in Drosophila
    Weiguo Zhang
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
    Development 133:229-35. 2006
  7. pmc POF and HP1 bind expressed exons, suggesting a balancing mechanism for gene regulation
    Anna Mia Johansson
    Umeå Center for Molecular Pathogens, Umea University, Umea, Sweden
    PLoS Genet 3:e209. 2007
  8. pmc High-resolution mapping reveals links of HP1 with active and inactive chromatin components
    Elzo de Wit
    Department of Molecular Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    PLoS Genet 3:e38. 2007
  9. pmc Heterochromatic silencing of Drosophila heat shock genes acts at the level of promoter potentiation
    D E Cryderman
    Department of Biochemistry, 4 772 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USA
    Nucleic Acids Res 27:3364-70. 1999
  10. pmc Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster
    Anna Mia Johansson
    UCMP, Umea University, Umea, Sweden
    EMBO J 26:2307-16. 2007

Research Grants

  1. DOSAGE COMPENSATION IN DROSOPHILA
    James Birchler; Fiscal Year: 2006
  2. DOSAGE COMPENSATION IN DROSOPHILA
    James A Birchler; Fiscal Year: 2010
  3. Regulation of chromatin structure and gene expression
    KRISTEN JOHANSEN; Fiscal Year: 2007
  4. Olfactory Genes in Mosquitoes
    Harald Biessmann; Fiscal Year: 2007
  5. INTERDISCIPLINARY TRAINING IN DEVELOPMENTAL BIOLOGY
    Barbara Wakimoto; Fiscal Year: 2007
  6. Mechanism of Meiotic Pairing in Drosophila
    Bruce D McKee; Fiscal Year: 2010
  7. Olfactory Genes in Mosquitoes
    Harald Biessmann; Fiscal Year: 2006
  8. MECHANISMS OF GENE SILENCING
    Lori Wallrath; Fiscal Year: 2005
  9. Mechanism of Meiotic Pairing in Drosophila
    BRUCE MCKEE; Fiscal Year: 2005
  10. MECHANISMS OF GENE SILENCING
    Lori Wallrath; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications145 found, 100 shown here

  1. pmc Heterochromatin protein 1 (HP1) modulates replication timing of the Drosophila genome
    Michaela Schwaiger
    Friedrich Miescher Institute for Biomedical Research, CH 4058 Basel, Switzerland
    Genome Res 20:771-80. 2010
    ..To gain insights into this question, we have studied the function of heterochromatin protein 1 (HP1), which is a reader of repressive methylation at histone H3 lysine 9, in genome-wide organization ..
  2. pmc Plasticity in patterns of histone modifications and chromosomal proteins in Drosophila heterochromatin
    Nicole C Riddle
    Department of Biology, Washington University St Louis, Missouri 63130, USA
    Genome Res 21:147-63. 2011
    ..pericentric heterochromatin and chromosome 4 are on average enriched for the "silencing" marks H3K9me2, H3K9me3, HP1a, and SU(VAR)3-9, and are generally depleted for marks associated with active transcription...
  3. pmc HP1 recruitment in the absence of argonaute proteins in Drosophila
    Nellie Moshkovich
    Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS Genet 6:e1000880. 2010
    ..we utilized transcriptional reporters and chromatin immunoprecipitation of the critical factor Heterochromatin Protein 1 (HP1) to monitor the heterochromatic state of piRNA clusters, which generate both endo-siRNAs and the ..
  4. pmc A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster
    Hang Yin
    Yale Stem Cell Center and Department of Cell Biology, Yale School of Medicine, New Haven, Connecticut, United States of America
    PLoS Genet 7:e1002380. 2011
    ..and its use to construct a high-resolution map of the Drosophila melanogaster key histone marks, heterochromatin protein 1a (HP1a) and RNA polymerase II (polII)...
  5. doi Retrotransposon silencing and telomere integrity in somatic cells of Drosophila depends on the cytosine-5 methyltransferase DNMT2
    Sameer Phalke
    Institute of Biology, Developmental Genetics, Martin Luther University Halle, Halle, Germany
    Nat Genet 41:696-702. 2009
    ..Together, these results demonstrate a previously unappreciated role of DNA methylation in retrotransposon silencing and telomere integrity in Drosophila...
  6. ncbi The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in Drosophila
    Weiguo Zhang
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
    Development 133:229-35. 2006
    ..of the JIL-1 histone H3S10 kinase results in the spreading of the major heterochromatin markers dimethyl H3K9 and HP1 to ectopic locations on the chromosome arms, with the most pronounced increase on the X chromosomes...
  7. pmc POF and HP1 bind expressed exons, suggesting a balancing mechanism for gene regulation
    Anna Mia Johansson
    Umeå Center for Molecular Pathogens, Umea University, Umea, Sweden
    PLoS Genet 3:e209. 2007
    ..fourth chromosome is specifically targeted by the Painting of Fourth (POF) protein, which, together with heterochromatin protein 1 (HP1), modulates the expression level of genes on the fourth chromosome...
  8. pmc High-resolution mapping reveals links of HP1 with active and inactive chromatin components
    Elzo de Wit
    Department of Molecular Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    PLoS Genet 3:e38. 2007
    b>Heterochromatin protein 1 (HP1) is commonly seen as a key factor of repressive heterochromatin, even though a few genes are known to require HP1-chromatin for their expression...
  9. pmc Heterochromatic silencing of Drosophila heat shock genes acts at the level of promoter potentiation
    D E Cryderman
    Department of Biochemistry, 4 772 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USA
    Nucleic Acids Res 27:3364-70. 1999
    ..These transgenes exhibit silencing that is partially suppressed by mutations in the gene encoding HP1. Micrococcal nuclease analysis revealed that the heterochromatic transgenes were packaged in a more regular ..
  10. pmc Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster
    Anna Mia Johansson
    UCMP, Umea University, Umea, Sweden
    EMBO J 26:2307-16. 2007
    ..Here we show that POF and heterochromatin protein 1 (HP1) are involved in the global regulation of the 4th chromosome...
  11. doi Telomere capping in Drosophila: dealing with chromosome ends that most resemble DNA breaks
    Yikang S Rong
    Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Chromosoma 117:235-42. 2008
    ..I review recent progress in Drosophila telomere studies, and challenge the notion that Drosophila may not be a relevant model for the study of telomere maintenance...
  12. ncbi Heterochromatin protein 1 binds transgene arrays
    L Fanti
    Istituto di Genetica, Universita di Bari, I 70126 Bari, Italy
    Chromosoma 107:286-92. 1998
    b>Heterochromatin protein 1 (HP1) of Drosophila and its homologs in vertebrates are key components of constitutive heterochromatin...
  13. pmc Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase
    Chia Hui Lin
    Stowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA
    Mol Cell 32:696-706. 2008
    ..Affinity purification and mass spectrometry analysis revealed that heterochromatin protein 1a (HP1a) associates with dKDMA4A...
  14. pmc Drosophila heterochromatin protein 1 (HP1)/origin recognition complex (ORC) protein is associated with HP1 and ORC and functions in heterochromatin-induced silencing
    M M Shareef
    School of Biological Sciences, University of Kentucky, Lexington, Kentucky 40506 0225, USA
    Mol Biol Cell 12:1671-85. 2001
    b>Heterochromatin protein 1 (HP1) is a conserved component of the highly compact chromatin of higher eukaryotic centromeres and telomeres...
  15. ncbi An epigenetic activation role of Piwi and a Piwi-associated piRNA in Drosophila melanogaster
    Hang Yin
    Department of Cell Biology, Duke University Medical School, Durham, North Carolina 27710, USA
    Nature 450:304-8. 2007
    ..3R-TAS loses euchromatic histone modifications yet accumulates heterochromatic histone modifications and Heterochromatin Protein 1a (HP1a)...
  16. pmc Drosophila PIWI associates with chromatin and interacts directly with HP1a
    Brent Brower-Toland
    Department of Biology, Washington University, Saint Louis, MO 63130, USA
    Genes Dev 21:2300-11. 2007
    ..family member that binds to Piwi-interacting RNAs (piRNAs), strongly and specifically interacts with heterochromatin protein 1a (HP1a), a central player in heterochromatic gene silencing...
  17. ncbi Heterochromatin protein 1 distribution during development and during the cell cycle in Drosophila embryos
    R Kellum
    Department of Biochemistry and Biophysics, University of California at San Francisco 94143 0448, USA
    J Cell Sci 108:1407-18. 1995
    b>Heterochromatin protein 1 (HP1) was initially discovered as a protein that is associated with the heterochromatin at the chromocenter of polytene chromosomes in Drosophila larval salivary glands...
  18. ncbi The Drosophila HOAP protein is required for telomere capping
    Giovanni Cenci
    Dipartimento di Genetica e Biologia Molecolare, Universita di Roma La Sapienza, 00185 Rome, Italy
    Nat Cell Biol 5:82-4. 2003
    ..been isolated from Drosophila melanogaster embryos as part of a cytoplasmic complex that contains heterochromatin protein 1 (HP1) and the origin recognition complex subunit 2 (ORC2)...
  19. pmc Reduced levels of Su(var)3-9 but not Su(var)2-5 (HP1) counteract the effects on chromatin structure and viability in loss-of-function mutants of the JIL-1 histone H3S10 kinase
    Huai Deng
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
    Genetics 177:79-87. 2007
    ..In the absence of JIL-1 kinase activity, the major heterochromatin markers histone H3K9me2 and HP1 spread in tandem to ectopic locations on the chromosome arms...
  20. pmc Central role of Drosophila SU(VAR)3-9 in histone H3-K9 methylation and heterochromatic gene silencing
    Gunnar Schotta
    Institute of Genetics, Biologicum, Martin Luther University Halle, Weinbergweg 10, D 06120 Halle, Germany
    EMBO J 21:1121-31. 2002
    ..SU (VAR)3-9 interacts with the heterochromatin-associated HP1 protein and with another silencing factor, SU(VAR)3-7...
  21. pmc A genetic and molecular characterization of two proximal heterochromatic genes on chromosome 3 of Drosophila melanogaster
    Sandra R Schulze
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada
    Genetics 169:2165-77. 2005
    ..Its expression appears to be compromised in a genetic background deficient for heterochromatin protein 1 (HP1), a protein associated with gene silencing in these regions...
  22. pmc A balance between euchromatic (JIL-1) and heterochromatic [SU(var)2-5 and SU(var)3-9] factors regulates position-effect variegation in Drosophila
    Chao Wang
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
    Genetics 188:745-8. 2011
    ....
  23. pmc Polycomb group-dependent, heterochromatin protein 1-independent, chromatin structures silence retrotransposons in somatic tissues outside ovaries
    J Dufourt
    Clermont Universite, Universite d Auvergne, France
    DNA Res 18:451-61. 2011
    ..We identified the Polycomb repressive complexes (PRC1 and 2), but not heterochromatin protein 1 to be necessary factors for silencing...
  24. pmc The HP1a disordered C terminus and chromo shadow domain cooperate to select target peptide partners
    Deanna L Mendez
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Chembiochem 12:1084-96. 2011
    Drosophila melanogaster heterochromatin protein 1a (HP1a) is essential for compacted heterochromatin structure and the associated gene silencing...
  25. pmc Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression
    Marc Lavigne
    Institut Pasteur, Departement de Biologie du Developpement, Unité de Recherche Associée URA2578 du Centre National de la Recherche Scientifique CNRS, Unité de Régulation Epigénétique, équipe AVENIR de l Institut National de la Santé Et de la Recherche Médicale INSERM, Paris, France
    PLoS Genet 5:e1000769. 2009
    The heterochromatin-enriched HP1 proteins play a critical role in regulation of transcription. These proteins contain two related domains known as the chromo- and the chromoshadow-domain...
  26. pmc HP1a recruitment to promoters is independent of H3K9 methylation in Drosophila melanogaster
    Margarida L A Figueiredo
    Department of Molecular Biology, Umea University, Umea, Sweden
    PLoS Genet 8:e1003061. 2012
    b>Heterochromatin protein 1 (HP1) proteins, recognized readers of the heterochromatin mark methylation of histone H3 lysine 9 (H3K9me), are important regulators of heterochromatin-mediated gene silencing and chromosome structure...
  27. pmc Heterochromatin protein 1 (HP1) connects the FACT histone chaperone complex to the phosphorylated CTD of RNA polymerase II
    So Hee Kwon
    Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA
    Genes Dev 24:2133-45. 2010
    b>Heterochromatin protein 1 (HP1) is well known as a silencing protein found at pericentric heterochromatin. Most eukaryotes have at least three isoforms of HP1 that play differential roles in heterochromatin and euchromatin...
  28. pmc Domains of heterochromatin protein 1 required for Drosophila melanogaster heterochromatin spreading
    Karrie A Hines
    Department of Biochemistry, University of Iowa, Iowa City, 52242, USA
    Genetics 182:967-77. 2009
    ..A heterochromatin protein 1 (HP1) tethering system was developed that generates "ectopic heterochromatin" at sites within ..
  29. pmc Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability
    Song Shi
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Nat Cell Biol 10:489-96. 2008
    ..Here, we demonstrate that Drosophila STAT (STAT92E) is involved in controlling heterochromatin protein 1 (HP1) distribution and heterochromatin stability...
  30. pmc Telomere elongation (Tel), a new mutation in Drosophila melanogaster that produces long telomeres
    Giorgia M Siriaco
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Genetica e Biologia Molecolare, Universita di Roma La Sapienza, Rome, Italy
    Genetics 160:235-45. 2002
    ..Associations between metaphase chromosomes are resolved during anaphase, suggesting that they are mediated by either proteinaceous links or DNA hydrogen bonding, rather than covalent DNA-DNA bonds...
  31. pmc Multiple SET methyltransferases are required to maintain normal heterochromatin domains in the genome of Drosophila melanogaster
    Brent Brower-Toland
    Department of Biology, Washington University, St Louis, MO 63130, USA
    Genetics 181:1303-19. 2009
    ..is a key feature of silent chromatin and plays an important role in stabilizing the interaction of heterochromatin protein 1 (HP1) with chromatin...
  32. ncbi Heterochromatin and gene regulation in Drosophila
    S C Elgin
    Washington University, Department of Biology, St Louis, Missouri 63130, USA
    Curr Opin Genet Dev 6:193-202. 1996
    ..The current data support a competition/chromatin structure model, in which multiprotein repressor complexes compete with transcriptional activators to assemble an active or inactive chromatin structure...
  33. ncbi Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila
    Nicholas J Brideau
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USA
    Science 314:1292-5. 2006
    ..Rapidly evolving heterochromatic DNA sequences may be driving the evolution of this incompatibility gene...
  34. ncbi Heterochromatin protein 1 interacts with 5'UTR of transposable element ZAM in a sequence-specific fashion
    Crescenzio Francesco Minervini
    Dipartimento di Genetica e Microbiologia, Universita di Bari, 70126 Bari, Italy
    Gene 393:1-10. 2007
    ..Here we provide evidence that a similar interaction should occur between ZAM, a gypsy-like element, and HP1, one of the most extensively studied chromatin proteins...
  35. pmc The effect of modifiers of position-effect variegation on the variegation of heterochromatic genes of Drosophila melanogaster
    M G Hearn
    Department of Genetics, University of Washington, Seattle 98195
    Genetics 128:785-97. 1991
    ..We conclude that these heterochromatic genes have fundamentally different regulatory requirements compared to those typical of euchromatic genes...
  36. pmc Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development
    Carmen M Koch
    Abteilung Stammzellbiologie, DFG Research Center for Molecular Physiology of the Brain CMPB, Georg August Universitat Gottingen, Gottingen, Germany
    PLoS Genet 5:e1000644. 2009
    ..3 lysine 9 (H3K9me3) leads to chromatin silencing and the formation of heterochromatin by recruitment of heterochromatin protein 1 (HP1)...
  37. ncbi The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3
    Ru Cao
    Department of Biochemistry and Biophysics, Curriculum in Genetics and Molecular Biology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, NC 27599 7295, USA
    Curr Opin Genet Dev 14:155-64. 2004
    ....
  38. ncbi The genetics of position-effect variegation modifying loci in Drosophila melanogaster
    G Wustmann
    Department of Genetics, Martin Luther University Halle, DDR
    Mol Gen Genet 217:520-7. 1989
    ..Most of these loci proved not to display significant triplo-effects (35). The group of haplo-abnormal loci with a triplo-effect may represent genes which play an important role in heterochromatin packaging...
  39. pmc Functional conservation of the Drosophila hybrid incompatibility gene Lhr
    Nicholas J Brideau
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14850, USA
    BMC Evol Biol 11:57. 2011
    ..simulans males. Previous genetic analyses showed that hybrid lethality is caused by D. simulans Lhr but not by D. melanogaster Lhr, confirming a critical prediction of asymmetry in the evolution of a hybrid incompatibility gene...
  40. pmc Enrichment of HP1a on Drosophila chromosome 4 genes creates an alternate chromatin structure critical for regulation in this heterochromatic domain
    Nicole C Riddle
    Department of Biology, Washington University in St Louis, St Louis, Missouri, United States of America
    PLoS Genet 8:e1002954. 2012
    ..pericentric heterochromatin: while there is a depletion of silencing marks at the transcription start sites (TSSs), HP1a and H3K9me3, but not H3K9me2, are enriched strongly over gene bodies...
  41. ncbi Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes
    D T Pak
    Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA
    Cell 91:311-23. 1997
    ..b>HP1, a heterochromatin-localized protein required for position effect variegation (PEV), colocalized with DmORC2 at ..
  42. ncbi Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery
    Manika Pal-Bhadra
    Division of Biological Sciences, 117 Tucker Hall, University of Missouri, Columbia, MO 65211, USA
    Science 303:669-72. 2004
    ..resulting in suppression of PEV have identified critical components of heterochromatin, including proteins HP1, HP2, and histone H3 lysine 9 methyltransferase...
  43. ncbi A heat shock-activated cDNA rescues the recessive lethality of mutations in the heterochromatin-associated protein HP1 of Drosophila melanogaster
    J C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, MO 63104 1079
    Mol Gen Genet 240:333-8. 1993
    b>HP1 is a small nonhistone chromosomal protein of Drosophila melanogaster predominantly localized to the pericentric heterochromatin...
  44. pmc Repeat-associated siRNAs cause chromatin silencing of retrotransposons in the Drosophila melanogaster germline
    Mikhail S Klenov
    Department of Molecular Genetics of Cell, Institute of Molecular Genetics, Russian Academy of Sciences, Moscow 123182, Russia
    Nucleic Acids Res 35:5430-8. 2007
    ..The spn-E mutation also causes depletion of HP1 content in the chromatin of transposable elements, especially along HeT-A arrays...
  45. pmc Epigenetic regulation of the Drosophila chromosome 4 by the histone H3K9 methyltransferase dSETDB1
    Tsai Yu Tzeng
    Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 115, Taiwan
    Proc Natl Acad Sci U S A 104:12691-6. 2007
    ..lysine 9 of histone H3 (H3K9) methylation of the chromocenter and consequent binding of the heterochromatin-protein HP1, the enzyme for painting of the fourth chromosome by H3K9 methylation has been elusive...
  46. pmc The role of Drosophila CID in kinetochore formation, cell-cycle progression and heterochromatin interactions
    M D Blower
    Molecular and Cell Biology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Cell Biol 3:730-9. 2001
    ..MEI-S332), centric condensation (PROD), kinetochore function (ROD, ZW10 and BUB1) and heterochromatin structure (HP1). CID localization is unaffected by mutations in mei-S332, Su(var)2-5 (HP1), prod or polo...
  47. pmc Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3
    S A Jacobs
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908, USA
    EMBO J 20:5232-41. 2001
    Recent studies show that heterochromatin-associated protein-1 (HP1) recognizes a 'histone code' involving methylated Lys9 (methyl-K9) in histone H3...
  48. pmc JAK signaling globally counteracts heterochromatic gene silencing
    Song Shi
    Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA
    Nat Genet 38:1071-6. 2006
    ..Moreover, mutations in the genes encoding heterochromatin components heterochromatin protein 1 (HP1) and Su(var)3-9 enhance tumorigenesis induced by an oncogenic JAK kinase without affecting JAK/STAT ..
  49. ncbi Position-effect variegation and the new biology of heterochromatin
    G H Karpen
    Molecular Biology and Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037 1099
    Curr Opin Genet Dev 4:281-91. 1994
    ..Investigations published within the past few years demonstrate that position-effect variegation is caused by multiple mechanisms, and that direct tests of hypotheses are possible with numerous model systems...
  50. pmc HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner
    Guanjun Gao
    LBMB, NCI, NIH, Bethesda, MD 20892, USA
    EMBO J 29:819-29. 2010
    ..To better understand this sequence-independent capping mechanism, we isolated proteins that interact with the HP1/ORC-associated protein (HOAP) capping protein, and identified HipHop as a subunit of the complex...
  51. pmc The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila
    R Paro
    Zentrum fur Molekulare Biologie, Universitat Heidelberg, Federal Republic of Germany
    Proc Natl Acad Sci U S A 88:263-7. 1991
    ..The deduced sequence of the Pc protein exhibits a homology to the heterochromatin-associated protein HP1 encoded by the suppressor of position effect variegation gene Su(var) 205...
  52. ncbi HP1 controls telomere capping, telomere elongation, and telomere silencing by two different mechanisms in Drosophila
    Barbara Perrini
    Fondazione Cenci Bolognetti and Dipartimento, di Genetica e Biologia Molecolare, Universita La Sapienza, 00185 Roma, Italy
    Mol Cell 15:467-76. 2004
    b>HP1 is a conserved chromosomal protein, first discovered in Drosophila, which is predominantly associated with the heterochromatin of many organisms...
  53. ncbi Role of Drosophila HP1 in euchromatic gene expression
    Diane E Cryderman
    Department of Biochemistry, University of Iowa, Iowa City, Iowa 52242, USA
    Dev Dyn 232:767-74. 2005
    b>Heterochromatin protein 1 (HP1), a gene silencing protein, localizes to centric heterochromatin through an interaction with methylated K9 of histone H3, a modification generated by the histone methyl transferase SU(VAR)3-9...
  54. ncbi Distribution patterns of HP1, a heterochromatin-associated nonhistone chromosomal protein of Drosophila
    T C James
    Department of Biology, Washington University, St Louis, MO 63130
    Eur J Cell Biol 50:170-80. 1989
    We have previously reported the identification of a nonhistone chromosomal protein (nhcp-19; now called HP1) preferentially associated with the heterochromatin of Drosophila melanogaster...
  55. pmc Drosophila SETDB1 is required for chromosome 4 silencing
    Carole Seum
    Department of Zoology and Animal Biology, University of Geneva, Geneva, Switzerland
    PLoS Genet 3:e76. 2007
    ..This study defines DmSETDB1 as a H3K9 methyltransferase that specifically targets euchromatin and the autosomal Chromosome 4 and shows that it is an essential factor for Chromosome 4 silencing...
  56. pmc Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential
    M S Lechner
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 20:6449-65. 2000
    ..repression requires binding to the KAP-1 corepressor, which in turn recruits members of the heterochromatin protein 1 (HP1) family...
  57. pmc Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation
    Thibaut Josse
    Laboratoire Dynamique du Genome et Evolution, Institut Jacques Monod, Paris, France
    PLoS Genet 3:1633-43. 2007
    ..silencing is highly sensitive to mutations affecting both heterochromatin formation (Su(var)205 encoding Heterochromatin Protein 1 and Su(var)3-7) and the repeat-associated small interfering RNA (or rasiRNA) silencing pathway (..
  58. ncbi HP1/ORC complex and heterochromatin assembly
    Mohammed M Shareef
    School of Biological Sciences, 101 T H Morgan Building, University of Kentucky, Lexington, KY 40506, USA
    Genetica 117:127-34. 2003
    We have used the highly conserved heterochromatin component, heterochromatin protein 1 (HP1), as a molecular tag for purifying other protein components of Drosophila heterochromatin...
  59. ncbi Genetic modification of heterochromatic association and nuclear organization in Drosophila
    A K Csink
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Nature 381:529-31. 1996
    ..This suggests that heterochromatin and proteins involved in its formation provide a structural framework for the interphase nucleus...
  60. ncbi Beyond the nucleosome: epigenetic aspects of position-effect variegation in Drosophila
    B T Wakimoto
    Department of Zoology, University of Washington, Seattle 98195, USA
    Cell 93:321-4. 1998
  61. pmc Transcription and RNA interference in the formation of heterochromatin
    Shiv I S Grewal
    Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 447:399-406. 2007
    ..Silencing of chromatin might involve trans-acting sources of the crucial small RNAs that carry out RNA interference, but in some cases, transcription of the region to be silenced seems to be required--an apparent contradiction...
  62. ncbi Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation
    Shinichi Osouda
    Department of Chemistry, Faculty of Science, Niigata University, Niigata 950 2181, Japan
    Dev Biol 284:219-32. 2005
    ..In contrast, both gonadal and CNS tissues exhibited underdevelopment...
  63. pmc Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline
    Alla I Kalmykova
    Institute of Molecular Genetics RAS Kurchatov square 2, 123 182 Moscow, Russia
    Nucleic Acids Res 33:2052-9. 2005
    ..Our results provide the first evidence that protein of the Argonaute family prevents retrotranspositions. It is supposed that the disturbance of RNA silencing system in germinal cells might cause transposition burst...
  64. pmc Characterization of Drosophila melanogaster JmjC+N histone demethylases
    Marta Lloret-Llinares
    Institute of Molecular Biology of Barcelona, CSIC, Institute for Research in Biomedicine IRB Barcelona, Parc Cientific de Barcelona, Josep Samitier, 1 5, 08028 Barcelona, Spain
    Nucleic Acids Res 36:2852-63. 2008
    ..dJMJD2(1)/CG15835 regulates heterochromatin organization, as its over-expression induces spreading of HP1, out of heterochromatin, into euchromatin, without affecting the actual pattern of histone modifications of ..
  65. pmc Drosophila sticky/citron kinase is a regulator of cell-cycle progression, genetically interacts with Argonaute 1 and modulates epigenetic gene silencing
    Sarah J Sweeney
    Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA
    Genetics 178:1311-25. 2008
    ..of the Drosophila sticky gene and we show that sticky/citron kinase is required for histone H3-K9 methylation, HP1 localization, and heterochromatin-mediated gene silencing...
  66. pmc Silencing at Drosophila telomeres: nuclear organization and chromatin structure play critical roles
    D E Cryderman
    Department of Biochemistry, 4 772 Bowen Science Building, University of Iowa, Iowa City, IA 52242, USA
    EMBO J 18:3724-35. 1999
    ..the second and third chromosomes is suppressed by mutations in Su(z)2, but not by mutations in Su(var)2-5 (encoding HP1), while the converse is true for telomeric PEV on the fourth chromosome...
  67. pmc Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila
    Anja Ebert
    Institute of Genetics, Biologicum, Martin Luther University Halle, D 06120 Halle, Germany
    Genes Dev 18:2973-83. 2004
    ....
  68. pmc cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four
    Fang Lin Sun
    Friedrich Miescher Institute for Biomedical Research, Basel, Switzerland
    Mol Cell Biol 24:8210-20. 2004
    ..histone hypoacetylation, high levels of histone H3 methylated on lysine 9 (H3-mK9), and association with heterochromatin protein 1 (HP1)...
  69. pmc Heterochromatin protein 2 interacts with Nap-1 and NURF: a link between heterochromatin-induced gene silencing and the chromatin remodeling machinery in Drosophila
    Gena E Stephens
    Department of Biology, Washington University, CB 1229, St Louis, Missouri 63130, USA
    Biochemistry 45:14990-9. 2006
    ..protein 2 (HP2) is a nonhistone chromosomal protein from Drosophila melanogaster that binds to heterochromatin protein 1 (HP1) and has been implicated in heterochromatin-induced gene silencing...
  70. pmc Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals
    Elzo de Wit
    Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Genome Res 15:1265-73. 2005
    b>Heterochromatin protein 1 (HP1) is a major component of heterochromatin. It was reported to bind to a large number of genes and to many, but not all, transposable elements (TEs)...
  71. pmc The drosophila fragile X protein dFMR1 is required during early embryogenesis for pole cell formation and rapid nuclear division cycles
    Girish Deshpande
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08540, USA
    Genetics 174:1287-98. 2006
    ..While the aberrations in nuclear division are correlated with a defect in the assembly of centromeric/centric heterochromatin, the defects in pole cell formation are associated with alterations in the actin-myosin cytoskeleton...
  72. pmc The large isoform of Drosophila melanogaster heterochromatin protein 2 plays a critical role in gene silencing and chromosome structure
    Christopher D Shaffer
    Department of Biology, Washington University, Saint Louis, MO 63130, USA
    Genetics 174:1189-204. 2006
    Drosophila melanogaster heterochromatin protein 2 (HP2) interacts with heterochromatin protein 1 (HP1). In polytene chromosomes, HP2 and HP1 colocalize at the chromocenter, telomeres, and the small fourth chromosome...
  73. ncbi The SuUR gene influences the distribution of heterochromatic proteins HP1 and SU(VAR)3-9 on nurse cell polytene chromosomes of Drosophila melanogaster
    Dmitry E Koryakov
    Institute of Cytology and Genetics, Novosibirsk, 630090, Russia
    Chromosoma 115:296-310. 2006
    ..investigated the distribution of three heterochromatic proteins [SUppressor of UnderReplication (SUUR), heterochromatin protein 1 (HP1), and SU(VAR)3-9] in chromosomes of nurse cells (NCs) and have compared the data obtained with the ..
  74. ncbi Heterochromatin protein 1: don't judge the book by its cover!
    Florence Hediger
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Curr Opin Genet Dev 16:143-50. 2006
    The name heterochromatin protein 1 (HP1) suggests that this small nuclear factor plays a role in forming heterochromatic domains...
  75. pmc HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors
    Ragnhild Eskeland
    Histone Modifications Group, Adolf Butenandt Institut, University of Munich, Schillerstrasse 44, 80336 Munich, Germany
    Mol Cell Biol 27:453-65. 2007
    ..Methylation of lysine 9 within histone H3 and the subsequent binding of the chromodomain protein heterochromatin protein 1 (HP1) are thought to initiate heterochromatin formation in vivo and to propagate a heterochromatic state ..
  76. ncbi Loss of the modifiers of variegation Su(var)3-7 or HP1 impacts male X polytene chromosome morphology and dosage compensation
    Anne Spierer
    Department of Zoology and Animal Biology, University of Geneva, 30 Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    J Cell Sci 118:5047-57. 2005
    Loss of Su(var)3-7 or HP1 suppresses the genomic silencing of position-effect variegation, whereas over-expression enhances it. In addition, loss of Su(var)3-7 results in preferential male lethality...
  77. pmc Interaction of heterochromatin protein 2 with HP1 defines a novel HP1-binding domain
    Gena E Stephens
    Department of Biology, Washington University, CB 1229, St Louis, Missouri 63130, USA
    Biochemistry 44:13394-403. 2005
    ..principally in the pericentric heterochromatin, telomeres, and fourth chromosome, all regions associated with HP1. Mutations in HP2 can suppress position effect variegation, indicating a role in gene silencing and heterochromatin ..
  78. pmc Element 1360 and RNAi components contribute to HP1-dependent silencing of a pericentric reporter
    Karmella A Haynes
    Department of Biology, Washington University, St Louis, Missouri 63130, USA
    Curr Biol 16:2222-7. 2006
    ..This 1360 element contributes to HP1-dependent variegation at a pericentric insertion site, as demonstrated by a decrease in silencing after FLP-..
  79. pmc Impairment of cytotype regulation of P-element activity in Drosophila melanogaster by mutations in the Su(var)205 gene
    Kevin J Haley
    Department of Genetics, Cell Biology and Development, University of Minnesota, St Paul, 55108, USA
    Genetics 171:583-95. 2005
    ..This regulation is impaired in long-term stocks heterozygous for mutations in Suppressor of variegation 205 [Su(var)205], a gene implicated in the control of telomere length...
  80. ncbi The HP1 chromo shadow domain binds a consensus peptide pentamer
    J F Smothers
    Howard Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Curr Biol 10:27-30. 2000
    Heterochromatin-associated protein 1 (HP1) is thought to affect chromatin structure through interactions with other proteins in heterochromatin...
  81. pmc Heterochromatin protein 1 is involved in control of telomere elongation in Drosophila melanogaster
    Mikhail Savitsky
    Department of Control of Genetic Processes, Institute of Gene Biology, Russian Academy of Sciences, 117334 Moscow, Russia
    Mol Cell Biol 22:3204-18. 2002
    ..Here we show that the Su(var)2-5 gene encoding heterochromatin protein 1 (HP1) is involved in regulation of telomere length...
  82. ncbi Expansions of transgene repeats cause heterochromatin formation and gene silencing in Drosophila
    D R Dorer
    Howard Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Cell 77:993-1002. 1994
    ..We propose that pairing of repeats underlies heterochromatin formation and is responsible for diverse gene silencing phenomena in animals and plants...
  83. ncbi Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail
    Steven A Jacobs
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA 22908 0733, USA
    Science 295:2080-3. 2002
    The chromodomain of the HP1 family of proteins recognizes histone tails with specifically methylated lysines...
  84. pmc The Drosophila Su(var)2-10 locus regulates chromosome structure and function and encodes a member of the PIAS protein family
    K L Hari
    Molecular and Cell Biology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Genes Dev 15:1334-48. 2001
    ..We propose that Su(var2-10 controls multiple aspects of chromosome structure and function by establishing/maintaining chromosome organization in interphase nuclei...
  85. pmc The hinge and chromo shadow domain impart distinct targeting of HP1-like proteins
    J F Smothers
    Howard Hughes Medical Institute, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Mol Cell Biol 21:2555-69. 2001
    ..proteins (HP1b and HP1c), comparing them with that of the originally described fly HP1 protein (here designated HP1a)...
  86. ncbi The genomic silencing of position-effect variegation in Drosophila melanogaster: interaction between the heterochromatin-associated proteins Su(var)3-7 and HP1
    M Delattre
    Department of Zoology and Animal Biology, University of Geneva, CH 1211 Geneva 4, Switzerland
    J Cell Sci 113:4253-61. 2000
    ..An increase in the amounts of the heterochromatin-associated Su(var)3-7 and HP1 proteins augments silencing...
  87. pmc The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation
    J C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, Missouri 63104
    Genetics 131:345-52. 1992
    ..The implications of these observations for mechanism of heterochromatic position effects and heterochromatin function are discussed...
  88. pmc P-Element repression in Drosophila melanogaster by a naturally occurring defective telomeric P copy
    L Marin
    Département Dynamique du Génome et Evolution, Institut Jacques Monod, 75251 Paris Cedex 05, France
    Genetics 155:1841-54. 2000
    ..Conversely, a second P-lacZ construct, in which the fusion with lacZ takes place in exon 3 of P, was successfully repressed by NA-P(1A). This suggests that NA-P(1A) repression involves a homology-dependent component...
  89. pmc SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation
    F Cléard
    Department of Zoology and Animal Biology, University of Geneva, 30 Quai Ernest Ansermet, CH 1211 Geneva 4, Switzerland
    EMBO J 16:5280-8. 1997
    ..resemble those described by others for the Su(var)2-5 locus and its heterochromatin-associated protein HP1, the presumed co-operation of the two proteins was tested further...
  90. ncbi The HP1 protein family: getting a grip on chromatin
    J C Eissenberg
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO 63104, USA
    Curr Opin Genet Dev 10:204-10. 2000
    b>HP1 was first described in Drosophila as a heterochromatin-associated protein with dosage-dependent effects on heterochromatin-induced gene silencing. Recently, membership of the HP1 protein family has expanded tremendously...
  91. ncbi Identification of in vivo DNA targets of chromatin proteins using tethered dam methyltransferase
    B van Steensel
    Fred Hutchinson Cancer Research Center and Howard Hughes Medical Institute, Seattle, WA 98109, USA
    Nat Biotechnol 18:424-8. 2000
    ..Using DamID, we identified a number of expected and unexpected target loci for Drosophila heterochromatin protein 1. DamID has potential for genome-wide mapping of in vivo targets of chromatin proteins in various ..
  92. ncbi Phosphorylation site mutations in heterochromatin protein 1 (HP1) reduce or eliminate silencing activity
    T Zhao
    Edward A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, St Louis, Missouri 63104, USA
    J Biol Chem 276:9512-8. 2001
    b>HP1 is an essential heterochromatin-associated protein in Drosophila...
  93. pmc Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin
    Lucia Piacentini
    Istituto Pasteur, Fondazione Cenci Bolognetti, Dipartimento di Genetica e Biologia Molecolare, Universita di Roma La Sapienza, 00185 Roma, Italy
    J Cell Biol 161:707-14. 2003
    b>Heterochromatin protein 1 (HP1) is a conserved nonhistone chromosomal protein, which is involved in heterochromatin formation and gene silencing in many organisms...
  94. pmc Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster
    J C Eissenberg
    E A Doisy Department of Biochemistry and Molecular Biology, St Louis University School of Medicine, MO 63104
    Proc Natl Acad Sci U S A 87:9923-7. 1990
    ..This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects...
  95. ncbi The role of brahma and related proteins in transcription and development
    J W Tamkun
    Department of Biology, University of California, Santa Cruz 95064, USA
    Curr Opin Genet Dev 5:473-7. 1995
    ....
  96. ncbi Telomerase-independent mechanisms of telomere elongation
    H Biessmann
    Developmental Biology Center, University of California, Irvine, California 92697, USA
    Cell Mol Life Sci 60:2325-33. 2003
    ..We will summarize current knowledge on these telomerase-independent elongation mechanisms in yeast and mammalian cells and will discuss in more detail the telomere elongation mechanism by retrotransposons in Drosophila melanogaster...
  97. ncbi Characterization of sequences associated with position-effect variegation at pericentric sites in Drosophila heterochromatin
    D E Cryderman
    Department of Biochemistry, University of Iowa, Iowa City, IA 52242, USA
    Chromosoma 107:277-85. 1998
    ..All of the transgenes show suppression of PEV in response to a mutation in the gene encoding heterochromatin protein 1 (HP1). This suppression correlates with a more accessible chromatin structure...
  98. ncbi Heterochromatin protein 1 is required for correct chromosome segregation in Drosophila embryos
    R Kellum
    Department of Biochemistry and Biophysics, University of California at San Francisco 94143 0448, USA
    J Cell Sci 108:1419-31. 1995
    b>Heterochromatin protein 1 is associated with centromeric heterochromatin in Drosophila, mice, and humans...
  99. ncbi Novel Drosophila heterochromatin protein 1 (HP1)/origin recognition complex-associated protein (HOAP) repeat motif in HP1/HOAP interactions and chromocenter associations
    Ramakrishna Badugu
    Department of Biology, University of Kentucky, Lexington, Kentucky 40506 0225, USA
    J Biol Chem 278:34491-8. 2003
    ..We find heterochromatin protein 1/origin recognition complex-associated protein (HOAP) to interact specifically with the originally ..
  100. pmc Functional analysis of the chromo domain of HP1
    J S Platero
    Edward A Doisy Department of Biochemistry and Molecular Biology, Saint Louis University Medical School, MO 63104 1079, USA
    EMBO J 14:3977-86. 1995
    b>Heterochromatin protein 1 (HP1) is a non-histone chromosomal protein in Drosophila with dosage-dependent effects on heterochromatin-mediated gene silencing...
  101. ncbi Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals
    Ian G Cowell
    Division of Gene Expression and Development, The Roslin Institute Edinburgh, Midlothian, UK
    Chromosoma 111:22-36. 2002
    ..Finally, we provide evidence that Me9H3 is neither necessary nor sufficient for localisation of heterochromatin protein 1 (HP1) to chromosomal DNA.

Research Grants66

  1. DOSAGE COMPENSATION IN DROSOPHILA
    James Birchler; Fiscal Year: 2006
    ..The proposed project will contribute to an understanding of how chromatin modifications become established along the length of the chromosome and how they affect gene expression. ..
  2. DOSAGE COMPENSATION IN DROSOPHILA
    James A Birchler; Fiscal Year: 2010
    ..The single active X chromosome in humans of both males and females must be up-regulated for viability. The proposed project will examine the type of mechanism responsible for this up-regulation. ..
  3. Regulation of chromatin structure and gene expression
    KRISTEN JOHANSEN; Fiscal Year: 2007
    ..and gene silencing at ectopic locations by methyltransferase mediated histone H3K9 dimethylation and HP1 recruitment...
  4. Olfactory Genes in Mosquitoes
    Harald Biessmann; Fiscal Year: 2007
    ..These studies will ultimately allow the development of better methods to interfere with the mosquito-host interaction and reduce transmission of the malaria parasite. ..
  5. INTERDISCIPLINARY TRAINING IN DEVELOPMENTAL BIOLOGY
    Barbara Wakimoto; Fiscal Year: 2007
    ....
  6. Mechanism of Meiotic Pairing in Drosophila
    Bruce D McKee; Fiscal Year: 2010
    ..mechanism by which SNM and MNM connect homologous chromatids? 4) What mechanisms are used by SUN and SOLO to connect sister chromatids? 5) How do SUN, SOLO, SNM and MNM interact to establish and maintain sister chromatid cohesion? ..
  7. Olfactory Genes in Mosquitoes
    Harald Biessmann; Fiscal Year: 2006
    ..These studies will ultimately allow the development of better methods to interfere with the mosquito-host interaction and reduce transmission of the malaria parasite. ..
  8. MECHANISMS OF GENE SILENCING
    Lori Wallrath; Fiscal Year: 2005
    ..Heterochromatin protein one, HP1, is an evolutionary conserved chromatin protein that is a component of silent chromatin...
  9. Mechanism of Meiotic Pairing in Drosophila
    BRUCE MCKEE; Fiscal Year: 2005
    ..Taken together, these experiments are expected to advance our understanding of chromosome pairing in Drosophila and to provide models for pairing mechanisms that can be tested in mammals. ..
  10. MECHANISMS OF GENE SILENCING
    Lori Wallrath; Fiscal Year: 2007
    ..The majority of gene expression is controlled through chromatin packaging. Heterochromatin Protein 1 (HP1) is an evolutionary conserved non-histone chromosomal protein required for chromatin packaging and ..
  11. MECHANISMS OF TRANSCRIPTIONAL REGULATION IN CHROMATIN
    Jerry Workman; Fiscal Year: 2007
    ..Finally, we will investigate mechansims by which SWI/SNF may act in concert with histone deacetylases to facilitate transcriptional repression. ..
  12. Noncoding RNAs and Chromatin Structure
    Richard Kelley; Fiscal Year: 2007
    ..A new model to explain how cis spreading operates will be tested. New search methods will be developed to identify currently unknown noncoding RNAs. ..
  13. Mechanism of Meiotic Pairing in Drosophila
    BRUCE MCKEE; Fiscal Year: 2009
    ..Better understanding of the mechanisms that underlie meiotic chromosome segregation could lead to improved treatments for infertility and chromosome segregation errors. ..
  14. Regulation of chromatin structure and gene expression
    Kristen M Johansen; Fiscal Year: 2010
    ..and gene silencing at ectopic locations by methyltransferase mediated histone H3K9 dimethylation and HP1 recruitment...
  15. MECHANISMS OF GENE SILENCING
    Lori Wallrath; Fiscal Year: 2009
    ..The majority of gene expression is controlled through chromatin packaging. Heterochromatin Protein 1 (HP1) is an evolutionary conserved non-histone chromosomal protein required for chromatin packaging and ..
  16. Mechanism of Meiotic Pairing in Drosophila
    BRUCE MCKEE; Fiscal Year: 2007
    ..3) What is the molecular basis for homologous pairing in early prophase. 4) How are homologous pairing and conjunction related? We will use predominant genetic and cell biological methods to address these questions. ..
  17. MECHANISMS OF GENE SILENCING
    Lori Wallrath; Fiscal Year: 2007
    ..The majority of gene expression is controlled through chromatin packaging. Heterochromatin Protein 1 (HP1) is an evolutionary conserved non-histone chromosomal protein required for chromatin packaging and ..
  18. Regulation of Chromatin Structure byPhosphorylation
    KRISTEN JOHANSEN; Fiscal Year: 2004
    ..abstract_text> ..
  19. MECHANISM OF MEIOTIC PAIRING IN DROSOPHILA MALES
    BRUCE MCKEE; Fiscal Year: 1993
    ....
  20. Analysis of MRG family and hTERT null phenotypes by RNAi
    Michael Bertram; Fiscal Year: 2002
    ..These experiments will lay the groundwork for further investigation into molecular and genetic interactions involving the MRG family and hTERT by providing an in vivo null system experimental system. ..
  21. MECHANISM OF MEIOTIC PAIRING IN DROSOPHILA MALES
    BRUCE MCKEE; Fiscal Year: 2002
    ..We will also search for sites outside the promoter region of the 240bp spacer repeats that are essential for pairing function of the repeats. ..
  22. STIMULATION OF CHROMOSOME PAIRING AND EXCHANGE BY RDNA
    BRUCE MCKEE; Fiscal Year: 1992
    ..In addition, non-allelic homologous recombination between dispersed repeated genes is a likely cause of chromosome rearrangements responsible for birth defects and cancer...