Su(var)205

Summary

Gene Symbol: Su(var)205
Description: Suppressor of variegation 205
Alias: CBX5, CG8409, DmHP-1, DmHP1, Dmel\CG8409, E(var)29, E(var)29A, FBgn0003607, HP-1, HP1, HP1-VS, HP1A, HP1a, HP1alpha, Hp1, Hp1a, SU(VAR)205, Su(Var)2-5, Su(Var)205, Su(var), Su(var)2-05, Su(var)2-5, Su(var)2-501, Su(var)29A, Su(var)[205], Su-var(2)5, Su[Var]205, Su[var]205, Suvar(2)5, Suvar2-5, dHP-1a, dHP1, hp1, hp1a, su(var)205, suppressor of variegation 205, C1A9-nuclear-antigen, CG8409-PA, CG8409-PB, Su(var)2-5, Su(var)205-PA, Su(var)205-PB, heterochromatic protein, heterochromatic protein 1, heterochromatic protein 1a, heterochromatin factor 1, heterochromatin protein 1, heterochromatin protein 1A, heterochromatin protein-1, heterochromatin-binding protein, heterochromatin-protein-1, histone protein 1, suppressor of variegated 205
Species: fruit fly
Products:     Su(var)205

Top Publications

  1. Ronsseray S, Boivin A, Anxolabehere D. P-Element repression in Drosophila melanogaster by variegating clusters of P-lacZ-white transgenes. Genetics. 2001;159:1631-42 pubmed
    ..Implications for models of transposable element silencing are discussed...
  2. Singh P, Miller J, Pearce J, Kothary R, Burton R, Paro R, et al. A sequence motif found in a Drosophila heterochromatin protein is conserved in animals and plants. Nucleic Acids Res. 1991;19:789-94 pubmed
    ..a known sequence homology, termed chromo box, between a suppressor of position-effect-variegation, Heterochromatin protein 1 (HP1), and a repressor of homeotic genes, Polycomb (Pc)...
  3. Fanti L, Dorer D, Berloco M, Henikoff S, Pimpinelli S. Heterochromatin protein 1 binds transgene arrays. Chromosoma. 1998;107:286-92 pubmed
    b>Heterochromatin protein 1 (HP1) of Drosophila and its homologs in vertebrates are key components of constitutive heterochromatin...
  4. Zhao T, Heyduk T, Eissenberg J. Phosphorylation site mutations in heterochromatin protein 1 (HP1) reduce or eliminate silencing activity. J Biol Chem. 2001;276:9512-8 pubmed
    b>HP1 is an essential heterochromatin-associated protein in Drosophila...
  5. Danzer J, Wallrath L. Mechanisms of HP1-mediated gene silencing in Drosophila. Development. 2004;131:3571-80 pubmed
    b>Heterochromatin Protein 1 (HP1) is a structural component of silent chromatin at telomeres and centromeres...
  6. Schwendemann A, Matkovic T, Linke C, Klebes A, Hofmann A, Korge G. Hip, an HP1-interacting protein, is a haplo- and triplo-suppressor of position effect variegation. Proc Natl Acad Sci U S A. 2008;105:204-9 pubmed
    The Drosophila heterochromatin protein 1 (HP1) regulates epigenetic gene silencing and heterochromatin formation by promoting and maintaining chromatin condensation...
  7. Joppich C, Scholz S, Korge G, Schwendemann A. Umbrea, a chromo shadow domain protein in Drosophila melanogaster heterochromatin, interacts with Hip, HP1 and HOAP. Chromosome Res. 2009;17:19-36 pubmed publisher
    Drosophila melanogaster HP1-interacting protein (Hip) is a partner of heterochromatin protein 1 (HP1) and is involved in transcriptional epigenetic gene silencing and the formation of heterochromatin...
  8. Steffen P, Ringrose L. What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory. Nat Rev Mol Cell Biol. 2014;15:340-56 pubmed publisher
    ..Several recent studies have advanced our understanding of the molecular mechanisms of this epigenetic memory during DNA replication and mitosis. ..
  9. Alekseyenko A, Gorchakov A, Zee B, Fuchs S, Kharchenko P, Kuroda M. Heterochromatin-associated interactions of Drosophila HP1a with dADD1, HIPP1, and repetitive RNAs. Genes Dev. 2014;28:1445-60 pubmed publisher
    b>Heterochromatin protein 1 (HP1a) has conserved roles in gene silencing and heterochromatin and is also implicated in transcription, DNA replication, and repair...

More Information

Publications102 found, 100 shown here

  1. Badugu R, Shareef M, Kellum R. Novel Drosophila heterochromatin protein 1 (HP1)/origin recognition complex-associated protein (HOAP) repeat motif in HP1/HOAP interactions and chromocenter associations. J Biol Chem. 2003;278:34491-8 pubmed
    ..We find heterochromatin protein 1/origin recognition complex-associated protein (HOAP) to interact specifically with the originally ..
  2. Perrini B, Piacentini L, Fanti L, Altieri F, Chichiarelli S, Berloco M, et al. HP1 controls telomere capping, telomere elongation, and telomere silencing by two different mechanisms in Drosophila. Mol Cell. 2004;15:467-76 pubmed
    b>HP1 is a conserved chromosomal protein, first discovered in Drosophila, which is predominantly associated with the heterochromatin of many organisms...
  3. Osouda S, Nakamura Y, de Saint Phalle B, McConnell M, Horigome T, Sugiyama S, et al. Null mutants of Drosophila B-type lamin Dm(0) show aberrant tissue differentiation rather than obvious nuclear shape distortion or specific defects during cell proliferation. Dev Biol. 2005;284:219-32 pubmed
    ..In contrast, both gonadal and CNS tissues exhibited underdevelopment. ..
  4. Brideau N, Flores H, Wang J, Maheshwari S, Wang X, Barbash D. Two Dobzhansky-Muller genes interact to cause hybrid lethality in Drosophila. Science. 2006;314:1292-5 pubmed
    ..Rapidly evolving heterochromatic DNA sequences may be driving the evolution of this incompatibility gene. ..
  5. Bassett A, Cooper S, Ragab A, Travers A. The chromatin remodelling factor dATRX is involved in heterochromatin formation. PLoS ONE. 2008;3:e2099 pubmed publisher
    ..show that there are two isoforms of the dATRX protein, the longer of which interacts directly with heterochromatin protein 1 (dHP-1) through a CxVxL motif both in vitro and in vivo...
  6. Koch C, Honemann Capito M, Egger Adam D, Wodarz A. Windei, the Drosophila homolog of mAM/MCAF1, is an essential cofactor of the H3K9 methyl transferase dSETDB1/Eggless in germ line development. PLoS Genet. 2009;5:e1000644 pubmed publisher
    ..3 lysine 9 (H3K9me3) leads to chromatin silencing and the formation of heterochromatin by recruitment of heterochromatin protein 1 (HP1)...
  7. Brideau N, Barbash D. Functional conservation of the Drosophila hybrid incompatibility gene Lhr. BMC Evol Biol. 2011;11:57 pubmed publisher
    ..We conclude that evolution of the hybrid lethality properties of Lhr between D. melanogaster and D. simulans did not involve extensive loss or gain of functions associated with protein interactions or localization to heterochromatin...
  8. Eissenberg J, Morris G, Reuter G, Hartnett T. The heterochromatin-associated protein HP-1 is an essential protein in Drosophila with dosage-dependent effects on position-effect variegation. Genetics. 1992;131:345-52 pubmed
    ..The implications of these observations for mechanism of heterochromatic position effects and heterochromatin function are discussed. ..
  9. Eissenberg J, Hartnett T. A heat shock-activated cDNA rescues the recessive lethality of mutations in the heterochromatin-associated protein HP1 of Drosophila melanogaster. Mol Gen Genet. 1993;240:333-8 pubmed
    b>HP1 is a small nonhistone chromosomal protein of Drosophila melanogaster predominantly localized to the pericentric heterochromatin...
  10. Deshpande G, Calhoun G, Schedl P. The drosophila fragile X protein dFMR1 is required during early embryogenesis for pole cell formation and rapid nuclear division cycles. Genetics. 2006;174:1287-98 pubmed
    ..While the aberrations in nuclear division are correlated with a defect in the assembly of centromeric/centric heterochromatin, the defects in pole cell formation are associated with alterations in the actin-myosin cytoskeleton. ..
  11. Shermoen A, McCleland M, O Farrell P. Developmental control of late replication and S phase length. Curr Biol. 2010;20:2067-77 pubmed publisher
    ..This onset of late replication required transcription. Satellites only accumulated abundant heterochromatin protein 1 (HP1) after replicating in S phase 14...
  12. Le Thomas A, Rogers A, Webster A, Marinov G, Liao S, Perkins E, et al. Piwi induces piRNA-guided transcriptional silencing and establishment of a repressive chromatin state. Genes Dev. 2013;27:390-9 pubmed publisher
    ..construct results in a decrease in Pol II occupancy and an increase in repressive H3K9me3 marks and heterochromatin protein 1 (HP1) on the reporter locus...
  13. Kellum R, Raff J, Alberts B. Heterochromatin protein 1 distribution during development and during the cell cycle in Drosophila embryos. J Cell Sci. 1995;108 ( Pt 4):1407-18 pubmed
    b>Heterochromatin protein 1 (HP1) was initially discovered as a protein that is associated with the heterochromatin at the chromocenter of polytene chromosomes in Drosophila larval salivary glands...
  14. Delattre M, Spierer A, Jaquet Y, Spierer P. Increased expression of Drosophila Su(var)3-7 triggers Su(var)3-9-dependent heterochromatin formation. J Cell Sci. 2004;117:6239-47 pubmed
    ..formation: it binds to pericentric heterochromatin, it potently suppresses variegation and it interacts with HP1. However, the mode of action of Su(var)3-7 is poorly understood...
  15. Badugu R, Yoo Y, Singh P, Kellum R. Mutations in the heterochromatin protein 1 (HP1) hinge domain affect HP1 protein interactions and chromosomal distribution. Chromosoma. 2005;113:370-84 pubmed
    b>Heterochromatin Protein 1 (HP1) is a conserved component of the highly compact chromatin found at centromeres and telomeres. A conserved feature of the protein is multiple phosphorylation...
  16. Cryderman D, Grade S, Li Y, Fanti L, Pimpinelli S, Wallrath L. Role of Drosophila HP1 in euchromatic gene expression. Dev Dyn. 2005;232:767-74 pubmed
    b>Heterochromatin protein 1 (HP1), a gene silencing protein, localizes to centric heterochromatin through an interaction with methylated K9 of histone H3, a modification generated by the histone methyl transferase SU(VAR)3-9...
  17. de Wit E, Greil F, van Steensel B. Genome-wide HP1 binding in Drosophila: developmental plasticity and genomic targeting signals. Genome Res. 2005;15:1265-73 pubmed
    b>Heterochromatin protein 1 (HP1) is a major component of heterochromatin. It was reported to bind to a large number of genes and to many, but not all, transposable elements (TEs)...
  18. Eskeland R, Eberharter A, Imhof A. HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors. Mol Cell Biol. 2007;27:453-65 pubmed
    ..Methylation of lysine 9 within histone H3 and the subsequent binding of the chromodomain protein heterochromatin protein 1 (HP1) are thought to initiate heterochromatin formation in vivo and to propagate a heterochromatic state ..
  19. Raffa G, Ciapponi L, Cenci G, Gatti M. Terminin: a protein complex that mediates epigenetic maintenance of Drosophila telomeres. Nucleus. 2011;2:383-91 pubmed publisher
    ..Based on these findings, we propose that concomitant with telomerase loss Drosophila rapidly evolved terminin to bind chromosome ends in a sequence-independent fashion, and that terminin is functionally analogous to shelterin. ..
  20. Brehm A, Tufteland K, Aasland R, Becker P. The many colours of chromodomains. Bioessays. 2004;26:133-40 pubmed
  21. Pal Bhadra M, Leibovitch B, Gandhi S, Chikka M, Rao M, Bhadra U, et al. Heterochromatic silencing and HP1 localization in Drosophila are dependent on the RNAi machinery. Science. 2004;303:669-72 pubmed
    ..resulting in suppression of PEV have identified critical components of heterochromatin, including proteins HP1, HP2, and histone H3 lysine 9 methyltransferase...
  22. Ciapponi L, Cenci G, Gatti M. The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability. Genetics. 2006;173:1447-54 pubmed
    ..In contrast, analysis of chromosome breakage indicated that the three components of the MRN complex function in a single pathway for the repair of the DNA damage leading to chromosome aberrations. ..
  23. de Wit E, Greil F, van Steensel B. High-resolution mapping reveals links of HP1 with active and inactive chromatin components. PLoS Genet. 2007;3:e38 pubmed
    b>Heterochromatin protein 1 (HP1) is commonly seen as a key factor of repressive heterochromatin, even though a few genes are known to require HP1-chromatin for their expression...
  24. Rudolph T, Yonezawa M, Lein S, Heidrich K, Kubicek S, Schafer C, et al. Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3. Mol Cell. 2007;26:103-15 pubmed
  25. Raffa G, Siriaco G, Cugusi S, Ciapponi L, Cenci G, Wojcik E, et al. The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection. Proc Natl Acad Sci U S A. 2009;106:2271-6 pubmed publisher
    Several proteins have been identified that protect Drosophila telomeres from fusion events. They include UbcD1, HP1, HOAP, the components of the Mre11-Rad50-Nbs (MRN) complex, the ATM kinase, and the putative transcription factor Woc...
  26. Lau N, Robine N, Martin R, Chung W, Niki Y, Berezikov E, et al. Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line. Genome Res. 2009;19:1776-85 pubmed publisher
    ..These data indicate that the restriction of certain TEs in somatic gonadal cells is largely mediated by a primary piRNA pathway. ..
  27. Stenberg P, Larsson J. Buffering and the evolution of chromosome-wide gene regulation. Chromosoma. 2011;120:213-25 pubmed publisher
    ..In this review, we discuss the origin and function of buffering and compensation using Drosophila as a model. ..
  28. Cenci G, Ciapponi L, Gatti M. The mechanism of telomere protection: a comparison between Drosophila and humans. Chromosoma. 2005;114:135-45 pubmed
    ..These proteins include the telomere capping factors HP1/ORC-associated protein (HOAP) and heterochromatin protein 1 (HP1), the Rad50 and Mre11 DNA repair proteins that are required for HOAP and HP1 localization at ..
  29. Andreyeva E, Belyaeva E, Semeshin V, Pokholkova G, Zhimulev I. Three distinct chromatin domains in telomere ends of polytene chromosomes in Drosophila melanogaster Tel mutants. J Cell Sci. 2005;118:5465-77 pubmed
    ..SUUR, HP2, SU(VAR)3-7 and H3Me3K27 localize to the cap region, as has been demonstrated for HP1. All these proteins are also found in pericentric heterochromatin...
  30. James T, Elgin S. Identification of a nonhistone chromosomal protein associated with heterochromatin in Drosophila melanogaster and its gene. Mol Cell Biol. 1986;6:3862-72 pubmed
    ..This general strategy should be effective for cloning the genes and identifying the genetic loci of chromosomal proteins which cannot be readily assayed by other means. ..
  31. Wallace J, Orr Weaver T. Replication of heterochromatin: insights into mechanisms of epigenetic inheritance. Chromosoma. 2005;114:389-402 pubmed
    ..complex, proliferating cell nuclear antigen, and chromatin-assembly factor 1 in recruiting the heterochromatin binding protein HP1, a histone methyltransferase, a DNA methyltransferase, and a chromatin remodeling complex...
  32. Elgin S. Heterochromatin and gene regulation in Drosophila. Curr Opin Genet Dev. 1996;6:193-202 pubmed
    ..The current data support a competition/chromatin structure model, in which multiprotein repressor complexes compete with transcriptional activators to assemble an active or inactive chromatin structure. ..
  33. Chauhan C, Zraly C, Parilla M, Diaz M, Dingwall A. Histone recognition and nuclear receptor co-activator functions of Drosophila cara mitad, a homolog of the N-terminal portion of mammalian MLL2 and MLL3. Development. 2012;139:1997-2008 pubmed publisher
    ..The evolutionary split of MLL2 into two distinct genes in Drosophila provides important insight into distinct epigenetic functions of conserved readers and writers of the histone code. ..
  34. Savitsky M, Kravchuk O, Melnikova L, Georgiev P. Heterochromatin protein 1 is involved in control of telomere elongation in Drosophila melanogaster. Mol Cell Biol. 2002;22:3204-18 pubmed
    ..Here we show that the Su(var)2-5 gene encoding heterochromatin protein 1 (HP1) is involved in regulation of telomere length...
  35. Fischle W, Wang Y, Jacobs S, Kim Y, Allis C, Khorasanizadeh S. Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev. 2003;17:1870-81 pubmed
    ..Here we show that the chromodomain proteins Polycomb (Pc) and HP1 (heterochromatin protein 1) are highly discriminatory for binding to these sites in vivo and in vitro...
  36. Zhang W, Deng H, Bao X, Lerach S, Girton J, Johansen J, et al. The JIL-1 histone H3S10 kinase regulates dimethyl H3K9 modifications and heterochromatic spreading in Drosophila. Development. 2006;133:229-35 pubmed
    ..of the JIL-1 histone H3S10 kinase results in the spreading of the major heterochromatin markers dimethyl H3K9 and HP1 to ectopic locations on the chromosome arms, with the most pronounced increase on the X chromosomes...
  37. Johansson A, Stenberg P, Bernhardsson C, Larsson J. Painting of fourth and chromosome-wide regulation of the 4th chromosome in Drosophila melanogaster. EMBO J. 2007;26:2307-16 pubmed
    ..Here we show that POF and heterochromatin protein 1 (HP1) are involved in the global regulation of the 4th chromosome...
  38. Josse T, Teysset L, Todeschini A, Sidor C, Anxolabehere D, Ronsseray S. Telomeric trans-silencing: an epigenetic repression combining RNA silencing and heterochromatin formation. PLoS Genet. 2007;3:1633-43 pubmed
    ..silencing is highly sensitive to mutations affecting both heterochromatin formation (Su(var)205 encoding Heterochromatin Protein 1 and Su(var)3-7) and the repeat-associated small interfering RNA (or rasiRNA) silencing pathway (..
  39. Yin H, Sweeney S, Raha D, Snyder M, Lin H. A high-resolution whole-genome map of key chromatin modifications in the adult Drosophila melanogaster. PLoS Genet. 2011;7:e1002380 pubmed publisher
    ..and its use to construct a high-resolution map of the Drosophila melanogaster key histone marks, heterochromatin protein 1a (HP1a) and RNA polymerase II (polII)...
  40. Cléard F, Delattre M, Spierer P. SU(VAR)3-7, a Drosophila heterochromatin-associated protein and companion of HP1 in the genomic silencing of position-effect variegation. EMBO J. 1997;16:5280-8 pubmed
    ..resemble those described by others for the Su(var)2-5 locus and its heterochromatin-associated protein HP1, the presumed co-operation of the two proteins was tested further...
  41. Piacentini L, Fanti L, Berloco M, Perrini B, Pimpinelli S. Heterochromatin protein 1 (HP1) is associated with induced gene expression in Drosophila euchromatin. J Cell Biol. 2003;161:707-14 pubmed
    b>Heterochromatin protein 1 (HP1) is a conserved nonhistone chromosomal protein, which is involved in heterochromatin formation and gene silencing in many organisms...
  42. Kelley R, Kuroda M. The Drosophila roX1 RNA gene can overcome silent chromatin by recruiting the male-specific lethal dosage compensation complex. Genetics. 2003;164:565-74 pubmed
    ..The potency with which an ectopic MSL complex overcomes silent chromatin suggests that its normal action on the X must be under strict regulation. ..
  43. Yoon J, Lee K, Park J, Yu K, Paik S, Kang Y. dSETDB1 and SU(VAR)3-9 sequentially function during germline-stem cell differentiation in Drosophila melanogaster. PLoS ONE. 2008;3:e2234 pubmed publisher
    ..Loss-of-function mutations in dsetdb1 or Su(var)3-9 abolish both H3K9me3 and heterochromatin protein-1 (HP1) signals from the anterior germarium and the developing egg chambers, respectively, and cause localization of ..
  44. Kharchenko P, Alekseyenko A, Schwartz Y, Minoda A, Riddle N, Ernst J, et al. Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. Nature. 2011;471:480-5 pubmed publisher
    ..This systematic profiling and integrative analysis of chromatin signatures provides insights into how genomic elements are regulated, and will serve as a resource for future experimental investigations of genome structure and function. ..
  45. Le H, Donaldson K, Cook K, Karpen G. A high proportion of genes involved in position effect variegation also affect chromosome inheritance. Chromosoma. 2004;112:269-76 pubmed
  46. Sun F, Haynes K, Simpson C, Lee S, Collins L, Wuller J, et al. cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four. Mol Cell Biol. 2004;24:8210-20 pubmed
    ..histone hypoacetylation, high levels of histone H3 methylated on lysine 9 (H3-mK9), and association with heterochromatin protein 1 (HP1)...
  47. Swaminathan J, Baxter E, Corces V. The role of histone H2Av variant replacement and histone H4 acetylation in the establishment of Drosophila heterochromatin. Genes Dev. 2005;19:65-76 pubmed
    ..show reduced acetylation of histone H4 at Lys 12, decreased methylation of histone H3 at Lys 9, and a reduction in HP1 recruitment to the centromeric region...
  48. Oikemus S, Queiroz Machado J, Lai K, McGinnis N, Sunkel C, Brodsky M. Epigenetic telomere protection by Drosophila DNA damage response pathways. PLoS Genet. 2006;2:e71 pubmed
    ..such as atm/tefu, mre11, or rad50 disrupt telomere protection and localization of the telomere-associated proteins HP1 and HOAP, suggesting that recognition of chromosome ends contributes to telomere protection...
  49. Peng J, Karpen G. H3K9 methylation and RNA interference regulate nucleolar organization and repeated DNA stability. Nat Cell Biol. 2007;9:25-35 pubmed
    ..These results suggest a mechanism for how local chromatin structure can regulate genome stability, and the organization of chromosomal elements and nuclear organelles. ..
  50. Shi S, Larson K, Guo D, Lim S, Dutta P, Yan S, et al. Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability. Nat Cell Biol. 2008;10:489-96 pubmed publisher
    ..Here, we demonstrate that Drosophila STAT (STAT92E) is involved in controlling heterochromatin protein 1 (HP1) distribution and heterochromatin stability...
  51. Gu T, Elgin S. Maternal depletion of Piwi, a component of the RNAi system, impacts heterochromatin formation in Drosophila. PLoS Genet. 2013;9:e1003780 pubmed publisher
    ..This implies that Piwi is involved in targeting HP1a when heterochromatin is established at the late blastoderm stage and possibly also during embryogenesis, but that ..
  52. Saunders W, Chue C, Goebl M, Craig C, Clark R, Powers J, et al. Molecular cloning of a human homologue of Drosophila heterochromatin protein HP1 using anti-centromere autoantibodies with anti-chromo specificity. J Cell Sci. 1993;104 ( Pt 2):573-82 pubmed
    ..DNA sequence analysis reveals this protein to be a human homologue of HP1, a heterochromatin protein of Drosophila melanogaster. We designate our cloned protein HP1Hs alpha...
  53. Smothers J, Henikoff S. The HP1 chromo shadow domain binds a consensus peptide pentamer. Curr Biol. 2000;10:27-30 pubmed
    Heterochromatin-associated protein 1 (HP1) is thought to affect chromatin structure through interactions with other proteins in heterochromatin...
  54. Lu B, Emtage P, Duyf B, Hilliker A, Eissenberg J. Heterochromatin protein 1 is required for the normal expression of two heterochromatin genes in Drosophila. Genetics. 2000;155:699-708 pubmed
    The Su(var)2-5 locus, an essential gene in Drosophila, encodes the heterochromatin-associated protein HP1. Here, we show that the Su(var)2-5 lethal period is late third instar...
  55. Seum C, Spierer A, Delattre M, Pauli D, Spierer P. A GAL4-HP1 fusion protein targeted near heterochromatin promotes gene silencing. Chromosoma. 2000;109:453-9 pubmed
    ..Indeed, a chimeric protein, made of the DNA binding site of GAL4 and of HP1, the modifier of PEV encoded by Su(var)2-5, is shown to enhance variegation of Heidi and Tell...
  56. Fanti L, Berloco M, Piacentini L, Pimpinelli S. Chromosomal distribution of heterochromatin protein 1 (HP1) in Drosophila: a cytological map of euchromatic HP1 binding sites. Genetica. 2003;117:135-47 pubmed
    The Heterochromatin Protein 1 (HP1) is a conserved protein which is best known for its strong association with the heterochromatin of Drosophila melanogaster...
  57. Pickersgill H, Kalverda B, de Wit E, Talhout W, Fornerod M, van Steensel B. Characterization of the Drosophila melanogaster genome at the nuclear lamina. Nat Genet. 2006;38:1005-14 pubmed
    ..This genome-wide analysis gives clear insight into the nature and dynamic behavior of the genome at the nuclear lamina, and implies that intergenic DNA functions in the global organization of chromatin in the nucleus. ..
  58. Bai X, Larschan E, Kwon S, Badenhorst P, Kuroda M. Regional control of chromatin organization by noncoding roX RNAs and the NURF remodeling complex in Drosophila melanogaster. Genetics. 2007;176:1491-9 pubmed
    ..Together, these results demonstrate the importance of a local balance between modifying activities that promote and antagonize chromatin compaction within defined chromatin domains in higher organisms. ..
  59. Olszak A, van Essen D, Pereira A, Diehl S, Manke T, Maiato H, et al. Heterochromatin boundaries are hotspots for de novo kinetochore formation. Nat Cell Biol. 2011;13:799-808 pubmed publisher
    ..Although overexpression of heterochromatin protein 1 (HP1) or increasing histone acetylation interferes with CID island formation on a global scale, ..
  60. Sun F, Cuaycong M, Craig C, Wallrath L, Locke J, Elgin S. The fourth chromosome of Drosophila melanogaster: interspersed euchromatic and heterochromatic domains. Proc Natl Acad Sci U S A. 2000;97:5340-5 pubmed
    ..is heterochromatic; the banded region includes blocks of middle repetitious DNA associated with heterochromatin protein 1 (HP1)...
  61. Ma J, Hwang K, Worman H, Courvalin J, Eissenberg J. Expression and functional analysis of three isoforms of human heterochromatin-associated protein HP1 in Drosophila. Chromosoma. 2001;109:536-44 pubmed
    Heterochromatin-associated protein 1 (HP1) is a nonhistone chromosomal protein associated with pericentromeric heterochromatin in Drosophila. HP1-like proteins have also been found associated with heterochromatin in human cells...
  62. Dialynas G, Speese S, Budnik V, Geyer P, Wallrath L. The role of Drosophila Lamin C in muscle function and gene expression. Development. 2010;137:3067-77 pubmed publisher
    ..These data demonstrate connections among the Drosophila A-type lamin, hormone-induced gene expression and muscle function. ..
  63. Wustmann G, Szidonya J, Taubert H, Reuter G. The genetics of position-effect variegation modifying loci in Drosophila melanogaster. Mol Gen Genet. 1989;217:520-7 pubmed
    ..Most of these loci proved not to display significant triplo-effects (35). The group of haplo-abnormal loci with a triplo-effect may represent genes which play an important role in heterochromatin packaging. ..
  64. Ciapponi L, Cenci G, Ducau J, Flores C, Johnson Schlitz D, Gorski M, et al. The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage. Curr Biol. 2004;14:1360-6 pubmed
    ..the roles of rad50 and mre11 in telomere protection, mutant chromosome preparations were immunostained for both HP1 and HOAP, two proteins that protect Drosophila telomeres from fusion...
  65. Kalmykova A, Klenov M, Gvozdev V. Argonaute protein PIWI controls mobilization of retrotransposons in the Drosophila male germline. Nucleic Acids Res. 2005;33:2052-9 pubmed
    ..Our results provide the first evidence that protein of the Argonaute family prevents retrotranspositions. It is supposed that the disturbance of RNA silencing system in germinal cells might cause transposition burst. ..
  66. Lomberk G, Wallrath L, Urrutia R. The Heterochromatin Protein 1 family. Genome Biol. 2006;7:228 pubmed
    b>Heterochromatin Protein 1 (HP1) was first discovered in Drosophila as a dominant suppressor of position-effect variegation and a major component of heterochromatin...
  67. Raffa G, Raimondo D, Sorino C, Cugusi S, Cenci G, Cacchione S, et al. Verrocchio, a Drosophila OB fold-containing protein, is a component of the terminin telomere-capping complex. Genes Dev. 2010;24:1596-601 pubmed publisher
    ..Drosophila telomeres are protected by terminin, a complex that includes the HOAP (Heterochromatin Protein 1/origin recognition complex-associated protein) and Moi (Modigliani) proteins and shares the properties ..
  68. Ferree P, Prasad S. How can satellite DNA divergence cause reproductive isolation? Let us count the chromosomal ways. Genet Res Int. 2012;2012:430136 pubmed publisher
    ..These findings have important implications for how loci that cause postzygotic reproductive isolation are viewed. ..
  69. Figueiredo M, Philip P, Stenberg P, Larsson J. HP1a recruitment to promoters is independent of H3K9 methylation in Drosophila melanogaster. PLoS Genet. 2012;8:e1003061 pubmed publisher
    b>Heterochromatin protein 1 (HP1) proteins, recognized readers of the heterochromatin mark methylation of histone H3 lysine 9 (H3K9me), are important regulators of heterochromatin-mediated gene silencing and chromosome structure...
  70. Eissenberg J, James T, Foster Hartnett D, Hartnett T, Ngan V, Elgin S. Mutation in a heterochromatin-specific chromosomal protein is associated with suppression of position-effect variegation in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1990;87:9923-7 pubmed
    ..This suggests that heterochromatin-specific proteins play a central role in the gene suppression associated with heterochromatic position effects. ..
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