Gene Symbol: stj
Description: straightjacket
Alias: CG12295, Dmel\CG12295, alpha[[2]]delta, alpha[[2]]delta-3, dalpha[[2]]delta-3, l(2)k10814, straightjacket, CG12295-PB, CG12295-PC, CG12295-PD, lethal (2) k10814, stj-PB, stj-PC, stj-PD
Species: fruit fly

Top Publications

  1. Dickman D, Kurshan P, Schwarz T. Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function. J Neurosci. 2008;28:31-8 pubmed publisher
    ..This is the first characterization of an alpha2delta-3 mutant in any organism and indicates a necessary role for alpha2delta-3 in presynaptic vesicle release and calcium channel expression at active zones. ..
  2. Ly C, Yao C, Verstreken P, Ohyama T, Bellen H. straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. J Cell Biol. 2008;181:157-70 pubmed publisher
    In a screen to identify genes involved in synaptic function, we isolated mutations in Drosophila melanogaster straightjacket (stj), an alpha(2)delta subunit of the voltage-gated calcium channel...
  3. Neely G, Hess A, Costigan M, Keene A, Goulas S, Langeslag M, et al. A genome-wide Drosophila screen for heat nociception identifies ?2?3 as an evolutionarily conserved pain gene. Cell. 2010;143:628-38 pubmed publisher
    ..identify hundreds of genes implicated in heat nociception, including the ?2? family calcium channel subunit straightjacket (stj). Mice mutant for the stj ortholog CACNA2D3 (?2?3) also exhibit impaired behavioral heat pain sensitivity...
  4. Neely G, Keene A, Duchek P, Chang E, Wang Q, Aksoy Y, et al. TrpA1 regulates thermal nociception in Drosophila. PLoS ONE. 2011;6:e24343 pubmed publisher
    ..thermal nociception in the fruit fly and have reported a large-scale screen that identified the Ca²? channel straightjacket (stj) as a conserved regulator of thermal nociception...
  5. Tian X, Gala U, Zhang Y, Shang W, Nagarkar Jaiswal S, di Ronza A, et al. A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biol. 2015;13:e1002103 pubmed publisher
    ..Loss of another subunit of the VGCC, α2δ or straightjacket (stj), causes phenotypes very similar to those caused by the loss of cac, indicating that the VGCC is required ..
  6. Mohr S, Smith J, Shamu C, Neumüller R, Perrimon N. RNAi screening comes of age: improved techniques and complementary approaches. Nat Rev Mol Cell Biol. 2014;15:591-600 pubmed publisher
  7. Ghimire S, Kim M. Defensive Behavior against Noxious Heat Stimuli Is Declined with Aging Due to Decreased Pain-Associated Gene Expression in Drosophila. Biomol Ther (Seoul). 2015;23:290-5 pubmed publisher
    ..However, we identified pain-related gene expression alteration with aging. We anticipate that our findings would help opening a new window onto developing the optimal pain treatment for the elderly. ..
  8. Hoopengardner B, Bhalla T, Staber C, Reenan R. Nervous system targets of RNA editing identified by comparative genomics. Science. 2003;301:832-6 pubmed
    ..These results point to a pivotal role for RNA editing in nervous system function. ..
  9. Kurshan P, Oztan A, Schwarz T. Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions. Nat Neurosci. 2009;12:1415-23 pubmed publisher
    ..strictly as an auxiliary subunit of the Ca(2+) channel, but the phenotype of alpha(2)delta-3 (also known as stj) mutations cannot be explained by a channel defect; embryos lacking the pore-forming alpha(1) subunit cacophony ..

More Information


  1. Kuromi H, Ueno K, Kidokoro Y. Two types of Ca2+ channel linked to two endocytic pathways coordinately maintain synaptic transmission at the Drosophila synapse. Eur J Neurosci. 2010;32:335-46 pubmed publisher
    ..Immunostaining of the Ca(2+) channel alpha(2)delta subunit encoded by straightjacket (stj) was found within the AZ, and a mutation in stj depressed the R-BayK-sensitive component but enhanced the ..
  2. Jepson J, Savva Y, Yokose C, Sugden A, Sahin A, Reenan R. Engineered alterations in RNA editing modulate complex behavior in Drosophila: regulatory diversity of adenosine deaminase acting on RNA (ADAR) targets. J Biol Chem. 2011;286:8325-37 pubmed publisher
    ..Our data demonstrate that network-wide temporal and spatial regulation of ADAR activity can tune the complex system of RNA-editing sites and modulate multiple ethologically relevant behavioral modalities. ..
  3. Galili D, Dylla K, Lüdke A, Friedrich A, Yamagata N, Wong J, et al. Converging circuits mediate temperature and shock aversive olfactory conditioning in Drosophila. Curr Biol. 2014;24:1712-22 pubmed publisher
    ..Temperature conditioning appears to require a subset of the dopamine neurons required for electric shock conditioning. We conclude that dopamine neurons integrate different noxious signals into a general aversive reinforcement pathway. ..