Gene Symbol: stj
Alias: CG12295, Dmel\CG12295, alpha[]delta, alpha[]delta-3, dalpha[]delta-3, l(2)k10814, straightjacket, CG12295-PB, CG12295-PC, CG12295-PD, lethal (2) k10814, stj-PB, stj-PC, stj-PD
Species: fruit fly
Dickman D, Kurshan P, Schwarz T. Mutations in a Drosophila alpha2delta voltage-gated calcium channel subunit reveal a crucial synaptic function. J Neurosci. 2008;28:31-8 pubmed publisher
..This is the first characterization of an alpha2delta-3 mutant in any organism and indicates a necessary role for alpha2delta-3 in presynaptic vesicle release and calcium channel expression at active zones. ..
Ly C, Yao C, Verstreken P, Ohyama T, Bellen H. straightjacket is required for the synaptic stabilization of cacophony, a voltage-gated calcium channel alpha1 subunit. J Cell Biol. 2008;181:157-70 pubmed publisher
In a screen to identify genes involved in synaptic function, we isolated mutations in Drosophila melanogaster straightjacket (stj), an alpha(2)delta subunit of the voltage-gated calcium channel...
Neely G, Hess A, Costigan M, Keene A, Goulas S, Langeslag M, et al
. A genome-wide Drosophila screen for heat nociception identifies ?2?3 as an evolutionarily conserved pain gene. Cell. 2010;143:628-38 pubmed publisher
..identify hundreds of genes implicated in heat nociception, including the ?2? family calcium channel subunit straightjacket (stj). Mice mutant for the stj ortholog CACNA2D3 (?2?3) also exhibit impaired behavioral heat pain sensitivity...
Neely G, Keene A, Duchek P, Chang E, Wang Q, Aksoy Y, et al
. TrpA1 regulates thermal nociception in Drosophila. PLoS ONE. 2011;6:e24343 pubmed publisher
..thermal nociception in the fruit fly and have reported a large-scale screen that identified the Ca²? channel straightjacket (stj) as a conserved regulator of thermal nociception...
Tian X, Gala U, Zhang Y, Shang W, Nagarkar Jaiswal S, di Ronza A, et al
. A voltage-gated calcium channel regulates lysosomal fusion with endosomes and autophagosomes and is required for neuronal homeostasis. PLoS Biol. 2015;13:e1002103 pubmed publisher
..Loss of another subunit of the VGCC, Î±2Î´ or straightjacket (stj), causes phenotypes very similar to those caused by the loss of cac, indicating that the VGCC is required ..
Mohr S, Smith J, Shamu C, NeumÃ¼ller R, Perrimon N. RNAi screening comes of age: improved techniques and complementary approaches. Nat Rev Mol Cell Biol. 2014;15:591-600 pubmed publisher
Ghimire S, Kim M. Defensive Behavior against Noxious Heat Stimuli Is Declined with Aging Due to Decreased Pain-Associated Gene Expression in Drosophila. Biomol Ther (Seoul). 2015;23:290-5 pubmed publisher
..However, we identified pain-related gene expression alteration with aging. We anticipate that our findings would help opening a new window onto developing the optimal pain treatment for the elderly. ..
Hoopengardner B, Bhalla T, Staber C, Reenan R. Nervous system targets of RNA editing identified by comparative genomics. Science. 2003;301:832-6 pubmed
..These results point to a pivotal role for RNA editing in nervous system function. ..
Kurshan P, Oztan A, Schwarz T. Presynaptic alpha2delta-3 is required for synaptic morphogenesis independent of its Ca2+-channel functions. Nat Neurosci. 2009;12:1415-23 pubmed publisher
..strictly as an auxiliary subunit of the Ca(2+) channel, but the phenotype of alpha(2)delta-3 (also known as stj) mutations cannot be explained by a channel defect; embryos lacking the pore-forming alpha(1) subunit cacophony ..