sti

Summary

Gene Symbol: sti
Description: sticky
Alias: CG10522, CIT-K, Citron K, DCK, Dmel\CG10522, STI, anon-WO0118547.388, cit, dck, l(3)7m-62, l(3)7m62, l(3)SG21, sti/Citron, sticky, CG10522-PA, CG10522-PB, citron, citron kinase, drosophila citron kinase, sti-PA, sti-PB
Species: fruit fly

Top Publications

  1. Bassi Z, Audusseau M, Riparbelli M, Callaini G, D Avino P. Citron kinase controls a molecular network required for midbody formation in cytokinesis. Proc Natl Acad Sci U S A. 2013;110:9782-7 pubmed publisher
    ..Here we show that Sticky (Sti), the Drosophila ortholog of the contractile ring component Citron kinase (CIT-K), interacts directly with two kinesins, Nebbish [the fly counterpart of human kinesin family member 14 (..
  2. D Avino P, Savoian M, Glover D. Mutations in sticky lead to defective organization of the contractile ring during cytokinesis and are enhanced by Rho and suppressed by Rac. J Cell Biol. 2004;166:61-71 pubmed
    ..sti encodes the Drosophila orthologue of the mammalian Citron kinase. RNA interference-mediated silencing of sti in cultured cells causes them to become multinucleate...
  3. Shandala T, Gregory S, Dalton H, Smallhorn M, Saint R. Citron kinase is an essential effector of the Pbl-activated Rho signalling pathway in Drosophila melanogaster. Development. 2004;131:5053-63 pubmed
    ..Here we report that the Drosophila citron gene encodes an essential effector kinase of Pbl-RhoA signalling in vivo...
  4. Sweeney S, Campbell P, Bosco G. Drosophila sticky/citron kinase is a regulator of cell-cycle progression, genetically interacts with Argonaute 1 and modulates epigenetic gene silencing. Genetics. 2008;178:1311-25 pubmed publisher
    The sticky/citron kinase protein is a conserved regulator of cell-cycle progression from invertebrates to humans...
  5. Hickson G, Echard A, O Farrell P. Rho-kinase controls cell shape changes during cytokinesis. Curr Biol. 2006;16:359-70 pubmed
    ..We show that cortical changes underlying cell elongation are more sensitive to depletion of Rok and myosin II, in comparison to other regulators of cytokinesis, and suggest that a distinct regulatory pathway promotes cell elongation. ..
  6. Dean S, Spudich J. Rho kinase's role in myosin recruitment to the equatorial cortex of mitotic Drosophila S2 cells is for myosin regulatory light chain phosphorylation. PLoS ONE. 2006;1:e131 pubmed
    ..Furthermore, the essential role of Citron in cytokinesis is not phosphorylation of the RLC...
  7. Gatti M, Baker B. Genes controlling essential cell-cycle functions in Drosophila melanogaster. Genes Dev. 1989;3:438-53 pubmed
  8. Naim V, Imarisio S, Di Cunto F, Gatti M, Bonaccorsi S. Drosophila citron kinase is required for the final steps of cytokinesis. Mol Biol Cell. 2004;15:5053-63 pubmed
    ..Flies bearing mutations in the Drosophila citron kinase (dck) gene were defective in both neuroblast and spermatocyte cytokinesis...
  9. Bassi Z, Verbrugghe K, Capalbo L, Gregory S, Montembault E, Glover D, et al. Sticky/Citron kinase maintains proper RhoA localization at the cleavage site during cytokinesis. J Cell Biol. 2011;195:595-603 pubmed publisher
    ..effectors like formins and Rho kinase is reasonably understood, the functions of another putative effector, Citron kinase (CIT-K), are still debated...

More Information

Publications27

  1. Gai M, Bianchi F, Vagnoni C, Vernì F, Bonaccorsi S, Pasquero S, et al. ASPM and CITK regulate spindle orientation by affecting the dynamics of astral microtubules. EMBO Rep. 2016;17:1396-1409 pubmed
    ..In this report, we show that ASPM may control spindle positioning by interacting with citron kinase (CITK), a protein whose loss is also responsible for severe microcephaly in mammals...
  2. Wilhelm J, Buszczak M, Sayles S. Efficient protein trafficking requires trailer hitch, a component of a ribonucleoprotein complex localized to the ER in Drosophila. Dev Cell. 2005;9:675-85 pubmed
    ..These findings raise exciting new possibilities for how the mRNA localization machinery could interface with the classical secretory pathway to promote efficient protein trafficking in the cell. ..
  3. Schweisguth F, Vincent A, Lepesant J. Genetic analysis of the cellularization of the Drosophila embryo. Biol Cell. 1991;72:15-23 pubmed
    ..Among them, the serendipity alpha gene encodes a membrane-associated protein, which is exclusively accumulated during cellularization, and is required for the reorganization of the microfilaments as the onset of cellularization. ..
  4. Das A, Shah S, Fan B, Paik D, DiSanto D, Hinman A, et al. Spindle Assembly and Chromosome Segregation Requires Central Spindle Proteins in Drosophila Oocytes. Genetics. 2016;202:61-75 pubmed publisher
    ..system, that the Centralspindlin component RacGAP50C and downstream regulators of cytokinesis Rho1, Sticky, and RhoGEF2 are required for homologous chromosome bi-orientation in metaphase I oocytes...
  5. Rocha J, Korolchuk V, Robinson I, O Kane C. A phagocytic route for uptake of double-stranded RNA in RNAi. PLoS ONE. 2011;6:e19087 pubmed publisher
    ..We could separate this phagocytic uptake route from that for RNAi induced by naked dsRNA. Therefore, phagocytic uptake of dsRNA offers a potential route for systemic spread of RNAi. ..
  6. D Avino P, Savoian M, Glover D. Cleavage furrow formation and ingression during animal cytokinesis: a microtubule legacy. J Cell Sci. 2005;118:1549-58 pubmed
    ..The same mechanism might be conserved in other organisms. ..
  7. Eggert U, Kiger A, Richter C, Perlman Z, Perrimon N, Mitchison T, et al. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2004;2:e379 pubmed
    ..Our study shows that parallel RNA interference and small molecule screening is a generally useful approach to identifying active small molecules and their target pathways...
  8. Glover D. Abbreviated and regulated cell cycles in Drosophila. Curr Opin Cell Biol. 1990;2:258-61 pubmed
  9. Gatti M, Goldberg M. Mutations affecting cell division in Drosophila. Methods Cell Biol. 1991;35:543-86 pubmed
  10. Carré C, Szymczak D, Pidoux J, Antoniewski C. The histone H3 acetylase dGcn5 is a key player in Drosophila melanogaster metamorphosis. Mol Cell Biol. 2005;25:8228-38 pubmed
    ..Our results establish dGcn5 as a major histone H3 acetylase in Drosophila which plays a key role in the control of specific morphogenetic cascades during developmental transitions. ..
  11. Yin Z, Zhou X, Bakal C, Li F, Sun Y, Perrimon N, et al. Using iterative cluster merging with improved gap statistics to perform online phenotype discovery in the context of high-throughput RNAi screens. BMC Bioinformatics. 2008;9:264 pubmed publisher
    ..In our findings, the proposed method is suitable for online phenotype discovery in diverse high-throughput image-based genetic and chemical screens. ..
  12. Castellanos E, Dominguez P, Gonzalez C. Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability. Curr Biol. 2008;18:1209-14 pubmed publisher
    ..We propose that such tumors might be caused by impaired asymmetric division of neural stem cells [4]. These results show that centrosome loss, far from being innocuous, is a potentially dangerous condition in flies...
  13. El Amine N, Kechad A, Jananji S, Hickson G. Opposing actions of septins and Sticky on Anillin promote the transition from contractile to midbody ring. J Cell Biol. 2013;203:487-504 pubmed publisher
    ..away excess membrane from the late CR/nascent MR via internalization, extrusion, and shedding, whereas the citron kinase Sticky acts on the N terminus of Anillin to retain it at the mature MR...
  14. Slack C, Somers W, Sousa Nunes R, Chia W, Overton P. A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions. BMC Genet. 2006;7:33 pubmed
    ..Taken together, these results demonstrate the value of mosaic screens in the identification of genes involved in neuroblast division. ..
  15. Kunda P, Pelling A, Liu T, Baum B. Moesin controls cortical rigidity, cell rounding, and spindle morphogenesis during mitosis. Curr Biol. 2008;18:91-101 pubmed publisher
    ..In doing so, they help to explain why dynamic changes in cortical architecture are a universal feature of mitosis in animal cells. ..
  16. Bauer C, Epstein A, Sweeney S, Zarnescu D, Bosco G. Genetic and systems level analysis of Drosophila sticky/citron kinase and dFmr1 mutants reveals common regulation of genetic networks. BMC Syst Biol. 2008;2:101 pubmed publisher
    In Drosophila, the genes sticky and dFmr1 have both been shown to regulate cytoskeletal dynamics and chromatin structure. These genes also genetically interact with Argonaute family microRNA regulators...
  17. Shearn A, Garen A. Genetic control of imaginal disc development in Drosophila. Proc Natl Acad Sci U S A. 1974;71:1393-7 pubmed
    ..Thus, both types of disc-specific functions are essential for normal disc development. ..
  18. Zacharogianni M, Kondylis V, Tang Y, Farhan H, Xanthakis D, Fuchs F, et al. ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association. EMBO J. 2011;30:3684-700 pubmed publisher
    ..These results reveal the existence of new signalling circuits participating in the complex regulation of cell growth. ..