Gene Symbol: stet
Description: stem cell tumor
Alias: B-Rho, Brho, CG12083, CG12504, CG33166, Dmel\CG33166, Rho-2, Rho2, brho, rho-2, rho2, stem cell tumor, CG33166-PA, CG33166-PB, brother of rhomboid, rhomboid-2, stet-PA, stet-PB
Species: fruit fly

Top Publications

  1. Guichard A, Roark M, Ronshaugen M, Bier E. brother of rhomboid, a rhomboid-related gene expressed during early Drosophila oogenesis, promotes EGF-R/MAPK signaling. Dev Biol. 2000;226:255-66 pubmed
    ..we report on a new rhomboid-related gene identified by sequence similarity searching that we have named brother of rhomboid (brho)...
  2. Parrott B, Hudson A, Brady R, Schulz C. Control of germline stem cell division frequency--a novel, developmentally regulated role for epidermal growth factor signaling. PLoS ONE. 2012;7:e36460 pubmed publisher
    ..In addition, regulation of GSC division frequency is a specific role for EGF signaling as it is not affected in all tumor models. These data advance our understanding concerning stem cell dynamics in normal tissues and in a tumor model. ..
  3. Parrott B, Chiang Y, Hudson A, Sarkar A, Guichet A, Schulz C. Nucleoporin98-96 function is required for transit amplification divisions in the germ line of Drosophila melanogaster. PLoS ONE. 2011;6:e25087 pubmed publisher
  4. Urban S, Lee J, Freeman M. A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands. EMBO J. 2002;21:4277-86 pubmed
    ..This is distinct from the metalloprotease-induced activation of mammalian EGF-like ligands. ..
  5. Schulz C, Wood C, Jones D, Tazuke S, Fuller M. Signaling from germ cells mediated by the rhomboid homolog stet organizes encapsulation by somatic support cells. Development. 2002;129:4523-34 pubmed
    ..that interactions between germ cells and somatic support cells in Drosophila depend on wild-type function of the stet gene...
  6. Urban S. Rhomboid proteins: conserved membrane proteases with divergent biological functions. Genes Dev. 2006;20:3054-68 pubmed
    ..Further study of these novel enzymes promises to reveal the evolutionary path of rhomboid protein function, which could provide insights into the forces that drive the molecular evolution of regulatory mechanisms. ..
  7. Fuller M, Spradling A. Male and female Drosophila germline stem cells: two versions of immortality. Science. 2007;316:402-4 pubmed
    ..Comparing these two stem cells and their niches in detail is likely to reveal how a common heritage has been adapted to the differing requirements of male and female gamete production. ..
  8. Yogev S, Schejter E, Shilo B. Drosophila EGFR signalling is modulated by differential compartmentalization of Rhomboid intramembrane proteases. EMBO J. 2008;27:1219-30 pubmed publisher
    ..These observations identify changes in intracellular compartment localization of Rho proteins as a basis for signal attenuation, in tissues where EGFR activation must be highly restricted in space and time. ..
  9. Wasserman J, Urban S, Freeman M. A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling. Genes Dev. 2000;14:1651-63 pubmed
    ..Rhomboid-1 and Roughoid/Rhomboid-3 act in the signal-emitting not signal-receiving cell, supporting the idea that Spitz activation is regulated by Rhomboid-like molecules. ..

More Information


  1. Kitadate Y, Kobayashi S. Notch and Egfr signaling act antagonistically to regulate germ-line stem cell niche formation in Drosophila male embryonic gonads. Proc Natl Acad Sci U S A. 2010;107:14241-6 pubmed publisher
    ..Thus, we propose that SGPs sense PGC number via signals from PGCs to SGPs that modulate niche size, and that this serves as a mechanism for securing GSCs...
  2. Debat V, Debelle A, Dworkin I. Plasticity, canalization, and developmental stability of the Drosophila wing: joint effects of mutations and developmental temperature. Evolution. 2009;63:2864-76 pubmed publisher
    ..It suggests as well that the developmental processes responsible for developmental stability and environmental canalization might be partially distinct. ..
  3. Jiang H, Edgar B. EGFR signaling regulates the proliferation of Drosophila adult midgut progenitors. Development. 2009;136:483-93 pubmed publisher
    ..Two stronger EGFR ligands, Spitz and Keren, are expressed by the AMPs themselves and provide an additional, autocrine mitogenic stimulus to the AMPs during late larval stages. ..
  4. Castro C, Piscopo D, Nakagawa T, Derynck R. Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells. J Cell Sci. 2007;120:2454-66 pubmed
    ..Thus, cornichon proteins represent a functionally conserved protein family that acts in the selective transport and maturation of TGFalpha family proteins. ..
  5. Liu M, Lim T, Cai Y. The Drosophila female germline stem cell lineage acts to spatially restrict DPP function within the niche. Sci Signal. 2010;3:ra57 pubmed publisher
    ..Thus, our data reveal that the reciprocal crosstalk between the GSCs and the somatic cells defines the spatial limits of DPP action and therefore the extent of the GSC niche. ..
  6. Matsuoka S, Hiromi Y, Asaoka M. Egfr signaling controls the size of the stem cell precursor pool in the Drosophila ovary. Mech Dev. 2013;130:241-53 pubmed publisher
    ..While excess GSC formation is compensated by the adult stage, insufficient GSC formation can lead to adult ovarioles that completely lack GSCs, suggesting that ensuring an absolute size of the PGC pool is crucial for the GSC system...
  7. Hudson A, Parrott B, Qian Y, Schulz C. A temporal signature of epidermal growth factor signaling regulates the differentiation of germline cells in testes of Drosophila melanogaster. PLoS ONE. 2013;8:e70678 pubmed publisher
  8. Urban S, Brown G, Freeman M. EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development. Development. 2004;131:1835-45 pubmed
    ..This strategy might guard against developmental errors, and may be conserved in mammalian epidermal patterning. ..
  9. Urban S, Freeman M. Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain. Mol Cell. 2003;11:1425-34 pubmed
    ..These results provide an explanation of how rhomboid proteases achieve specificity, and allow some rhomboid substrates to be predicted from sequence information. ..
  10. Ghiglione C, Bach E, Paraiso Y, Carraway K, Noselli S, Perrimon N. Mechanism of activation of the Drosophila EGF Receptor by the TGFalpha ligand Gurken during oogenesis. Development. 2002;129:175-86 pubmed
    ..We find that the two transmembrane proteins Star and Brho potentiate the activity of mbGrk...
  11. Herz H, Mohan M, Garrett A, Miller C, Casto D, Zhang Y, et al. Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila. Mol Cell Biol. 2012;32:1683-93 pubmed publisher
    ..Identification of Jarid2 as a conserved PRC2 interactor in flies provides an opportunity to begin to probe some of its novel functions in Drosophila development. ..
  12. Klämbt C. EGF receptor signalling: the importance of presentation. Curr Biol. 2000;10:R388-91 pubmed
    ..Recent studies have shed new light on the role of two transmembrane proteins, Star and Rhomboid, in the presentation and subsequent proteolytic processing of Spitz. ..
  13. Freeman M. The rhomboid-like superfamily: molecular mechanisms and biological roles. Annu Rev Cell Dev Biol. 2014;30:235-54 pubmed publisher
    ..Their potential medical significance is now becoming apparent in several areas. ..
  14. Barton L, Lovander K, Pinto B, Geyer P. Drosophila male and female germline stem cell niches require the nuclear lamina protein Otefin. Dev Biol. 2016;415:75-86 pubmed publisher
    ..Finally, our data add to growing evidence that LEM-D proteins have critical roles in stem cell survival and tissue homeostasis. ..