Gene Symbol: Stat92E
Description: Signal-transducer and activator of transcription protein at 92E
Alias: CG4257, D-STAT, D-Stat, D-stat, D-stat/stat92E, DRODSRC, DSRC, DSTAT, DmSTAT, Dmel\CG4257, Dstat, Dstat 92E, Dstat92E, SD-stat, STAT, STAT 92E, STAT92E, STAT92e, Stat, Stat1alpha-like, Stat92, Stat92e, d-STAT, dSTAT, dSTAT92E, dSTAT92E/marelle, dstat, l(3)06346, l(3)j6C8, mrL, mrl, mrl stat92E, pSTAT, stat, stat92, stat92E, stat92e, stat[92E], Signal-transducer and activator of transcription protein at 92E, CG4257-PB, CG4257-PC, CG4257-PE, CG4257-PF, CG4257-PG, CG4257-PH, CG4257-PI, CG4257-PJ, CG4257-PK, CG4257-PL, CG4257-PM, Signal-transducer and activator of transcription protein, Stat92E-PB, Stat92E-PC, Stat92E-PE, Stat92E-PF, Stat92E-PG, Stat92E-PH, Stat92E-PI, Stat92E-PJ, Stat92E-PK, Stat92E-PL, Stat92E-PM, marelle, signal transducer and activator of transcription, signal transducers and activator of transcription
Species: fruit fly
Products:     Stat92E

Top Publications

  1. Stec W, Zeidler M. Drosophila SOCS Proteins. J Signal Transduct. 2011;2011:894510 pubmed publisher
    The importance of signal transduction cascades such as the EGFR and JAK/STAT pathways for development and homeostasis is highlighted by the high levels of molecular conservation maintained between organisms as evolutionary diverged as ..
  2. Beebe K, Lee W, Micchelli C. JAK/STAT signaling coordinates stem cell proliferation and multilineage differentiation in the Drosophila intestinal stem cell lineage. Dev Biol. 2010;338:28-37 pubmed publisher
    ..Here we investigate the role of the conserved JAK/STAT signaling pathway in the Drosophila intestinal stem cell (ISC) lineage...
  3. Fujioka M, Emi Sarker Y, Yusibova G, Goto T, Jaynes J. Analysis of an even-skipped rescue transgene reveals both composite and discrete neuronal and early blastoderm enhancers, and multi-stripe positioning by gap gene repressor gradients. Development. 1999;126:2527-38 pubmed
    ..Additionally, a strong pairing-sensitive repression element was localized to the 3' end of the locus, but was not found to contribute to efficient functional rescue. ..
  4. Silver D, Montell D. Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila. Cell. 2001;107:831-41 pubmed
    The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival, is constitutively active in various human cancers, including ovarian...
  5. Singh S, Zhen W, Zheng Z, Wang H, Oh S, Liu W, et al. The Drosophila homolog of the human tumor suppressor gene BHD interacts with the JAK-STAT and Dpp signaling pathways in regulating male germline stem cell maintenance. Oncogene. 2006;25:5933-41 pubmed
    ..genetic interaction experiments suggest that DBHD regulates GSC maintenance downstream or in parallel of the JAK/STAT and Dpp signal-transduction pathways...
  6. Amoyel M, Sanny J, Burel M, Bach E. Hedgehog is required for CySC self-renewal but does not contribute to the GSC niche in the Drosophila testis. Development. 2013;140:56-65 pubmed publisher
    ..does not contribute to the niche function of CySCs, as Hh-sustained CySCs are unable to maintain GSCs in the absence of Stat92E. Therefore, the extended niche function of CySCs is solely attributable to JAK/STAT pathway function.
  7. Darnell J. STATs and gene regulation. Science. 1997;277:1630-5 pubmed
    ..Mouse genetics experiments have defined crucial roles for each known mammalian STAT. The discovery of a STAT in Drosophila, and most recently in Dictyostelium discoideum, implies an ancient ..
  8. Starz Gaiano M, Melani M, Meinhardt H, Montell D. Interpretation of the UPD/JAK/STAT morphogen gradient in Drosophila follicle cells. Cell Cycle. 2009;8:2917-25 pubmed
    ..Using genetics we identified a gene regulatory network that controls the dynamic pattern of activation of JAK/STAT in anterior follicle cells...
  9. Denef N, Schupbach T. Patterning: JAK-STAT signalling in the Drosophila follicular epithelium. Curr Biol. 2003;13:R388-90 pubmed
    ..During Drosophila oogenesis the follicular epithelium becomes subdivided into distinct cell populations. New reports have established that the Janus kinase (JAK) signalling pathway plays an important role in this process. ..

More Information


  1. Buchon N, Broderick N, Kuraishi T, Lemaitre B. Drosophila EGFR pathway coordinates stem cell proliferation and gut remodeling following infection. BMC Biol. 2010;8:152 pubmed publisher
    ..induced in the surrounding visceral muscles in part under the control of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway...
  2. Yan R, Luo H, Darnell J, Dearolf C. A JAK-STAT pathway regulates wing vein formation in Drosophila. Proc Natl Acad Sci U S A. 1996;93:5842-7 pubmed
    We present evidence that the JAK-STAT signal transduction pathway regulates multiple developmental processes in Drosophila...
  3. Jinks T, Polydorides A, Calhoun G, Schedl P. The JAK/STAT signaling pathway is required for the initial choice of sexual identity in Drosophila melanogaster. Mol Cell. 2000;5:581-7 pubmed
    ..upd also functions as a numerator element in regulating wild-type Sxl-Pe reporters. We demonstrate that the JAK kinase, Hopscotch, and the STAT DNA-binding protein, Marelle, are also required for Sxl-Pe activation.
  4. Kiger A, Jones D, Schulz C, Rogers M, Fuller M. Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue. Science. 2001;294:2542-5 pubmed
    ..Hub cells express the ligand Unpaired (Upd), which activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway in adjacent germ cells to specify self-renewal and continual maintenance ..
  5. Noselli S, Perrimon N. Signal transduction. Are there close encounters between signaling pathways?. Science. 2000;290:68-9 pubmed
  6. Copf T, Goguel V, Lampin Saint Amaux A, Scaplehorn N, Preat T. Cytokine signaling through the JAK/STAT pathway is required for long-term memory in Drosophila. Proc Natl Acad Sci U S A. 2011;108:8059-64 pubmed publisher
    ..required in the mushroom bodies for olfactory aversive long-term memory but the Upd receptor Dome, as well as the Drosophila JAK and STAT homologs Hop and Stat92E, are also required, while being dispensable for less stable memory forms.
  7. McGregor J, Xi R, Harrison D. JAK signaling is somatically required for follicle cell differentiation in Drosophila. Development. 2002;129:705-17 pubmed
    ..Mosaic analysis of both JAK pathway transducers, hopscotch and Stat92E, reveals that JAK signaling is specifically required in the somatic follicle cells...
  8. Tsai Y, Sun Y. Long-range effect of upd, a ligand for Jak/STAT pathway, on cell cycle in Drosophila eye development. Genesis. 2004;39:141-53 pubmed
    ..Upd regulates eye size through the Dome/Jak(Hop)/STAT92 signaling pathway to promote cell proliferation...
  9. Vidal O, Stec W, Bausek N, Smythe E, Zeidler M. Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking. J Cell Sci. 2010;123:3457-66 pubmed publisher
    ..Strikingly, a recent report has suggested that the endocytic trafficking of the Drosophila JAK-STAT pathway receptor Domeless (Dome) does not act to downregulate pathway activity, but rather is necessary for in vivo ..
  10. Makki R, Meister M, Pennetier D, Ubeda J, Braun A, Daburon V, et al. A short receptor downregulates JAK/STAT signalling to control the Drosophila cellular immune response. PLoS Biol. 2010;8:e1000441 pubmed publisher
    ..manner to maintain janus tyrosine kinase/signal transducers and activators of transcription (JAK/STAT) signalling in hematopoietic progenitors (prohemocytes), thereby preserving the multipotent character necessary for ..
  11. Hayashi Y, Sexton T, Dejima K, Perry D, Takemura M, Kobayashi S, et al. Glypicans regulate JAK/STAT signaling and distribution of the Unpaired morphogen. Development. 2012;139:4162-71 pubmed publisher
    ..of the Unpaired (Upd) family activate the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway. The JAK/STAT pathway controls many developmental events, including multiple functions in the ovary...
  12. Xi R, McGregor J, Harrison D. A gradient of JAK pathway activity patterns the anterior-posterior axis of the follicular epithelium. Dev Cell. 2003;4:167-77 pubmed
    ..Further, the coordinated activities of the JAK/STAT and epidermal growth factor receptor (EGFR) pathways are required to specify the posterior terminal cell fate...
  13. Rørth P. Initiating and guiding migration: lessons from border cells. Trends Cell Biol. 2002;12:325-31 pubmed
    ..This article discusses the implications of these studies and compares (invasive) migration through a tissue with what is known about cells crawling on a flat substratum. ..
  14. Cordero J, Stefanatos R, Myant K, Vidal M, Sansom O. Non-autonomous crosstalk between the Jak/Stat and Egfr pathways mediates Apc1-driven intestinal stem cell hyperplasia in the Drosophila adult midgut. Development. 2012;139:4524-35 pubmed publisher
    ..high Wg in ISCs results in non-cell-autonomous upregulation of upd3 in enterocytes and subsequent activation of Jak/Stat signaling in ISCs...
  15. Yan R, Small S, Desplan C, Dearolf C, Darnell J. Identification of a Stat gene that functions in Drosophila development. Cell. 1996;84:421-30 pubmed
    A Drosophila Stat gene (D-Stat) with a zygotic segmental expression pattern was identified. This protein becomes phosphorylated on Tyr-704 when coexpressed in Schneider cells with a Drosophila janus kinase (JAK), Hopscotch (HOP)...
  16. Singh S, Liu W, Hou S. The adult Drosophila malpighian tubules are maintained by multipotent stem cells. Cell Stem Cell. 2007;1:191-203 pubmed publisher
    ..that several differentiated cells in the Malpighian tubules arise from the stem cells and an autocrine JAK-STAT signaling regulates the stem cells' self-renewal...
  17. Gutierrez Aviño F, Ferres Marco D, Dominguez M. The position and function of the Notch-mediated eye growth organizer: the roles of JAK/STAT and four-jointed. EMBO Rep. 2009;10:1051-8 pubmed publisher
    ..organizer at the mid-first instar, and through its ligand, unpaired, the Janus kinase (JAK)/signal transducers and activator of transcription (STAT) pathway is thought to mediate global growth downstream of the organizer...
  18. Minakhina S, Tan W, Steward R. JAK/STAT and the GATA factor Pannier control hemocyte maturation and differentiation in Drosophila. Dev Biol. 2011;352:308-16 pubmed publisher
    ..JAK/STAT is one of these pathways which have essential roles in vertebrate and fly hematopoiesis...
  19. Delaney J, Stoven S, Uvell H, Anderson K, Engstrom Y, Mlodzik M. Cooperative control of Drosophila immune responses by the JNK and NF-kappaB signaling pathways. EMBO J. 2006;25:3068-77 pubmed
    ..Our data indicate that dTAK1 is not required for Relish activation, but instead is required in JNK signaling for antimicrobial peptide gene expression. ..
  20. Yoon W, Meinhardt H, Montell D. miRNA-mediated feedback inhibition of JAK/STAT morphogen signalling establishes a cell fate threshold. Nat Cell Biol. 2011;13:1062-9 pubmed publisher
    ..morphogen Unpaired (Upd) specify the migratory border-cell population by activating the signal transducer and activator of transcription (STAT)...
  21. Silver D, Geisbrecht E, Montell D. Requirement for JAK/STAT signaling throughout border cell migration in Drosophila. Development. 2005;132:3483-92 pubmed
    The evolutionarily conserved JAK/STAT signaling pathway is essential for the proliferation, survival and differentiation of many cells including cancer cells...
  22. Bastock R, Strutt D. The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis. Development. 2007;134:3055-64 pubmed
    ..We conclude that, during collective cell migration, the planar polarity pathway can mediate communication between motile and non-motile cells, which enhances the efficiency of migration via the modulation of actin dynamics. ..
  23. Li J, Xia F, Li W. Coactivation of STAT and Ras is required for germ cell proliferation and invasive migration in Drosophila. Dev Cell. 2003;5:787-98 pubmed
    ..Embryos mutant for stat92E or Ras1 have fewer PGCs, and these cells migrate slowly, errantly, and fail to coalesce...
  24. Devergne O, Ghiglione C, Noselli S. The endocytic control of JAK/STAT signalling in Drosophila. J Cell Sci. 2007;120:3457-64 pubmed
    Domeless (Dome) is an IL-6-related cytokine receptor that activates a conserved JAK/STAT signalling pathway during Drosophila development...
  25. Zhang Y, You J, Ren W, Lin X. Drosophila glypicans Dally and Dally-like are essential regulators for JAK/STAT signaling and Unpaired distribution in eye development. Dev Biol. 2013;375:23-32 pubmed publisher
    The highly conserved janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is a well-known signaling system that is involved in many biological processes...
  26. Small S, Blair A, Levine M. Regulation of two pair-rule stripes by a single enhancer in the Drosophila embryo. Dev Biol. 1996;175:314-24 pubmed
    ..enhancer appears to be regulated by one or more ubiquitously distributed activators, including components of a JAK-Stat pathway. The two-stripe pattern results via multiple tiers of repressors which delimit this ubiquitous activation...
  27. Jiang H, Patel P, Kohlmaier A, Grenley M, McEwen D, Edgar B. Cytokine/Jak/Stat signaling mediates regeneration and homeostasis in the Drosophila midgut. Cell. 2009;137:1343-55 pubmed publisher
    ..enteric infection, or JNK-mediated stress signaling, they produce cytokines (Upd, Upd2, and Upd3) that activate Jak/Stat signaling in ISCs, promoting their rapid division...
  28. Wang W, Li Y, Zhou L, Yue H, Luo H. Role of JAK/STAT signaling in neuroepithelial stem cell maintenance and proliferation in the Drosophila optic lobe. Biochem Biophys Res Commun. 2011;410:714-20 pubmed publisher
    ..The JAK/STAT pathway plays pleiotropic roles in Drosophila development and in the larval brain, has been shown to inhibit ..
  29. Sheng X, Brawley C, MATUNIS E. Dedifferentiating spermatogonia outcompete somatic stem cells for niche occupancy in the Drosophila testis. Cell Stem Cell. 2009;5:191-203 pubmed publisher
    ..a cluster of stromal cells called the hub creates a niche by locally activating Janus kinase-signal transducer and activator of transcription (Jak-STAT) signaling in adjacent germline and somatic stem cells...
  30. Herz H, Chen Z, Scherr H, Lackey M, Bolduc C, Bergmann A. vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis. Development. 2006;133:1871-80 pubmed
    ..non-autonomous proliferation through a failure to downregulate Notch signaling, which activates the mitogenic JAK/STAT pathway. Hid and JNK contribute to apoptosis of vps25 mutant cells...
  31. Herranz H, Hong X, Hung N, Voorhoeve P, Cohen S. Oncogenic cooperation between SOCS family proteins and EGFR identified using a Drosophila epithelial transformation model. Genes Dev. 2012;26:1602-11 pubmed publisher
    ..The human ortholog of SOCS36E, SOCS5, behaves as a candidate tumor suppressor in cellular transformation in cooperation with EGFR/RAS pathway activation. ..
  32. Li W, Agaisse H, Mathey Prevot B, Perrimon N. Differential requirement for STAT by gain-of-function and wild-type receptor tyrosine kinase Torso in Drosophila. Development. 2002;129:4241-8 pubmed
    ..In contrast, we find that STAT, encoded by marelle (mrl; DStat92E), is essential for the gain-of-function mutant Tor (Tor(GOF)) to activate ectopic gene expression...
  33. Liu W, Singh S, Hou S. JAK-STAT is restrained by Notch to control cell proliferation of the Drosophila intestinal stem cells. J Cell Biochem. 2010;109:992-9 pubmed publisher
    ..Here we identified a molecular mechanism to unite these two contradictory functions. We found JAK-STAT signaling controls ISC proliferation and this ability is negatively regulated by Notch at least through a ..
  34. Harrison D, McCoon P, Binari R, Gilman M, Perrimon N. Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway. Genes Dev. 1998;12:3252-63 pubmed
    ..displays the same distinctive embryonic mutant defects as mutations in the Drosophila JAK (hopscotch) and STAT (stat92E) genes. Upd is a secreted protein, associated with the extracellular matrix, that activates the JAK pathway...
  35. Lin G, Xu N, Xi R. Paracrine unpaired signaling through the JAK/STAT pathway controls self-renewal and lineage differentiation of drosophila intestinal stem cells. J Mol Cell Biol. 2010;2:37-49 pubmed publisher
    ..the identification of Unpaired as another paracrine signal from the muscular niche, which activates a canonical JAK/STAT signaling cascade in Drosophila ISCs to regulate ISC self-renewal and differentiation...
  36. Leatherman J, Dinardo S. Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal. Cell Stem Cell. 2008;3:44-54 pubmed publisher
    ..These stem cells require chemokine activation of Jak/STAT signaling for self-renewal...
  37. Classen A, Bunker B, Harvey K, Vaccari T, Bilder D. A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling. Nat Genet. 2009;41:1150-5 pubmed publisher
    ..The mitogenic JAK-STAT pathway is strongly and specifically activated in mutant tissue; activation is driven by transcriptional ..
  38. Hombria J, Brown S. The fertile field of Drosophila Jak/STAT signalling. Curr Biol. 2002;12:R569-75 pubmed
    The JAK/STAT pathway plays important roles in vertebrate and invertebrate development. The recent cloning and characterisation of the receptor in Drosophila shows that the pathway is conserved across phyla...
  39. Kim L, Choi U, Cho H, Lee J, Lee W, Kim J, et al. Down-regulation of NF-kappaB target genes by the AP-1 and STAT complex during the innate immune response in Drosophila. PLoS Biol. 2007;5:e238 pubmed
    ..As the levels of dAP-1 and Stat92E increase due to continuous immune signaling, they play a repressive role by forming a repressosome complex with ..
  40. Osman D, Buchon N, Chakrabarti S, Huang Y, Su W, Poidevin M, et al. Autocrine and paracrine unpaired signaling regulate intestinal stem cell maintenance and division. J Cell Sci. 2012;125:5944-9 pubmed publisher
    The Janus kinase (JAK) signal transducer and activator of transcription (STAT) pathway is involved in the regulation of intestinal stem cell (ISC) activity to ensure a continuous renewal of the adult Drosophila midgut...
  41. Issigonis M, Tulina N, de Cuevas M, Brawley C, Sandler L, Matunis E. JAK-STAT signal inhibition regulates competition in the Drosophila testis stem cell niche. Science. 2009;326:153-6 pubmed publisher
    ..In the Drosophila testis, Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling is directly required for maintenance of the resident germline and ..
  42. López Onieva L, Fernández Miñán A, González Reyes A. Jak/Stat signalling in niche support cells regulates dpp transcription to control germline stem cell maintenance in the Drosophila ovary. Development. 2008;135:533-40 pubmed publisher
    ..Here we demonstrate that removal of the Jak/Stat pathway in support cells of the Drosophila ovarian niche leads to germline stem cell loss by differentiation...
  43. Assa Kunik E, Torres I, Schejter E, Johnston D, Shilo B. Drosophila follicle cells are patterned by multiple levels of Notch signaling and antagonism between the Notch and JAK/STAT pathways. Development. 2007;134:1161-9 pubmed
    ..We further demonstrate that mutual antagonism between the Notch and JAK/STAT signaling pathways provides a crucial facet of follicle cell patterning...
  44. Decotto E, Spradling A. The Drosophila ovarian and testis stem cell niches: similar somatic stem cells and signals. Dev Cell. 2005;9:501-10 pubmed
    ..Moreover, while both niches utilize BMP signaling, the testis niche requires a key JAK/STAT signal. We now show, by lineage marking, that the ovarian niche also contains a second type of stem cell...
  45. Shi S, Larson K, Guo D, Lim S, Dutta P, Yan S, et al. Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability. Nat Cell Biol. 2008;10:489-96 pubmed publisher
    STAT (Signal transducer and activator of transcription) is a potent transcription factor and its aberrant activation by phosphorylation is associated with human cancers...
  46. Wu M, Pastor Pareja J, Xu T. Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion. Nature. 2010;463:545-8 pubmed publisher
    ..between Ras(V12) and scrib(-) clones involves JNK signalling propagation and JNK-induced upregulation of JAK/STAT-activating cytokines, a compensatory growth mechanism for tissue homeostasis...
  47. Betz A, Lampen N, Martinek S, Young M, Darnell J. A Drosophila PIAS homologue negatively regulates stat92E. Proc Natl Acad Sci U S A. 2001;98:9563-8 pubmed
    ..modifications in Drosophila, we demonstrate the in vivo functional interaction of the Drosophila homologues stat92E and a Drosophila PIAS gene (dpias)...
  48. Schroeder M, Pearce M, Fak J, Fan H, Unnerstall U, Emberly E, et al. Transcriptional control in the segmentation gene network of Drosophila. PLoS Biol. 2004;2:E271 pubmed
    ..The study demonstrates that computational methods are a powerful complement to experimental approaches in the analysis of transcription networks. ..
  49. Tsurumi A, Xia F, Li J, Larson K, Lafrance R, Li W. STAT is an essential activator of the zygotic genome in the early Drosophila embryo. PLoS Genet. 2011;7:e1002086 pubmed publisher
    ..Here, we show that Drosophila STAT (STAT92E) functions as a general transcription factor that, together with the transcription factor Zelda, induces ..
  50. Takashima S, Mkrtchyan M, Younossi Hartenstein A, Merriam J, Hartenstein V. The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling. Nature. 2008;454:651-5 pubmed publisher
  51. Tulina N, Matunis E. Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling. Science. 2001;294:2546-9 pubmed
    ..The hub specifically expresses Unpaired, a ligand activating the JAK-STAT (Janus kinase-signal transducer and activator of transcription) signaling cascade...
  52. Issigonis M, Matunis E. The Drosophila BCL6 homolog Ken and Barbie promotes somatic stem cell self-renewal in the testis niche. Dev Biol. 2012;368:181-92 pubmed publisher cells called the hub creates a stem cell niche by locally activating the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) pathway in two adjacent types of stem cells: germline stem cells (GSCs) and ..
  53. Bach E, Ekas L, Ayala Camargo A, Flaherty M, Lee H, Perrimon N, et al. GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Gene Expr Patterns. 2007;7:323-31 pubmed
    ..By placing a fragment of the Stat92E target gene Socs36E, which contains at least two putative Stat92E binding sites, upstream of GFP, we generated ..
  54. Luo H, Rose P, Barber D, Hanratty W, Lee S, Roberts T, et al. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol Cell Biol. 1997;17:1562-71 pubmed
    ..We determined that Hop(Tum-1) and Hop(T42) both hyperphosphorylated and hyperactivated D-Stat when overexpressed in Drosophila cells...
  55. Rivas M, Cobreros L, Zeidler M, Hombria J. Plasticity of Drosophila Stat DNA binding shows an evolutionary basis for Stat transcription factor preferences. EMBO Rep. 2008;9:1114-20 pubmed publisher
    In vertebrates, seven signal transducer and activator of transcription (STAT) proteins bind to palindromic sites separated by spacers of two or three nucleotides (STAT1), four nucleotides (STAT6) or three nucleotides (STAT2 to STAT5a/b)...
  56. Kim J, He X, Sinha S. Evolution of regulatory sequences in 12 Drosophila species. PLoS Genet. 2009;5:e1000330 pubmed publisher
  57. Brown S, Hu N, Hombría J. Identification of the first invertebrate interleukin JAK/STAT receptor, the Drosophila gene domeless. Curr Biol. 2001;11:1700-5 pubmed
    The JAK/STAT signaling pathway plays important roles in vertebrate development and the regulation of complex cellular processes...
  58. Karsten P, Plischke I, Perrimon N, Zeidler M. Mutational analysis reveals separable DNA binding and trans-activation of Drosophila STAT92E. Cell Signal. 2006;18:819-29 pubmed
    ..Here we describe a missense mutation in the SH2 domain of the single Drosophila STAT92E homologue which results in an amino-acid substitution conserved in both the canonical SH2 domain and STAT-like ..
  59. Luo H, Dearolf C. The JAK/STAT pathway and Drosophila development. Bioessays. 2001;23:1138-47 pubmed
    The JAK/STAT signal transduction pathway plays a critical role in mammalian cells, particularly in hematopoiesis and immune responses. Several components of this pathway have been identified and characterized in Drosophila...
  60. Wright V, Vogt K, Smythe E, Zeidler M. Differential activities of the Drosophila JAK/STAT pathway ligands Upd, Upd2 and Upd3. Cell Signal. 2011;23:920-7 pubmed publisher
    JAK/STAT signalling in vertebrates is activated by multiple cytokines and growth factors. By contrast, the Drosophila genome encodes for only three related JAK/STAT ligands, Upd, Upd2 and Upd3...
  61. Ren F, Wang B, Yue T, Yun E, Ip Y, Jiang J. Hippo signaling regulates Drosophila intestine stem cell proliferation through multiple pathways. Proc Natl Acad Sci U S A. 2010;107:21064-9 pubmed publisher
    ..cells increases the production of cytokines of the Upd family and multiple EGFR ligands that activate JAK-STAT and EGFR signaling pathways in ISCs to stimulate their proliferation, thus revealing a unique non-cell-autonomous ..
  62. Baksa K, Parke T, Dobens L, Dearolf C. The Drosophila STAT protein, stat92E, regulates follicle cell differentiation during oogenesis. Dev Biol. 2002;243:166-75 pubmed
    b>Signal transducer and activator of transcription (STAT) proteins are transcription factors that play a critical role in the response of a variety of eukaryotic cells to cytokine and growth factor signaling...
  63. Moberg K, Schelble S, Burdick S, Hariharan I. Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev Cell. 2005;9:699-710 pubmed
    ..and ectopic expression of the Notch target gene unpaired (upd), which encodes the secreted ligand of the JAK-STAT pathway. Activation of JAK-STAT signaling in surrounding wild-type cells correlates with their overgrowth...
  64. Flaherty M, Salis P, Evans C, Ekas L, Marouf A, Zavadil J, et al. chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. Dev Cell. 2010;18:556-68 pubmed publisher
    The Drosophila STAT transcription factor Stat92E regulates diverse functions, including organ development and stem cell self-renewal. However, the Stat92E functional effectors that mediate these processes are largely unknown...
  65. Arnosti D, Gray S, Barolo S, Zhou J, Levine M. The gap protein knirps mediates both quenching and direct repression in the Drosophila embryo. EMBO J. 1996;15:3659-66 pubmed
    ..Our studies suggest that short-range repression represents a flexible form of gene regulation, exhibiting enhancer- or promoter-specific effects depending on the location of repressor binding sites. ..
  66. Leatherman J, Dinardo S. Germline self-renewal requires cyst stem cells and stat regulates niche adhesion in Drosophila testes. Nat Cell Biol. 2010;12:806-11 pubmed publisher
    ..We show here that the principal signalling pathway implicated in this niche, chemokine activation of STAT, does not primarily regulate self-renewal of germline stem cells (GSCs), but rather governs GSC adhesion to hub ..
  67. Robinson B, Huang J, Hong Y, Moberg K. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol. 2010;20:582-90 pubmed publisher
  68. Torres I, Lopez Schier H, St Johnston D. A Notch/Delta-dependent relay mechanism establishes anterior-posterior polarity in Drosophila. Dev Cell. 2003;5:547-58 pubmed
    ..from the older cyst induces the anterior polar follicle cells, the anterior polar cells signal through the JAK/STAT pathway to induce the formation of the stalk between adjacent cysts, and the stalk polarizes the younger anterior ..
  69. Ekas L, Baeg G, Flaherty M, Ayala Camargo A, Bach E. JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila. Development. 2006;133:4721-9 pubmed
    ..Conversely, tissue lacking stat92E, which cannot transduce JAK/STAT signals, is transformed from retinal tissue into head cuticle, a phenotype that ..
  70. Kwon E, Park H, Kim Y, Oh E, Nishida Y, Matsukage A, et al. Transcriptional regulation of the Drosophila raf proto-oncogene by Drosophila STAT during development and in immune response. J Biol Chem. 2000;275:19824-30 pubmed
    The Drosophila raf (D-raf) gene promoter contains a recognition consensus sequence for Drosophila STAT (D-STAT)...
  71. Yasugi T, Umetsu D, Murakami S, Sato M, Tabata T. Drosophila optic lobe neuroblasts triggered by a wave of proneural gene expression that is negatively regulated by JAK/STAT. Development. 2008;135:1471-80 pubmed publisher
    ..Thus, proneural wave precedes and induces transition of NE cells to NBs. Unpaired (Upd), the ligand for the JAK/STAT signaling pathway, is expressed in the most lateral NE cells...
  72. Okegbe T, Dinardo S. The endoderm specifies the mesodermal niche for the germline in Drosophila via Delta-Notch signaling. Development. 2011;138:1259-67 pubmed publisher
    ..Because in mammals primordial germ cells also track through endoderm on their way to the genital ridge, our work raises the possibility that conserved mechanisms are employed to regulate germline niche formation...
  73. Ghiglione C, Devergne O, Georgenthum E, Carballès F, Medioni C, Cerezo D, et al. The Drosophila cytokine receptor Domeless controls border cell migration and epithelial polarization during oogenesis. Development. 2002;129:5437-47 pubmed
    In mammals, the JAK/STAT (Janus Kinase/Signal Transducer and Activator of Transcription) signaling pathway is activated in response to cytokines and growth factors to control blood cell development, proliferation and cell determination...
  74. Sotillos S, Díaz Meco M, Moscat J, Castelli Gair Hombría J. Polarized subcellular localization of Jak/STAT components is required for efficient signaling. Curr Biol. 2008;18:624-9 pubmed publisher
    ..Despite the large body of research on the vertebrate JAK/STAT pathway, there are no reports indicating polarized signaling...
  75. Johansen K, Iwaki D, Lengyel J. Localized JAK/STAT signaling is required for oriented cell rearrangement in a tubular epithelium. Development. 2003;130:135-45 pubmed
    ..Taken together with the appearance of STAT92E in a gradient in the hindgut epithelium, these results support a model in which an anteroposterior gradient of ..
  76. Mondal B, Mukherjee T, Mandal L, Evans C, Sinenko S, Martinez Agosto J, et al. Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance. Cell. 2011;147:1589-600 pubmed publisher
    ..Similar homeostatic mechanisms are likely to be utilized in other systems that maintain relatively large numbers of progenitors that are not all in direct contact with the cells of the niche...
  77. Rajan A, Perrimon N. Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell. 2012;151:123-37 pubmed publisher
    ..Upd2 activates JAK/STAT signaling in a population of GABAergic neurons that project onto the IPCs...
  78. Li J, Li W, Calhoun H, Xia F, Gao F, Li W. Patterns and functions of STAT activation during Drosophila embryogenesis. Mech Dev. 2003;120:1455-68 pubmed
    ..examined the tissue-specific localization of the tyrosine-phosphorylated, or activated form of Drosophila STAT, STAT92E. Here we show that during Drosophila embryonic development STAT92E activation is prominently detected in multiple ..
  79. Lin H. The stem-cell niche theory: lessons from flies. Nat Rev Genet. 2002;3:931-40 pubmed
    ..These findings are illuminating our understanding of the self-renewing mechanisms of tissue stem cells in general. ..
  80. Johansen K, Green R, Iwaki D, Hernandez J, Lengyel J. The Drm-Bowl-Lin relief-of-repression hierarchy controls fore- and hindgut patterning and morphogenesis. Mech Dev. 2003;120:1139-51 pubmed
    ..effect of Lin on Bowl, and Bowl then acts to promote spatially localized expression of genes (particularly the JAK/STAT pathway ligand encoded by upd) that control fore- and hindgut morphogenesis...
  81. Arbouzova N, Bach E, Zeidler M. Ken & barbie selectively regulates the expression of a subset of Jak/STAT pathway target genes. Curr Biol. 2006;16:80-8 pubmed
    ..Ken genetically interacts with the pathway in vivo and recognizes a DNA consensus sequence overlapping that of STAT92E in vitro...
  82. Vaccari T, Bilder D. The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. Dev Cell. 2005;9:687-98 pubmed
    ..Increased Notch activity leads to ectopic production of the mitogenic JAK-STAT pathway ligand Unpaired, which is secreted from mutant cells to induce overproliferation of the surrounding ..
  83. Remillieux Leschelle N, Santamaria P, Randsholt N. Regulation of larval hematopoiesis in Drosophila melanogaster: a role for the multi sex combs gene. Genetics. 2002;162:1259-74 pubmed
    ..We propose that mxc provides one of the regulatory inputs in larval hematopoiesis that control normal rates of plasmatocyte and crystal lineage proliferation as well as normal rates and timing of hemocyte differentiation. ..
  84. Agaisse H, Petersen U, Boutros M, Mathey Prevot B, Perrimon N. Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell. 2003;5:441-50 pubmed
    To characterize the features of JAK/STAT signaling in Drosophila immune response, we have identified totA as a gene that is regulated by the JAK/STAT pathway in response to septic injury...
  85. Beccari S, Teixeira L, Rørth P. The JAK/STAT pathway is required for border cell migration during Drosophila oogenesis. Mech Dev. 2002;111:115-23 pubmed
    ..Here we identify Drosophila Stat92E (signal transducer and activator of transcription) in a screen for gain-of-function suppressors of the slbo mutant phenotype...
  86. Pek J, Lim A, Kai T. Drosophila maelstrom ensures proper germline stem cell lineage differentiation by repressing microRNA-7. Dev Cell. 2009;17:417-24 pubmed publisher
    ..We propose that Mael ensures proper differentiation in the GSC lineage by repressing miR-7. ..