Gene Symbol: Stam
Description: Signal transducing adaptor molecule
Alias: CG6521, Dmel\CG6521, Dstam, STAM, Stam1, dstam, stam, signal transducing adaptor molecule, CG6521-PA, Stam-PA, signal transducer adaptor molecule, signal-transducing adaptor molecule
Species: fruit fly

Top Publications

  1. Zeidler M, Bach E, Perrimon N. The roles of the Drosophila JAK/STAT pathway. Oncogene. 2000;19:2598-606 pubmed publisher
    ..Oncogene (2000)...
  2. Issman Zecharya N, Schuldiner O. The PI3K class III complex promotes axon pruning by downregulating a Ptc-derived signal via endosome-lysosomal degradation. Dev Cell. 2014;31:461-73 pubmed publisher
    ..Taken together, our in vivo study demonstrates that the PI3K-cIII complex is essential for downregulating Patched via the endosomal-lysosomal pathway to execute axon pruning. ..
  3. Chanut Delalande H, Jung A, Baer M, Lin L, Payre F, Affolter M. The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development. PLoS ONE. 2010;5:e10245 pubmed publisher
    ..Hrs and Stam constitute the ESCRT-0 complex that controls the initial selection of ubiquitinated proteins, which will ..
  4. Chanut Delalande H, Jung A, Lin L, Baer M, Bilstein A, Cabernard C, et al. A genetic mosaic analysis with a repressible cell marker screen to identify genes involved in tracheal cell migration during Drosophila air sac morphogenesis. Genetics. 2007;176:2177-87 pubmed
    ..Three of the mutants were mapped to either the Mhc or the stam complementation groups...
  5. Michelet X, Djeddi A, Legouis R. Developmental and cellular functions of the ESCRT machinery in pluricellular organisms. Biol Cell. 2010;102:191-202 pubmed publisher
    ..The present review summarizes recent research on the developmental and cellular functions of the ESCRT in Caenorhabditis elegans, Drosophila melanogaster, Mus musculus or Arabidopsis thaliana. ..
  6. Du J, Zhang J, Su Y, Liu M, Ospina J, Yang S, et al. In vivo RNAi screen reveals neddylation genes as novel regulators of Hedgehog signaling. PLoS ONE. 2011;6:e24168 pubmed publisher
    ..Our study reveals a conserved molecular mechanism of the neddylation pathway in Drosophila and sheds light on the complex post-translational regulations in Hh signaling. ..
  7. Mesilaty Gross S, Reich A, Motro B, Wides R. The Drosophila STAM gene homolog is in a tight gene cluster, and its expression correlates to that of the adjacent gene ial. Gene. 1999;231:173-86 pubmed
    Drosophila STAM is a homolog of mammalian STAM genes, which encode Jak associated signal-transducing adapter molecules. A 20-kilobase stretch of genomic DNA at 32B on chromosome arm 2L, which contains Drosophila STAM, has been sequenced...
  8. Galasso A, Pane L, Russo M, Grimaldi M, Verrotti A, Gigliotti S, et al. dSTAM expression pattern during wild type and mutant egg chamber development in D. melanogaster. Gene Expr Patterns. 2007;7:730-7 pubmed
    ..Its transcript is present throughout egg chamber development in all germ-line cells, including the oocyte. dSTAM is firstly detected in germarial region 2, where the protein is present in the newly formed germ-line cysts and is ..
  9. Parsons L, Portela M, Grzeschik N, Richardson H. Lgl regulates Notch signaling via endocytosis, independently of the apical aPKC-Par6-Baz polarity complex. Curr Biol. 2014;24:2073-2084 pubmed publisher lgl- tissue requires dynamin- and Rab5-mediated endocytosis and vesicle acidification but is independent of Hrs/Stam or Rab11 activity...

More Information


  1. Mattissek C, Teis D. The role of the endosomal sorting complexes required for transport (ESCRT) in tumorigenesis. Mol Membr Biol. 2014;31:111-9 pubmed publisher
    ..Therefore the aim of this review is to provide an overview on different model systems used to study the role of the ESCRT machinery in cancer development, to highlight common grounds and present certain controversies in the field. ..
  2. Politi Y, Gal L, Kalifa Y, Ravid L, Elazar Z, Arama E. Paternal mitochondrial destruction after fertilization is mediated by a common endocytic and autophagic pathway in Drosophila. Dev Cell. 2014;29:305-20 pubmed publisher
    ..Finally, we show that the ubiquitin ligase Parkin is not involved in PMD, implying a divergence from the autophagic pathway of damaged mitochondria. ..
  3. Troost T, Jaeckel S, Ohlenhard N, Klein T. The tumour suppressor Lethal (2) giant discs is required for the function of the ESCRT-III component Shrub/CHMP4. J Cell Sci. 2012;125:763-76 pubmed publisher
  4. Tognon E, Wollscheid N, Cortese K, Tacchetti C, Vaccari T. ESCRT-0 is not required for ectopic Notch activation and tumor suppression in Drosophila. PLoS ONE. 2014;9:e93987 pubmed publisher
    ..Here, we report that two Drosophila epithelia lacking activity of Stam, the other known components of the ESCRT-0 complex, or of both Hrs and Stam, accumulate the signaling receptors ..
  5. Moser T, Jones R, Thompson C, Coyne C, Cherry S. A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. PLoS Pathog. 2010;6:e1000954 pubmed publisher
    ..Therefore, AMPK plays a highly conserved role in poxvirus infection and actin dynamics independent of its role as an energy regulator. ..
  6. Hombria J, Brown S. The fertile field of Drosophila Jak/STAT signalling. Curr Biol. 2002;12:R569-75 pubmed
    ..Drosophila's streamlined pathway offers a simple model to find new elements and analyse the function of existing ones. ..
  7. Gomez Lamarca M, Snowdon L, Seib E, Klein T, Bray S. Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling. J Cell Biol. 2015;210:303-18 pubmed publisher
    ..Likewise, depletion of ESCRT-0 components Hrs or Stam in combination with Rme-8 also led to high levels of ectopic Notch activity...
  8. Sheng Z, Yu L, Zhang T, Pei X, Li X, Zhang Z, et al. ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling. J Cell Sci. 2016;129:2075-84 pubmed publisher
    ..we identified synthetic lethal interactions between mutations of fly Rb (rbf) and the ESCRT-0 components stam and hrs We show that inactivation of ESCRT-0 sensitizes rbf-mutant cells to undergo apoptosis through inhibition of ..
  9. Loncle N, Agromayor M, Martin Serrano J, Williams D. An ESCRT module is required for neuron pruning. Sci Rep. 2015;5:8461 pubmed publisher
    ..Furthermore we show that this ESCRT module requires a direct, in vivo, interaction between Shrub/CHMP4B and the accessory protein Myopic/HD-PTP. ..