Gene Symbol: ssx
Alias: CG3056, Dmel\CG3056, EG:132E8.1, anon-EST:Posey102, cg3056, sister-of-Sex-lethal, CG3056-PB, CG3056-PC, CG3056-PD, CG3056-PE, ssx-PB, ssx-PC, ssx-PD, ssx-PE
Species: fruit fly
Gempe T, Beye M. Function and evolution of sex determination mechanisms, genes and pathways in insects. Bioessays. 2011;33:52-60 pubmed publisher
..This review summarises recent findings in insects, surveys evidence of how and why sex determination mechanisms can change rapidly and suggests fruitful areas of future research. ..
Traut W, Niimi T, Ikeo K, Sahara K. Phylogeny of the sex-determining gene Sex-lethal in insects. Genome. 2006;49:254-62 pubmed publisher
..The D. melanogaster, D. erecta, and D. pseudoobscura genomes, however, contain 2 paralogous genes, Sxl and CG3056, which are orthologous to the Anopheles, Apis, Bombyx, and Tribolium Sxl...
Cline T, Dorsett M, Sun S, Harrison M, Dines J, Sefton L, et al
. Evolution of the Drosophila feminizing switch gene Sex-lethal. Genetics. 2010;186:1321-36 pubmed publisher
..of Sxl's closest paralog allowed Sxl to lose essential ancestral non-female-specific functions, we determined the CG3056 null phenotype. That phenotype failed to support this hypothesis...
Ibrahim Z, Ngom A, Tawfik A. Using qualitative probability in reverse-engineering gene regulatory networks. IEEE/ACM Trans Comput Biol Bioinform. 2011;8:326-34 pubmed publisher
..The model is compared to the existing literature using the known gene regulatory interactions of Drosophila Melanogaster. ..
Ayres J, Freitag N, Schneider D. Identification of Drosophila mutants altering defense of and endurance to Listeria monocytogenes infection. Genetics. 2008;178:1807-15 pubmed publisher
..By using a whole-animal model and screening for host survival, we revealed genes involved in physiologies different from those that were found in previous screens, which all had defects in defensive immune signaling. ..
Mullon C, Pomiankowski A, Reuter M. Molecular evolution of Drosophila Sex-lethal and related sex determining genes. BMC Evol Biol. 2012;12:5 pubmed publisher
EirÃn LÃ³pez J, SÃ¡nchez L. The comparative study of five sex-determining proteins across insects unveils high rates of evolution at basal components of the sex determination cascade. Dev Genes Evol. 2015;225:23-30 pubmed publisher
..Altogether, these results underscore the importance of the position of sex determining genes in the cascade, constituting a major constraint shaping the molecular evolution of the insect sex determination pathway. ..
Khan M, Li L, PÃ©rez SÃ¡nchez C, Saraf A, Florens L, Slaughter B, et al
. Amyloidogenic Oligomerization Transforms Drosophila Orb2 from a Translation Repressor to an Activator. Cell. 2015;163:1468-83 pubmed publisher