Gene Symbol: Srp54
Alias: CG4602, Dmel\CG4602, SRP54, SRp54, anon-EST:Liang-2.16, clone 2.16, dSRp54, p75, srp54, Srp54, CG4602-PA, Srp54-PA
Species: fruit fly
Ashton Beaucage D, Therrien M. The exon junction complex: a splicing factor for long intron containing transcripts?. Fly (Austin). 2011;5:224-33 pubmed
..The importance of intron length in determining sensitivity to EJC disruption suggests that the EJC is functioning in exon definition, a splicing mechanism that occurs for long introns in particular. ..
Kennedy C, Kramer A, Berget S. A role for SRp54 during intron bridging of small introns with pyrimidine tracts upstream of the branch point. Mol Cell Biol. 1998;18:5425-34 pubmed
..The tracts are shown to bind both U2AF and the SR protein SRp54 but not SF1...
Doumanis J, Wada K, Kino Y, Moore A, Nukina N. RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation. PLoS ONE. 2009;4:e7275 pubmed publisher
..Newly identified modifiers including genes related to nuclear transport, nucleotide processes, and signaling, may be involved in polyglutamine aggregate formation and Huntington disease cascades. ..
Olson S, Blanchette M, Park J, Savva Y, Yeo G, Yeakley J, et al
. A regulator of Dscam mutually exclusive splicing fidelity. Nat Struct Mol Biol. 2007;14:1134-40 pubmed
..Thus, the fidelity of mutually exclusive splicing in the exon 6 cluster is governed by an intricate combination of alternative RNA structures and a globally acting splicing repressor. ..
Bradley T, Cook M, Blanchette M. SR proteins control a complex network of RNA-processing events. RNA. 2015;21:75-92 pubmed publisher
Saccone G, Louis C, Zhang H, Petrella V, Di Natale M, Perri M, et al
. Male-specific phosphorylated SR proteins in adult flies of the Mediterranean fruitfly Ceratitis capitata. BMC Genet. 2014;15 Suppl 2:S6 pubmed publisher
..capitata suggesting that differential phosphorylation may also contribute to the regulation of sex-specific splicing in the Medfly. ..
Robard C, Daviau A, Di Fruscio M. Phosphorylation status of the Kep1 protein alters its affinity for its protein binding partner alternative splicing factor ASF/SF2. Biochem J. 2006;400:91-7 pubmed
Stoiber M, Olson S, May G, Duff M, Manent J, Obar R, et al
. Extensive cross-regulation of post-transcriptional regulatory networks in Drosophila. Genome Res. 2015;25:1692-702 pubmed publisher
..From the simultaneous acquisition and integrative analysis of protein and RNA constituents of RNPs, we identify extensive cross-regulatory and hierarchical interactions in post-transcriptional control. ..
Huang Y, Xie J, Wang T. A Fluorescence-Based Genetic Screen to Study Retinal Degeneration in Drosophila. PLoS ONE. 2015;10:e0144925 pubmed publisher
..Our findings demonstrate that this "Rh1::GFP ey-flp/hid" method enables high-throughput F1 genetic screens to rapidly and precisely identify mutations of retinal degeneration. ..