Gene Symbol: Src64B
Description: Src oncogene at 64B
Alias: C-src1, CG7524, D-Src64B, D-src, DSRC64, DSrc, DSrc64, DSrc64B, Dm SRC1, DmHD-358, Dmel\CG7524, Dsrc, Dsrc64, Dsrc64B, HD-358, MRE5, SRC 64B, SRC64B, Src, Src1, Src64, Src64b, c-src, dSrc, dsrc, src, src1, src64, src64B, src64b, Src oncogene at 64B, CG7524-PB, CG7524-PC, CG7524-PD, CG7524-PE, CG7524-PF, CG7524-PH, CG7524-PI, CG7524-PJ, CG7524-PK, Src proto oncogene sequence, Src64B-PB, Src64B-PC, Src64B-PD, Src64B-PE, Src64B-PF, Src64B-PH, Src64B-PI, Src64B-PJ, Src64B-PK, mRNA-like ncRNA in embryogenesis 5
Species: fruit fly

Top Publications

  1. Guarnieri D, Dodson G, Simon M. SRC64 regulates the localization of a Tec-family kinase required for Drosophila ring canal growth. Mol Cell. 1998;1:831-40 pubmed
    Mutation of the Src64 gene of Drosophila results in ovarian ring canal defects and reduced female fertility. We used a dosage-sensitive modifier screen to search for downstream components of the SRC64 signaling pathway...
  2. Singh J, Aaronson S, Mlodzik M. Drosophila Abelson kinase mediates cell invasion and proliferation through two distinct MAPK pathways. Oncogene. 2010;29:4033-45 pubmed publisher
    ..Our in vivo data indicate that dAbl acts downstream of the Src kinases, which are known regulators of cell adhesion and invasion...
  3. Robinson D, Cooley L. Stable intercellular bridges in development: the cytoskeleton lining the tunnel. Trends Cell Biol. 1996;6:474-9 pubmed
  4. Dodson G, Guarnieri D, Simon M. Src64 is required for ovarian ring canal morphogenesis during Drosophila oogenesis. Development. 1998;125:2883-92 pubmed
    ..In order to understand further the role of Src family kinases, we have generated loss-of-function mutations in Src64, one of two Src family kinases known in Drosophila melanogaster...
  5. Tsai P, Kao H, Grabbe C, Lee Y, Ghose A, Lai T, et al. Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth. Neural Dev. 2008;3:26 pubmed publisher
    ..that FAK mediates the signaling pathway of the integrin alphaPS3betanu heterodimer and functions redundantly with Src. At NMJs, Fak56 downregulates ERK activity, as shown by diphospho-ERK accumulation in Fak56 mutants, and ..
  6. O Reilly A, Ballew A, Miyazawa B, Stocker H, Hafen E, Simon M. Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells. Development. 2006;133:2627-38 pubmed
    The Src family protein tyrosine kinases (SFKs) are crucial regulators of cellular morphology. In Drosophila, Src64 controls complex morphological events that occur during oogenesis...
  7. Takahashi M, Takahashi F, Ui Tei K, Kojima T, Saigo K. Requirements of genetic interactions between Src42A, armadillo and shotgun, a gene encoding E-cadherin, for normal development in Drosophila. Development. 2005;132:2547-59 pubmed
    ..Src42A, which is functionally redundant to Src64, was found to interact genetically with shotgun, a gene encoding E-cadherin, and armadillo, a Drosophila beta-..
  8. Sokol N, Cooley L. Drosophila filamin encoded by the cheerio locus is a component of ovarian ring canals. Curr Biol. 1999;9:1221-30 pubmed
    ..contains cytoskeletal proteins encoded by the hu-li-tao shao (hts) and kelch genes, and is regulated by the Src64 and Tec29 tyrosine kinases...
  9. Pedraza L, Stewart R, Li D, Xu T. Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis. Oncogene. 2004;23:4754-62 pubmed
    ..Overexpression of either wild-type Drosophila SFK (Src64 and Src42) is sufficient to induce ectopic proliferation in G1/G0-arrested, uncommitted cells in eye imaginal ..

More Information


  1. Tateno M, Nishida Y, Adachi Yamada T. Regulation of JNK by Src during Drosophila development. Science. 2000;287:324-7 pubmed
    ..Mutants for Src42A, a Drosophila c-src protooncogene homolog, are described...
  2. Thomas J, Wieschaus E. src64 and tec29 are required for microfilament contraction during Drosophila cellularization. Development. 2004;131:863-71 pubmed
    ..Mutations in src64 and tec29 reveal a novel role for these genes in controlling contraction of the actin-myosin microfilament ring ..
  3. Cooper J, Simon M, Kussick S. Signaling by ectopically expressed Drosophila Src64 requires the protein-tyrosine phosphatase corkscrew and the adapter downstream of receptor kinases. Cell Growth Differ. 1996;7:1435-41 pubmed
    Vertebrate Src can be activated by specific mutations to become oncogenic. Analogous mutations in Drosophila Src64 (DSrc) induce abnormal differentiation of photoreceptor cells when expressed ectopically in the developing Drosophila ..
  4. Vidal M, Warner S, Read R, Cagan R. Differing Src signaling levels have distinct outcomes in Drosophila. Cancer Res. 2007;67:10278-85 pubmed
    High levels of Src activity are found in a broad spectrum of cancers...
  5. Roulier E, Panzer S, Beckendorf S. The Tec29 tyrosine kinase is required during Drosophila embryogenesis and interacts with Src64 in ring canal development. Mol Cell. 1998;1:819-29 pubmed
    ..Mutants lacking the Drosophila Src homolog Src64 show the same phenotype, and we show that Src64 is required for the localization of Tec29 to the ring canals...
  6. Takahashi F, Endo S, Kojima T, Saigo K. Regulation of cell-cell contacts in developing Drosophila eyes by Dsrc41, a new, close relative of vertebrate c-src. Genes Dev. 1996;10:1645-56 pubmed
    In Drosophila, Dsrc64 is considered a unique ortholog of the vertebrate c-src; however, we show evidence to the contrary...
  7. Pechkovsky A, Lahav M, Bitman E, Salzberg A, Kleinberger T. E4orf4 induces PP2A- and Src-dependent cell death in Drosophila melanogaster and at the same time inhibits classic apoptosis pathways. Proc Natl Acad Sci U S A. 2013;110:E1724-33 pubmed publisher
    ..Drosophila PP2A-B55 (twins/abnormal anaphase resolution) and Src64B contributed additively to this form of cell death...
  8. Kussick S, Basler K, Cooper J. Ras1-dependent signaling by ectopically-expressed Drosophila src gene product in the embryo and developing eye. Oncogene. 1993;8:2791-803 pubmed
    The cellular functions of the Drosophila src 64B (Dsrc) gene product, Dsrc, and of most vertebrate Src-family kinases, are unknown...
  9. Worby C, Simonson Leff N, Clemens J, Huddler D, Muda M, Dixon J. Drosophila Ack targets its substrate, the sorting nexin DSH3PX1, to a protein complex involved in axonal guidance. J Biol Chem. 2002;277:9422-8 pubmed
    ..These results suggest that the phosphorylation of DSH3PX1 by DAck targets this sorting nexin to a protein complex that includes Dock, an adaptor protein important for axonal guidance. ..
  10. Read R, Bach E, Cagan R. Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways. Mol Cell Biol. 2004;24:6676-89 pubmed
    b>Src family kinases regulate multiple cellular processes including proliferation and oncogenesis. C-terminal Src kinase (Csk) encodes a critical negative regulator of Src family kinases...
  11. Kelso R, Hudson A, Cooley L. Drosophila Kelch regulates actin organization via Src64-dependent tyrosine phosphorylation. J Cell Biol. 2002;156:703-13 pubmed
    ..Two-dimensional electrophoresis demonstrated that Kelch is tyrosine phosphorylated in a src64-dependent pathway. Site-directed mutagenesis determined that tyrosine residue 627 is phosphorylated...
  12. Simon M, Drees B, Kornberg T, Bishop J. The nucleotide sequence and the tissue-specific expression of Drosophila c-src. Cell. 1985;42:831-40 pubmed
    We have examined the coding capability and expression of the Drosophila homolog of the vertebrate proto-oncogene c-src. Sequence analysis of a cDNA clone representing the Drosophila c-src locus suggests that the gene encodes a 62 kd ..
  13. Shindo M, Wada H, Kaido M, Tateno M, Aigaki T, Tsuda L, et al. Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis. Development. 2008;135:1355-64 pubmed publisher
    ..Src42A and Src64B are required for tracheal development and to increase the rate of adherens junction turnover...
  14. Palmer R, Fessler L, Edeen P, Madigan S, McKeown M, Hunter T. DFak56 is a novel Drosophila melanogaster focal adhesion kinase. J Biol Chem. 1999;274:35621-9 pubmed
    ..Our results imply a role for DFak56 in adhesion-dependent signaling pathways in vivo during D. melanogaster development. ..
  15. Karim F, Chang H, Therrien M, Wassarman D, Laverty T, Rubin G. A screen for genes that function downstream of Ras1 during Drosophila eye development. Genetics. 1996;143:315-29 pubmed
    ..At least two suppressors appear to function either between Ras1 and Raf or in parallel to Raf. ..
  16. Williams M. The c-src homologue Src64B is sufficient to activate the Drosophila cellular immune response. J Innate Immun. 2009;1:335-9 pubmed publisher
    ..Overexpression of the Drosophila c-src homologue Src64B disrupts the sessile-haemocyte banding pattern...
  17. Enomoto M, Igaki T. Src controls tumorigenesis via JNK-dependent regulation of the Hippo pathway in Drosophila. EMBO Rep. 2013;14:65-72 pubmed publisher
    ..Using Drosophila genetics, we show that the oncoprotein Src controls tumour microenvironment by Jun N-terminal kinase (JNK)-dependent regulation of the Hippo pathway...
  18. Laberge G, Douziech M, Therrien M. Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism. EMBO J. 2005;24:487-98 pubmed
    ..Together, these findings suggest that the integration of RTK-induced RAS and Src42 signals by CNK as a two-component input is essential for RAF activation in Drosophila. ..
  19. Edgar B. From cell structure to transcription: Hippo forges a new path. Cell. 2006;124:267-73 pubmed
    ..This conserved signaling pathway contains several tumor-suppressor genes and regulates the contact inhibition of proliferation in cultured cells. ..
  20. Inagaki S, Numata K, Kondo T, Tomita M, Yasuda K, Kanai A, et al. Identification and expression analysis of putative mRNA-like non-coding RNA in Drosophila. Genes Cells. 2005;10:1163-73 pubmed
    ..This is the first report that the majority of mRNA-like ncRNAs in a model organism are expressed in specific tissues and cell types. ..
  21. Wills Z, Bateman J, Korey C, Comer A, Van Vactor D. The tyrosine kinase Abl and its substrate enabled collaborate with the receptor phosphatase Dlar to control motor axon guidance. Neuron. 1999;22:301-12 pubmed
    ..These data suggest that Dlar, Abl, and Ena define a phosphorylation state-dependent switch that controls growth cone behavior by transmitting signals at the cell surface to the actin cytoskeleton. ..
  22. Song J, Giniger E, Desai C. The receptor protein tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila. Mech Dev. 2008;125:247-56 pubmed
    ..We also find that mutation of the gene encoding the cytoplasmic Src64B tyrosine kinase exacerbates Ptp69D phenotypes, suggesting that two different cytoplasmic tyrosine kinases, Abl and ..
  23. Bugga L, Ratnaparkhi A, Zinn K. The cell surface receptor Tartan is a potential in vivo substrate for the receptor tyrosine phosphatase Ptp52F. Mol Cell Biol. 2009;29:3390-400 pubmed publisher
    ..quot; Trn can bind to the Ptp52F substrate-trapping mutant in transfected Drosophila S2 cells if v-Src kinase, which phosphorylates Trn, is also expressed...
  24. Fradkin L, Dura J, Noordermeer J. Ryks: new partners for Wnts in the developing and regenerating nervous system. Trends Neurosci. 2010;33:84-92 pubmed publisher
    ..Ryk via multiple mechanisms, including nuclear translocation of their intracellular domains and pathways employing Src Family Kinases and members of the canonical Wnt pathway...
  25. Gorfinkiel N, Arias A. Requirements for adherens junction components in the interaction between epithelial tissues during dorsal closure in Drosophila. J Cell Sci. 2007;120:3289-98 pubmed
    ..Our results show that regulated cell adhesion is a crucial element of the interactions that shape epithelial sheets in morphogenetic processes. ..
  26. Nicolaï M, Lasbleiz C, Dura J. Gain-of-function screen identifies a role of the Src64 oncogene in Drosophila mushroom body development. J Neurobiol. 2003;57:291-302 pubmed
    ..RNA-binding protein, microtubule-severing protein, vesicle trafficking proteins, axon guidance receptor, and the Src64 cytoplasmic protein tyrosine kinase. These genes are involved in key features of neuron cell biology...
  27. Hoffman Falk H, Einat P, Shilo B, Hoffmann F. Drosophila melanogaster DNA clones homologous to vertebrate oncogenes: evidence for a common ancestor to the src and abl cellular genes. Cell. 1983;32:589-98 pubmed
    ..sequence homologous to the v-abl oncogene, and two types of phage clones containing sequences homologous to the v-src probe. The D...
  28. Kimchie Z, Segev O, Lev Z. Maternal and embryonic transcripts of Drosophila proto-oncogenes are expressed in Schneider 2 culture cells but not in l(2)gl transformed neuroblasts. Cell Differ Dev. 1989;26:79-86 pubmed
    The transcription patterns of Drosophila melanogaster src, abl and two ras homologs were analyzed in normal Drosophila tissue, in neuroblasts derived from tumorous larval brain of the mutant lethal(2)giant larvae [l(2)gl] and in ..
  29. Hirabayashi S, Baranski T, Cagan R. Transformed Drosophila cells evade diet-mediated insulin resistance through wingless signaling. Cell. 2013;154:664-75 pubmed publisher
    ..We demonstrate that high dietary sugar also converts Ras/Src-transformed tissue from localized growths to aggressive tumors with emergent metastases...
  30. MacDougall L, Gagou M, Leevers S, Hafen E, Waterfield M. Targeted expression of the class II phosphoinositide 3-kinase in Drosophila melanogaster reveals lipid kinase-dependent effects on patterning and interactions with receptor signaling pathways. Mol Cell Biol. 2004;24:796-808 pubmed
    ..The phenotypes obtained are markedly distinct from those generated by expression of the Drosophila class I PI3K, which affects growth but not pattern formation. ..
  31. Lev Z, Leibovitz N, Segev O, Shilo B. Expression of the src and abl cellular oncogenes during development of Drosophila melanogaster. Mol Cell Biol. 1984;4:982-4 pubmed
    Transcription of the Drosophila homologs of the abl and src cellular oncogenes, termed Dash and Dsrc , respectively, was studied...
  32. O Donnell M, Bashaw G. Src inhibits midline axon crossing independent of Frazzled/Deleted in Colorectal Carcinoma (DCC) receptor tyrosine phosphorylation. J Neurosci. 2013;33:305-14 pubmed publisher
    ..b>Src family kinases are thought to be major signaling effectors of Netrin/DCC...
  33. Wadsworth S. Drosophila src family proteins. Comp Biochem Physiol B. 1990;97:403-6 pubmed
  34. Turkel N, Portela M, Poon C, Li J, Brumby A, Richardson H. Cooperation of the BTB-Zinc finger protein, Abrupt, with cytoskeletal regulators in Drosophila epithelial tumorigenesis. Biol Open. 2015;4:1024-39 pubmed publisher
    ..Herein, we show that co-expression of ab with actin cytoskeletal regulators, RhoGEF2 or Src64B, in the developing eye-antennal epithelial tissue results in the formation of overgrown amorphous tumours, whereas ..
  35. Macagno J, Díaz Vera J, Yu Y, MacPherson I, Sandilands E, Palmer R, et al. FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells. PLoS Genet. 2014;10:e1004262 pubmed publisher
    ..Therefore, the FAK-mediated negative regulation of RTK/MAPK signalling described here may have potential implications in the designing of therapy strategies for RTK-driven tumours. ..
  36. van Der Flier A, Sonnenberg A. Structural and functional aspects of filamins. Biochim Biophys Acta. 2001;1538:99-117 pubmed
    ..In this review aspects of filamin structure, its splice variants, binding partners and biological function will be discussed. ..
  37. Ho D, Pallavi S, Artavanis Tsakonas S. The Notch-mediated hyperplasia circuitry in Drosophila reveals a Src-JNK signaling axis. elife. 2015;4:e05996 pubmed publisher a novel synergistic relationship between Notch and either of the non-receptor tyrosine kinases Src42A and Src64B to promote hyperplasia and tissue disorganization, which results in cell cycle perturbation, JAK/STAT signal ..
  38. Elkins T, Zinn K, McAllister L, Hoffmann F, Goodman C. Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations. Cell. 1990;60:565-75 pubmed
    ..The double mutant shows a clear defect in growth cone guidance; for example, the RP1 growth cone (normally fas I positive) does not follow its normal path across the commissure. ..
  39. Kussick S, Cooper J. Overexpressed Drosophila src 64B is phosphorylated at its carboxy-terminal tyrosine, but is not catalytically repressed, in cultured Drosophila cells. Oncogene. 1992;7:2461-70 pubmed
    ..We have studied the relationship between the phosphorylation state of the Drosophila src 64B (Dsrc) gene product, p62D, and its tyrosine kinase activity in Drosophila Schneider 2 cells, using wild-type and ..
  40. Marchetti G, Reichardt I, Knoblich J, Besse F. The TRIM-NHL protein Brat promotes axon maintenance by repressing src64B expression. J Neurosci. 2014;34:13855-64 pubmed publisher
    ..We found that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction...
  41. Drees B, Ali Z, Soeller W, Coleman K, Poole S, Kornberg T. The transcription unit of the Drosophila engrailed locus: an unusually small portion of a 70,000 bp gene. EMBO J. 1987;6:2803-9 pubmed
    ..We presume that the unusually large silent region at the periphery of the engrailed transcription unit signify the presence of special mechanisms that regulate its expression. ..
  42. Wadsworth S, Madhavan K, Bilodeau Wentworth D. Maternal inheritance of transcripts from three Drosophila src-related genes. Nucleic Acids Res. 1985;13:2153-70 pubmed
    The Drosophila genome contains three major sequences related to the v-src gene. Previously published molecular studies have confirmed the structural homology between v-src and two of the Drosophila sequences...
  43. Cordero J, Ridgway R, Valeri N, Nixon C, Frame M, Muller W, et al. c-Src drives intestinal regeneration and transformation. EMBO J. 2014;33:1474-91 pubmed publisher
    The non-receptor tyrosine kinase c-Src, hereafter referred to as Src, is overexpressed or activated in multiple human malignancies...
  44. Fashena S, Zinn K. Transmembrane glycoprotein gp150 is a substrate for receptor tyrosine phosphatase DPTP10D in Drosophila cells. Mol Cell Biol. 1997;17:6859-67 pubmed
    ..cells, gp150 becomes tyrosine phosphorylated following incubation with PTP inhibitors or upon coexpression of the Dsrc tyrosine kinase...
  45. Chang H, Karim F, O Neill E, Rebay I, Solomon N, Therrien M, et al. Ras signal transduction pathway in Drosophila eye development. Cold Spring Harb Symp Quant Biol. 1994;59:147-53 pubmed
  46. Akalal D, Yu D, Davis R. The long-term memory trace formed in the Drosophila ?/? mushroom body neurons is abolished in long-term memory mutants. J Neurosci. 2011;31:5643-7 pubmed publisher
    ..These observations elevate the significance of this LTM trace given that 26 independent mutants all exhibit a defect in the trace, and further suggest that the calcium trace is a fundamental mechanism underlying Drosophila LTM...
  47. Öztürk Çolak A, Moussian B, Araújo S, Casanova J. A feedback mechanism converts individual cell features into a supracellular ECM structure in Drosophila trachea. elife. 2016;5: pubmed publisher
    ..Therefore, we propose that Src42A phosphorylation levels provide a link for the ECM environment to ensure proper cytoskeletal organisation. ..
  48. Djagaeva I, Doronkin S, Beckendorf S. Src64 is involved in fusome development and karyosome formation during Drosophila oogenesis. Dev Biol. 2005;284:143-56 pubmed
    ..Here, we show that during early oogenesis Src64 mutations lead to uneven accumulation of cortical actin, defects in fusome formation, mislocalization of septins, ..
  49. Allard J, Herbst R, Carroll P, Simon M. Mutational analysis of the SRC homology 2 domain protein-tyrosine phosphatase Corkscrew. J Biol Chem. 1998;273:13129-35 pubmed
    The SRC homology 2 (SH2) domain protein-tyrosine phosphatase, Corkscrew (CSW) is required for signaling by receptor tyrosine kinases, including the Sevenless receptor tyrosine kinase (SEV), which directs Drosophila R7 photoreceptor cell ..
  50. Cooley L. Drosophila ring canal growth requires Src and Tec kinases. Cell. 1998;93:913-5 pubmed
  51. Jackson S, Berg C. An A-kinase anchoring protein is required for protein kinase A regulatory subunit localization and morphology of actin structures during oogenesis in Drosophila. Development. 2002;129:4423-33 pubmed
    ..Akap200 mutations suppressed the small ring canal phenotype produced by Src64B mutants, linking Akap200 with the non-receptor tyrosine kinase pathway...
  52. Suga H, Kuma K, Iwabe N, Nikoh N, Ono K, Koyanagi M, et al. Intermittent divergence of the protein tyrosine kinase family during animal evolution. FEBS Lett. 1997;412:540-6 pubmed
    ..These results strongly suggest that the PTKs diverged intermittently, but not gradually, during animal evolution. ..
  53. Shishido E, Emori Y, Saigo K. Identification of seven novel protein-tyrosine kinase genes of Drosophila by the polymerase chain reaction. FEBS Lett. 1991;289:235-8 pubmed
  54. Lu N, Guarnieri D, Simon M. Localization of Tec29 to ring canals is mediated by Src64 and PtdIns(3,4,5)P3-dependent mechanisms. EMBO J. 2004;23:1089-100 pubmed
    Two tyrosine kinases, Src64 and Tec29, regulate the growth of actin rich-ring canals in the Drosophila ovary...
  55. Hoffmann F, Fresco L, Hoffman Falk H, Shilo B. Nucleotide sequences of the Drosophila src and abl homologs: conservation and variability in the src family oncogenes. Cell. 1983;35:393-401 pubmed
    Two cloned Drosophila sequences, Dash and Dsrc, were previously isolated by hybridization to the viral oncogenes v-abl and v-src...
  56. Comer A, Ahern Djamali S, Juang J, Jackson P, Hoffmann F. Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of Enabled. Mol Cell Biol. 1998;18:152-60 pubmed
    ..Phosphorylation of Ena by Abl inhibited the binding of Ena to SH3 domains in vitro, suggesting that one effect of Ena phosphorylation may be to modulate its association with other proteins. ..
  57. Kussick S, Cooper J. Phosphorylation and regulatory effects of the carboxy terminus of a Drosophila src homolog. Oncogene. 1992;7:1577-86 pubmed
    The kinase activities of the vertebrate src family members are repressed by phosphorylation of a tyrosine residue in the carboxy-terminal 'tail' of these molecules...
  58. Xia F, Li J, Hickey G, Tsurumi A, Larson K, Guo D, et al. Raf activation is regulated by tyrosine 510 phosphorylation in Drosophila. PLoS Biol. 2008;6:e128 pubmed publisher
    ..Y510 of Draf is phosphorylated by the c-src homolog Src64B. Acidic substitution of Y510 promotes and phenylalanine substitution impairs Draf activation without affecting its ..
  59. Tsarouhas V, Yao L, Samakovlis C. Src kinases and ERK activate distinct responses to Stitcher receptor tyrosine kinase signaling during wound healing in Drosophila. J Cell Sci. 2014;127:1829-39 pubmed publisher
    ..Drk (Downstream of receptor kinase) and Src family tyrosine kinases bind to the same docking site in the Stit intracellular domain...
  60. Petrova I, Lahaye L, Martiáñez T, de Jong A, Malessy M, Verhaagen J, et al. Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B. Mol Cell Biol. 2013;33:4116-27 pubmed publisher
    ..domain with the immunoglobulin Fc domain results in an increased recruitment of the Src family kinase SRC64B, a previously identified downstream pathway effector...
  61. Spring A, Brusich D, Frank C. C-terminal Src Kinase Gates Homeostatic Synaptic Plasticity and Regulates Fasciclin II Expression at the Drosophila Neuromuscular Junction. PLoS Genet. 2016;12:e1005886 pubmed publisher
    ..We identified C-terminal Src Kinase (Csk) as a potential regulator of synaptic homeostasis through an RNAi- and electrophysiology-based genetic ..
  62. van Swinderen B, McCartney A, Kauffman S, Flores K, Agrawal K, Wagner J, et al. Shared visual attention and memory systems in the Drosophila brain. PLoS ONE. 2009;4:e5989 pubmed publisher
  63. Clark C, Liu Y, Cooper H. The Yin and Yang of Wnt/Ryk axon guidance in development and regeneration. Sci China Life Sci. 2014;57:366-71 pubmed publisher
    ..Thus, we also discuss this opposing aspect of Ryk function in axonal regeneration where its activity is a major impediment to axon regrowth (the Yang function). ..
  64. Langton P, Colombani J, Chan E, Wepf A, Gstaiger M, Tapon N. The dASPP-dRASSF8 complex regulates cell-cell adhesion during Drosophila retinal morphogenesis. Curr Biol. 2009;19:1969-78 pubmed publisher
    ..We previously identified dASPP as a positive regulator of dCsk (Drosophila C-terminal Src kinase)...
  65. Flourakis M, Kula Eversole E, Hutchison A, Han T, Aranda K, Moose D, et al. A Conserved Bicycle Model for Circadian Clock Control of Membrane Excitability. Cell. 2015;162:836-48 pubmed publisher
    ..Remarkably, daily antiphase cycles of sodium and potassium currents also drive mouse clock neuron rhythms. Thus, we reveal an evolutionarily ancient strategy for the neural mechanisms that govern daily sleep and wake. ..
  66. Tutor A, Prieto Sánchez S, Ruiz Gomez M. Src64B phosphorylates Dumbfounded and regulates slit diaphragm dynamics: Drosophila as a model to study nephropathies. Development. 2014;141:367-76 pubmed publisher
    ..Here, we show that Dumbfounded/Neph1, a key diaphragm constituent, is a target of the Src kinase Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by ..
  67. Ohsawa S, Takemoto D, Igaki T. Dissecting tumour heterogeneity in flies: genetic basis of interclonal oncogenic cooperation. J Biochem. 2014;156:129-36 pubmed publisher
    ..This review focuses on describing recent findings obtained from Drosophila genetics that provide genetic basis of interclonal oncogenic cooperation in heterogeneous tumour tissue. ..
  68. Sotillos S, Krahn M, Espinosa Vázquez J, Hombria J. Src kinases mediate the interaction of the apical determinant Bazooka/PAR3 with STAT92E and increase signalling efficiency in Drosophila ectodermal cells. Development. 2013;140:1507-16 pubmed publisher
    ..Here, we find that Baz-STAT92E interaction depends on the presence of the Drosophila Src kinases...
  69. Kohlmaier A, Fassnacht C, Jin Y, Reuter H, Begum J, Dutta D, et al. Src kinase function controls progenitor cell pools during regeneration and tumor onset in the Drosophila intestine. Oncogene. 2015;34:2371-84 pubmed publisher
    ..We found that Drosophila Src42a and Src64b were required for optimal regenerative ISC division...
  70. Booth A, Blanchard G, Adams R, Röper K. A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation. Dev Cell. 2014;29:562-576 pubmed publisher
    ..The medial actomyosin network interacts with the minus ends of acentrosomal microtubule bundles through the cytolinker protein Shot, and disruption of Shot also impairs apical constriction. ..