Gene Symbol: spn-F
Description: spn-F
Alias: 1130/03, CG12114, Dmel\CG12114, Spn-F, SpnF, l(3)S113003b, spn-F, CG12114-PA, CG12114-PB, Spindle-F, lethal (3) S113003b, spindle F, spn-F-PA, spn-F-PB
Species: fruit fly
Products:     spn-F

Top Publications

  1. Abdu U, Bar D, Sch pbach T. spn-F encodes a novel protein that affects oocyte patterning and bristle morphology in Drosophila. Development. 2006;133:1477-84 pubmed publisher
    ..Our results show that we have identified a novel protein that affects oocyte axis determination and the organization of microtubules during Drosophila oogenesis...
  2. Dubin Bar D, Bitan A, Bakhrat A, Kaiden Hasson R, Etzion S, Shaanan B, et al. The Drosophila IKK-related kinase (Ik2) and Spindle-F proteins are part of a complex that regulates cytoskeleton organization during oogenesis. BMC Cell Biol. 2008;9:51 pubmed publisher
    ..Interestingly, Ik2 in this complex does not function as a typical IKK in that it does not direct SpnF for degradation following phosphorylation.
  3. Bergmann A. IKK epsilon signaling: not just NF-kappaB. Curr Biol. 2006;16:R588-90 pubmed
    ..Surprisingly, three recent reports implicate IKKs in Drosophila in seemingly unrelated functions, including non-apoptotic caspase activation and cytoskeleton organization. ..
  4. Gervais L, Claret S, Januschke J, Roth S, Guichet A. PIP5K-dependent production of PIP2 sustains microtubule organization to establish polarized transport in the Drosophila oocyte. Development. 2008;135:3829-38 pubmed publisher
  5. Bitan A, Guild G, Bar Dubin D, Abdu U. Asymmetric microtubule function is an essential requirement for polarized organization of the Drosophila bristle. Mol Cell Biol. 2010;30:496-507 pubmed publisher
    ..Thus, our results show that MTs are organized in a polarized manner within the highly elongated bristle and that this organization is essential for biased bristle axial growth. ..
  6. Dubin Bar D, Bitan A, Bakhrat A, Amsalem S, Abdu U. Drosophila javelin-like encodes a novel microtubule-associated protein and is required for mRNA localization during oogenesis. Development. 2011;138:4661-71 pubmed publisher
    ..Jvl physically interacts with SpnF and is required for its localization...
  7. Otani T, Oshima K, Kimpara A, Takeda M, Abdu U, Hayashi S. A transport and retention mechanism for the sustained distal localization of Spn-F-IKKε during Drosophila bristle elongation. Development. 2015;142:2338-51 pubmed publisher
    ..These results suggest that polarized transport and selective retention regulate the distal tip localization of the Spn-F-IKKε complex during bristle cell elongation. ..
  8. Lin T, Pan P, Lai Y, Chiang K, Hsieh H, Wu Y, et al. Spindle-F Is the Central Mediator of Ik2 Kinase-Dependent Dendrite Pruning in Drosophila Sensory Neurons. PLoS Genet. 2015;11:e1005642 pubmed publisher
    ..Our findings reveal a novel regulatory mechanism for dendrite pruning achieved by temporal activation of Ik2 kinase and dynein-mediated redistribution of Ik2/Spn-F complex in neurons. ..
  9. Pare C, Suter B. Subcellular localization of Bic-D::GFP is linked to an asymmetric oocyte nucleus. J Cell Sci. 2000;113 ( Pt 12):2119-27 pubmed
    ..The subcellular polarity defined by the Bic-D focus and the nuclear polarity marks some of the first steps in antero-posterior and subsequently in dorso-ventral polarity formation. ..

More Information


  1. Shapira S, Bakhrat A, Bitan A, Abdu U. The Drosophila javelin gene encodes a novel actin-associated protein required for actin assembly in the bristle. Mol Cell Biol. 2011;31:4582-92 pubmed publisher
    ..Thus, we report that Jv is a novel actin-associated protein required for actin assembly during Drosophila bristle development. ..
  2. Amsalem S, Bakrhat A, Otani T, Hayashi S, Goldstein B, Abdu U. Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like. Mol Cell Biol. 2013;33:4371-80 pubmed publisher
    ..In summary, our results demonstrate that Spn-F mediates the interaction between Ik2 and Jvl to control Ik2 activity. ..