Gene Symbol: spel1
Description: spellchecker1
Alias: BG:DS01068.9, CG4215, Dmel\CG4215, Msh2, SPEL1, spel, spel-1, spellchecker1, CG4215-PA, CG4215-PD, CG4215-PE, CG4215-PF, spel1-PA, spel1-PD, spel1-PE, spel1-PF, spellchecker, spellchecker 1
Species: fruit fly

Top Publications

  1. Lopez A, Xamena N, Marcos R, Velazquez A. Germ cells microsatellite instability. The effect of different mutagens in a mismatch repair mutant of Drosophila (spel1). Mutat Res. 2002;514:87-94 pubmed
    ..EB) was evaluated in vivo, by using a Drosophila melanogaster-null mutant of the msh2 mismatch repair gene (spel1)...
  2. Flores C, Engels W. Microsatellite instability in Drosophila spellchecker1 (MutS homolog) mutants. Proc Natl Acad Sci U S A. 1999;96:2964-9 pubmed
    We have cloned a mutS homolog from Drosophila melanogaster called spellchecker1 (spel1) and have constructed spel1 mutant flies...
  3. Sekelsky J, Brodsky M, Burtis K. DNA repair in Drosophila: insights from the Drosophila genome sequence. J Cell Biol. 2000;150:F31-6 pubmed
  4. Harr B, Todorova J, Schlotterer C. Mismatch repair-driven mutational bias in D. melanogaster. Mol Cell. 2002;10:199-205 pubmed
    ..cells have the highest mutation rate at (GT)(n) repeats, (AT)(n) repeats were the least stable ones in spel1(-/-) flies lacking functional mismatch repair...
  5. Kappeler M, Kranz E, Woolcock K, Georgiev O, Schaffner W. Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences. Nucleic Acids Res. 2008;36:6907-17 pubmed publisher
    ..Unexpectedly, distinct from its function in Saccharomyces cerevisiae, the mismatch repair factor Msh2 encoded by spel1 does not suppress homeologous SSA in Drosophila.
  6. King E, Kislukhin G, Walters K, Long A. Using Drosophila melanogaster to identify chemotherapy toxicity genes. Genetics. 2014;198:31-43 pubmed publisher
    ..One QTL is associated with fly orthologs of a priori human carboplatin candidate genes ABCC2 and MSH2, and a second QTL is associated with fly orthologs of human gemcitabine candidate genes RRM2 and RRM2B...
  7. Gaasterland T, Sczyrba A, Thomas E, Aytekin Kurban G, Gordon P, Sensen C. MAGPIE/EGRET annotation of the 2.9-Mb Drosophila melanogaster Adh region. Genome Res. 2000;10:502-10 pubmed
    ..The software modules that add eukaryotic genome annotation capability to MAGPIE are available as EGRET (Eukaryotic Genome Rapid Evaluation Tool). ..
  8. Ainsley J, Pettus J, Bosenko D, Gerstein C, Zinkevich N, Anderson M, et al. Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1. Curr Biol. 2003;13:1557-63 pubmed
  9. Sawamura K, Roote J, Wu C, Yamamoto M. Genetic complexity underlying hybrid male sterility in Drosophila. Genetics. 2004;166:789-96 pubmed
    ..Such an epistatic view, even in the less-related species, suggests that the genetic complexity is special to hybrid male sterility. ..

More Information


  1. Wegman L, Ainsley J, Johnson W. Developmental timing of a sensory-mediated larval surfacing behavior correlates with cessation of feeding and determination of final adult size. Dev Biol. 2010;345:170-9 pubmed publisher
    ..These results suggest a peripheral sensory mechanism functioning to alter the relationship between the animal and its environment thereby contributing to the length of the larval TGP and determination of final adult size. ..
  2. Williams S, Wilson J, Clark A, Mitson Salazar A, Tomashevski A, Ananth S, et al. Functional and physical interaction between the mismatch repair and FA-BRCA pathways. Hum Mol Genet. 2011;20:4395-410 pubmed publisher
    ..Here we show that FANCD2 interacts with the MMR proteins MSH2 and MLH1...
  3. Ellegren H. Mismatch repair and mutational bias in microsatellite DNA. Trends Genet. 2002;18:552 pubmed
  4. Jackson S, Whitworth A, Greene J, Libby R, Baccam S, Pallanck L, et al. A SCA7 CAG/CTG repeat expansion is stable in Drosophila melanogaster despite modulation of genomic context and gene dosage. Gene. 2005;347:35-41 pubmed
    ..In all cases, perfect repeat stability was preserved, suggesting that Drosophila may not be a suitable system for determining the molecular basis of SCA7 CAG repeat instability. ..
  5. Zhong L, Hwang R, Tracey W. Pickpocket is a DEG/ENaC protein required for mechanical nociception in Drosophila larvae. Curr Biol. 2010;20:429-34 pubmed publisher
    ..Our results suggest that neurons that detect harsh touch in Drosophila utilize similar mechanosensory molecules. ..