spastin

Summary

Gene Symbol: spastin
Description: spastin
Alias: CG5977, D-spastin, Dmel\CG5977, Dspastin, Spas, CG5977-PA, CG5977-PB, CG5977-PC, D-spastin, Dm-Spastin, dspastin, spas-PA, spas-PB, spas-PC, spasin
Species: fruit fly

Top Publications

  1. ncbi The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules
    Antonina Roll-Mecak
    The Howard Hughes Medical Institute and the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Curr Biol 15:650-5. 2005
  2. pmc Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin
    Antonina Roll-Mecak
    Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, USA
    Nature 451:363-7. 2008
  3. pmc Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function
    Nina Tang Sherwood
    Broad Center, Division of Biology, California Institute of Technology Pasadena, California, USA
    PLoS Biol 2:e429. 2004
  4. pmc Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes
    Dong Zhang
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 177:231-42. 2007
  5. ncbi Transiently reorganized microtubules are essential for zippering during dorsal closure in Drosophila melanogaster
    Ferenc Jankovics
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Cell 11:375-85. 2006
  6. ncbi Identification of the Drosophila melanogaster homolog of the human spastin gene
    Lars Kammermeier
    Institute of Zoology, Biozentrum Pharmazentrum, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Dev Genes Evol 213:412-5. 2003
  7. ncbi The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function
    Nick Trotta
    Department of Biological Sciences, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37235, USA
    Curr Biol 14:1135-47. 2004
  8. pmc Normal spastin gene dosage is specifically required for axon regeneration
    Michelle C Stone
    Department of Biochemistry and Molecular Biology, Penn State, University Park, PA 16802, USA
    Cell Rep 2:1340-50. 2012
  9. pmc Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo
    Brian Stramer
    Randall Division of Cell and Molecular Biophysics, King s College London, London SE1 1UL, England, UK
    J Cell Biol 189:681-9. 2010
  10. doi A mathematical model for dorsal closure
    Luis Almeida
    Laboratoire J A Dieudonne, Universite de Nice, UMR 6621 CNRS, Parc Valrose, F 06108 Nice Cedex 02, France
    J Theor Biol 268:105-19. 2011

Scientific Experts

  • Brian Stramer
  • Lars Kammermeier
  • Bing Ye
  • Véronique Brodu
  • Luis Almeida
  • Nicole Gorfinkiel
  • Nina Tang Sherwood
  • Melissa M Rolls
  • Michelle C Stone
  • Antonina Roll-Mecak
  • Emily F Ozdowski
  • Thomas Eckert
  • Andrea Stewart
  • Li Chen
  • Juan Tao
  • NINA T SHERWOOD
  • Veronique Van de Bor
  • C Meghana
  • Stacie A Dilks
  • Stéphane Noselli
  • Louis Gervais
  • Fang Du
  • Geng Chen
  • Chloe Thomas
  • Shan Jin
  • Mihye Lee
  • Bing Zhang
  • Shiho Jinushi-Nakao
  • Dong Zhang
  • Kiichiro Taniguchi
  • Ronald D Vale
  • Ferenc Jankovics
  • Xiufang Guo
  • Nick Trotta
  • Günther Woehlke
  • Kyle W Gheres
  • Asako Tsubouchi
  • Doan Tuong Van Le
  • Kavitha Rao
  • Christin T Folker
  • Seahee Kim
  • Caroline La Rochelle
  • Lena Friedmann
  • Susanne Link
  • W Daniel Tracey
  • Sophia Gayle
  • Delphine Cerezo
  • Sebastien Schaub
  • Hong Bao
  • G V Shivashankar
  • Maithreyi Narasimha
  • Feroz Meeran Hameed
  • Madan Rao
  • Nisha Ramdas
  • Geordie Zimniak
  • Stephen Dinardo
  • Jordi Casanova
  • Sang Chul Nam
  • Garrett P League
  • Ingrid K Kotowski
  • Douglas A Marchuk
  • C Justin Lee
  • Qifu Wang
  • Hyun Man Kim
  • Zhiheng Xu
  • Yong Chul Bae
  • Min Jung Lee
  • Yoon Jung Kim
  • Seungbok Lee
  • Luyuan Pan
  • Sang Kyoo Paik
  • Jeongbin Yim
  • Sungdae Kim
  • Raphaël Rousset
  • Soo Jin Oh
  • Minyeop Nahm
  • Yong Q Zhang
  • Zhihua Liu
  • David J Sharp
  • Shunya Hozumi
  • Reiko Amikura
  • Daniel W Buster
  • Takashi Okumura
  • Ramanathan Arvind
  • Adrian Walton Moore
  • Gregory C Rogers
  • Reo Maeda
  • Emi Kinameri
  • Kenji Matsuno
  • Andrew Winston Liu

Detail Information

Publications30

  1. ncbi The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules
    Antonina Roll-Mecak
    The Howard Hughes Medical Institute and the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Curr Biol 15:650-5. 2005
    ..disorders characterized by lower-extremity spasticity and weakness, are most commonly caused by mutations in the spastin gene, which encodes a AAA+ ATPase related to the microtubule-severing protein katanin...
  2. pmc Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin
    Antonina Roll-Mecak
    Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, USA
    Nature 451:363-7. 2008
    b>Spastin, the most common locus for mutations in hereditary spastic paraplegias, and katanin are related microtubule-severing AAA ATPases involved in constructing neuronal and non-centrosomal microtubule arrays and in segregating ..
  3. pmc Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function
    Nina Tang Sherwood
    Broad Center, Division of Biology, California Institute of Technology Pasadena, California, USA
    PLoS Biol 2:e429. 2004
    ..form of human autosomal dominant hereditary spastic paraplegia (AD-HSP) is caused by mutations in the SPG4 (spastin) gene, which encodes an AAA ATPase closely related in sequence to the microtubule-severing protein Katanin...
  4. pmc Three microtubule severing enzymes contribute to the "Pacman-flux" machinery that moves chromosomes
    Dong Zhang
    Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 177:231-42. 2007
    ..in Drosophila melanogaster incorporates the activities of three different microtubule severing enzymes, Spastin, Fidgetin, and Katanin...
  5. ncbi Transiently reorganized microtubules are essential for zippering during dorsal closure in Drosophila melanogaster
    Ferenc Jankovics
    Cell Biology and Biophysics Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Dev Cell 11:375-85. 2006
    ..We provide a clearly defined example where cells of a developing organism transiently reorganize their microtubules to fulfill a specialized morphogenetic task...
  6. ncbi Identification of the Drosophila melanogaster homolog of the human spastin gene
    Lars Kammermeier
    Institute of Zoology, Biozentrum Pharmazentrum, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Dev Genes Evol 213:412-5. 2003
    The human SPG4 locus encodes the spastin gene, which is responsible for the most prevalent form of autosomal dominant hereditary spastic paraplegia (AD-HSP), a neurodegenerative disorder...
  7. ncbi The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function
    Nick Trotta
    Department of Biological Sciences, Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37235, USA
    Curr Biol 14:1135-47. 2004
    ..Over 20 genes have been linked to HSP in humans; however, mutations in one gene, spastin (SPG4), are the cause of >40% of all cases...
  8. pmc Normal spastin gene dosage is specifically required for axon regeneration
    Michelle C Stone
    Department of Biochemistry and Molecular Biology, Penn State, University Park, PA 16802, USA
    Cell Rep 2:1340-50. 2012
    ..We found that axon regeneration is extremely sensitive to levels of the microtubule-severing protein spastin. Although microtubule behavior in uninjured neurons was not perturbed in animals heterozygous for a spastin null ..
  9. pmc Clasp-mediated microtubule bundling regulates persistent motility and contact repulsion in Drosophila macrophages in vivo
    Brian Stramer
    Randall Division of Cell and Molecular Biophysics, King s College London, London SE1 1UL, England, UK
    J Cell Biol 189:681-9. 2010
    ..align just before cell-cell repulsion, and we show that forcing depolymerization of microtubules by expression of Spastin leads to their defective polarity and failure to contact inhibit from one another...
  10. doi A mathematical model for dorsal closure
    Luis Almeida
    Laboratoire J A Dieudonne, Universite de Nice, UMR 6621 CNRS, Parc Valrose, F 06108 Nice Cedex 02, France
    J Theor Biol 268:105-19. 2011
    ..native setting and also test it further in embryos where the zipping force is perturbed through the expression of spastin (a microtubule severing protein)...
  11. doi Asymmetric localisation of cytokine mRNA is essential for JAK/STAT activation during cell invasiveness
    Veronique Van de Bor
    Institute of Developmental Biology and Cancer UMR6543 CNRS, University of Nice Sophia Antipolis, Parc Valrose, 06108 Nice Cedex 2, France
    Development 138:1383-93. 2011
    ..These findings reveal a novel post-transcriptional regulatory mechanism of JAK/STAT signalling in the control of epithelial cell invasiveness...
  12. pmc Integrin adhesion drives the emergent polarization of active cytoskeletal stresses to pattern cell delamination
    C Meghana
    Department of Biological Sciences, Tata Institute of Fundamental Research, Mumbai 400005, India
    Proc Natl Acad Sci U S A 108:9107-12. 2011
    ..We suggest that differential contributions of adhesion, cytoskeletal, and external stresses must underlie differences in spatial pattern...
  13. pmc Loss of Drosophila melanogaster p21-activated kinase 3 suppresses defects in synapse structure and function caused by spastin mutations
    Emily F Ozdowski
    Department of Biology Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina 27710, USA
    Genetics 189:123-35. 2011
    ..The AAA ATPase Spastin severs microtubules along their lengths and is thought to regulate the balance between long, stable filaments and ..
  14. pmc Axon injury and stress trigger a microtubule-based neuroprotective pathway
    Li Chen
    Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 109:11842-7. 2012
    ..We conclude that axon injury or stress triggers a microtubule-based neuroprotective pathway that stabilizes neurons against degeneration...
  15. pmc Katanin p60-like1 promotes microtubule growth and terminal dendrite stability in the larval class IV sensory neurons of Drosophila
    Andrea Stewart
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    J Neurosci 32:11631-42. 2012
    ..Although loss of the related microtubule-severing protein Spastin also reduces the class IV dendrite arbor, microtubule polymerization within dendrites is unaffected...
  16. pmc Non-cell-autonomous control of denticle diversity in the Drosophila embryo
    Stacie A Dilks
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Development 137:1395-404. 2010
    ..We propose that stripe mediates its effect on hook orientation, in part, via upregulation of shot...
  17. pmc Spastin's microtubule-binding properties and comparison to katanin
    Thomas Eckert
    Department of Physics E22 Biophysics, Technische Universitat Munchen, Garching, Germany
    PLoS ONE 7:e50161. 2012
    b>Spastin and katanin are ring-shaped hexameric AAA ATPases that sever microtubules, and thus crucially depend on a physical interaction with microtubules...
  18. doi JNK signalling influences intracellular trafficking during Drosophila morphogenesis through regulation of the novel target gene Rab30
    Chloe Thomas
    Institute of Developmental Biology and Cancer, University of Nice, UMR CNRS, France
    Dev Biol 331:250-60. 2009
    ..We propose that JNK activity upregulates genes involved in intracellular transport in order to provide an increased level of trafficking activity in cells undergoing complex morphogenetic arrangements such as dorsal closure...
  19. pmc Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia
    Fang Du
    Department of Biology and Institute for Genome Sciences and Policy, Duke University, Durham, NC 27708, USA
    Hum Mol Genet 19:1883-96. 2010
    Mutations in spastin are the most frequent cause of the neurodegenerative disease autosomal dominant-hereditary spastic paraplegia (AD-HSP)...
  20. ncbi The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses
    Xiufang Guo
    Arizona Research Laboratories, Division of Neurobiology, University of Arizona, Tucson, Arizona 85721, USA
    Neuron 47:379-93. 2005
    ..Together, our findings suggest that dMiro is required for controlling anterograde transport of mitochondria and their proper distribution within nerve terminals...
  21. ncbi Knot/Collier and cut control different aspects of dendrite cytoskeleton and synergize to define final arbor shape
    Shiho Jinushi-Nakao
    RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    Neuron 56:963-78. 2007
    ..Knot increases dendritic arbor outgrowth through promoting the expression of Spastin, a microtubule-severing protein disrupted in autosomal dominant hereditary spastic paraplegia (AD-HSP)...
  22. ncbi Roles of type I myosins in Drosophila handedness
    Kiichiro Taniguchi
    Department of Biological Science and Technology, Tokyo University of Science, Noda, Chiba, Japan
    Fly (Austin) 1:287-90. 2007
    ..We propose that the actin-based functions of type I Myosins play critical roles in generating LR asymmetry in invertebrates...
  23. doi Drosophila Tubulin-specific chaperone E functions at neuromuscular synapses and is required for microtubule network formation
    Shan Jin
    Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Development 136:1571-81. 2009
    ..Genetic analyses revealed an antagonistic interaction between TBCE and the microtubule-severing protein Spastin. Moreover, treatment of muscles with the microtubule-depolymerizing drug nocodazole implicated TBCE as a tubulin ..
  24. doi Drosophila Atlastin regulates the stability of muscle microtubules and is required for synapse development
    Mihye Lee
    Department of Cell and Developmental Biology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul 110 740, Republic of Korea
    Dev Biol 330:250-62. 2009
    ..We also provide evidence that Atl functions with the microtubule-severing protein Spastin to disassemble microtubules in muscles...
  25. pmc Differential regulation of dendritic and axonal development by the novel Krüppel-like factor Dar1
    Bing Ye
    Life Sciences Institute and Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Neurosci 31:3309-19. 2011
    ..that Dar1 promotes dendrite growth in part by suppressing the expression of the microtubule-severing protein Spastin. Our study thus uncovers a novel transcriptional program for microtubule regulation that preferentially controls ..
  26. pmc Mechanical control of global cell behaviour during dorsal closure in Drosophila
    Nicole Gorfinkiel
    Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK
    Development 136:1889-98. 2009
    ..Our mutant analysis reveals the contribution of mechanical elements to the rate and pattern of DC...
  27. doi A developmentally regulated two-step process generates a noncentrosomal microtubule network in Drosophila tracheal cells
    Véronique Brodu
    Institut Jacques Monod CNRS, 15 Rue H Brion, 75205 Paris Cedex 13, France
    Dev Cell 18:790-801. 2010
    ..MTOC components are first released from the centrosome by the activity of the MT-severing protein Spastin, and then anchored apically through the transmembrane protein Piopio...
  28. pmc Role of spastin in apical domain control along the rhabdomere elongation in Drosophila photoreceptor
    Geng Chen
    Department of Biology, Baylor University, Waco, Texas, United States of America
    PLoS ONE 5:e9480. 2010
    Mutations in spastin are the most common cause of hereditary spastin paraplegia, a neurodegenerative disease. In this study, the role of spastin was examined in Drosophila photoreceptor development.
  29. doi In vivo coupling of cell elongation and lumen formation in a single cell
    Louis Gervais
    Institut de Biologia Molecular de Barcelona CSIC, Baldiri Reixac 10 12, 08028 Barcelona, Spain
    Curr Biol 20:359-66. 2010
    ..Given the similarities in the formation of fine respiratory tubes and capillaries, we propose that an inward membrane growth model could account for lumen formation in both processes...

Research Grants2

  1. Signaling Pathways That Differentiate Dendrite and Axon Development
    Bing Ye; Fiscal Year: 2010
    ..The proposed research will provide the knowledge needed to develop therapeutic strategies having subcellular precision to correct defective dendrites and axons in human diseases. ..