Gene Symbol: Sod2
Description: Superoxide dismutase 2 (Mn)
Alias: CG8905, Dmel\CG8905, Mito SOD, Mn SOD, Mn-SOD, Mn-SOD2, MnSOD, MnSODII, Mn[2+]SOD, SOD, SOD-2, SOD2, Sod-2, dSOD2, dSod2, mitSOD2, mnSOD, sod2, superoxide dismutase 2 (Mn), CG8905-PA, CG8905-PB, Mn superoxide dismutase, Mn-superoxide dismutase, MnSOD, Sod2-PA, Sod2-PB, manganese superoxide dismutase, manganese-SOD, mitochodnrial SOD, mitochondrial Mn-superoxide dismutase 2, mitochondrial MnSOD, mitochondrial superoxide dismutase 2, superoxide dismutase, superoxide dismutase 2, superoxide dismutase-2, superoxide dismutatase 2
Species: fruit fly
Products:     Sod2

Top Publications

  1. Magwere T, West M, Riyahi K, Murphy M, Smith R, Partridge L. The effects of exogenous antioxidants on lifespan and oxidative stress resistance in Drosophila melanogaster. Mech Ageing Dev. 2006;127:356-70 pubmed
    We used the fruit fly Drosophila melanogaster to test the effects of feeding the superoxide dismutase (SOD) mimetic drugs Euk-8 and -134 and the mitochondria-targeted mitoquinone (MitoQ) on lifespan and oxidative stress resistance of wild ..
  2. Duttaroy A, Paul A, Kundu M, Belton A. A Sod2 null mutation confers severely reduced adult life span in Drosophila. Genetics. 2003;165:2295-9 pubmed
    A null mutation for the Sod2 gene, Sod2n283, was obtained in Drosophila melanogaster...
  3. Paul A, Belton A, Nag S, Martin I, Grotewiel M, Duttaroy A. Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging. Mech Ageing Dev. 2007;128:706-16 pubmed
    b>Manganese superoxide dismutase (MnSOD or SOD2) is a key mitochondrial enzymatic antioxidant. Arguably the most striking phenotype associated with complete loss of SOD2 in flies and mice is shortened life span...
  4. Mockett R, Orr W, Rahmandar J, Benes J, Radyuk S, Klichko V, et al. Overexpression of Mn-containing superoxide dismutase in transgenic Drosophila melanogaster. Arch Biochem Biophys. 1999;371:260-9 pubmed
    ..Two alternative hypotheses were tested: (i) that overexpression of Mn superoxide dismutase (Mn SOD) in the mitochondria of Drosophila melanogaster would slow the accrual of oxidative damage and ..
  5. Hirano Y, Kuriyama Y, Miyashita T, Horiuchi J, Saitoe M. Reactive oxygen species are not involved in the onset of age-related memory impairment in Drosophila. Genes Brain Behav. 2012;11:79-86 pubmed publisher
    ..Thus we propose that ROS production does not affect AMI onset in Drosophila. ..
  6. Li Y, Chan H, Yao X, Huang Y, Chen Z. Green tea catechins and broccoli reduce fat-induced mortality in Drosophila melanogaster. J Nutr Biochem. 2008;19:376-83 pubmed
    ..melanogaster maintained on the GTC- and BE-supplemented diet. Accordingly, catalase and superoxide dismutase (SOD) activities increased significantly in the flies fed with a GTC or a BE diet compared with those fed ..
  7. Mockett R, Orr W, Rahmandar J, Sohal B, Sohal R. Antioxidant status and stress resistance in long- and short-lived lines of Drosophila melanogaster. Exp Gerontol. 2001;36:441-63 pubmed
  8. Belton A, Paul A, Duttaroy A. Deletions encompassing the manganese superoxide dismutase gene in the Drosophila melanogaster genome. Genome. 2006;49:746-51 pubmed
    Two deletions, Df(2R)Sod2-11 and Df(2R)Sod2-332, are recovered that encompass the manganese superoxide dismutase (MnSOD) gene or a null mutant referred to as SOD2n283 in Drosophila...
  9. Anderson P, Kirby K, Hilliker A, Phillips J. RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila. Hum Mol Genet. 2005;14:3397-405 pubmed
    ..Finally, overexpression of Sod1, Sod2 or Cat does not suppress the failure of DFH-deficient animals to successfully complete eclosion, suggesting a ..

More Information


  1. Milton V, Jarrett H, Gowers K, Chalak S, Briggs L, Robinson I, et al. Oxidative stress induces overgrowth of the Drosophila neuromuscular junction. Proc Natl Acad Sci U S A. 2011;108:17521-6 pubmed publisher
    ..Our data describe a previously unexplored link between oxidative stress and synapse overgrowth via the JNK signaling pathway. ..
  2. Bayne A, Mockett R, Orr W, Sohal R. Enhanced catabolism of mitochondrial superoxide/hydrogen peroxide and aging in transgenic Drosophila. Biochem J. 2005;391:277-84 pubmed
    ..physiological changes and extend the lifespan was tested by simultaneous overexpression of MnSOD (manganese superoxide dismutase) and catalase, ectopically targeted to the mitochondrial matrix of transgenic Drosophila melanogaster...
  3. Helfand S, Rogina B. Molecular genetics of aging in the fly: is this the end of the beginning?. Bioessays. 2003;25:134-41 pubmed
  4. Owusu Ansah E, Banerjee U. Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation. Nature. 2009;461:537-41 pubmed publisher
    ..Our results lead to a model that could be extended to reveal a probable signalling role for ROS in the differentiation of CMPs in mammalian haematopoietic development and oxidative stress response. ..
  5. Ford D, Hoe N, Landis G, Tozer K, Luu A, Bhole D, et al. Alteration of Drosophila life span using conditional, tissue-specific expression of transgenes triggered by doxycyline or RU486/Mifepristone. Exp Gerontol. 2007;42:483-97 pubmed
    ..Moderate level over-expression of MnSOD has beneficial effects on life span. Here high-level over-expression of MnSOD was found to have toxic effects...
  6. Le Bourg E -. Oxidative stress, aging and longevity in Drosophila melanogaster. FEBS Lett. 2001;498:183-6 pubmed
    ..It is concluded that antioxidant enzymes are probably poorly connected to the normal aging process, but they allow the organism to cope with stressful conditions. ..
  7. Orr W, Mockett R, Benes J, Sohal R. Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster. J Biol Chem. 2003;278:26418-22 pubmed
    The overexpression of antioxidative enzymes such as CuZn-superoxide dismutase (SOD), Mn-SOD, and catalase has previously been reported to extend life span in transgenic flies (Drosophila melanogaster)...
  8. Martin I, Jones M, Rhodenizer D, Zheng J, Warrick J, Seroude L, et al. Sod2 knockdown in the musculature has whole-organism consequences in Drosophila. Free Radic Biol Med. 2009;47:803-13 pubmed publisher
    ..In Drosophila, RNAi-mediated silencing of the mitochondrial antioxidant manganese superoxide dismutase (SOD2) throughout the body dramatically reduces life span, accelerates senescence of locomotor ..
  9. Landis G, Tower J. Superoxide dismutase evolution and life span regulation. Mech Ageing Dev. 2005;126:365-79 pubmed
    ..b>Superoxide dismutase (SOD) enzymes catalyze the breakdown of superoxide into hydrogen peroxide and water and are therefore ..
  10. Martin I, Jones M, Grotewiel M. Manipulation of Sod1 expression ubiquitously, but not in the nervous system or muscle, impacts age-related parameters in Drosophila. FEBS Lett. 2009;583:2308-14 pubmed publisher
    b>Superoxide dismutase 1 (SOD1) is an important antioxidant previously shown to impact life span in Drosophila...
  11. Curtis C, Landis G, Folk D, Wehr N, Hoe N, Waskar M, et al. Transcriptional profiling of MnSOD-mediated lifespan extension in Drosophila reveals a species-general network of aging and metabolic genes. Genome Biol. 2007;8:R262 pubmed
    ..growth factor-like signaling (IIS), FOXO transcription factor activation, dietary restriction, and superoxide dismutase (SOD) over-expression...
  12. Sun J, Folk D, Bradley T, Tower J. Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. Genetics. 2002;161:661-72 pubmed
    A transgenic system ("FLP-out") based on yeast FLP recombinase allowed induced overexpression of MnSOD enzyme in adult Drosophila melanogaster...
  13. Vrailas Mortimer A, Del Rivero T, Mukherjee S, Nag S, Gaitanidis A, Kadas D, et al. A muscle-specific p38 MAPK/Mef2/MnSOD pathway regulates stress, motor function, and life span in Drosophila. Dev Cell. 2011;21:783-95 pubmed publisher
    ..Mechanistically, p38K modulates expression of the mitochondrial MnSOD enzyme through the transcription factor Mef2, and predictably, perturbations in MnSOD modify p38K-dependent ..
  14. Sun J, Molitor J, Tower J. Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span. Mech Ageing Dev. 2004;125:341-9 pubmed
    ..of over-expression achieved varies between independent transgenic lines, and previously for both Cu/ZnSOD and MnSOD life span was found to be increased in proportion to the increase in enzyme activity...
  15. Clancy D, Gems D, Harshman L, Oldham S, Stocker H, Hafen E, et al. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science. 2001;292:104-6 pubmed
    ..The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved. ..
  16. Peng C, Zuo Y, Kwan K, Liang Y, Ma K, Chan H, et al. Blueberry extract prolongs lifespan of Drosophila melanogaster. Exp Gerontol. 2012;47:170-8 pubmed publisher
    ..extend the mean lifespan of fruit flies by 10%, accompanied by up-regulating gene expression of superoxide dismutase (SOD), catalase (CAT) and Rpn11 and down-regulating Methuselah (MTH) gene...
  17. Piazza N, Hayes M, Martin I, Duttaroy A, Grotewiel M, Wessells R. Multiple measures of functionality exhibit progressive decline in a parallel, stochastic fashion in Drosophila Sod2 null mutants. Biogerontology. 2009;10:637-48 pubmed publisher
    ..we examine functional deterioration in short-lived flies mutant for the mitochondrial antioxidant Manganese Superoxide Dismutase (Sod2)...
  18. Arking R, Burde V, Graves K, Hari R, Feldman E, Zeevi A, et al. Forward and reverse selection for longevity in Drosophila is characterized by alteration of antioxidant gene expression and oxidative damage patterns. Exp Gerontol. 2000;35:167-85 pubmed
  19. Kirby K, Hu J, Hilliker A, Phillips J. RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress. Proc Natl Acad Sci U S A. 2002;99:16162-7 pubmed
    ..respiration is the principal source of reactive oxygen within cells, the mitochondrially localized superoxide dismutase (SOD) 2 is thought to play an important front-line defensive role against aging-related oxidative stress...
  20. Boulianne G. Neuronal regulation of lifespan: clues from flies and worms. Mech Ageing Dev. 2001;122:883-94 pubmed
  21. Missirlis F, Hu J, Kirby K, Hilliker A, Rouault T, Phillips J. Compartment-specific protection of iron-sulfur proteins by superoxide dismutase. J Biol Chem. 2003;278:47365-9 pubmed
    ..IRP1 is strongly activated by silencing and genetic mutation of the cytosolic superoxide dismutase (Sod1), but is unaffected by silencing of mitochondrial Sod2...
  22. Liu Z, Celotto A, Romero G, Wipf P, Palladino M. Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis. Neurobiol Dis. 2012;45:362-8 pubmed publisher
    ..These studies identify the role of ROS in pathogenesis associated with mitochondrial disease and demonstrate the utility of genetically encoded redox sensors in Drosophila. ..
  23. Underwood B, Imarisio S, Fleming A, Rose C, Krishna G, Heard P, et al. Antioxidants can inhibit basal autophagy and enhance neurodegeneration in models of polyglutamine disease. Hum Mol Genet. 2010;19:3413-29 pubmed publisher
    ..Thus, the potential benefits in neurodegenerative diseases of some classes of antioxidants may be compromised by their autophagy-blocking properties. ..
  24. Blackney M, Cox R, Shepherd D, Parker J. Cloning and expression analysis of Drosophila extracellular Cu Zn superoxide dismutase. Biosci Rep. 2014;34:e00164 pubmed publisher
    In the present study, we cloned and sequenced the mRNAs of the Sod3 [extracellular Cu Zn SOD (superoxide dismutase)] gene in Drosophila and identified two mRNA products formed by alternative splicing...
  25. Wang Y, Lee C, Lee L, Tung L, Hsieh Li H, Lee Chen G, et al. Mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of spinocerebellar ataxia type 12 (SCA12). J Biol Chem. 2011;286:21742-54 pubmed publisher
    ..By contrast, ectopic Drosophila Sod2 expression and antioxidant treatment reduced ROS and caspase 3 activity and extended the life span of the SCA12 fly ..
  26. Kwong L, Mockett R, Bayne A, Orr W, Sohal R. Decreased mitochondrial hydrogen peroxide release in transgenic Drosophila melanogaster expressing intramitochondrial catalase. Arch Biochem Biophys. 2000;383:303-8 pubmed
    ..This in vivo system provides a novel model for examining the functional significance of decreased mitochondrial H2O2 release. ..
  27. Hosamani R. Acute exposure of Drosophila melanogaster to paraquat causes oxidative stress and mitochondrial dysfunction. Arch Insect Biochem Physiol. 2013;83:25-40 pubmed publisher
    ..caused a concentration-dependent increase in mitochondrial superoxide generation and activity of manganese-superoxide dismutase (Mn-SOD)...
  28. Gupte T. Mitochondrial Fragmentation Due to Inhibition of Fusion Increases Cyclin B through Mitochondrial Superoxide Radicals. PLoS ONE. 2015;10:e0126829 pubmed publisher
    ..Our results provide an insight into the need for mitofusin-degradation during mitosis and also help in understanding the mechanism by which mitofusins may function as tumor suppressors. ..
  29. Bhandari P, Song M, Dorn G. Dissociation of mitochondrial from sarcoplasmic reticular stress in Drosophila cardiomyopathy induced by molecularly distinct mitochondrial fusion defects. J Mol Cell Cardiol. 2015;80:71-80 pubmed publisher
    ..Inhibiting ROS by overexpressing superoxide dismutase (SOD) or suppressing ROMO1 prevented mitochondrial and heart tube dysfunction provoked by Opa1 RNAi, but ..
  30. Terhzaz S, Finlayson A, Stirrat L, Yang J, Tricoire H, Woods D, et al. Cell-specific inositol 1,4,5 trisphosphate 3-kinase mediates epithelial cell apoptosis in response to oxidative stress in Drosophila. Cell Signal. 2010;22:737-48 pubmed publisher
    ..Finally, targeted over-expression of either debcl or buffy to tubule principal cells does not impact on tubule caspase-9 activity. Thus, IP(3)K-1 modulates epithelial cell apoptosis without involvement of bcl-2-type proteins. ..
  31. Sun Y, Yolitz J, Alberico T, Sun X, Zou S. Lifespan extension by cranberry supplementation partially requires SOD2 and is life stage independent. Exp Gerontol. 2014;50:57-63 pubmed publisher
    ..Moreover, lifespan extension induced by cranberry was partially suppressed by knockdown of SOD2, a major mitochondrial superoxide scavenger...
  32. Johnson T. Genetic influences on aging. Exp Gerontol. 1997;32:11-22 pubmed
  33. Rival T, Page R, Chandraratna D, Sendall T, Ryder E, Liu B, et al. Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease. Eur J Neurosci. 2009;29:1335-47 pubmed publisher
  34. Godenschwege T, Forde R, Davis C, Paul A, Beckwith K, Duttaroy A. Mitochondrial superoxide radicals differentially affect muscle activity and neural function. Genetics. 2009;183:175-84 pubmed publisher
    ..radicals following its catalysis by superoxide dismutase (SOD) enzymes and also by autocatalysis (autodismutation) reactions...
  35. Tsuda M, Ootaka R, Ohkura C, Kishita Y, Seong K, Matsuo T, et al. Loss of Trx-2 enhances oxidative stress-dependent phenotypes in Drosophila. FEBS Lett. 2010;584:3398-401 pubmed publisher
    ..Trx-2 mutants express high levels of anti-oxidant genes, such as superoxide dismutase, catalase, and glutathione synthetase...
  36. Jovanović B, Cvetković V, Mitrović T. Effects of human food grade titanium dioxide nanoparticle dietary exposure on Drosophila melanogaster survival, fecundity, pupation and expression of antioxidant genes. Chemosphere. 2016;144:43-9 pubmed publisher
    ..gene for catalase was markedly downregulated by the treatment, while the effect on the downregulation of superoxide dismutase 2 was less pronounced...
  37. Xun Z, Sowell R, Kaufman T, Clemmer D. Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease. Mol Cell Proteomics. 2008;7:1191-203 pubmed publisher
    ..alpha-synuclein-mediated toxicity and PD; three up-regulated proteins (muscle LIM protein at 60A, manganese-superoxide dismutase, and troponin T) and two down-regulated proteins (chaoptin and retinal degeneration A) have literature-..
  38. Clark I, Dodson M, Jiang C, Cao J, Huh J, Seol J, et al. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature. 2006;441:1162-6 pubmed
    ..The role of the pink1-parkin pathway in regulating mitochondrial function underscores the importance of mitochondrial dysfunction as a central mechanism of Parkinson's disease pathogenesis. ..
  39. Chen Z, Qi Y, French S, Zhang G, Covian Garcia R, Balaban R, et al. Genetic mosaic analysis of a deleterious mitochondrial DNA mutation in Drosophila reveals novel aspects of mitochondrial regulation and function. Mol Biol Cell. 2015;26:674-84 pubmed publisher
    ..Our results demonstrate a novel approach for Drosophila mtDNA genetics and its application in modeling mtDNA diseases. ..
  40. Duttaroy A, Parkes T, Emtage P, Kirby K, Boulianne G, Wang X, et al. The manganese superoxide dismutase gene of Drosophila: structure, expression, and evidence for regulation by MAP kinase. DNA Cell Biol. 1997;16:391-9 pubmed
    The gene encoding manganese superoxide dismutase (MnSOD) from Drosophila melanogaster has been isolated and its expression has been studied...
  41. Söderberg J, Birse R, Nassel D. Insulin production and signaling in renal tubules of Drosophila is under control of tachykinin-related peptide and regulates stress resistance. PLoS ONE. 2011;6:e19866 pubmed publisher
    ..Manipulations of S6 kinase and superoxide dismutase (SOD2) in principal cells also affect survival at stress, suggesting that DILP5 acts locally on tubules, ..
  42. Fogle K, Baik L, Houl J, Tran T, Roberts L, Dahm N, et al. CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel β-subunit redox sensor. Proc Natl Acad Sci U S A. 2015;112:2245-50 pubmed publisher
    ..Light activation of CRY is transduced to membrane depolarization, increased firing rate, and acute behavioral responses by the Kvβ subunit redox sensor. ..
  43. Alaraby M, Demir E, Hernández A, Marcos R. Assessing potential harmful effects of CdSe quantum dots by using Drosophila melanogaster as in vivo model. Sci Total Environ. 2015;530-531:66-75 pubmed publisher
    ..To reduce the observed side-effects of Cd based QDs biocompatible coats would be required to avoid cadmium's undesirable effects. ..
  44. Wang S, Gao Y, Song X, Ma X, Zhu X, Mao Y, et al. Wnt signaling-mediated redox regulation maintains the germ line stem cell differentiation niche. elife. 2015;4:e08174 pubmed publisher
    ..Therefore, this study has revealed a novel strategy for Wnt signaling in regulating the cellular redox state and maintaining the differentiation niche. ..
  45. Bahadorani S, Hilliker A. Cocoa confers life span extension in Drosophila melanogaster. Nutr Res. 2008;28:377-82 pubmed publisher
    ..Under hyperoxia or in a Cu/Zn-superoxide dismutase-deficient background, cocoa exhibited a strong antioxidant activity, significantly increasing the average ..
  46. Grover D, Ford D, Brown C, Hoe N, Erdem A, Tavare S, et al. Hydrogen peroxide stimulates activity and alters behavior in Drosophila melanogaster. PLoS ONE. 2009;4:e7580 pubmed publisher
    ..Conditional over-expression of the hydrogen peroxide-producing enzyme superoxide dismutase (SOD) also increased fly activity and altered the patterns of locomotor activity across days and weeks...
  47. Duttaroy A, Meidinger R, Kirby K, Carmichael S, Hilliker A, Phillips J. A manganese superoxide dismutase-encoding cDNA from Drosophila melanogaster. Gene. 1994;143:223-5 pubmed
    A cDNA encoding manganese superoxide dismutase (MnSOD) has been cloned and sequenced from Drosophila melanogaster...
  48. Fang Y, Soares L, Teng X, Geary M, Bonini N. A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity. Curr Biol. 2012;22:590-5 pubmed publisher
    ..Together, these findings demonstrate an essential role of endogenous Nmnat in maintaining axonal integrity that may rely on and function by stabilizing mitochondria. ..
  49. Sun X, Komatsu T, Lim J, Laslo M, Yolitz J, Wang C, et al. Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster. Aging Cell. 2012;11:783-93 pubmed publisher
    ..However, how ROS modulate dietary effects on lifespan remains poorly understood. Superoxide dismutase 1 (SOD1) is a major cytosolic enzyme responsible for scavenging superoxides...
  50. Vincent A, Briggs L, Chatwin G, Emery E, Tomlins R, Oswald M, et al. parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stress. Hum Mol Genet. 2012;21:1760-9 pubmed publisher
    ..We therefore propose that mitochondrial dysfunction in parkin mutants induces Parkinsonian bradykinesia via a neuronal energy deficit and resulting synaptic failure, rather than as a consequence of downstream oxidative stress. ..
  51. Muliyil S, Narasimha M. Mitochondrial ROS regulates cytoskeletal and mitochondrial remodeling to tune cell and tissue dynamics in a model for wound healing. Dev Cell. 2014;28:239-52 pubmed publisher
    ..They identify a pathway triggered by ROS and mediated by the Rho effector ROCK and its substrates that influences tissue patterning and homeostasis through the coordinate regulation of both mitochondrial morphology and tissue tension. ..
  52. Peng C, Chan H, Huang Y, Yu H, Chen Z. Apple polyphenols extend the mean lifespan of Drosophila melanogaster. J Agric Food Chem. 2011;59:2097-106 pubmed publisher
    ..investigated the effect of AP on the lifespan of fruit flies and their interaction with gene expressions of superoxide dismutase (SOD), catalase (CAT), methuselah (MTH), Rpn11, and cytochrome c oxidase (CcO) subunits III and VIb...
  53. Mukherjee S, Basar M, Davis C, Duttaroy A. Emerging functional similarities and divergences between Drosophila Spargel/dPGC-1 and mammalian PGC-1 protein. Front Genet. 2014;5:216 pubmed publisher
    ..This led us to hypothesize that the discovery of newer biological functions in Drosophila Spargel/dPGC-1 will pave the way to uncover novel functional equivalents in mammals. ..
  54. Zuo Y, Peng C, Liang Y, Ma K, Yu H, Edwin Chan H, et al. Black rice extract extends the lifespan of fruit flies. Food Funct. 2012;3:1271-9 pubmed publisher
    ..lifespan-prolonging activity of black rice extracts (BREs) and its effect on gene expressions of CuZnSOD (SOD1), MnSOD (SOD2), catalase (CAT), methuselah (Mth) and Rpn11 involved in the antioxidant system and ageing of fruit flies...
  55. Bhandari P, Jones M, Martin I, Grotewiel M. Dietary restriction alters demographic but not behavioral aging in Drosophila. Aging Cell. 2007;6:631-7 pubmed
    ..strains, in our standard white laboratory stock, and in short-lived flies with reduced expression of superoxide dismutase 2. As expected, dietary restriction extended lifespan in all of these strains...
  56. Yang Y, Ouyang Y, Yang L, Beal M, McQuibban A, Vogel H, et al. Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery. Proc Natl Acad Sci U S A. 2008;105:7070-5 pubmed publisher
    ..These results reveal a cell biological role for Pink1 and establish mitochondrial fission/fusion as a paradigm for PD research. Compounds that modulate mitochondrial fission/fusion could have therapeutic value in PD intervention. ..
  57. Gao H, Wu X, Simon L, Fossett N. Antioxidants maintain E-cadherin levels to limit Drosophila prohemocyte differentiation. PLoS ONE. 2014;9:e107768 pubmed publisher
    ..Specifically, we show that knockdown of the antioxidants, Superoxide dismutatase 2 and Catalase reduce E-cadherin protein levels prior to the loss of Odd-skipped-expressing prohemocytes...
  58. Clavier A, Ruby V, Rincheval Arnold A, Mignotte B, Guénal I. The Drosophila retinoblastoma protein, Rbf1, induces a Debcl- and Drp1-dependent mitochondrial apoptosis. J Cell Sci. 2015;128:3239-49 pubmed publisher
    ..These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis, and shed light on a link between Rbf1 and mitochondrial dynamics in vivo. ..
  59. Chen K, Lin G, Haelterman N, Ho T, Li T, Li Z, et al. Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. elife. 2016;5: pubmed publisher
    ..Our results indicate that an iron/sphingolipid/Pdk1/Mef2 pathway may play a role in FRDA. ..
  60. Kim K, Lin Y, Park Y. Enhancement of stress resistances and downregulation of Imd pathway by lower developmental temperature in Drosophila melanogaster. Exp Gerontol. 2010;45:984-7 pubmed publisher
    ..We also showed that development at a lower temperature represented by 18°C significantly downregulates anti-microbial peptide genes, AttA and DptB, of Imd pathway. ..
  61. Lashmanova E, Proshkina E, Zhikrivetskaya S, Shevchenko O, Marusich E, Leonov S, et al. Fucoxanthin increases lifespan of Drosophila melanogaster and Caenorhabditis elegans. Pharmacol Res. 2015;100:228-41 pubmed publisher
    ..elegans were revealed only for fucoxanthin. In presence of carotenoids decreased flies' fecundity, increased spontaneous locomotor activity and resistance to oxidative stress were detected. ..
  62. Arking R, Burde V, Graves K, Hari R, Feldman E, Zeevi A, et al. Identical longevity phenotypes are characterized by different patterns of gene expression and oxidative damage. Exp Gerontol. 2000;35:353-73 pubmed
    ..The theoretical and empirical implications of these findings are discussed. ..
  63. Kim G, Lee Y, Lee G, Cho Y, Lee Y, Jang Y, et al. Overexpression of malic enzyme in the larval stage extends Drosophila lifespan. Biochem Biophys Res Commun. 2015;456:676-82 pubmed publisher
    ..Our results suggest that metabolic changes mediated by Men during development might be related to the control of ROS tolerance and the longevity of Drosophila. ..
  64. Calap Quintana P, Soriano S, Llorens J, Al Ramahi I, Botas J, Moltó M, et al. TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia. PLoS ONE. 2015;10:e0132376 pubmed publisher
    ..These results point to the TORC1 pathway as a new potential therapeutic target for FRDA and as a guide to finding new promising molecules for disease treatment. ..
  65. Koh H, Kim H, Kim M, Park J, Lee H, Chung J. Silent information regulator 2 (Sir2) and Forkhead box O (FOXO) complement mitochondrial dysfunction and dopaminergic neuron loss in Drosophila PTEN-induced kinase 1 (PINK1) null mutant. J Biol Chem. 2012;287:12750-8 pubmed publisher
    ..Moreover, overexpression of FOXO or its downstream target gene such as SOD2 or Thor markedly ameliorated PINK1 loss-of-function defects, suggesting that FOXO mediates the mitochondrial ..
  66. Kirby K, Jensen L, Binnington J, Hilliker A, Ulloa J, Culotta V, et al. Instability of superoxide dismutase 1 of Drosophila in mutants deficient for its cognate copper chaperone. J Biol Chem. 2008;283:35393-401 pubmed publisher
    Copper,zinc superoxide dismutase (SOD1) in mammals is activated principally via a copper chaperone (CCS) and to a lesser degree by a CCS-independent pathway of unknown nature...
  67. de Aguiar L, Figueira F, Gottschalk M, da Rosa C. Glyphosate-based herbicide exposure causes antioxidant defence responses in the fruit fly Drosophila melanogaster. Comp Biochem Physiol C Toxicol Pharmacol. 2016;185-186:94-101 pubmed publisher
    ..In addition, the mRNA expression of antioxidant genes (i.e., keap1, sod, sod2, cat, irc, gclc, gclm, gss, trxt, trxr-1 and trxr-2) was evaluated via RT-PCR...
  68. Carvalho G, Ja W, Benzer S. Non-lethal PCR genotyping of single Drosophila. Biotechniques. 2009;46:312-4 pubmed publisher
    ..This advance should significantly facilitate several of the most fundamental and routine techniques in Drosophila genetics. ..
  69. Itsara L, Kennedy S, Fox E, Yu S, Hewitt J, Sánchez Contreras M, et al. Oxidative stress is not a major contributor to somatic mitochondrial DNA mutations. PLoS Genet. 2014;10:e1003974 pubmed publisher T?A transversions, a signature of oxidative damage, and loss-of-function mutations in the mitochondrial superoxide dismutase, Sod2, had no detectable influence on the somatic mtDNA mutation frequency...
  70. Wolkow C. Life span: getting the signal from the nervous system. Trends Neurosci. 2002;25:212-6 pubmed
    ..This review examines the evidence for nervous system control of longevity and discusses the implications for popular models for aging. ..
  71. Tower J. Mitochondrial maintenance failure in aging and role of sexual dimorphism. Arch Biochem Biophys. 2015;576:17-31 pubmed publisher
    ..The data suggest that metazoan life span interventions may act through a common hormesis mechanism involving liver UPRmt, mitochondrial maintenance and sexual differentiation. ..
  72. Zhang Z, Han S, Wang H, Wang T. Lutein extends the lifespan of Drosophila melanogaster. Arch Gerontol Geriatr. 2014;58:153-9 pubmed publisher
    ..Real-time polymerase chain reaction (RT-PCR) analysis indicated the gene expression of superoxide dismutase (SOD; SOD1 and SOD2), and catalase (CAT) in the lutein-treated group was up-regulated relative to that of ..
  73. Scialò F, Sriram A, Fernández Ayala D, Gubina N, Lõhmus M, Nelson G, et al. Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan. Cell Metab. 2016;23:725-34 pubmed publisher
    ..These results illustrate that the source of a ROS signal is vital in determining its effects on cellular physiology and establish that manipulation of ubiquinone redox state is a valid strategy to delay aging. ..
  74. Ruiz M, Ganfornina M, Correnti C, Strong R, Sanchez D. Ligand binding-dependent functions of the lipocalin NLaz: an in vivo study in Drosophila. FASEB J. 2014;28:1555-67 pubmed publisher
    ..Control of energy metabolites on starvation appears to be, however, insensitive to the modification of the NLaz binding pocket. ..
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    ..Quantitative real-time PCR (qRT-PCR) analysis of Mn-superoxide dismutase (Mn-SOD), catalase (CAT) and glutathione-synthetase (GS) expressions demonstrated that these markers ..