Gene Symbol: Sod1
Description: Superoxide dismutase 1
Alias: CG11793, Cu-Zn SOD, Cu/Zn SOD, Cu/Zn sod, Cu/Zn superoxide dismutase, Cu/ZnSOD, CuSOD, CuZn SOD, CuZn-SOD, CuZn-SOD1, CuZnSOD, Cu[2+]/Zn[2+]SOD, Dmel\CG11793, Mn SOD, SOD, SOD-1, SOD1, SODC_DROME, Sod, Sod-1, To-1, Zn SOD, Zn Sod, Zn-SOD, ZnSod, cSOD, cSod, dSOD1, l(3)108, l(3)68Af', sod, sod1, superoxide dismutase 1, CG11793-PA, CG11793-PD, Cu, Zn superoxide dismutase, Cu-Zn superoxide dismutase, Cu/Zn superoxide dismutase, Cu/Zn-Superoxide dismutase, CuZn superoxide dismutase, CuZn-superoxide dismutase, CuZn-superoxide dismutase (SOD)1, CuZnSOD, Cu[2+] Zn[2+] superoxide dismutase, Cu[2+]Zn[2+] superoxide dismutase, Mn superoxide dismutase, Sod1-PA, Sod1-PD, complementation group G, copper and zinc SOD, copper-zinc superoxide, copper-zinc superoxide dismutase, cytoplasmic Cu/ZnSOD, dismutase, heart morphogenesis; GO:0003007 , IMP, paracrine signaling; GO:0038001 , IMP, reactive oxygen species metabolic process; GO:0072593 , IMP, super oxide dismutase, superoxidase dismutase, superoxide dismutase, superoxide dismutatase, superoxide-dismutase, superoxido dismutase, tetrazolium oxidase, tetrazolium oxidase-1
Species: fruit fly
Products:     Sod1

Top Publications

  1. Phillips J, Tainer J, Getzoff E, Boulianne G, Kirby K, Hilliker A. Subunit-destabilizing mutations in Drosophila copper/zinc superoxide dismutase: neuropathology and a model of dimer dysequilibrium. Proc Natl Acad Sci U S A. 1995;92:8574-8 pubmed
    Mutations in Cu/Zn superoxide dismutase (SOD), a hallmark of familial amyotrophic lateral sclerosis (FALS) in humans, are shown here to confer striking neuropathology in Drosophila...
  2. Zhang W, Jin Y, Ji Y, Girton J, Johansen J, Johansen K. Genetic and phenotypic analysis of alleles of the Drosophila chromosomal JIL-1 kinase reveals a functional requirement at multiple developmental stages. Genetics. 2003;165:1341-54 pubmed
    ..We propose that JIL-1 may exert such effects by a general regulation of chromatin structure affecting gene expression. ..
  3. Liu S, Lu B. Reduction of protein translation and activation of autophagy protect against PINK1 pathogenesis in Drosophila melanogaster. PLoS Genet. 2010;6:e1001237 pubmed publisher
    ..Our results reveal complex cellular responses to PINK1 inactivation and suggest novel therapeutic strategies through manipulation of the compensatory responses. ..
  4. Clancy D, Gems D, Harshman L, Oldham S, Stocker H, Hafen E, et al. Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science. 2001;292:104-6 pubmed
    ..The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved. ..
  5. Ruan H, Wu C. Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants. Proc Natl Acad Sci U S A. 2008;105:7506-10 pubmed publisher
    ..We found that short-lived Drosophila mutants of the antioxidant enzyme Cu/Zn superoxide dismutase displayed a robust lifespan extension, with improved stress resistance and motor ability, upon cohousing ..
  6. Sun J, Tower J. FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies. Mol Cell Biol. 1999;19:216-28 pubmed
    ..a binary transgenic system ("FLP-OUT") to allow induced overexpression of catalase and/or Cu/Zn-superoxide dismutase (Cu/ZnSOD) in adult Drosophila melanogaster...
  7. Missirlis F, Hu J, Kirby K, Hilliker A, Rouault T, Phillips J. Compartment-specific protection of iron-sulfur proteins by superoxide dismutase. J Biol Chem. 2003;278:47365-9 pubmed
    ..IRP1 is strongly activated by silencing and genetic mutation of the cytosolic superoxide dismutase (Sod1), but is unaffected by silencing of mitochondrial Sod2...
  8. Peng C, Zuo Y, Kwan K, Liang Y, Ma K, Chan H, et al. Blueberry extract prolongs lifespan of Drosophila melanogaster. Exp Gerontol. 2012;47:170-8 pubmed publisher
    ..extend the mean lifespan of fruit flies by 10%, accompanied by up-regulating gene expression of superoxide dismutase (SOD), catalase (CAT) and Rpn11 and down-regulating Methuselah (MTH) gene...
  9. Vontas J, Tsakas S, Loukas M, Hemingway J. Low-activity allele of copper-zinc superoxide dismutase (CuZnSOD) in Drosophila increases paraquat genotoxicity but does not affect near UV radiation damage. Genome. 2001;44:597-601 pubmed
    ..We incorporated a low-activity allele of copper-zinc superoxide dismutase (CuZnSOD), recovered from natural populations of Drosophila melanogaster, into standard marked strains and ..

More Information


  1. Arking R, Burde V, Graves K, Hari R, Feldman E, Zeevi A, et al. Forward and reverse selection for longevity in Drosophila is characterized by alteration of antioxidant gene expression and oxidative damage patterns. Exp Gerontol. 2000;35:167-85 pubmed the La strain is correlated with enhanced antioxidant defense system gene expression, accumulation of CuZnSOD protein, and an increase in ADS enzyme activities...
  2. Hari R, Burde V, Arking R. Immunological confirmation of elevated levels of CuZn superoxide dismutase protein in an artificially selected long-lived strain of Drosophila melanogaster. Exp Gerontol. 1998;33:227-37 pubmed
    ..b>CuZnSOD is one of the major antioxidant enzymes and has been shown to play an important role in the extended longevity of ..
  3. Orr W, Mockett R, Benes J, Sohal R. Effects of overexpression of copper-zinc and manganese superoxide dismutases, catalase, and thioredoxin reductase genes on longevity in Drosophila melanogaster. J Biol Chem. 2003;278:26418-22 pubmed
    The overexpression of antioxidative enzymes such as CuZn-superoxide dismutase (SOD), Mn-SOD, and catalase has previously been reported to extend life span in transgenic flies (Drosophila melanogaster)...
  4. Sun J, Molitor J, Tower J. Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span. Mech Ageing Dev. 2004;125:341-9 pubmed
    ..The amount of over-expression achieved varies between independent transgenic lines, and previously for both Cu/ZnSOD and MnSOD life span was found to be increased in proportion to the increase in enzyme activity...
  5. Orr W, Sohal R. Effects of Cu-Zn superoxide dismutase overexpression of life span and resistance to oxidative stress in transgenic Drosophila melanogaster. Arch Biochem Biophys. 1993;301:34-40 pubmed
    ..The role of the enzyme copper-zinc superoxide dismutase (Cu-Zn SOD; superoxide:superoxide oxidoreductase; EC 1.15.1...
  6. Li Y, Chan H, Yao X, Huang Y, Chen Z. Green tea catechins and broccoli reduce fat-induced mortality in Drosophila melanogaster. J Nutr Biochem. 2008;19:376-83 pubmed
    ..melanogaster maintained on the GTC- and BE-supplemented diet. Accordingly, catalase and superoxide dismutase (SOD) activities increased significantly in the flies fed with a GTC or a BE diet compared with those fed ..
  7. Sun X, Komatsu T, Lim J, Laslo M, Yolitz J, Wang C, et al. Nutrient-dependent requirement for SOD1 in lifespan extension by protein restriction in Drosophila melanogaster. Aging Cell. 2012;11:783-93 pubmed publisher
    ..However, how ROS modulate dietary effects on lifespan remains poorly understood. Superoxide dismutase 1 (SOD1) is a major cytosolic enzyme responsible for scavenging superoxides...
  8. Kwiatowski J, Skarecky D, Bailey K, Ayala F. Phylogeny of Drosophila and related genera inferred from the nucleotide sequence of the Cu,Zn Sod gene. J Mol Evol. 1994;38:443-54 pubmed
    ..We present the coding nucleotide sequence of the Cu,Zn superoxide dismutase gene (Sod) for 15 species, which include the medfly Ceratitis capitata (family Tephritidae), the genera ..
  9. Paul A, Belton A, Nag S, Martin I, Grotewiel M, Duttaroy A. Reduced mitochondrial SOD displays mortality characteristics reminiscent of natural aging. Mech Ageing Dev. 2007;128:706-16 pubmed
    Manganese superoxide dismutase (MnSOD or SOD2) is a key mitochondrial enzymatic antioxidant. Arguably the most striking phenotype associated with complete loss of SOD2 in flies and mice is shortened life span...
  10. Martin I, Jones M, Grotewiel M. Manipulation of Sod1 expression ubiquitously, but not in the nervous system or muscle, impacts age-related parameters in Drosophila. FEBS Lett. 2009;583:2308-14 pubmed publisher
    b>Superoxide dismutase 1 (SOD1) is an important antioxidant previously shown to impact life span in Drosophila...
  11. Duttaroy A, Paul A, Kundu M, Belton A. A Sod2 null mutation confers severely reduced adult life span in Drosophila. Genetics. 2003;165:2295-9 pubmed
    ..Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment. ..
  12. Parkes T, Kirby K, Phillips J, Hilliker A. Transgenic analysis of the cSOD-null phenotypic syndrome in Drosophila. Genome. 1998;41:642-51 pubmed
    Cu-Zn superoxide dismutase (cSOD) is an enzyme of critical importance for the inactivation of superoxide radicals generated by cellular metabolic processes...
  13. Anderson P, Kirby K, Hilliker A, Phillips J. RNAi-mediated suppression of the mitochondrial iron chaperone, frataxin, in Drosophila. Hum Mol Genet. 2005;14:3397-405 pubmed
    ..Finally, overexpression of Sod1, Sod2 or Cat does not suppress the failure of DFH-deficient animals to successfully complete eclosion, suggesting a ..
  14. Kirby K, Jensen L, Binnington J, Hilliker A, Ulloa J, Culotta V, et al. Instability of superoxide dismutase 1 of Drosophila in mutants deficient for its cognate copper chaperone. J Biol Chem. 2008;283:35393-401 pubmed publisher
    Copper,zinc superoxide dismutase (SOD1) in mammals is activated principally via a copper chaperone (CCS) and to a lesser degree by a CCS-independent pathway of unknown nature...
  15. Tatarenkov A, Kwiatowski J, Skarecky D, Barrio E, Ayala F. On the evolution of Dopa decarboxylase (Ddc) and Drosophila systematics. J Mol Evol. 1999;48:445-62 pubmed
    ..Drosophila phylogeny are resolved by analysis of the Ddc sequences alone or in combination with three other genes, Sod, Adh, and Gpdh...
  16. Rival T, Page R, Chandraratna D, Sendall T, Ryder E, Liu B, et al. Fenton chemistry and oxidative stress mediate the toxicity of the beta-amyloid peptide in a Drosophila model of Alzheimer's disease. Eur J Neurosci. 2009;29:1335-47 pubmed publisher
  17. Watson M, Lagow R, Xu K, Zhang B, Bonini N. A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1. J Biol Chem. 2008;283:24972-81 pubmed publisher
    ..About 5% of cases are inherited, with the majority of identified linkages in the gene encoding copper, zinc-superoxide dismutase (SOD1). Strong evidence indicates that the SOD1 mutations confer dominant toxicity on the protein...
  18. Seto N, Hayashi S, Tener G. Overexpression of Cu-Zn superoxide dismutase in Drosophila does not affect life-span. Proc Natl Acad Sci U S A. 1990;87:4270-4 pubmed
    ..The enzyme copper-zinc superoxide dismutase (Cu-Zn SOD; superoxide:superoxide oxidoreductase, EC 1.15.1...
  19. Tatar M, Kopelman A, Epstein D, Tu M, Yin C, Garofalo R. A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science. 2001;292:107-10 pubmed
  20. Mockett R, Orr W, Rahmandar J, Benes J, Radyuk S, Klichko V, et al. Overexpression of Mn-containing superoxide dismutase in transgenic Drosophila melanogaster. Arch Biochem Biophys. 1999;371:260-9 pubmed
    ..Two alternative hypotheses were tested: (i) that overexpression of Mn superoxide dismutase (Mn SOD) in the mitochondria of Drosophila melanogaster would slow the accrual of oxidative damage and ..
  21. Phillips J, Campbell S, Michaud D, Charbonneau M, Hilliker A. Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity. Proc Natl Acad Sci U S A. 1989;86:2761-5 pubmed
    The role of copper/zinc-containing superoxide dismutase (cSOD; superoxide:superoxide oxidoreductase, EC 1.15.1...
  22. Wicks S, Bain N, Duttaroy A, Hilliker A, Phillips J. Hypoxia rescues early mortality conferred by superoxide dismutase deficiency. Free Radic Biol Med. 2009;46:176-81 pubmed publisher
    ..Here we show that the premature mortality of Drosophila deficient in superoxide scavengers, superoxide dismutase (SOD) 1 or SOD2, is rescued by chronic hypoxia...
  23. Landis G, Tower J. Superoxide dismutase evolution and life span regulation. Mech Ageing Dev. 2005;126:365-79 pubmed
    ..b>Superoxide dismutase (SOD) enzymes catalyze the breakdown of superoxide into hydrogen peroxide and water and are therefore ..
  24. Sun J, Folk D, Bradley T, Tower J. Induced overexpression of mitochondrial Mn-superoxide dismutase extends the life span of adult Drosophila melanogaster. Genetics. 2002;161:661-72 pubmed
    ..Cu/ZnSOD overexpression also increases mean and maximum life span...
  25. Woodruff R, Phillips J, Hilliker A. Increased spontaneous DNA damage in Cu/Zn superoxide dismutase (SOD1) deficient Drosophila. Genome. 2004;47:1029-35 pubmed
    ..We have previously shown that genetic disruption of CuZn SOD (SOD1) in Drosophila imparts a recessive phenotype of reduced lifespan, infertility, and hypersensitivity to ..
  26. Parker J, Parker K, Keller L. Molecular phylogenetic evidence for an extracellular Cu Zn superoxide dismutase gene in insects. Insect Mol Biol. 2004;13:587-94 pubmed
    Representatives of three ancient gene families of the antioxidant enzyme superoxide dismutase (SOD) can be found in most metazoans...
  27. Helfand S, Rogina B. Molecular genetics of aging in the fly: is this the end of the beginning?. Bioessays. 2003;25:134-41 pubmed
  28. Sun X, Seeberger J, Alberico T, Wang C, Wheeler C, Schauss A, et al. Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet. Exp Gerontol. 2010;45:243-51 pubmed publisher
    ..Furthermore, açai increased the lifespan of oxidative stressed females caused by sod1 RNAi...
  29. Sohal R, Agarwal A, Agarwal S, Orr W. Simultaneous overexpression of copper- and zinc-containing superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster. J Biol Chem. 1995;270:15671-4 pubmed was to elucidate the nature of the mechanisms by which overexpression of copper- and zinc-containing superoxide dismutase (Cu,Zn-SOD) and catalase extends life span of Drosophila melanogaster...
  30. Parkes T, Elia A, Dickinson D, Hilliker A, Phillips J, Boulianne G. Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat Genet. 1998;19:171-4 pubmed
    ..The association between mutations in the gene encoding the oxygen radical metabolizing enzyme CuZn superoxide dismutase (SOD1) and loss of motorneurons in the brain and spinal cord that occurs in the life-shortening ..
  31. Spencer C, Howell C, Wright A, Promislow D. Testing an 'aging gene' in long-lived drosophila strains: increased longevity depends on sex and genetic background. Aging Cell. 2003;2:123-30 pubmed
    ..of the past decade have led to the discovery of a myriad of 'aging genes' (methuselah, Indy, InR, Chico, superoxide dismutase) that extend Drosophila lifespan by up to 85%...
  32. Fortini M, Bonini N. Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer. Trends Genet. 2000;16:161-7 pubmed
    ..With the advent of complete genomic sequencing on the horizon, Drosophila will continue to be an outstanding model system in which to unravel the complexities, causes and treatments for human neural degeneration. ..
  33. Mockett R, Radyuk S, Benes J, Orr W, Sohal R. Phenotypic effects of familial amyotrophic lateral sclerosis mutant Sod alleles in transgenic Drosophila. Proc Natl Acad Sci U S A. 2003;100:301-6 pubmed
    ..from familial amyotrophic lateral sclerosis (FALS) exhibit point mutations in the gene encoding Cu-Zn superoxide dismutase [superoxide:superoxide oxidoreductase, EC (SOD)]...
  34. Kirby K, Hu J, Hilliker A, Phillips J. RNA interference-mediated silencing of Sod2 in Drosophila leads to early adult-onset mortality and elevated endogenous oxidative stress. Proc Natl Acad Sci U S A. 2002;99:16162-7 pubmed
    ..respiration is the principal source of reactive oxygen within cells, the mitochondrially localized superoxide dismutase (SOD) 2 is thought to play an important front-line defensive role against aging-related oxidative stress...
  35. Campbell S, Hilliker A, Phillips J. Cytogenetic analysis of the cSOD microregion in Drosophila melanogaster. Genetics. 1986;112:205-15 pubmed
    ..The gene for cytoplasmic superoxide dismutase (cSOD) maps within this interval, as does low xanthine dehydrogenase (lxd)...
  36. Rogina B, Helfand S. Cu, Zn superoxide dismutase deficiency accelerates the time course of an age-related marker in Drosophila melanogaster. Biogerontology. 2000;1:163-9 pubmed
    ..of this we show that in adult Drosophila melanogaster, with a deficiency in the anti-oxidant enzyme Cu, Zn superoxide dismutase (Sod), an increase in oxidative stress, and a shortened life span, there is acceleration in the normal age-..
  37. Taormina G, Mirisola M. Calorie restriction in mammals and simple model organisms. Biomed Res Int. 2014;2014:308690 pubmed publisher
    ..The comprehension of the mechanisms underpinning these findings is crucial since it may increase the beneficial effects of calorie restriction making it accessible to a broader population as well. ..
  38. Leips J, Mackay T. Quantitative trait loci for life span in Drosophila melanogaster: interactions with genetic background and larval density. Genetics. 2000;155:1773-88 pubmed
    ..Further fine-scale mapping is necessary to determine whether candidate genes within the regions to which the QTL map are actually responsible for the observed variation in life span. ..
  39. Stephan W. An improved method for estimating the rate of fixation of favorable mutations based on DNA polymorphism data. Mol Biol Evol. 1995;12:959-62 pubmed
  40. Jelnes J. Identification of hexokinases and localisation of a fructokinase and a tetrazolium oxidase locus in Drosophila melanogaster. Hereditas. 1971;67:291-3 pubmed
  41. Abolaji A, Kamdem J, Lugokenski T, Farombi E, Souza D, da Silva Loreto Ã, et al. Ovotoxicants 4-vinylcyclohexene 1,2-monoepoxide and 4-vinylcyclohexene diepoxide disrupt redox status and modify different electrophile sensitive target enzymes and genes in Drosophila melanogaster. Redox Biol. 2015;5:328-39 pubmed publisher
    ..05). These effects were accompanied by disruptions in the transcription of the genes encoding the proteins superoxide dismutase (SOD1), kelch-like erythroid-derived cap-n-collar (CNC) homology (ECH)-associated protein 1 (Keap-1), ..
  42. Mast J, Tomalty K, Vogel H, Clandinin T. Reactive oxygen species act remotely to cause synapse loss in a Drosophila model of developmental mitochondrial encephalopathy. Development. 2008;135:2669-79 pubmed publisher
    ..Thus, alterations in electron transport chain function explain many of the neurodegenerative changes seen in both early- and late-onset disorders. ..
  43. Tuxworth R, Chen H, Vivancos V, Carvajal N, Huang X, Tear G. The Batten disease gene CLN3 is required for the response to oxidative stress. Hum Mol Genet. 2011;20:2037-47 pubmed publisher
    ..Together, our data suggest that the lack of CLN3 function leads to a failure to manage the response to oxidative stress and this may be the key deficit in JNCL that leads to neuronal degeneration. ..
  44. Šerý M, Frydrychová R, Krůček T, Korandová M, Szakosová K. Effect of low doses of herbicide paraquat on antioxidant defense in Drosophila. Arch Insect Biochem Physiol. 2015;88:235-48 pubmed publisher
    ..We examined the enzymatic activity of superoxide dismutase (SOD) and catalase, and the transcript levels of both enzymes...
  45. Peng C, Chan H, Li Y, Huang Y, Chen Z. Black tea theaflavins extend the lifespan of fruit flies. Exp Gerontol. 2009;44:773-83 pubmed publisher
    ..Gene expression of superoxide dismutase (SOD1 and SOD2), catalase (CAT), and methuselah (MTH) was characterized by an increase in young and then a ..
  46. Chen K, Lin G, Haelterman N, Ho T, Li T, Li Z, et al. Loss of Frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration. elife. 2016;5: pubmed publisher
    ..Our results indicate that an iron/sphingolipid/Pdk1/Mef2 pathway may play a role in FRDA. ..
  47. Nusbaum T, Rose M. Aging in Drosophila. Comp Biochem Physiol Physiol. 1994;109:33-8 pubmed
  48. Carulli J, Krane D, Hartl D, Ochman H. Compositional heterogeneity and patterns of molecular evolution in the Drosophila genome. Genetics. 1993;134:837-45 pubmed
  49. Le Bourg E -. Oxidative stress, aging and longevity in Drosophila melanogaster. FEBS Lett. 2001;498:183-6 pubmed
    ..It is concluded that antioxidant enzymes are probably poorly connected to the normal aging process, but they allow the organism to cope with stressful conditions. ..
  50. Sezgin E, Duvernell D, Matzkin L, Duan Y, Zhu C, Verrelli B, et al. Single-locus latitudinal clines and their relationship to temperate adaptation in metabolic genes and derived alleles in Drosophila melanogaster. Genetics. 2004;168:923-31 pubmed
    ..of latitudinal clines for 23 SNPs embedded in 13 genes (Pgi, Gapdh1, UGPase, Pglym78, Pglym87, Eno, Men, Gdh, Sod, Pgk, Mdh1, TreS, Treh) representing various metabolic enzymes...
  51. Tarr o R, Rodr guez Trelles F, Ayala F. Shared nucleotide composition biases among species and their impact on phylogenetic reconstructions of the Drosophilidae. Mol Biol Evol. 2001;18:1464-73 pubmed publisher
    ..Our analyses confidently place the Chymomyza genus as an outgroup closer than the genus Scaptodrosophila to the Drosophila genus and conclusively support the monophyly of the Sophophora subgenus...
  52. Seto N, Hayashi S, Tener G. Drosophila Cu-Zn superoxide dismutase cDNA sequence. Nucleic Acids Res. 1987;15:5483 pubmed
  53. Bosveld F, Rana A, van der Wouden P, Lemstra W, Ritsema M, Kampinga H, et al. De novo CoA biosynthesis is required to maintain DNA integrity during development of the Drosophila nervous system. Hum Mol Genet. 2008;17:2058-69 pubmed publisher
    ..Surprisingly, our findings reveal a major role of this conserved pathway in maintaining DNA and cellular integrity, explaining how impaired CoA synthesis during CNS development can elicit a neurodegenerative phenotype. ..
  54. Sun Y, Yolitz J, Alberico T, Sun X, Zou S. Lifespan extension by cranberry supplementation partially requires SOD2 and is life stage independent. Exp Gerontol. 2014;50:57-63 pubmed publisher
    ..These findings suggest that cranberry supplementation is sufficient to promote longevity when implemented during any life stage, likely through reducing oxidative damage. ..
  55. Terhzaz S, Finlayson A, Stirrat L, Yang J, Tricoire H, Woods D, et al. Cell-specific inositol 1,4,5 trisphosphate 3-kinase mediates epithelial cell apoptosis in response to oxidative stress in Drosophila. Cell Signal. 2010;22:737-48 pubmed publisher
    ..Finally, targeted over-expression of either debcl or buffy to tubule principal cells does not impact on tubule caspase-9 activity. Thus, IP(3)K-1 modulates epithelial cell apoptosis without involvement of bcl-2-type proteins. ..
  56. Muraro N, Moffat K. Down-regulation of torp4a, encoding the Drosophila homologue of torsinA, results in increased neuronal degeneration. J Neurobiol. 2006;66:1338-53 pubmed
  57. Vitushynska M, Matiytsiv N, Chernyk Y. [Influence of tissue-specific superoxide dismutase genes expression in brain cells on Drosophila melanogaster sensitivity to oxidative stress and viability]. Tsitol Genet. 2015;49:21-8 pubmed
    ..Altered Sod gene expression in glial tissue leads to degenerative changes in Drosophila brain at the young age...
  58. Pragya P, Shukla A, Murthy R, Abdin M, Kar Chowdhuri D. Over-expression of superoxide dismutase ameliorates Cr(VI) induced adverse effects via modulating cellular immune system of Drosophila melanogaster. PLoS ONE. 2014;9:e88181 pubmed publisher
    ..Cr(VI), on cellular immune response using Drosophila melanogaster and subsequently the protective role of superoxide dismutase (SOD) based on the comparable performance of the tested anti-oxidant enzymes...
  59. Mora M, Bonilla E, Medina Leendertz S, Bravo Y, Arcaya J. Minocycline increases the activity of superoxide dismutase and reduces the concentration of nitric oxide, hydrogen peroxide and mitochondrial malondialdehyde in manganese treated Drosophila melanogaster. Neurochem Res. 2014;39:1270-8 pubmed publisher
    ..We investigated the effect of minocycline in the activities of superoxide dismutase (SOD) and catalase, and in the concentrations of nitric oxide (NO), hydrogen peroxide (H2O2) and ..
  60. Parsch J, Meiklejohn C, Hauschteck Jungen E, Hunziker P, Hartl D. Molecular evolution of the ocnus and janus genes in the Drosophila melanogaster species subgroup. Mol Biol Evol. 2001;18:801-11 pubmed publisher
    ..These results are consistent with previous studies that have detected an increased rate of evolution in genes with reproductive function...
  61. Longo V. Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells. Neurobiol Aging. 1999;20:479-86 pubmed
    ..Taken together, the published studies suggest that survival may be regulated by similar fundamental mechanisms in many eukaryotes and that simple model systems will contribute to our understanding of the aging process in mammals. ..
  62. Bahadorani S, Hilliker A. Antioxidants cannot suppress the lethal phenotype of a Drosophila melanogaster model of Huntington's disease. Genome. 2008;51:392-5 pubmed publisher
    ..Here we investigated the effects of superoxide dismutase (cytoplasmic Cu/ZnSOD and mitochondrial MnSOD) and supplementation with dietary antioxidants (alpha-..
  63. Fogarty C, Diwanji N, Lindblad J, Tare M, Amcheslavsky A, Makhijani K, et al. Extracellular Reactive Oxygen Species Drive Apoptosis-Induced Proliferation via Drosophila Macrophages. Curr Biol. 2016;26:575-84 pubmed publisher
    ..These data illustrate a bidirectional cell-cell communication pathway with implication for tissue repair, regeneration, and cancer. ..
  64. van der Linde K, Houle D, Spicer G, Steppan S. A supermatrix-based molecular phylogeny of the family Drosophilidae. Genet Res (Camb). 2010;92:25-38 pubmed publisher
    ..We argue that these results support a taxonomic revision of the genus Drosophila...
  65. Prasad S, Muralidhara -. Neuroprotective effect of geraniol and curcumin in an acrylamide model of neurotoxicity in Drosophila melanogaster: relevance to neuropathy. J Insect Physiol. 2014;60:7-16 pubmed publisher
    ..However, the precise mechanism/s by which geraniol offers neuroprotection needs to be investigated in appropriate neuronal cell models. ..
  66. Kwiatowski J, Skarecky D, Tyler R, Pascual M, Ayala F. A truncated P element is inserted in the transcribed region of the Cu,Zn SOD gene of an SOD "null" strain of Drosophila melanogaster. Free Radic Res Commun. 1991;12-13 Pt 1:429-35 pubmed
    The decreased Cu,Zn SOD activity (less than 5%) in a "null" SODCA1 Drosophila melanogaster strain isolated in our laboratory is due to the insertion of a truncated P element into the transcribed region of the Cu,Zn SOD gene...
  67. Jahromi S, Haddadi M, Shivanandappa T, Ramesh S. Neuroprotective effect of Decalepis hamiltonii in paraquat-induced neurotoxicity in Drosophila melanogaster: biochemical and behavioral evidences. Neurochem Res. 2013;38:2616-24 pubmed publisher
    ..glutathione depletion, lipid peroxidation and enhanced activities of antioxidant enzymes such as catalase, superoxide dismutase as well as elevated levels of acetylcholine esterase. Pretreatment of flies by feeding with Dh extract (0...
  68. Mutsuddi M, Nambu J. Neural disease: Drosophila degenerates for a good cause. Curr Biol. 1998;8:R809-11 pubmed
    ..Recent studies suggest that molecular genetic approaches in Drosophila may shed important new light on conserved mechanisms underlying such disorders. ..
  69. Kovac I, Marinkovic D. Analysis of background-dependent genetic interactions without inbred strains. Biochem Genet. 1999;37:23-40 pubmed
    ..The newly developing functional genomics research and the absence of inbreeding make CIFA directly applicable to complex human traits in large samples. ..
  70. Milton V, Jarrett H, Gowers K, Chalak S, Briggs L, Robinson I, et al. Oxidative stress induces overgrowth of the Drosophila neuromuscular junction. Proc Natl Acad Sci U S A. 2011;108:17521-6 pubmed publisher
    ..Our data describe a previously unexplored link between oxidative stress and synapse overgrowth via the JNK signaling pathway. ..