sNPF

Summary

Gene Symbol: sNPF
Description: short neuropeptide F precursor
Alias: 38B.2, CG13968, Dmel\CG13968, Drm-sNPF, Drm-sNPF-1, Drm-sNPF-2, Drm-sNPF-3, Drm-sNPF-4, Drm-sNPF-AP1, LRLRFamide, SNPF, lrlrfa, s-NPF, sNPF-1, sNPF-1[4-11], sNPF-2, sNPF-2[12-19], sNPF-2s, sNPF-3, sNPF-4, sNPF1, sNPF3, short NPF, snpf, short neuropeptide F precursor, CG13968-PB, LRLRFamides, neuropeptide F (short), precursor of short neuropeptide F, sNPF precursor, sNPF-PB, short NPF, short neuropeptide F, short neuropeptide F-1, short neuropeptide F1, small neuropeptide F, small neuropeptide F-1, small neuropeptide-F
Species: fruit fly

Top Publications

  1. De Loof A, Baggerman G, Breuer M, Claeys I, Cerstiaens A, Clynen E, et al. Gonadotropins in insects: an overview. Arch Insect Biochem Physiol. 2001;47:129-38 pubmed
    ..The seeming absence of uniformity in gonadotropins in insects might be due to a multitude of factors that can stimulate ecdysteroid production and/or to the use of different bioassays. Arch. ..
  2. Wegener C, Reinl T, Jänsch L, Predel R. Direct mass spectrometric peptide profiling and fragmentation of larval peptide hormone release sites in Drosophila melanogaster reveals tagma-specific peptide expression and differential processing. J Neurochem. 2006;96:1362-74 pubmed
    ..Our results show that the peptidome of the neurohaemal organs is tagma-specific and does not change during metamorphosis. We also provide evidence for the first case of differential prohormone processing in Drosophila. ..
  3. Meeusen T, Mertens I, Clynen E, Baggerman G, Nichols R, Nachman R, et al. Identification in Drosophila melanogaster of the invertebrate G protein-coupled FMRFamide receptor. Proc Natl Acad Sci U S A. 2002;99:15363-8 pubmed
    ..To our knowledge, the cloned DrmFMRFa-R is the first functionally active FMRFamide G protein-coupled receptor described in invertebrates to date. ..
  4. Lee K, Hong S, Kim A, Ju S, Kwon O, Yu K. Processed short neuropeptide F peptides regulate growth through the ERK-insulin pathway in Drosophila melanogaster. FEBS Lett. 2009;583:2573-7 pubmed publisher
    ..In addition, the sNPF precursor and the processed sNPF peptide were co-localized in the neurons of the central nervous system...
  5. Iversen A, Cazzamali G, Williamson M, Hauser F, Grimmelikhuijzen C. Molecular identification of the first insect ecdysis triggering hormone receptors. Biochem Biophys Res Commun. 2002;299:924-31 pubmed
    ..Ecdysis (cuticle shedding) is an important behaviour, allowing growth and metamorphosis in insects and other arthropods. Our paper is the first report on the molecular identification of ecdysis triggering hormone receptors from insects. ..
  6. Baggerman G, Cerstiaens A, De Loof A, Schoofs L. Peptidomics of the larval Drosophila melanogaster central nervous system. J Biol Chem. 2002;277:40368-74 pubmed
    ..This neuropeptide expression profiling study also opens perspectives for other eukaryotic model systems, for which genome projects are completed or in progress. ..
  7. Mertens I, Meeusen T, Huybrechts R, De Loof A, Schoofs L. Characterization of the short neuropeptide F receptor from Drosophila melanogaster. Biochem Biophys Res Commun. 2002;297:1140-8 pubmed
    ..The response is dose-dependent and appeared to be very specific. The short NPF receptor was not activated by any of the other tested arthropod peptides, not even by FMRFamide-related peptides ..
  8. Johard H, Yoishii T, Dircksen H, Cusumano P, Rouyer F, Helfrich Forster C, et al. Peptidergic clock neurons in Drosophila: ion transport peptide and short neuropeptide F in subsets of dorsal and ventral lateral neurons. J Comp Neurol. 2009;516:59-73 pubmed publisher
    ..using a screen for candidate neuromediators in clock neurons, we discovered ion transport peptide (ITP) and short neuropeptide F (sNPF) as novel neuropeptides in subpopulations of dorsal (LN(d)s) and ventral (s-LN(v)s) LNs...
  9. Yew J, Wang Y, Barteneva N, Dikler S, Kutz Naber K, Li L, et al. Analysis of neuropeptide expression and localization in adult drosophila melanogaster central nervous system by affinity cell-capture mass spectrometry. J Proteome Res. 2009;8:1271-84 pubmed publisher
    ..Neuropeptide profiling also was performed on targeted populations of cells which were enriched with immunoaffinity purification using a genetically expressed marker. ..

More Information

Publications62

  1. Nassel D, Enell L, Santos J, Wegener C, Johard H. A large population of diverse neurons in the Drosophila central nervous system expresses short neuropeptide F, suggesting multiple distributed peptide functions. BMC Neurosci. 2008;9:90 pubmed publisher
    ..One of these widely expressed genes, snpf, encodes the precursor of short neuropeptide F (sNPF)...
  2. Garczynski S, Brown M, Crim J. Structural studies of Drosophila short neuropeptide F: Occurrence and receptor binding activity. Peptides. 2006;27:575-82 pubmed
    ..For Drosophila melanogaster, the nucleotide sequence for the sNPF precursor protein encodes four distinctive candidate sNPFs...
  3. Baggerman G, Boonen K, Verleyen P, De Loof A, Schoofs L. Peptidomic analysis of the larval Drosophila melanogaster central nervous system by two-dimensional capillary liquid chromatography quadrupole time-of-flight mass spectrometry. J Mass Spectrom. 2005;40:250-60 pubmed
    ..This clearly demonstrates that the two-dimensional capillary LC approach enhances the coverage of the peptidomic analysis. ..
  4. Root C, Ko K, Jafari A, Wang J. Presynaptic facilitation by neuropeptide signaling mediates odor-driven food search. Cell. 2011;145:133-44 pubmed publisher
    ..We found that a local signal by short neuropeptide F (sNPF) and a global metabolic cue by insulin are integrated at specific odorant receptor neurons (ORNs) to ..
  5. Carlsson M, Diesner M, Schachtner J, Nassel D. Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits. J Comp Neurol. 2010;518:3359-80 pubmed publisher
    ..These were short neuropeptide F, tachykinin related peptide, allatostatin A, myoinhibitory peptide, SIFamide, IPNamide, and myosuppressin...
  6. Lee K, Kwon O, Lee J, Kwon K, Min K, Jung S, et al. Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling. Nat Cell Biol. 2008;10:468-75 pubmed publisher
    ..Here we show that Drosophila short neuropeptide F (sNPF), an orthologue of mammalian neuropeptide Y (NPY), and sNPF receptor sNPFR1 regulate expression of ..
  7. Lee K, You K, Choo J, Han Y, Yu K. Drosophila short neuropeptide F regulates food intake and body size. J Biol Chem. 2004;279:50781-9 pubmed
    ..However, the function of the structurally related short neuropeptide F (sNPF) was unknown...
  8. Predel R, Wegener C, Russell W, Tichy S, Russell D, Nachman R. Peptidomics of CNS-associated neurohemal systems of adult Drosophila melanogaster: a mass spectrometric survey of peptides from individual flies. J Comp Neurol. 2004;474:379-92 pubmed
    ..and the neurohemal release sites of the brain contain pyrokinin-1(2-15), pyrokinin-2, corazonin, myosuppressin, and sNPF as their major putative release products...
  9. Rosenkilde C, Cazzamali G, Williamson M, Hauser F, Søndergaard L, DeLotto R, et al. Molecular cloning, functional expression, and gene silencing of two Drosophila receptors for the Drosophila neuropeptide pyrokinin-2. Biochem Biophys Res Commun. 2003;309:485-94 pubmed
    ..The two Drosophila pyrokinin receptors are, to our knowledge, the first invertebrate pyrokinin receptors to be identified. ..
  10. J rgensen L, Hauser F, Cazzamali G, Williamson M, Grimmelikhuijzen C. Molecular identification of the first SIFamide receptor. Biochem Biophys Res Commun. 2006;340:696-701 pubmed publisher
    ..This paper is the first report on the identification of a SIFamide receptor...
  11. Johard H, Enell L, Gustafsson E, Trifilieff P, Veenstra J, Nassel D. Intrinsic neurons of Drosophila mushroom bodies express short neuropeptide F: relations to extrinsic neurons expressing different neurotransmitters. J Comp Neurol. 2008;507:1479-96 pubmed publisher
    ..Here we show expression of the gene snpf and its neuropeptide products (short neuropeptide F; sNPFs) in larval and adult Drosophila Kenyon cells by means of in situ hybridization and antisera against ..
  12. Feng G, Reale V, Chatwin H, Kennedy K, Venard R, Ericsson C, et al. Functional characterization of a neuropeptide F-like receptor from Drosophila melanogaster. Eur J Neurosci. 2003;18:227-38 pubmed
    ..Maximum receptor activation was achieved with short, putative Drosophila neuropeptide F peptides (Drm-sNPF-1, 2 and 2s)...
  13. Iversen A, Cazzamali G, Williamson M, Hauser F, Grimmelikhuijzen C. Molecular cloning and functional expression of a Drosophila receptor for the neuropeptides capa-1 and -2. Biochem Biophys Res Commun. 2002;299:628-33 pubmed
    ..Because capa-1 and -2 and related insect neuropeptides stimulate fluid secretion in insect Malpighian (renal) tubules, the identification of this first insect capa receptor will advance our knowledge on insect renal function. ..
  14. Cazzamali G, Grimmelikhuijzen C. Molecular cloning and functional expression of the first insect FMRFamide receptor. Proc Natl Acad Sci U S A. 2002;99:12073-8 pubmed
    ..To our knowledge, this article is the first report on the molecular identification of an invertebrate FMRFamide receptor. ..
  15. Knapek S, Kahsai L, Winther A, Tanimoto H, Nassel D. Short neuropeptide F acts as a functional neuromodulator for olfactory memory in Kenyon cells of Drosophila mushroom bodies. J Neurosci. 2013;33:5340-5 pubmed publisher
    ..Here we show that a neuropeptide precursor gene encoding four types of short neuropeptide F (sNPF) is required in the Kenyon cells for appetitive olfactory memory...
  16. Salisbury J, Boggio K, Hsu Y, Quijada J, Sivachenko A, Gloeckner G, et al. A rapid MALDI-TOF mass spectrometry workflow for Drosophila melanogaster differential neuropeptidomics. Mol Brain. 2013;6:60 pubmed publisher
    ..While the data analysis methods should be compatible with other sample preparations, the presented sample preparation method was sufficient to identify previously unconfirmed D. melanogaster neuropeptides. ..
  17. Wegener C, Herbert H, Kahnt J, Bender M, Rhea J. Deficiency of prohormone convertase dPC2 (AMONTILLADO) results in impaired production of bioactive neuropeptide hormones in Drosophila. J Neurochem. 2011;118:581-95 pubmed publisher
    ..The lack of AMON activity resulted in a deficiency of L3 larva to enter the wandering phase. In conclusion, our findings provide the first direct evidence that AMON is a key enzyme in the production of neuropeptides in the fruitfly. ..
  18. Cazzamali G, Hauser F, Kobberup S, Williamson M, Grimmelikhuijzen C. Molecular identification of a Drosophila G protein-coupled receptor specific for crustacean cardioactive peptide. Biochem Biophys Res Commun. 2003;303:146-52 pubmed
    ..Furthermore, we identified a gene sequence in the genomic database from the malaria mosquito Anopheles gambiae that very likely codes for a crustacean cardioactive peptide receptor. ..
  19. Egerod K, Reynisson E, Hauser F, Williamson M, Cazzamali G, Grimmelikhuijzen C. Molecular identification of the first insect proctolin receptor. Biochem Biophys Res Commun. 2003;306:437-42 pubmed
    ..The Drosophila receptor reported here is the first invertebrate proctolin receptor to be identified. ..
  20. Nässel D, Williams M. Cholecystokinin-Like Peptide (DSK) in Drosophila, Not Only for Satiety Signaling. Front Endocrinol (Lausanne). 2014;5:219 pubmed publisher
    ..Activity in the DSK-producing neurons is regulated by octopamine. We discuss mechanisms behind CCK function in satiety, aggression, and locomotion in some detail and highlight similarities to mammalian CCK signaling. ..
  21. Lushchak O, Carlsson M, Nässel D. Food odors trigger an endocrine response that affects food ingestion and metabolism. Cell Mol Life Sci. 2015;72:3143-55 pubmed publisher
    ..Thus, we show that food odor can induce a transient anticipatory endocrine response, and that boosted sensitivity to this odor affects food intake, as well as metabolism and hormonal signaling. ..
  22. Damulewicz M, Pyza E. The clock input to the first optic neuropil of Drosophila melanogaster expressing neuronal circadian plasticity. PLoS ONE. 2011;6:e21258 pubmed publisher
  23. Kahsai L, Winther A. Chemical neuroanatomy of the Drosophila central complex: distribution of multiple neuropeptides in relation to neurotransmitters. J Comp Neurol. 2011;519:290-315 pubmed publisher
    ..of acetylcholine, glutamate, GABA, monoamines, and eight different neuropeptides; Drosophila tachykinin, short neuropeptide F, myoinhibitory peptide, allatostatin A, proctolin, SIFamide, neuropeptide F, and FMRFamide...
  24. Reiher W, Shirras C, Kahnt J, Baumeister S, Isaac R, Wegener C. Peptidomics and peptide hormone processing in the Drosophila midgut. J Proteome Res. 2011;10:1881-92 pubmed publisher
    ..The identification of enteroendocrine peptides in the fruit fly provides a platform to address functions of gut peptide hormones in the regulation of feeding and metabolism. ..
  25. Liu Y, Liao S, Veenstra J, Nässel D. Drosophila insulin-like peptide 1 (DILP1) is transiently expressed during non-feeding stages and reproductive dormancy. Sci Rep. 2016;6:26620 pubmed publisher
    ..Furthermore, the DILP1 expression in IPCs is regulated by short neuropeptide F, juvenile hormone and presence of larval adipocytes...
  26. Cazzamali G, Saxild N, Grimmelikhuijzen C. Molecular cloning and functional expression of a Drosophila corazonin receptor. Biochem Biophys Res Commun. 2002;298:31-6 pubmed
    ..Furthermore, a receptor that is structurally very similar to the Drosophila corazonin receptor can be found in the genomic database from the malaria mosquito Anopheles gambiae. ..
  27. Erion R, Sehgal A. Regulation of insect behavior via the insulin-signaling pathway. Front Physiol. 2013;4:353 pubmed publisher
    ..Here we review the role of insulin signaling in two specific insect behaviors: feeding and locomotion. ..
  28. Hong S, Lee K, Kwak S, Kim A, Bai H, Jung M, et al. Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals. PLoS Genet. 2012;8:e1002857 pubmed publisher
    ..Drosophila melanogaster short neuropeptide F (sNPF) and the mammalian functional homolog neuropeptide Y (NPY) regulate food intake...
  29. Liang X, Holy T, Taghert P. A Series of Suppressive Signals within the Drosophila Circadian Neural Circuit Generates Sequential Daily Outputs. Neuron. 2017;94:1173-1189.e4 pubmed publisher
    ..Neuropeptide sNPF, released from s-LNv and LNd pacemakers, produces Ca2+ activation in the DN1 group late in the night...
  30. Hur J, Bahadorani S, Graniel J, Koehler C, Ulgherait M, Rera M, et al. Increased longevity mediated by yeast NDI1 expression in Drosophila intestinal stem and progenitor cells. Aging (Albany NY). 2013;5:662-81 pubmed
    ..Together, these results demonstrate that ndi1 expression in the intestinal epithelium is an effective strategy to delay tissue and organismal aging. ..
  31. Zhu Y. The Drosophila visual system: From neural circuits to behavior. Cell Adh Migr. 2013;7:333-44 pubmed publisher
  32. Chen W, Shi W, Li L, Zheng Z, Li T, Bai W, et al. Regulation of sleep by the short neuropeptide F (sNPF) in Drosophila melanogaster. Insect Biochem Mol Biol. 2013;43:809-19 pubmed publisher
    The short neuropeptide F (sNPF), a neuropeptide in the central nervous system (CNS) of Drosophila melanogaster, is expressed in a large population of diverse neurons of brain...
  33. Bendena W, Campbell J, Zara L, Tobe S, Chin Sang I. Select Neuropeptides and their G-Protein Coupled Receptors in Caenorhabditis Elegans and Drosophila Melanogaster. Front Endocrinol (Lausanne). 2012;3:93 pubmed publisher
    ..melanogaster and C. elegans and the behaviors that have been uncovered through genetic manipulation. ..
  34. Kahsai L, Kapan N, Dircksen H, Winther A, Nassel D. Metabolic stress responses in Drosophila are modulated by brain neurosecretory cells that produce multiple neuropeptides. PLoS ONE. 2010;5:e11480 pubmed publisher
    ..neurosecretory cells in two clusters (designated ipc-1 and ipc-2a): Drosophila tachykinin (DTK), short neuropeptide F (sNPF) and ion transport peptide (ITP)...
  35. Carlsson M, Enell L, Nassel D. Distribution of short neuropeptide F and its receptor in neuronal circuits related to feeding in larval Drosophila. Cell Tissue Res. 2013;353:511-23 pubmed publisher
    Four forms of short neuropeptide F (sNPF1-4), derived from the gene snpf, have been identified in Drosophila and are known to act on a single G-protein-coupled receptor (sNPFR)...
  36. Kapan N, Lushchak O, Luo J, Nassel D. Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin. Cell Mol Life Sci. 2012;69:4051-66 pubmed publisher
    ..One of these, short neuropeptide F (sNPF), regulates food intake, growth and Dilp transcript levels in IPCs via the sNPF receptor (sNPFR1) ..
  37. Su C, Wang J. Modulation of neural circuits: how stimulus context shapes innate behavior in Drosophila. Curr Opin Neurobiol. 2014;29:9-16 pubmed publisher
  38. Ida T, Takahashi T, Tominaga H, Sato T, Kume K, Ozaki M, et al. Identification of the novel bioactive peptides dRYamide-1 and dRYamide-2, ligands for a neuropeptide Y-like receptor in Drosophila. Biochem Biophys Res Commun. 2011;410:872-7 pubmed publisher
    ..Recently, Drosophila neuropeptide F (dNPF) and short NPF (sNPF), the Drosophila homologs of the vertebrate NPY, were identified to characterize the functions of NPFs in ..
  39. Dissel S, Melnattur K, Shaw P. Sleep, Performance, and Memory in Flies. Curr Sleep Med Rep. 2015;1:47-54 pubmed publisher
    ..We conclude that as Drosophila sleep researchers expand their analysis beyond sleep time, the opportunities to discover the function of sleep will be enhanced. ..
  40. Bergland A, Tobler R, González J, Schmidt P, Petrov D. Secondary contact and local adaptation contribute to genome-wide patterns of clinal variation in Drosophila melanogaster. Mol Ecol. 2016;25:1157-74 pubmed publisher
    ..melanogaster and provide a context for future studies seeking to identify loci contributing to local adaptation in a wide variety of organisms, including other invasive species as well as temperate endemics. ..
  41. Kim W, Jan L, Jan Y. A PDF/NPF neuropeptide signaling circuitry of male Drosophila melanogaster controls rival-induced prolonged mating. Neuron. 2013;80:1190-205 pubmed publisher
    ..Moreover, rival exposure modifies the neuronal activities of a subset of clock neurons involved in neuropeptide signaling for LMD. ..
  42. Shang Y, Donelson N, Vecsey C, Guo F, Rosbash M, Griffith L. Short neuropeptide F is a sleep-promoting inhibitory modulator. Neuron. 2013;80:171-83 pubmed publisher
    ..regulation, we screened for sleep-promoting cells and identified neurons expressing neuropeptide Y-like short neuropeptide F (sNPF). Sleep induction by sNPF meets all relevant criteria...
  43. Kahsai L, Carlsson M, Winther A, Nässel D. Distribution of metabotropic receptors of serotonin, dopamine, GABA, glutamate, and short neuropeptide F in the central complex of Drosophila. Neuroscience. 2012;208:11-26 pubmed publisher
    ..DopR), the metabotropic GABA(B) receptor (GABA(B)R), the metabotropic glutamate receptor (DmGluR(A)) and a short neuropeptide F receptor (sNPFR1). Five of the six GPCRs were mapped to different neurons in the EB (sNPFR1 was not seen)...
  44. Vecsey C, P rez N, Griffith L. The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on central neurons. J Neurophysiol. 2014;111:1033-45 pubmed publisher
    ..We focused on two neuropeptides, pigment-dispersing factor (PDF) and small neuropeptide F (sNPF), which play important roles in sleep/rhythms and feeding/metabolism...
  45. Kahsai L, Martin J, Winther A. Neuropeptides in the Drosophila central complex in modulation of locomotor behavior. J Exp Biol. 2010;213:2256-65 pubmed publisher
    ..Here we have investigated the roles of two different neuropeptides, Drosophila tachykinin (DTK) and short neuropeptide F (sNPF), in aspects of locomotor behavior...
  46. Pool A, Scott K. Feeding regulation in Drosophila. Curr Opin Neurobiol. 2014;29:57-63 pubmed publisher
    ..These neuromodulators in turn promote or inhibit discrete feeding behavioral subprograms. This review highlights the links between physiological needs, neuromodulatory states, and feeding decisions. ..
  47. Inagaki H, Panse K, Anderson D. Independent, reciprocal neuromodulatory control of sweet and bitter taste sensitivity during starvation in Drosophila. Neuron. 2014;84:806-20 pubmed publisher
    ..In this way, state-intensity-dependent, reciprocal regulation of appetitive and aversive peripheral gustatory sensitivity permits flexible, adaptive feeding decisions. ..
  48. Egerod K, Reynisson E, Hauser F, Cazzamali G, Williamson M, Grimmelikhuijzen C. Molecular cloning and functional expression of the first two specific insect myosuppressin receptors. Proc Natl Acad Sci U S A. 2003;100:9808-13 pubmed
    ..To our knowledge, this paper is the first report on the molecular identification of specific insect myosuppressin receptors. ..
  49. Wegener C, Gorbashov A. Molecular evolution of neuropeptides in the genus Drosophila. Genome Biol. 2008;9:R131 pubmed publisher
    ..The last common ancestor of Drosophila obviously had a set of neuropeptides and peptide hormones identical to that of modern fruit flies. This is remarkable, since drosophilid flies have adapted to very different environments. ..
  50. Ruiz M, Ganfornina M, Correnti C, Strong R, Sanchez D. Ligand binding-dependent functions of the lipocalin NLaz: an in vivo study in Drosophila. FASEB J. 2014;28:1555-67 pubmed publisher
    ..Control of energy metabolites on starvation appears to be, however, insensitive to the modification of the NLaz binding pocket. ..
  51. Kula Eversole E, Nagoshi E, Shang Y, Rodriguez J, Allada R, Rosbash M. Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila. Proc Natl Acad Sci U S A. 2010;107:13497-502 pubmed publisher
    ..The results suggest that RNA cycling is much more prominent in circadian neurons than elsewhere in heads and may be particularly important for the functioning of these neurons. ..
  52. Slade J, Staveley B. Manipulation of components that control feeding behavior in Drosophila melanogaster increases sensitivity to amino acid starvation. Genet Mol Res. 2016;15: pubmed publisher
    ..Drosophila and other insects bear a shorter form of NPF known as short NPF (sNPF) that can influence feeding...
  53. Farhan A, Gulati J, Groβe Wilde E, Vogel H, Hansson B, Knaden M. The CCHamide 1 receptor modulates sensory perception and olfactory behavior in starved Drosophila. Sci Rep. 2013;3:2765 pubmed publisher
    ..Silencing several genes that become up-regulated under starvation confirmed the involvement of the short neuropeptide f receptor in the starvation effect...