SMSr

Summary

Gene Symbol: SMSr
Description: SMSr
Alias: CG32380, CG8572, CG8576, Css3beta, Dmel\CG32380, dSMSr, dmSMSr, SMSr, CG32380-PA, CPE synthase, SMSr-PA
Species: fruit fly
Products:     SMSr

Top Publications

  1. Huitema K, van den Dikkenberg J, Brouwers J, Holthuis J. Identification of a family of animal sphingomyelin synthases. EMBO J. 2004;23:33-44 pubmed
    ..Whereas human SMS1 is localised to the Golgi, SMS2 resides primarily at the plasma membrane. Collectively, these findings open up important new avenues for studying sphingolipid function in animals. ..
  2. Svensson M, Stenberg P, Larsson J. Organization and regulation of sex-specific thioredoxin encoding genes in the genus Drosophila. Dev Genes Evol. 2007;217:639-50 pubmed
    ..In addition, we show that the 50-70 C terminal amino acids of TrxT constitute a hyper-variable domain, which could play a role in sexual conflict and male-female co-evolution. ..
  3. Vacaru A, van den Dikkenberg J, Ternes P, Holthuis J. Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen. J Biol Chem. 2013;288:11520-30 pubmed publisher
    ..The corresponding CPE synthase shares mechanistic features with enzymes mediating phospholipid biosynthesis via the Kennedy pathway...
  4. Vacaru A, Tafesse F, Ternes P, Kondylis V, Hermansson M, Brouwers J, et al. Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. J Cell Biol. 2009;185:1013-27 pubmed publisher
    ..In this study, we report the identification of an SMS1-related (SMSr) enzyme, which catalyses the synthesis of the SM analogue ceramide phosphoethanolamine (CPE) in the ER lumen...