Gene Symbol: SMC2
Description: Structural maintenance of chromosomes 2
Alias: AAF58197, CG10212, DmSMC2, Dmel\CG10212, Smc2, dSMC2, smc-2, structural maintenance of chromosomes 2, CG10212-PA, SMC2-PA
Species: fruit fly

Top Publications

  1. Schuldiner O, Berdnik D, Levy J, Wu J, Luginbuhl D, Gontang A, et al. piggyBac-based mosaic screen identifies a postmitotic function for cohesin in regulating developmental axon pruning. Dev Cell. 2008;14:227-38 pubmed publisher
    ..We also demonstrate a postmitotic role for SMC1 in dendrite targeting of olfactory projection neurons. We suggest that cohesin regulates diverse aspects of neuronal morphogenesis...
  2. Savvidou E, Cobbe N, Steffensen S, Cotterill S, Heck M. Drosophila CAP-D2 is required for condensin complex stability and resolution of sister chromatids. J Cell Sci. 2005;118:2529-43 pubmed
    ..We demonstrate that a condensin complex exists in Drosophila embryos, containing CAP-D2, the anticipated SMC2 and SMC4 proteins, the CAP-H/Barren and CAP-G (non-SMC) subunits...
  3. Cobbe N, Savvidou E, Heck M. Diverse mitotic and interphase functions of condensins in Drosophila. Genetics. 2006;172:991-1008 pubmed
    ..This suggests either that the role of condensin proteins in interphase differs from their expected role in mitosis or that the way we envision condensin's activity needs to be modified to accommodate alternative possibilities. ..
  4. Ono T, Losada A, Hirano M, Myers M, Neuwald A, Hirano T. Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. Cell. 2003;115:109-21 pubmed
    ..We propose that the two condensin complexes make distinct mechanistic contributions to mitotic chromosome architecture in vertebrate cells. ..
  5. Oliveira R, Coelho P, Sunkel C. The condensin I subunit Barren/CAP-H is essential for the structural integrity of centromeric heterochromatin during mitosis. Mol Cell Biol. 2005;25:8971-84 pubmed
    ..Taken together, our data suggest that the condensin I complex is required not only to promote sister chromatid resolution but also to maintain the structural integrity of centromeric heterochromatin during mitosis. ..
  6. Carter S, Sjögren C. The SMC complexes, DNA and chromosome topology: right or knot?. Crit Rev Biochem Mol Biol. 2012;47:1-16 pubmed publisher
    ..This review focuses on the details of the relationship between the SMC complexes and topology. It also discusses the possibility that the SMC complexes are united by a capability to sense the geometrical chirality of DNA crossings. ..
  7. Hirano T. Condensins: universal organizers of chromosomes with diverse functions. Genes Dev. 2012;26:1659-78 pubmed publisher
    ..Future studies on condensins will not only enhance our understanding of chromosome architecture and dynamics, but also help address a previously underappreciated yet profound set of questions in chromosome biology. ..
  8. Haering C, Nasmyth K. Building and breaking bridges between sister chromatids. Bioessays. 2003;25:1178-91 pubmed
    ..New research suggests that these ancient regulators of chromosome structure might function as topological devices that trap chromosomal DNA between 50 nm long coiled coils. ..
  9. Longworth M, Herr A, Ji J, Dyson N. RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3. Genes Dev. 2008;22:1011-24 pubmed publisher
    ..These results uncover an unexpected link between pRB/RBF1 and chromatin condensation, providing a mechanism by which the functional inactivation of RB family members in human tumor cells may contribute to genome instability. ..

More Information


  1. Harvey S, Krien M, O Connell M. Structural maintenance of chromosomes (SMC) proteins, a family of conserved ATPases. Genome Biol. 2002;3:REVIEWS3003 pubmed
    ..Recent studies are beginning to decipher molecular details of how these processes are carried out. ..
  2. Buster D, Daniel S, Nguyen H, Windler S, Skwarek L, Peterson M, et al. SCFSlimb ubiquitin ligase suppresses condensin II-mediated nuclear reorganization by degrading Cap-H2. J Cell Biol. 2013;201:49-63 pubmed publisher
    ..Therefore, SCF(Slimb)-mediated down-regulation of condensin II is required to maintain proper organization and morphology of the interphase nucleus. ..
  3. Liu Y, Ge Q, Chan B, Liu H, Singh S, Manley J, et al. Whole-animal genome-wide RNAi screen identifies networks regulating male germline stem cells in Drosophila. Nat Commun. 2016;7:12149 pubmed publisher
    ..We also find that mitosis/cytokinesis proteins are especially important for male GSC maintenance. Our findings provide valuable insights and resources for studying stem cell regulation at the organismal level. ..
  4. Beck E, Llopart A. Widespread Positive Selection Drives Differentiation of Centromeric Proteins in the Drosophila melanogaster subgroup. Sci Rep. 2015;5:17197 pubmed publisher
    ..e., SMC2, SMC4, Cap-H, Cap-D2, and Cap-G) and HP1s...
  5. Nikalayevich E, Ohkura H. The NuRD nucleosome remodelling complex and NHK-1 kinase are required for chromosome condensation in oocytes. J Cell Sci. 2015;128:566-75 pubmed
    ..We further show that NHK-1 is important for chromosome condensation during mitosis as well as in oocytes. ..
  6. Herzog S, Nagarkar Jaiswal S, Urban E, Riemer A, Fischer S, Heidmann S. Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I. PLoS Genet. 2013;9:e1003463 pubmed publisher
    ..condensin I and condensin II, which contain the same structural maintenance of chromosomes (SMC) subunits SMC2 and SMC4, but differ in their composition of non-SMC subunits...
  7. D Avino P, Archambault V, Przewloka M, Zhang W, Laue E, Glover D. Isolation of protein complexes involved in mitosis and cytokinesis from Drosophila cultured cells. Methods Mol Biol. 2009;545:99-112 pubmed publisher
    ..Although this method has proven very successful in isolating mitotic and cytokinetic complexes, it can also be used to characterise protein complexes involved in many other cellular processes. ..
  8. White G, Erickson H. The coiled coils of cohesin are conserved in animals, but not in yeast. PLoS ONE. 2009;4:e4674 pubmed publisher
    ..We reported recently that the coiled coils of mammalian condensin (SMC2/4) showed moderate sequence divergence (approximately 10-15%) consistent with their functioning as spacer rods...
  9. Radford S, Goley E, Baxter K, McMahan S, Sekelsky J. Drosophila ERCC1 is required for a subset of MEI-9-dependent meiotic crossovers. Genetics. 2005;170:1737-45 pubmed
    ..We conclude that MEI-9 can generate some meiotic crossovers in an ERCC1-independent manner. ..