Gene Symbol: SmB
Description: Small ribonucleoprotein particle protein SmB
Alias: CG5352, Dmel\CG5352, SYM10, Sm B, SmB1, dSmB, l(2)SH0509, l(2)SH2 0509, smb, snRNP B, small ribonucleoprotein particle protein SmB, CG5352-PB, SmB-PB, lethal (2) SH0509, polypeptide B, small ribonucleoprotein particle protein B
Species: fruit fly

Top Publications

  1. Deshpande G, Samuels M, Schedl P. Sex-lethal interacts with splicing factors in vitro and in vivo. Mol Cell Biol. 1996;16:5036-47 pubmed
    ..This model helps explain how the Sxl protein is able to promote the sex-specific splicing of Sxl transcripts, utilizing target sequences that are distant from the regulated splice sites. ..
  2. Xiong X, Vogler G, Kurthkoti K, Samsonova A, Zhou R. SmD1 Modulates the miRNA Pathway Independently of Its Pre-mRNA Splicing Function. PLoS Genet. 2015;11:e1005475 pubmed publisher
  3. Natalizio A, Matera A. Identification and characterization of Drosophila Snurportin reveals a role for the import receptor Moleskin/importin-7 in snRNP biogenesis. Mol Biol Cell. 2013;24:2932-42 pubmed publisher
    ..These data indicate that Ketel/importin-? does not play a significant role in Drosophila snRNP import and demonstrate a crucial function for Msk in snRNP biogenesis. ..
  4. Kroiss M, Brünger K, Wiesner J, Grimmler M, Sickmann A, Fischer U. Native purification of protein and RNA-protein complexes using a novel affinity procedure. Fly (Austin). 2009;3:221-8 pubmed
    ..In addition, RNA-peptide hybrid molecules may become a novel tool to purify RNA binding proteins. ..
  5. Paterson T, Beggs J, Finnegan D, Luhrmann R. Polypeptide components of Drosophila small nuclear ribonucleoprotein particles. Nucleic Acids Res. 1991;19:5877-82 pubmed
  6. Cryderman D, Grade S, Li Y, Fanti L, Pimpinelli S, Wallrath L. Role of Drosophila HP1 in euchromatic gene expression. Dev Dyn. 2005;232:767-74 pubmed
    ..Collectively, these data demonstrate multiple mechanisms for HP1 localization within euchromatin and show that some genes associated with HP1 are not affected by alterations in Su(var)3-9 dosage. ..
  7. Raisin Tani S, Leopold P. Drosophila crooked-neck protein co-fractionates in a multiprotein complex with splicing factors. Biochem Biophys Res Commun. 2002;296:288-92 pubmed
    ..Fractionation of nuclear extracts on sucrose gradients revealed Crn in a 900 kDa multiproteic complex together with snRNPs, suggesting that Crn participates in the assembly of the splicing machinery in vivo. ..
  8. Muraro N, Moffat K. Down-regulation of torp4a, encoding the Drosophila homologue of torsinA, results in increased neuronal degeneration. J Neurobiol. 2006;66:1338-53 pubmed
  9. Anne J, Ollo R, Ephrussi A, Mechler B. Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila. Development. 2007;134:137-46 pubmed
    ..Our results thus reveal the role of a PRMT in protein localization in germ cells. ..

More Information


  1. Wu H, Sun L, Wen Y, Liu Y, Yu J, Mao F, et al. Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans. Proc Natl Acad Sci U S A. 2016;113:4134-9 pubmed publisher
  2. Gonsalvez G, Rajendra T, Wen Y, Praveen K, Matera A. Sm proteins specify germ cell fate by facilitating oskar mRNA localization. Development. 2010;137:2341-51 pubmed publisher
    ..We demonstrate that Drosophila SmB and SmD3 are specific components of the oskar messenger ribonucleoprotein (mRNP), proper localization of which is ..
  3. Gonsalvez G, Rajendra T, Tian L, Matera A. The Sm-protein methyltransferase, dart5, is essential for germ-cell specification and maintenance. Curr Biol. 2006;16:1077-89 pubmed
    ..elegans show that Sm proteins are required for germ-granule localization, we propose that Sm protein methylation is a pivotal event in germ-cell development. ..
  4. Boulanger M, Miranda T, Clarke S, Di Fruscio M, Suter B, Lasko P, et al. Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4. Biochem J. 2004;379:283-9 pubmed
    ..The presence of PRMTs in D. melanogaster suggest that flies are a suitable genetic system to study arginine methylation. ..
  5. Labourier E, Rio D. Purification of Drosophila snRNPs and characterization of two populations of functional U1 particles. RNA. 2001;7:457-70 pubmed
  6. Rajendra T, Gonsalvez G, Walker M, Shpargel K, Salz H, Matera A. A Drosophila melanogaster model of spinal muscular atrophy reveals a function for SMN in striated muscle. J Cell Biol. 2007;176:831-41 pubmed
    ..The sarcomeric localization of Smn is conserved in mouse myofibrils. These observations suggest a muscle-specific function for SMN and underline the importance of this tissue in modulating SMA severity. ..
  7. Gonsalvez G, Praveen K, Hicks A, Tian L, Matera A. Sm protein methylation is dispensable for snRNP assembly in Drosophila melanogaster. RNA. 2008;14:878-87 pubmed publisher
    ..protein binds with high affinity to symmetric dimethylarginine (sDMA) residues present on the C-terminal tails of SmB, SmD1, and SmD3. This post-translational modification is thought to play a crucial role in snRNP assembly...
  8. Anne J. Arginine methylation of SmB is required for Drosophila germ cell development. Development. 2010;137:2819-28 pubmed publisher
    ..In this study, a tissue-specific function of arginine methylation of the SmB protein was identified in Drosophila...
  9. Azzouz T, Schumperli D. Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster. RNA. 2003;9:1532-41 pubmed
    ..cells indicate that the Drosophila Lsm10 and Lsm11 orthologs (dLsm10 and dLsm11) associate with each other and with Sm B, but not with Sm D1 and D2...
  10. Xiong X, Kurthkoti K, Chang K, Lichinchi G, De N, Schneemann A, et al. Core small nuclear ribonucleoprotein particle splicing factor SmD1 modulates RNA interference in Drosophila. Proc Natl Acad Sci U S A. 2013;110:16520-5 pubmed publisher
  11. Shulman J, Imboywa S, Giagtzoglou N, Powers M, Hu Y, Devenport D, et al. Functional screening in Drosophila identifies Alzheimer's disease susceptibility genes and implicates Tau-mediated mechanisms. Hum Mol Genet. 2014;23:870-7 pubmed publisher
    ..Our results highlight cell adhesion pathways as important in Tau toxicity and AD susceptibility and demonstrate the power of model organism genetic screens for the functional follow-up of human GWAS. ..
  12. Brunet C, Quan T, Craft J. Comparison of the Drosophila melanogaster, human and murine Sm B cDNAs: evolutionary conservation. Gene. 1993;124:269-73 pubmed
    To analyze the evolutionary stability of the Sm B polypeptides, the cDNA nucleotide (nt) sequence was derived for the Drosophila melanogaster Sm B polypeptide and compared to the cDNAs encoding human and murine Sm B...