Gene Symbol: slo
Description: slowpoke
Alias: BcDNA:GH10751, CG10693, Dmel\CG10693, Dslo, Slo, Slo1, dSlo, dSlo1, dslo, fSlo, slowpoke, CG10693-PA, CG10693-PB, CG10693-PC, CG10693-PD, CG10693-PE, CG10693-PF, CG10693-PH, CG10693-PI, CG10693-PJ, CG10693-PK, CG10693-PL, CG10693-PM, CG10693-PN, CG10693-PO, CG10693-PP, CG10693-PQ, CG10693-PR, CG10693-PS, CG10693-PT, CG10693-PU, CG10693-PV, CG10693-PW, CG10693-PX, slo-PA, slo-PB, slo-PC, slo-PD, slo-PE, slo-PF, slo-PH, slo-PI, slo-PJ, slo-PK, slo-PL, slo-PM, slo-PN, slo-PO, slo-PP, slo-PQ, slo-PR, slo-PS, slo-PT, slo-PU, slo-PV, slo-PW, slo-PX
Species: fruit fly
Products:     slo

Top Publications

  1. Esguerra M, Wang J, Foster C, Adelman J, North R, Levitan I. Cloned Ca(2+)-dependent K+ channel modulated by a functionally associated protein kinase. Nature. 1994;369:563-5 pubmed
    ..The recent cloning of complementary DNAs encoding Slo KCa channels has enabled KCa channel modulation to be investigated...
  2. Warbington L, Hillman T, Adams C, Stern M. Reduced transmitter release conferred by mutations in the slowpoke-encoded Ca2(+)-activated K+ channel gene of Drosophila. Invert Neurosci. 1996;2:51-60 pubmed
    ..Here we describe the effects of mutations in the slowpoke gene, which is the structural gene for a calcium activated potassium channel, on transmitter release at the ..
  3. Schopperle W, Holmqvist M, Zhou Y, Wang J, Wang Z, Griffith L, et al. Slob, a novel protein that interacts with the Slowpoke calcium-dependent potassium channel. Neuron. 1998;20:565-73 pubmed
    Slob, a novel protein that binds to the carboxy-terminal domain of the Drosophila Slowpoke (dSlo) calcium-dependent potassium channel, was identified with a yeast two-hybrid screen...
  4. Atkinson N, Brenner R, Bohm R, Yu J, Wilbur J. Behavioral and electrophysiological analysis of Ca-activated K-channel transgenes in Drosophila. Ann N Y Acad Sci. 1998;860:296-305 pubmed
    The slowpoke gene of Drosophila melanogaster encodes a Ca-activated K channel. This gene is expressed in neurons, muscles, tracheal cells, and the copper and iron cells of the midgut...
  5. Adelman J, Shen K, Kavanaugh M, Warren R, Wu Y, Lagrutta A, et al. Calcium-activated potassium channels expressed from cloned complementary DNAs. Neuron. 1992;9:209-16 pubmed
    ..were expressed in Xenopus oocytes by injection of RNA transcribed in vitro from complementary DNAs derived from the slo locus of Drosophila melanogaster. Many cDNAs were found that encode closely related proteins of about 1200 aa...
  6. Peng I, Wu C. Drosophila cacophony channels: a major mediator of neuronal Ca2+ currents and a trigger for K+ channel homeostatic regulation. J Neurosci. 2007;27:1072-81 pubmed
    ..However, Ca2+ current expression levels remained unaltered in several K+ channel mutants, illustrating a key role of cac in developmental regulation of Drosophila neuronal excitability. ..
  7. Engel J, Wu C. Genetic dissection of functional contributions of specific potassium channel subunits in habituation of an escape circuit in Drosophila. J Neurosci. 1998;18:2254-67 pubmed
    ..Our results show that mutations altering each of four K+ channel subunits (Sh, slo, eag, and Hk) have distinct effects on habituation at least as strong as those of dunce and rutabaga, memory ..
  8. Peixoto A, Hall J. Analysis of temperature-sensitive mutants reveals new genes involved in the courtship song of Drosophila. Genetics. 1998;148:827-38 pubmed
    ..Analysis of the courtship song of some TS physiological mutants showed that slowpoke mutations, which affect a calcium-activated potassium channel, cause severe song abnormalities...
  9. Guan Z, Saraswati S, Adolfsen B, Littleton J. Genome-wide transcriptional changes associated with enhanced activity in the Drosophila nervous system. Neuron. 2005;48:91-107 pubmed
    ..These data identify a collection of activity-regulated transcripts that may link changes in neuronal firing patterns to transcription-dependent modulation of brain function, including activity-dependent synaptic rewiring. ..

More Information


  1. Elkins T, Ganetzky B. The roles of potassium currents in Drosophila flight muscles. J Neurosci. 1988;8:428-34 pubmed
    ..In contrast, when IC was specifically eliminated with the slowpoke (slo) mutation, there was no delay before excitation, the amplitude of the spikes was significantly increased, ..
  2. Singh S, Wu C. Properties of potassium currents and their role in membrane excitability in Drosophila larval muscle fibers. J Exp Biol. 1990;152:59-76 pubmed
    ..The Shaker (Sh) and the slowpoke (slo) mutations, respectively, eliminate the voltage-activated fast K+ current (IA) and the Ca2(+)-activated fast ..
  3. Lee J, Ueda A, Wu C. Pre- and post-synaptic mechanisms of synaptic strength homeostasis revealed by slowpoke and shaker K+ channel mutations in Drosophila. Neuroscience. 2008;154:1283-96 pubmed publisher
    ..synaptic strength and D-V differentials at physiological Ca(2+) levels were not significantly altered in slowpoke (slo) and Shaker (Sh) mutants, despite their defects in two major repolarizing forces, Ca(2+)-activated Slo (BK) ..
  4. Jaramillo A, Zeng H, Fei H, Zhou Y, Levitan I. Expression and function of variants of slob, slowpoke channel binding protein, in Drosophila. J Neurophysiol. 2006;95:1957-65 pubmed
    Slob binds to and modulates the Drosophila Slowpoke (dSlo) calcium-activated potassium channel and also recruits the ubiquitous signaling protein 14-3-3 to the channel regulatory complex...
  5. Atkinson N, Robertson G, Ganetzky B. A component of calcium-activated potassium channels encoded by the Drosophila slo locus. Science. 1991;253:551-5 pubmed
    ..The Drosophila slowpoke (slo) locus, mutations of which specifically abolish a Ca(2+)-activated K+ current in muscles and neurons, ..
  6. Jaramillo A, Zheng X, Zhou Y, Amado D, Sheldon A, Sehgal A, et al. Pattern of distribution and cycling of SLOB, Slowpoke channel binding protein, in Drosophila. BMC Neurosci. 2004;5:3 pubmed
    SLOB binds to and modulates the activity of the Drosophila Slowpoke (dSlo) calcium activated potassium channel. Recent microarray analyses demonstrated circadian cycling of slob mRNA...
  7. Gho M, Ganetzky B. Analysis of repolarization of presynaptic motor terminals in Drosophila larvae using potassium-channel-blocking drugs and mutations. J Exp Biol. 1992;170:93-111 pubmed
    ..One is affected by aminopyridines or Sh mutations, a second component is affected by the slo mutation, a third is sensitive to quinidine and one or more additional components are blocked by tetraethylammonium...
  8. DiChiara T, Reinhart P. Distinct effects of Ca2+ and voltage on the activation and deactivation of cloned Ca(2+)-activated K+ channels. J Physiol. 1995;489 ( Pt 2):403-18 pubmed
    1. Cloned large-conductance Ca(2+)-activated K+ channels from Drosophila (dslo) and human (hslo) were expressed in Xenopus oocytes...
  9. Kuebler D, Zhang H, Ren X, Tanouye M. Genetic suppression of seizure susceptibility in Drosophila. J Neurophysiol. 2001;86:1211-25 pubmed
    ..These results demonstrate the utility of Drosophila as a model system for studying seizure susceptibility and identify physiological processes that modify seizure susceptibility...
  10. Bohm R, Wang B, Brenner R, Atkinson N. Transcriptional control of Ca(2+)-activated K(+) channel expression: identification of a second, evolutionarily conserved, neuronal promoter. J Exp Biol. 2000;203:693-704 pubmed
    ..The Drosophila slowpoke gene encodes a Ca(2+)-activated K(+) channel used throughout the nervous system...
  11. Fernández M, Chu J, Villella A, Atkinson N, Kay S, Ceriani M. Impaired clock output by altered connectivity in the circadian network. Proc Natl Acad Sci U S A. 2007;104:5650-5 pubmed
    ..taken advantage of flies exhibiting a distinctive arrhythmic phenotype due to mutation of the potassium channel slowpoke (slo) to examine the relevance of specific neuronal populations involved in the circadian control of behavior...
  12. Ghezzi A, Pohl J, Wang Y, Atkinson N. BK channels play a counter-adaptive role in drug tolerance and dependence. Proc Natl Acad Sci U S A. 2010;107:16360-5 pubmed publisher
    ..The Drosophila slo gene encodes a BK-type Ca(2+)-activated K(+) channel implicated in functional tolerance to alcohol and volatile ..
  13. Panda S, Hogenesch J, Kay S. Circadian rhythms from flies to human. Nature. 2002;417:329-35 pubmed
    ..To gain the initial insights into circadian mechanisms, researchers turned to genetically tractable model organisms such as Drosophila. ..
  14. Elkins T, Ganetzky B, Wu C. A Drosophila mutation that eliminates a calcium-dependent potassium current. Proc Natl Acad Sci U S A. 1986;83:8415-9 pubmed
    A mutation of Drosophila, slowpoke (slo), specifically abolishes a Ca2+-dependent K+ current, IC, from dorsal longitudinal flight muscles of adult flies...
  15. Cowmeadow R, Krishnan H, Atkinson N. The slowpoke gene is necessary for rapid ethanol tolerance in Drosophila. Alcohol Clin Exp Res. 2005;29:1777-86 pubmed
    ..Recently, the slowpoke BK-type calcium-activated potassium channel gene has been shown to be involved in ethanol sensitivity in ..
  16. Derst C, Messutat S, Walther C, Eckert M, Heinemann S, Wicher D. The large conductance Ca2+-activated potassium channel (pSlo) of the cockroach Periplaneta americana: structure, localization in neurons and electrophysiology. Eur J Neurosci. 2003;17:1197-212 pubmed
    ..The amino acid sequence of pSlo shows 88% identity to dSlo from Drosophila...
  17. Zhou Y, Wang J, Wen H, Kucherovsky O, Levitan I. Modulation of Drosophila slowpoke calcium-dependent potassium channel activity by bound protein kinase a catalytic subunit. J Neurosci. 2002;22:3855-63 pubmed
    Drosophila Slowpoke (dSlo) calcium-dependent potassium channels bind directly to the catalytic subunit of cAMP-dependent protein kinase (PKAc)...
  18. Kwon Y, Kim S, Ronderos D, Lee Y, Akitake B, Woodward O, et al. Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. Curr Biol. 2010;20:1672-8 pubmed publisher
    ..Absence of the Ca(2+)-activated K(+) channel (BK channel) Slowpoke results in a similar impairment in citronellal avoidance and an increase in the frequency of action potentials...
  19. Hoopengardner B, Bhalla T, Staber C, Reenan R. Nervous system targets of RNA editing identified by comparative genomics. Science. 2003;301:832-6 pubmed
    ..These results point to a pivotal role for RNA editing in nervous system function. ..
  20. Shahidullah M, Reddy S, Fei H, Levitan I. In vivo role of a potassium channel-binding protein in regulating neuronal excitability and behavior. J Neurosci. 2009;29:13328-37 pubmed publisher
    ..The Drosophila large-conductance calcium-activated potassium channel (dSlo) binds to and is modulated by its binding partner Slob...
  21. Zhou Y, Schopperle W, Murrey H, Jaramillo A, Dagan D, Griffith L, et al. A dynamically regulated 14-3-3, Slob, and Slowpoke potassium channel complex in Drosophila presynaptic nerve terminals. Neuron. 1999;22:809-18 pubmed
    Slob is a novel protein that binds to the carboxy-terminal domain of the Drosophila Slowpoke (dSlo) calcium-dependent potassium (K(Ca)) channel...
  22. Ma H, Zhang J, Levitan I. Slob, a Slowpoke channel-binding protein, modulates synaptic transmission. J Gen Physiol. 2011;137:225-38 pubmed publisher
    ..b>Slowpoke (Slo), a potassium channel critical for action potential repolarization and transmitter release, is regulated by ..
  23. Ghezzi A, Al Hasan Y, Larios L, Bohm R, Atkinson N. slo K(+) channel gene regulation mediates rapid drug tolerance. Proc Natl Acad Sci U S A. 2004;101:17276-81 pubmed
    ..In Drosophila, a single sedation with the anesthetic benzyl alcohol changes the expression of the slo K(+) channel gene and induces rapid drug tolerance...
  24. Bian S, Favre I, Moczydlowski E. Ca2+-binding activity of a COOH-terminal fragment of the Drosophila BK channel involved in Ca2+-dependent activation. Proc Natl Acad Sci U S A. 2001;98:4776-81 pubmed
    ..To pursue this question, we overexpressed the COOH-terminal 280 residues of the Drosophila slowpoke BK channel (Dslo-C280) as a FLAG- and His(6)-tagged protein in Escherichia coli...
  25. Adamson A, Shearn A. Molecular genetic analysis of Drosophila ash2, a member of the trithorax group required for imaginal disc pattern formation. Genetics. 1996;144:621-33 pubmed
    ..The ash2 gene is located in cytogenetic region 96A17-19 flanked by slowpoke and tolloid and is included in a cosmid that contains part of slowpoke. The ash2 transcript is 2...
  26. Chang W, Bohm R, Strauss J, Kwan T, Thomas T, Cowmeadow R, et al. Muscle-specific transcriptional regulation of the slowpoke Ca(2+)-activated K(+) channel gene. J Biol Chem. 2000;275:3991-8 pubmed
    Transcriptional regulation of the Drosophila slowpoke calcium-activated potassium channel gene is complex...
  27. Atkinson N, Brenner R, Chang W, Wilbur J, Larimer J, Yu J. Molecular separation of two behavioral phenotypes by a mutation affecting the promoters of a Ca-activated K channel. J Neurosci. 2000;20:2988-93 pubmed
    The Drosophila slowpoke gene encodes a BK-type calcium-activated potassium channel. Null mutations in slowpoke perturb the signaling properties of neurons and muscles and cause behavioral defects...
  28. Brenner R, Yu J, Srinivasan K, Brewer L, Larimer J, Wilbur J, et al. Complementation of physiological and behavioral defects by a slowpoke Ca(2+) -activated K(+) channel transgene. J Neurochem. 2000;75:1310-9 pubmed
    The Drosophila slowpoke gene encodes a large conductance calcium-activated potassium channel used in neurons, muscle, and some epithelial cells...
  29. Xia X, Hirschberg B, Smolik S, Forte M, Adelman J. dSLo interacting protein 1, a novel protein that interacts with large-conductance calcium-activated potassium channels. J Neurosci. 1998;18:2360-9 pubmed
    ..a modified two-hybrid approach, the interaction trap, we have identified a novel protein from Drosophila, dSLIP1 (dSLo interacting protein), which specifically interacts with Drosophila and human BK channels and has partial homology ..
  30. Becker M, Brenner R, Atkinson N. Tissue-specific expression of a Drosophila calcium-activated potassium channel. J Neurosci. 1995;15:6250-9 pubmed
    The Drosophila slowpoke (slo) gene encodes a subunit of a CAK channel homologous to the vertebrate BK channel. We have examined slo expression throughout development...
  31. Brenner R, Thomas T, Becker M, Atkinson N. Tissue-specific expression of a Ca(2+)-activated K+ channel is controlled by multiple upstream regulatory elements. J Neurosci. 1996;16:1827-35 pubmed
    ..To understand how ion-channel gene expression is regulated, we are studying the tissue-specific regulation of the slowpoke (slo) Ca(2+)-activated K+ channel gene...
  32. Crocker A, Shahidullah M, Levitan I, Sehgal A. Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior. Neuron. 2010;65:670-81 pubmed publisher
    ..These studies define the cellular and molecular basis of octopamine action and suggest that the PI is a sleep:wake-regulating neuroendocrine structure like the mammalian hypothalamus. ..
  33. Saito M, Wu C. Expression of ion channels and mutational effects in giant Drosophila neurons differentiated from cell division-arrested embryonic neuroblasts. J Neurosci. 1991;11:2135-50 pubmed
    ..Neurons from the mutant slowpoke (slo), which is known to lack a component of the Ca(2+)-activated K+ currents in muscles, exhibited prolonged ..
  34. Wang J, Zhou Y, Wen H, Levitan I. Simultaneous binding of two protein kinases to a calcium-dependent potassium channel. J Neurosci. 1999;19:RC4 pubmed that endogenous protein kinase activity coimmunoprecipitates with both native and recombinant Drosophila Slowpoke (dSlo) calcium-dependent potassium channels...
  35. Zeng H, Weiger T, Fei H, Jaramillo A, Levitan I. The amino terminus of Slob, Slowpoke channel binding protein, critically influences its modulation of the channel. J Gen Physiol. 2005;125:631-40 pubmed
    The Drosophila Slowpoke calcium-dependent potassium channel (dSlo) binding protein Slob was discovered by a yeast two-hybrid screen using the carboxy-terminal tail region of dSlo as bait. Slob binds to and modulates the dSlo channel...
  36. Lee J, Wu C. Orchestration of stepwise synaptic growth by K+ and Ca2+ channels in Drosophila. J Neurosci. 2010;30:15821-33 pubmed publisher
    ..We found striking synaptic overgrowth caused by Drosophila K(+)-channel mutations of the seizure and slowpoke genes, encoding Erg and Ca(2+)-activated large-conductance (BK) channels, respectively...
  37. Wang Y, Krishnan H, Ghezzi A, Yin J, Atkinson N. Drug-induced epigenetic changes produce drug tolerance. PLoS Biol. 2007;5:e265 pubmed
    ..The slo gene encodes the pore-forming subunit of BK-type Ca(2+)-activated K(+) channels, which regulate many aspects of ..
  38. Martínez Padrón M, Ferrus A. Presynaptic recordings from Drosophila: correlation of macroscopic and single-channel K+ currents. J Neurosci. 1997;17:3412-24 pubmed
    ..KL (44-54 pS) channels produced a noninactivating ensemble average and may contribute to the delayed macroscopic current observed. ..
  39. Cobb M. Genotypic and phenotypic characterization of the Drosophila melanogaster olfactory mutation Indifferent. Genetics. 1996;144:1577-87 pubmed
    ..The overall responses of IndfA, IndfB and the deficiencies indicate that Indf is involved in processing organic odors of between eight and 10 carbons in length. ..
  40. Brenner R, Atkinson N. Developmental- and eye-specific transcriptional control elements in an intronic region of a Ca(2+)-activated K+ channel gene. Dev Biol. 1996;177:536-43 pubmed
    ..The Drosophila slowpoke Ca(2+)-activated K+ channel gene has four distinct promoters...
  41. Moss B, Silberberg S, Nimigean C, Magleby K. Ca2+-dependent gating mechanisms for dSlo, a large-conductance Ca2+-activated K+ (BK) channel. Biophys J. 1999;76:3099-117 pubmed
    The Ca2+-dependent gating mechanism of cloned BK channels from Drosophila (dSlo) was studied...
  42. Sheldon A, Zhang J, Fei H, Levitan I. SLOB, a SLOWPOKE channel binding protein, regulates insulin pathway signaling and metabolism in Drosophila. PLoS ONE. 2011;6:e23343 pubmed publisher
    ..The Drosophila melanogaster large conductance calcium-activated potassium channel SLOWPOKE (SLO) undergoes modulation via its binding partner SLO-binding protein (SLOB)...
  43. Sandstrom D. Extracellular protons reduce quantal content and prolong synaptic currents at the Drosophila larval neuromuscular junction. J Neurogenet. 2011;25:104-14 pubmed publisher
    ..pH was not altered by mutations in genes encoding Transient Receptor Potential, Mucolipin subfamily (TRPML) and Slowpoke ion channels, which had previously been implicated as possible targets of extracellular protons...
  44. Kraliz D, Singh S. Selective blockade of the delayed rectifier potassium current by tacrine in Drosophila. J Neurobiol. 1997;32:1-10 pubmed
  45. Copley R. Evolutionary convergence of alternative splicing in ion channels. Trends Genet. 2004;20:171-6 pubmed
    ..The result has important implications for the analysis of regulation of alternative splicing using comparative genomics and our understanding of molecular evolution. ..
  46. Gertner D, Desai S, Lnenicka G. Synaptic excitation is regulated by the postsynaptic dSK channel at the Drosophila larval NMJ. J Neurophysiol. 2014;111:2533-43 pubmed publisher
    ..It is proposed that spontaneous and evoked transmitter release activate the postsynaptic dSK channel to limit synaptic excitation and stabilize synapses. ..
  47. Yang M, Lee J, Padgett R, Edery I. Circadian regulation of a limited set of conserved microRNAs in Drosophila. BMC Genomics. 2008;9:83 pubmed publisher
    ..Intriguingly, the mature forms of dme-miR-263a and -263b are very similar in sequence to several miRNAs recently shown to be under circadian regulation in the mouse retina, suggesting conserved functions. ..
  48. Komatsu A, Singh S, Rathe P, Wu C. Mutational and gene dosage analysis of calcium-activated potassium channels in Drosophila: correlation of micro- and macroscopic currents. Neuron. 1990;4:313-21 pubmed
    ..The slowpoke (slo) mutation eliminates ICF specifically...
  49. Ford K, Davis G. Archaerhodopsin voltage imaging: synaptic calcium and BK channels stabilize action potential repolarization at the Drosophila neuromuscular junction. J Neurosci. 2014;34:14517-25 pubmed publisher
    ..Here we demonstrate that this effect is caused by a concomitant loss of both Shaker and slowpoke (slo) channel activity because of the low extracellular calcium concentrations (0.2-0...
  50. Yu J, Upadhyaya A, Atkinson N. Tissue-specific alternative splicing of BK channel transcripts in Drosophila. Genes Brain Behav. 2006;5:329-39 pubmed
    ..In both Drosophila and mammals, BK channels are encoded by the slowpoke gene...
  51. McKiernan E. Effects of manipulating slowpoke calcium-dependent potassium channel expression on rhythmic locomotor activity in Drosophila larvae. Peerj. 2013;1:e57 pubmed publisher
    ..Mutations in slowpoke (slo) genes encoding BK channels result in motor disturbances...
  52. Tolar L, Pallanck L. NSF function in neurotransmitter release involves rearrangement of the SNARE complex downstream of synaptic vesicle docking. J Neurosci. 1998;18:10250-6 pubmed
  53. Babcock D, Ganetzky B. An improved method for accurate and rapid measurement of flight performance in Drosophila. J Vis Exp. 2014;:e51223 pubmed publisher
    ..These improvements allow for the rapid, quantitative assessment of flight behavior, useful for large datasets and large-scale genetic screens. ..
  54. Xu X, Chien F, Butler A, Salkoff L, Montell C. TRPgamma, a drosophila TRP-related subunit, forms a regulated cation channel with TRPL. Neuron. 2000;26:647-57 pubmed
    ..While TRPL and TRPgamma homomultimers are constitutively active, we demonstrate that TRPL-TRPgamma heteromultimers form a regulated phospholipase C- (PLC-) stimulated channel. ..
  55. Ghezzi A, Atkinson N. Homeostatic control of neural activity: a Drosophila model for drug tolerance and dependence. Int Rev Neurobiol. 2011;99:23-50 pubmed publisher
    ..Here we review the role of the BK channel gene (slo) and genes that encode other synaptic proteins in the process of producing functional tolerance...
  56. Overend G, Luo Y, Henderson L, Douglas A, Davies S, Dow J. Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Sci Rep. 2016;6:27242 pubmed publisher
    ..These results demonstrate that the acidic gut region protects the insect and gut microbiome from pathological disruption, and shed light on the mechanisms by which low pH can be maintained in the absence of H(+), K(+) ATPase. ..
  57. Broadie K, Bate M. Development of larval muscle properties in the embryonic myotubes of Drosophila melanogaster. J Neurosci. 1993;13:167-80 pubmed embryogenesis (late stage 17), the calcium-dependent, outward potassium currents [rapid, inactivating (ICF; slowpoke) then delayed, noninactivating (ICS)] develop, completing the complement of macroscopic currents in the mature ..
  58. Waddell S, Quinn W. What can we teach Drosophila? What can they teach us?. Trends Genet. 2001;17:719-26 pubmed
  59. Moss G, Marshall J, Morabito M, Howe J, Moczydlowski E. An evolutionarily conserved binding site for serine proteinase inhibitors in large conductance calcium-activated potassium channels. Biochemistry. 1996;35:16024-35 pubmed
    ..This cloned mammalian KCa channel (Bslo) and its homolog from Drosophila (Dslo) were expressed in the HEK293 human embryonic kidney cell line...
  60. Crisford A, Ebbinghaus Kintscher U, Schoenhense E, Harder A, Raming K, O Kelly I, et al. The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits. PLoS Negl Trop Dis. 2015;9:e0004062 pubmed publisher a selective activation of the nematode isoform of an evolutionary conserved Ca2+-activated K+ channel, SLO-1...
  61. Lee U, Shi J, Cui J. Modulation of BK channel gating by the ß2 subunit involves both membrane-spanning and cytoplasmic domains of Slo1. J Neurosci. 2010;30:16170-9 pubmed publisher
    ..BK channels are composed of four Slo1 subunits, which contain the voltage-sensing and pore-gate domains in the membrane and Ca(2+) binding sites in the ..
  62. Xu T, Gong N, Xu T. Divalent cation modulation of a-type potassium channels in acutely dissociated central neurons from wide-type and mutant Drosophila. J Neurogenet. 2005;19:87-107 pubmed
    ..The same results were obtained in Ca(2+)-free external solution, and from slo1 mutation, which eliminates transient Ca(2+)-activated K+ current...
  63. Sattelle D, Jones A, Sattelle B, Matsuda K, Reenan R, Biggin P. Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster. Bioessays. 2005;27:366-76 pubmed
    ..We present here three-dimensional models constructed for insect nAChRs, which show that many variations introduced by alternative splicing and RNA editing may influence receptor function. ..
  64. Fogle K, Baik L, Houl J, Tran T, Roberts L, Dahm N, et al. CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel β-subunit redox sensor. Proc Natl Acad Sci U S A. 2015;112:2245-50 pubmed publisher
    ..Light activation of CRY is transduced to membrane depolarization, increased firing rate, and acute behavioral responses by the Kvβ subunit redox sensor. ..
  65. Meera P, Wallner M, Song M, Toro L. Large conductance voltage- and calcium-dependent K+ channel, a distinct member of voltage-dependent ion channels with seven N-terminal transmembrane segments (S0-S6), an extracellular N terminus, and an intracellular (S9-S10) C terminus. Proc Natl Acad Sci U S A. 1997;94:14066-71 pubmed
    ..Further, our results indicate that hydrophobic segments S9-S10 in the C terminus are cytoplasmic and unequivocally demonstrate that S0 forms an additional transmembrane segment leading to an exoplasmic N terminus. ..
  66. Zeng H, Weiger T, Fei H, Levitan I. Mechanisms of two modulatory actions of the channel-binding protein Slob on the Drosophila Slowpoke calcium-dependent potassium channel. J Gen Physiol. 2006;128:583-91 pubmed
    Slob57 is an ion channel auxiliary protein that binds to and modulates the Drosophila Slowpoke calcium-dependent potassium channel (dSlo)...
  67. Richmond J, Broadie K. The synaptic vesicle cycle: exocytosis and endocytosis in Drosophila and C. elegans. Curr Opin Neurobiol. 2002;12:499-507 pubmed
    ..In neuromodulation, dcaps mutants provide the first genetic insight into possible roles of the CAPS protein in mediating dense core vesicle fusion and modulating synaptic vesicle fusion. ..